Abstract:
:C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid CRP/MxA immunoassay to identify clinically significant bacterial infection with host response and acute pathogenic viral infection. The reference standard for classifying URI etiology was an algorithm that included throat bacterial culture, upper respiratory PCR for viral and atypical pathogens, procalcitonin, white blood cell count, and bandemia. The algorithm also allowed for physician override. Among 205 patients, 25 (12.2%) were classified as bacterial, 53 (25.9%) as viral, and 127 (62.0%) negative by the reference standard. For bacterial detection, agreement between FebriDx and the reference standard was 91.7%, with FebriDx having a sensitivity of 80% (95% CI: 59-93%), specificity of 93% (89-97%), positive predictive value (PPV) of 63% (45-79%), and a negative predictive value (NPV) of 97% (94-99%). For viral detection, agreement was 84%, with a sensitivity of 87% (75-95%), specificity of 83% (76-89%), PPV of 64% (63-75%), and NPV of 95% (90-98%). FebriDx may help to identify clinically significant immune responses associated with bacterial and viral URIs that are more likely to require clinical management or therapeutic intervention, and has potential to assist with antibiotic stewardship.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Self WH,Rosen J,Sharp SC,Filbin MR,Hou PC,Parekh AD,Kurz MC,Shapiro NIdoi
10.3390/jcm6100094subject
Has Abstractpub_date
2017-10-07 00:00:00issue
10issn
2077-0383pii
jcm6100094journal_volume
6pub_type
杂志文章abstract:OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020277
更新日期:2019-02-25 00:00:00
abstract:BACKGROUND:The long-term stability after soft tissue graft for covering gingival recession remains a pivotal goal for both patient and periodontist. Therefore, the aim of this study was to compare the four-year outcomes of the coronally advanced flap (CAF) versus the pouch/tunnel (POT) technique, both combined with con...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082641
更新日期:2020-08-14 00:00:00
abstract::We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolut...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm7100324
更新日期:2018-10-04 00:00:00
abstract::Crohn's disease (CD) is characterized by compromised immune tolerance to the intestinal commensal microbiota, intestinal barrier inflammation, and hyperplasia of creeping fat (CF) and mesenteric adipose tissue (AT), which seems to be directly related to disease activity. Gut microbiota dysbiosis might be a determining...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082448
更新日期:2020-07-31 00:00:00
abstract::The widespread epidemic of obesity and type 2 diabetes (T2D), suggests that both disorders are closely linked. Several pre-clinical and clinical studies have showed that adipose-derived mesenchymal stem cells (ASC) transplantation is efficient and safe. Moreover, scientists have already highlighted the therapeutic cap...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060765
更新日期:2019-05-30 00:00:00
abstract::Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current trea...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020519
更新日期:2020-02-14 00:00:00
abstract::(1) Objective: To compare the accuracy of different indexes of adiposity and/or body composition in identifying metabolic syndrome (MetS) in adult patients suffering from Prader‒Willi syndrome (PWS). (2) Study Design: One hundred and twenty PWS patients (69 females and 51 males), aged 29.1 ± 9.4 years, body mass index...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061646
更新日期:2020-05-30 00:00:00
abstract::We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9124032
更新日期:2020-12-13 00:00:00
abstract::Metastasis remains the major cause of death from colon cancer. We intend to identify differentially expressed genes that are associated with the metastatic process and prognosis in colon cancer. ATP synthase epsilon subunit (ATP5E) gene was found to encode the mitochondrial F0F1 ATP synthase subunit epsilon that was o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071070
更新日期:2019-07-21 00:00:00
abstract:BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100296
更新日期:2018-09-21 00:00:00
abstract:BACKGROUND:Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. METHODS:Children with OSA between age 4 and 12 receiving T&A ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041028
更新日期:2020-04-05 00:00:00
abstract::The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051503
更新日期:2020-05-16 00:00:00
abstract::Rhinosinusitis (RS) is a common disease in children, significantly affecting their quality of life. Chronic rhinosinusitis (CRS) is frequently linked to other respiratory diseases, including asthma. Children affected by CRS may be candidates for surgery in the case of failure of maximal medical therapy comprising thre...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050684
更新日期:2019-05-15 00:00:00
