Abstract：
:Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. This kind of treatment is safe and cheap, and contrary to classic laser photocoagulation, it leaves the retinal cells intact. A modern theory of micropulse laser interaction with retinal tissue and a possible explanation of this mechanism are presented in this review. The authors present all the relevant literature on the application of micropulse lasers in different retinal disorders. The efficacy of this treatment is analyzed on the basis of available studies and then placed in the perspective of other therapeutic methods that are used in retinal diseases.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Gawęcki Mdoi
10.3390/jcm8020242subject
Has Abstractpub_date
2019-02-13 00:00:00issue
2issn
2077-0383pii
jcm8020242journal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010035
更新日期：2020-12-24 00:00:00
abstract：:An increasing number of studies implicates the NF-κB (Nuclear Factor of kappa light chain gene enhancer in B cells) alternative pathway in non-small-cell lung cancer (NSCLC). We assessed the clinical significance of CD40 (Tumor necrosis factor receptor superfamily member 5, TNFRSF5), BAFFR (B-cell activating factor re...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050741
更新日期：2019-05-24 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092762
更新日期：2020-08-26 00:00:00
abstract：:Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111895
更新日期：2019-11-06 00:00:00
abstract：BACKGROUND:Patients with diabetic kidney disease (DKD) are at higher risk of hypoglycemia than diabetic patients without DKD. We aimed to investigate the temporal trends of severe hypoglycemia in advanced DKD patients transitioning to dialysis and examine risk factors associated with severe hypoglycemia. We also invest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040420
更新日期：2019-03-27 00:00:00
abstract：BACKGROUND:Sarcopenia is a prevalent muscle abnormality characterized by progressive and generalized loss of skeletal muscle mass and strength, common among patients with decompensated advanced chronic liver disease (dACLD). Irisin is a recently identified myokine, which is mainly expressed and secreted by skeletal mus...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103158
更新日期：2020-09-29 00:00:00
abstract：:In the United States, one out of every 500 African American children have sickle cell disease (SCD), and SCD affects approximately 100,000 Americans. Significant advances in the treatment of this monogenetic disorder have failed to substantially extend the life expectancy of adults with SCD over the past two decades. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111997
更新日期：2019-11-15 00:00:00
abstract：:Pulmonary hypertension (PH) in patients with heart failure (HF) contributes to a poorer prognosis. However, in those with dilated cardiomyopathy (DCM), the true prevalence and role of PH is unclear. Therefore, this study aimed to analyze the profile of DCM patients at various levels of PH risk, determined via echocard...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061660
更新日期：2020-06-01 00:00:00
abstract：:After normal survival has been achieved in most patients with chronic myeloid leukemia (CML), a new goal for treating CML is survival at good quality of life, with treatment discontinuation in sustained deep molecular response (DMR; MR4 or deeper) and treatment-free remission (TFR). Four tyrosine kinase inhibitors (TK...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113671
更新日期：2020-11-16 00:00:00
abstract：:Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030767
更新日期：2020-03-12 00:00:00
abstract：:Studies have reported controversial findings on the association between fetal growth restriction (FGR) or intertwin weight discordance and the risk of hypertensive disorders of pregnancy (HDP) in twin pregnancies. The aim of this study was to investigate the association between twin growth disorders and HDP. Twin preg...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103276
更新日期：2020-10-13 00:00:00
abstract：:Differentiation syndrome (DS) is a potentially fatal adverse drug reaction caused by the so-called differentiating agents such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), used for remission induction in the treatment of the M3 subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103342
更新日期：2020-10-18 00:00:00
abstract：:Purpose: This study aimed to evaluate the effects of a child-centered exergaming program and a traditional teacher-led physical activity (PA) program on preschoolers' executive functions and perceived competence. Methods: Sixty children aged 4⁻5 years from an urban childcare center in China completed an 8-week exergam...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040469
更新日期：2019-04-06 00:00:00
abstract：BACKGROUND:Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality. Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense. Altered salivary sialoglycoprotein carbohy...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061747
更新日期：2020-06-05 00:00:00
abstract：:ST-elevation myocardial infarction (STEMI) is one of the main reasons for morbidity and mortality worldwide. In addition to the classic biomarker NT-proBNP, new biomarkers like ST2 and Pentraxin-3 (Ptx-3) have emerged as potential tools in stratifying risk in cardiac patients. Indeed, multimarker approaches to estimat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020550
更新日期：2020-02-18 00:00:00
abstract：:: Protein-bound uremic toxin is a cardiovascular (CV) risk factor for patients with end-stage renal disease. Indole-3-acetic acid (IAA) was found to be associated with CV disease but the detailed pathophysiology remains unknown. Moreover, mitogen-activated protein kinase (MAPK) signaling cascades play an important rol...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010124
更新日期：2020-01-02 00:00:00
abstract：:This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050630
更新日期：2019-05-08 00:00:00
abstract：:Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately predict the risk of cancer progression. The pluripotency transcription ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101744
更新日期：2019-10-21 00:00:00
abstract：:Neuroendocrine breast cancer (NEBC) is a rare histotype of breast carcinoma that presents, in most cases, positive hormone receptors and negative HER2. Indeed, the analysis of gene expression profiles revealed that NEBC belongs mainly to the luminal subtype. Cases of HER2-positive and triple-negative NEBC are rare. Th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051452
更新日期：2020-05-13 00:00:00
abstract：:Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081102
更新日期：2019-07-25 00:00:00
abstract：:Haemoglobinopathies are common monogenic disorders with diverse clinical manifestations, partly attributed to the influence of modifier genes. Recent years have seen enormous growth in the amount of genetic data, instigating the need for ranking methods to identify candidate genes with strong modifying effects. Here, ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111927
更新日期：2019-11-09 00:00:00
abstract：:Histological evaluation of renal biopsies is currently the gold standard for acquiring important diagnostic and prognostic information in diabetic nephropathy (DN) patients. Nevertheless, there is an unmet clinical need for new biomarkers that allow earlier diagnosis and risk stratification. As biochemical changes in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071022
更新日期：2019-07-12 00:00:00
abstract：:The new allocation criteria classify patients on veno-arterial extracorporeal membranous oxygenation (VA-ECMO) as the highest priority for receiving orthotopic heart transplantation (OHT) especially if they are considered not candidates for ventricular assist devices. The outcomes of patients who receive ventricular a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050572
更新日期：2019-04-26 00:00:00
abstract：:We investigated the prognostic influence of androgen receptor (AR) on breast cancer. AR status was assessed using immunohistochemistry with tissue microarrays from 395 operable primary breast cancer patients who received curative surgery. The Kaplan-Meier estimator was used to analyze the survival rates and a log-rank...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041083
更新日期：2020-04-10 00:00:00
abstract：:The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061718
更新日期：2020-06-03 00:00:00
abstract：:Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their im...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4051156
更新日期：2015-05-21 00:00:00
abstract：:Active vision therapy using perceptual learning and/or dichoptic or binocular environments has shown its potential effectiveness in amblyopia, but some doubts remain about the type of stimuli and the mode and sequence of presentation that should be used. A search was performed in PubMed, obtaining 143 articles with in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9123985
更新日期：2020-12-09 00:00:00
abstract：:Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate collectively commonly as small clusters. Such collectively migrating cancer...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050725
更新日期：2019-05-22 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that support...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6060060
更新日期：2017-06-09 00:00:00
abstract：:In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non-hematopoietic tissues including the nervous system. Epo protects cells from apoptosis, reduces inflammatory responses and supports re-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7020024
更新日期：2018-02-02 00:00:00
