Abstract：
:Tumor recurrence is now the leading cause of breast cancer-related death. These recurrences are believed to arise from residual cancer stem cells that survive initial therapeutic intervention. Therefore, a comprehensive understanding of cancer stem cell biology is needed to generate more effective therapies. Here we investigate the association between dysregulation of lipid metabolism and breast cancer stem cells. Focusing specifically on lipid droplets, we found that the lipid droplet number correlates with stemness in a panel of breast cell lines. Using a flow cytometry-based method developed for this study, we establish a means to isolate cells with augmented lipid droplet loads from total populations and show that they are enriched in cancer stem cells. Furthermore, pharmacological targeting of fatty acid metabolism reveals a metabolic addiction in a subset of cell lines. Our results highlight a key role for the lipid metabolism in the maintenance of the breast cancer stem cell pool, and as such, suggest it as a potential therapeutic target.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Hershey BJ,Vazzana R,Joppi DL,Havas KMdoi
10.3390/jcm9010087subject
Has Abstractpub_date
2019-12-29 00:00:00issue
1issn
2077-0383pii
jcm9010087journal_volume
9pub_type
杂志文章abstract：:The repair of bone defects caused by trauma, infection or tumor resection is a major clinical orthopedic challenge. The application of bone grafts in orthopedic procedures is associated with a problem of inadequate vascularization in the initial phase after implantation. Meanwhile, the survival of cells within the imp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2019-10-03 00:00:00
abstract：BACKGROUND:Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. METHODS:A 1:2 retrospective case-control study...
journal_title：Journal of clinical medicine
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更新日期：2020-06-11 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Journal of clinical medicine
pub_type： 已发布勘误
doi：10.3390/jcm8030389
更新日期：2019-03-20 00:00:00
abstract：:To investigate the clinicopathological features and treatment outcomes in patients with stage I, high-risk endometrial cancer. Patients with International Federation of Gynecology and Obstetrics stage I, papillary serous, clear cell, or grade 3 endometrioid carcinoma treated between 2000 and 2012 were analyzed for the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090254
更新日期：2018-09-04 00:00:00
abstract：:The exact roles of adipokines in the pathogenesis of type 2 diabetes and obesity are still unclear. The aim of the study was to evaluate fatty acid binding protein 4 (FABP4) concentrations in the serum and urine of women with excessive gestational weight gain (EGWG) and gestational diabetes mellitus (GDM) in the early...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120505
更新日期：2018-12-02 00:00:00
abstract：:Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6020017
更新日期：2017-02-13 00:00:00
abstract：:Self-management (SM) includes activities that patients initiate and perform in the interest of controlling their disease and maintaining good health and well-being. This review examines the health literacy and patient activation elements of self-management interventions for Chronic Obstructive Pulmonary Diseases (COPD...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-02-28 00:00:00
abstract：AIM:This study examined the fertility performance of women after combined hysterolaparoscopic surgical management of endometriosis. Design: This study is a hospital-based retrospective review. MATERIALS AND METHODS:Data collected from the records of all patients presented with endometriosis-related infertility using a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-02-13 00:00:00
abstract：BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093004
更新日期：2020-09-17 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10020300
更新日期：2021-01-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051411
更新日期：2020-05-10 00:00:00
abstract：:The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-15 00:00:00
abstract：INTRODUCTION:Immunoglobulin G4-related disease (IgG4-RD) is a systemic immune-mediated disease characterised pathologically by the infiltration of IgG4-bearing plasma cells into the involved organs. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis with a heavy lymphocytic infiltration and two distinct hi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020409
更新日期：2020-02-03 00:00:00
abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020277
更新日期：2019-02-25 00:00:00
abstract：BACKGROUND:Abdominal trauma, leading to intra-abdominal bleeding, is a life-threatening condition that might need emergency surgical intervention. Sonography and Computed Tomography (CT) are most commonly used to detect free intra-abdominal fluid. This study investigates the accuracy of CT to distinguish between ascite...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010076
更新日期：2020-12-28 00:00:00
abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5030034
更新日期：2016-03-07 00:00:00
abstract：:Multidisciplinary interventions have been developed for patients with atopic dermatitis (AD) and their families, with the aim of improving outcomes such as disease control, adherence, and quality of life. We reviewed the content of different multidisciplinary approaches to intervention for AD and evidence for their im...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4051156
更新日期：2015-05-21 00:00:00
abstract：:Atopic eczema (AE) in the elderly is gradually increasing and has been added to the classification of AE in recent years. This investigation retrospectively analyzed 60 patients with elderly AE. Among the clinical characteristics, a male predominance, existence of several patterns of onset and clinical course, and ass...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm4050979
更新日期：2015-05-18 00:00:00
abstract：:Ticagrelor, an antiplatelet adenosine diphosphate (ADP)-P2Y12 receptor antagonist, increases the risk of bleeding. Its management is challenging because platelet transfusion is ineffective and no specific antidote is currently available. Epinephrine, a vasopressor catecholamine prescribed during shock, restores platel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030809
更新日期：2020-03-16 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study invest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091366
更新日期：2019-09-02 00:00:00
abstract：:Pain is the main impetus for osteoarthritis (OA) patients to seek healthcare including joint replacement. The pain experience in OA is heterogeneous and affected by factors across multiple domains-peripheral, psychological, and neurological. This indicates the existence of homogenous subgroups/phenotypes within OA pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030632
更新日期：2020-02-27 00:00:00
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journal_title：Journal of clinical medicine
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doi：10.3390/jcm9010221
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103316
更新日期：2020-10-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101598
更新日期：2019-10-03 00:00:00
abstract：:Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4061293
更新日期：2015-06-17 00:00:00
abstract：:Cutaneous nerve entrapment plays an important role in neuropathic pain syndrome. Due to the advancement of ultrasound technology, the cutaneous nerves can be visualized by high-resolution ultrasound. As the cutaneous nerves course superficially in the subcutaneous layer, they are vulnerable to entrapment or collateral...
journal_title：Journal of clinical medicine
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doi：10.3390/jcm7110457
更新日期：2018-11-21 00:00:00
abstract：:Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041085
更新日期：2020-04-11 00:00:00
abstract：:This phase II randomized controlled trial tested whether intracoronary autologous CD34+ cell therapy could further improve left ventricular (LV) systolic function in patients with diffuse coronary artery disease (CAD) with relatively preserved LV ejection fraction (defined as LVEF >40%) unsuitable for coronary interve...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041043
更新日期：2020-04-07 00:00:00
abstract：:Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122225
更新日期：2019-12-16 00:00:00
abstract：BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010061
更新日期：2019-01-08 00:00:00