abstract::Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072019
更新日期:2020-06-27 00:00:00
abstract::CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) in arterial thr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122072
更新日期:2019-11-26 00:00:00
abstract::Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with a long half-life, high selectivity, and rapid onset of action. Because the safety of using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been a problem worldwide, this paper primarily focuses on the safety assessments performed in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060856
更新日期:2019-06-15 00:00:00
abstract::Clinically, in young immunocompetent adults, Epstein-Barr virus (EBV) usually manifests as infectious mononucleosis (IM). Typical clinical findings of EBV IM include fever, profound fatigue, pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly. Respiratory involvement with EBV IM may occur, but is di...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm6090083
更新日期:2017-09-04 00:00:00
abstract::Abnormalities in body composition are associated with poor prognosis in cancer patients. We investigated the association between body composition and 90-day mortality in cancer patients who developed septic shock. We included consecutive septic shock patients with active cancer from 2010 to 2017. The muscle area at th...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101583
更新日期:2019-10-02 00:00:00
abstract::Limited data are available regarding optimal treatment for refractory Mycobacterium avium complex-pulmonary disease (MAC-PD). We evaluated outcomes of inhaled amikacin (AMK) with clofazimine (CFZ) regimens as an add-on salvage therapy for refractory MAC-PD. We retrospectively analyzed 52 patients with refractory MAC-P...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092968
更新日期:2020-09-14 00:00:00
abstract::Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It has been identified as one of the most common comorbidities associated with femoral neck fracture (FNF). The aim of this review was to evaluate the impact of physical therapy on FNF patients' ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103115
更新日期:2020-09-26 00:00:00
abstract::The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7090247
更新日期:2018-08-29 00:00:00
abstract::Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8101669
更新日期:2019-10-12 00:00:00
abstract::This study aims to evaluate clinical and ulcer characteristics as well the outcomes of patients with diabetic foot ulcers (DFUs). The study group was composed of DFUs patients managed by a limb salvage protocol according to guidance. Clinical and ulcers findings were described, and 1-year outcomes defined as limb salv...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061780
更新日期:2020-06-08 00:00:00
abstract:PURPOSE:The risk of epiphora after medial maxillectomy with lacrimal duct transection is difficult to assess. The data available in the literature are inconclusive due to various operating techniques used by the authors of medical publications, different additional procedures aimed at improving tear drainage after maxi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020245
更新日期:2021-01-12 00:00:00
abstract:PURPOSE:Evasion of the immune system by cancer cells allows for the progression of tumors. Antitumor immunotherapy has shown remarkable effects in a diverse range of cancers. The aim of this study was to determine the clinicopathological significance of human epidermal growth factor receptor 2 (HER2), indoleamine 2,3-d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051265
更新日期:2020-04-27 00:00:00
abstract:OBJECTIVES:Non-alcoholic fatty liver disease (NAFLD) is considered a well-known pathology that is determined without using alcohol and has emerged as a growing public health problem. Lipotoxicity is known to promote hepatocyte death, which, in the context of NAFLD, is termed lipoapoptosis. The severity of NAFLD correla...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051294
更新日期:2020-05-01 00:00:00
abstract::The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data (n = 1025) partic...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082676
更新日期:2020-08-18 00:00:00
abstract:BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with out...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092896
更新日期:2020-09-08 00:00:00
abstract:BACKGROUND:Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. METHODS:Whole blood from ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050708
更新日期:2019-05-18 00:00:00
abstract:BACKGROUND:Postoperative Acute Kidney Injury (AKI) is a common and serious complication associated with significant morbidity and mortality. While several pre- and intra-operative risk factors for AKI have been recognized in cardiac surgery patients, relatively few data are available regarding the incidence and risk fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110431
更新日期:2018-11-09 00:00:00