Abstract:
:The repair of bone defects caused by trauma, infection or tumor resection is a major clinical orthopedic challenge. The application of bone grafts in orthopedic procedures is associated with a problem of inadequate vascularization in the initial phase after implantation. Meanwhile, the survival of cells within the implanted graft and its integration with the host tissue is strongly dependent on nutrient and gaseous exchange, as well as waste product removal, which are effectuated by blood microcirculation. In the bone tissue, the vasculature also delivers the calcium and phosphate indispensable for the mineralization process. The critical role of vascularization for bone healing and function, led the researchers to the idea of generating a capillary-like network within the bone graft in vitro, which could allow increasing the cell survival and graft integration with a host tissue. New strategies for engineering pre-vascularized bone grafts, that apply the co-culture of endothelial and bone-forming cells, have recently gained interest. However, engineering of metabolically active graft, containing two types of cells requires deep understanding of the underlying mechanisms of interaction between these cells. The present review focuses on the best-characterized endothelial cells-human umbilical vein endothelial cells (HUVECs)-attempting to estimate whether the co-culture approach, using these cells, could bring us closer to development and possible clinical application of prevascularized bone grafts.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kocherova I,Bryja A,Mozdziak P,Angelova Volponi A,Dyszkiewicz-Konwińska M,Piotrowska-Kempisty H,Antosik P,Bukowska D,Bruska M,Iżycki D,Zabel M,Nowicki M,Kempisty Bdoi
10.3390/jcm8101602subject
Has Abstractpub_date
2019-10-03 00:00:00issue
10issn
2077-0383pii
jcm8101602journal_volume
8pub_type
杂志文章,评审abstract::The incidence of melanoma has been increasing worldwide during recent decades. The objective of the study was to analyse the trends in incidence for in situ and invasive melanoma in the Spanish region of Catalonia during the period of 2008-2017. We designed a cross-sectional study with an age-period-cohort analysis of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113396
更新日期:2020-10-23 00:00:00
abstract::C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6100094
更新日期:2017-10-07 00:00:00
abstract:BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010061
更新日期:2019-01-08 00:00:00
abstract::Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6020017
更新日期:2017-02-13 00:00:00
abstract::The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine sampl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111899
更新日期:2019-11-07 00:00:00
abstract::Surgery, including minimally invasive surgery, and radiotherapy are key modalities in the treatment of gynecological malignancies. The aim of this review is to offer the multidisciplinary care team a comprehensive summary of the intersections of surgery and radiotherapy in the local treatment of gynecological malignan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010093
更新日期:2020-12-29 00:00:00
abstract::After normal survival has been achieved in most patients with chronic myeloid leukemia (CML), a new goal for treating CML is survival at good quality of life, with treatment discontinuation in sustained deep molecular response (DMR; MR4 or deeper) and treatment-free remission (TFR). Four tyrosine kinase inhibitors (TK...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113671
更新日期:2020-11-16 00:00:00
abstract::Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the gastrointestinal (GI) tract is one of the main extra-pulmonary targets of SARS-CoV-2 with respect to symptom occurrence and is a potential route fo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113630
更新日期:2020-11-11 00:00:00
abstract:BACKGROUND:Abdominal trauma, leading to intra-abdominal bleeding, is a life-threatening condition that might need emergency surgical intervention. Sonography and Computed Tomography (CT) are most commonly used to detect free intra-abdominal fluid. This study investigates the accuracy of CT to distinguish between ascite...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010076
更新日期:2020-12-28 00:00:00
abstract:OBJECTIVE:To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analy...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010020
更新日期:2019-12-19 00:00:00
abstract::Cardiovascular disease (CVD) is a major underlying cause of death, with high economic burden in most countries, including the United States. Lifestyle modifications and the use of antiplatelet therapy, such as aspirin, can contribute significantly to secondary prevention of CVD in adults. This study examined the preva...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020264
更新日期:2019-02-20 00:00:00
abstract::An increasing number of patients with coronary artery disease are at high operative risk due to advanced age, severe comorbidities, complex coronary anatomy, and reduced ejection fraction. Consequently, these high-risk patients are often offered percutaneous coronary intervention (PCI) as an alternative to coronary ar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113414
更新日期:2020-10-25 00:00:00
