Abstract:
:Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with a long half-life, high selectivity, and rapid onset of action. Because the safety of using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been a problem worldwide, this paper primarily focuses on the safety assessments performed in the Tadalafil Treatment for Fetuses with Early-Onset Growth Restriction (TADAFER) II population. Neonatal and maternal adverse events were analyzed, in addition to fetal, neonatal, and infant death cases, six months after stopping the trial. Eighty-nine pregnant women with FGR were studied between September 2016 and March 2018 (45 and 44 in the tadalafil and conventional treatment groups, respectively). Seven (16%) deaths (four fetal, one neonatal, and two infant) in the control group, whereas only one neonatal death occurred in the tadalafil group. Although headache, facial flushing, and nasal hemorrhage occurred more frequently in the tadalafil group, these symptoms were Grade 1 and transient. In conclusion, this trial showed that tadalafil decreased the fetal and infant deaths associated with FGR. This is thought to be primarily due to pregnancy prolongation. Further studies are warranted to evaluate the efficacy of tadalafil in treating early-onset FGR.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Maki S,Tanaka H,Tsuji M,Furuhashi F,Magawa S,Kaneda MK,Nii M,Tanaka K,Kondo E,Tamaru S,Ogura T,Nishimura Y,Endoh M,Kimura T,Kotani T,Sekizawa A,Ikeda Tdoi
10.3390/jcm8060856subject
Has Abstractpub_date
2019-06-15 00:00:00issue
6issn
2077-0383pii
jcm8060856journal_volume
8pub_type
杂志文章abstract::Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-03-12 00:00:00
abstract::The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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journal_title:Journal of clinical medicine
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更新日期:2020-11-06 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2020-06-19 00:00:00
abstract::Microbial contamination could compromise the stability of dental implants increasing the risk of inflammatory reactions in the surrounding soft tissues. In this human, randomized, double-blind, clinical study, the presence of Porphyromonas gingivalis on the healing abutment and the inflammatory infiltrate surrounding ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-01-20 00:00:00
abstract::Von Hippel-Lindau (VHL), is a rare autosomal dominant inherited cancer in which the lack of VHL protein triggers the development of multisystemic tumors such us retinal hemangioblastomas (HB), CNS-HB, and clear cell renal cell carcinoma (ccRCC). ccRCC ranks third in terms of incidence and first in cause of death. Stan...
journal_title:Journal of clinical medicine
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更新日期:2020-08-25 00:00:00
abstract::In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071080
更新日期:2019-07-23 00:00:00
abstract:BACKGROUND:The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101742
更新日期:2019-10-20 00:00:00
abstract:BACKGROUND:Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. METHODS:Relevant studies published through June 2020 were identified through database s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082584
更新日期:2020-08-10 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072019
更新日期:2020-06-27 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030295
更新日期:2019-03-01 00:00:00
abstract::During surgery, ATP from damaged cells induces the release of interleukin-1β, a potent pro-inflammatory cytokine that contributes to the development of postoperative systemic inflammation, sepsis and multi-organ damage. We recently demonstrated that C-reactive protein (CRP) inhibits the ATP-induced release of monocyti...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103340
更新日期:2020-10-18 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Elderly and/or frail women with ovarian cancer are often undertreated. The aim of the study is to compare the effects of age and frailty on surgical approaches, postoperative complications, and prognosis in elderly women with ovarian cancer. METHODS:A retrospective multicenter study of women ≥...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051339
更新日期:2020-05-04 00:00:00
abstract::Hypertrophy of facet joints is associated with a high risk of central lumbar spinal stenosis (CLSS). However, no research has reported the effect of inferior articular process hypertrophy in CLSS. We hypothesize that the inferior articular process's cross-sectional area (IAPCSA) is larger in patients with CLSS compare...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010214
更新日期:2020-01-13 00:00:00
abstract:BACKGROUND:Depression is commonly treated with anti-depressant medication and/or psychological interventions. Patients with depression are common users of complementary therapies, such as acupuncture, either as a replacement for, or adjunct to, their conventional treatments. This systematic review and meta-analysis exa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8081140
更新日期:2019-07-31 00:00:00
abstract::Spinal disorders and associated interventions are costly in the United States, putting them in the limelight of economic analyses. The Patient-Reported Outcomes Measurement Information System Global Health Survey (PROMIS-GHS) requires mapping to other surveys for economic investigation. Previous studies have proposed ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101506
更新日期:2019-09-20 00:00:00
abstract::Bronchopulmonary dysplasia (BPD) is a chronic lung disease most commonly seen in premature infants who required mechanical ventilation and oxygen therapy for acute respiratory distress. While advances in neonatal care have resulted in improved survival rates of premature infants, limited progress has been made in redu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6010004
更新日期:2017-01-06 00:00:00
abstract::Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cel...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081151
更新日期:2019-08-01 00:00:00
abstract::(1) Introduction: Several surgical therapy options for the treatment of pathologies of the long biceps tendon (LHB) have been established. However, tenotomy, as well as established tenodesis techniques, has disadvantages, such as cosmetic deformities, functional impairments and residual shoulder pain. This study prese...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030432
更新日期:2021-01-23 00:00:00
abstract::The focus of the presented work was to isolate and characterize circulating endometrial cells (CECs) enriched from peripheral blood (PB) of patients with diagnosed endometriosis. The molecular characteristics of CECs could be supportive for an understanding of endometriosis pathogenesis and treatment decisions in the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111938
更新日期:2019-11-11 00:00:00
abstract:BACKGROUND:Compared to typically developing individuals, individuals with attention-deficit-hyperactivity disorder (ADHD) are on average more often exposed to stressful conditions (e.g., school failure, family conflicts, financial problems). We hypothesized that high exposure to stress relates to a more persistent and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111824
更新日期:2019-11-01 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7100303
更新日期:2018-09-25 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050684
更新日期:2019-05-15 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-12-29 00:00:00
abstract::The relationship between serum uric acid (SUA) and hypertension has been a subject of increasing interest since the 1870 discovery by Frederick Akbar Mahomed. Several epidemiological studies have shown a strong association between high SUA levels and the presence or the development of hypertension. Genetic analyses ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10030448
更新日期:2021-01-24 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-09-14 00:00:00
abstract::The aim of the study was to examine the usefulness of targeted musculoskeletal ultrasonography (MSUS) in assessing the disease activity of patients with early inflammatory arthritis (EIA). Twenty-eight patients with EIA were enrolled. The MSUS examination of joints with arthritic signs (tenderness or swelling), measur...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2021-01-14 00:00:00
abstract::The aim of this study was to determine whether elevated serum level of uric acid (sUA) could predict renal outcome after contrast-enhanced computerized tomography (CCT). We used a historical cohort of 58,106 non-dialysis adult patients who received non-ionic iso-osmolar CCT from 1 June 2008 to 31 March 2015 to evaluat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071003
更新日期:2019-07-10 00:00:00
abstract::The current study explored the differences in the effectiveness of first and second generation long-acting injections and orally administered antipsychotics in reducing the rehospitalization rate among patients with schizophrenia receiving home care services in a medical center in Southern Taiwan. Longitudinal data be...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2019-06-09 00:00:00
abstract::The aim of this study was to compare surgical and refractive outcomes between phacotrabeculectomy (P-Trab) and phaco with Ex-PRESS (P-Ex-PRESS) for glaucoma at a 6-month follow-up. This prospective randomized controlled trial included 81 eyes; 43 eyes (53%) and 38 eyes (47%) were assigned to the P-Ex-PRESS and P-Trab ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2021-01-22 00:00:00