abstract::Aim: This study aimed to compare mortality risks across uric acid (UA) levels between non-diabetes adults and participants with diabetes and to investigate the association between hyperuricemia and mortality risks in low-risk adults. Methods: We analyzed data from adults aged >18 years without coronary heart disease a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122127
更新日期:2019-12-03 00:00:00
abstract::About one-fifth of couples has fertility problems in Western countries. Male factors are present in about half of them, either alone or in combination with female causes. Therefore, both partners should be evaluated simultaneously. The fertility status and/or specific conditions of each partner influence the clinical ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061644
更新日期:2020-05-30 00:00:00
abstract:BACKGROUND:There is a need for analytical tools predicting the risk of periodontitis. The purpose of this study was to estimate and evaluate a risk score for prediction of periodontitis. MATERIALS AND METHODS:This case-cohort study included a random sample of 155 cases (with periodontitis) and 175 controls (randomly s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030307
更新日期:2019-03-05 00:00:00
abstract:BACKGROUND:CSF1/CSF1R neuroinflammatory signaling is emerging as an important pathway involved in the pathogenesis of Parkinson's disease (PD). However, the genetic associations between CSF1/CSF1R and PD have not yet been explored. METHODS:We investigated the effects of two functional genetic variants, including CSF1 ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101529
更新日期:2019-09-24 00:00:00
abstract::Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030392
更新日期:2021-01-20 00:00:00
abstract::Background: Due to the higher frequency of ischemic stroke in men compared to women, we aimed to determine if gender differences exist regarding periodontal status and several plasma biomarkers in patients with a recent large artery atherosclerosis ischemic stroke (IS). Material and methods: Patients with their first ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061744
更新日期:2020-06-04 00:00:00
abstract::With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm7020028
更新日期:2018-02-09 00:00:00
abstract::The Scapula Reposition Test (SRT) is proposed to determine if a relationship exists between scapular dyskinesis and shoulder pathology. The purpose of this study was to evaluate intra-rater and inter-rater reliability of the SRT in subjects with rotator cuff tendinopathy and scapular dyskinesis. In addition, we compar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010080
更新日期:2019-12-28 00:00:00
abstract::Current therapy of Clostridium difficile diarrhea (CDD) is problematic. Optimal treatment for CDD remains oral vancomycin, but there is little data on oral vancomycin dosing regimens. The objective of this C. difficile diarrhea study was to compare the efficacy of "high dose" vancomycin, 500 mg (PO) q6h, as sole treat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7040075
更新日期:2018-04-10 00:00:00
abstract::The purpose of this study is to describe the Minimally Invasive Intraoral Approach (MIIA) performed on selected cases of abscesses and neck phlegmons of odontogenic origin when the infection has not spread beyond the inferior mandibular margin. This technique allows us to avoid cervicotomy by a direct approach to the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092971
更新日期:2020-09-14 00:00:00
abstract::Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030767
更新日期:2020-03-12 00:00:00
abstract::An elevation of serum low-density lipoprotein cholesterol (LDL-C) levels has been associated with endothelial dysfunction in statin naïve subjects. However, there is no information on endothelial function in subjects with extremely low levels of LDL-C. The purpose of the present study was to determine the relationship...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123796
更新日期:2020-11-24 00:00:00
abstract::One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092749
更新日期:2020-08-25 00:00:00
abstract:BACKGROUND:There is a lack of evidence regarding the link between apolipoproteins and cancer mortality. By using two nationally representative samples of US adults, we prospectively evaluated the associations between apolipoprotein B (apoB) levels and apoB/apoA-I ratio with cancer mortality. We also examined the role o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010170
更新日期:2020-01-08 00:00:00
abstract:BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101642
更新日期:2019-10-08 00:00:00
abstract::α-Klotho is a known anti-aging protein that exerts diverse physiological effects, including phosphate homeostasis. Klotho expression occurs predominantly in the kidney and is significantly decreased in patients with chronic kidney disease. However, changes in serum klotho levels and impacts of klotho on outcomes among...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061834
更新日期:2020-06-12 00:00:00
abstract::The focus of the presented work was to isolate and characterize circulating endometrial cells (CECs) enriched from peripheral blood (PB) of patients with diagnosed endometriosis. The molecular characteristics of CECs could be supportive for an understanding of endometriosis pathogenesis and treatment decisions in the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111938
更新日期:2019-11-11 00:00:00
abstract::The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060765
更新日期:2019-05-30 00:00:00