Abstract：
:The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host response. Sepsis survival is not improved by blocking one or many immune pathways. Similarly, sepsis is resistant to treatment by normalizing one or many physiologic parameters simultaneously. The vast majority of interventions are either ineffective or harmful. With this track record of failure, it is time to consider the alternative hypothesis-regulation instead of dysregulation-and the possibility that sepsis traits are often functional, and that some physiologic alterations in sepsis do more good than harm, while others are neutral. This review discusses the implications of this perspective for the future of sepsis research.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Alcock Jdoi
10.3390/jcm7090247subject
Has Abstractpub_date
2018-08-29 00:00:00issue
9issn
2077-0383pii
jcm7090247journal_volume
7pub_type
杂志文章,评审abstract：:The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and futu...
journal_title：Journal of clinical medicine
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abstract：:Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction. The clinical picture includes progre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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abstract：OBJECTIVE:To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analy...
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更新日期：2019-12-19 00:00:00
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journal_title：Journal of clinical medicine
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doi：10.3390/jcm8111820
更新日期：2019-11-01 00:00:00
abstract：:In the SImplification of Medications Prescribed to Long-tErm care Residents (SIMPLER) cluster-randomized controlled trial, we evaluated the impact of structured medication regimen simplification on medication administration times, falls, hospitalization, and mortality at 8 residential aged care facilities (RACFs) at 1...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041053
更新日期：2020-04-08 00:00:00
abstract：:Coronary artery calcification (CAC) is a feature of coronary atherosclerosis and a well-known risk factor for cardiovascular disease (CVD). As the absence of CAC is associated with a lower incidence rate of CVD, measurement of a CAC score is helpful for risk stratification when the risk decision is uncertain. This was...
journal_title：Journal of clinical medicine
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更新日期：2021-01-25 00:00:00
abstract：:This study was designed to determine the influence of microvesicles (MVs) derived from multipotent stromal cells isolated from human adipose tissue (hASCs) on retinal functionality in dogs with various types of retinal degeneration. The biological properties of hASC-MVs were first determined using an in vitro model of...
journal_title：Journal of clinical medicine
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更新日期：2019-04-13 00:00:00
abstract：:Adipokines are powerful agents involved in the development of obesity-dependent cancers. This prospective study aimed to investigate the association between pre-treatment body mass index (BMI) and serum YKL-40, leptin, and adiponectin concentrations as well as the plasma activity of tissue factor (TF) and the future p...
journal_title：Journal of clinical medicine
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更新日期：2020-06-04 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-11-24 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2018-12-02 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-11-04 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-09-13 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-04-15 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-06-03 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101744
更新日期：2019-10-21 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123897
更新日期：2020-12-01 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020529
更新日期：2020-02-15 00:00:00
abstract：:The causes of disordered sleep, frequently reported by patients with inflammatory bowel diseases (IBD), are poorly understood. The study aimed to evaluate sleep quality in IBD patients and to identify factors affecting their sleep. IBD patients (n = 133) and healthy controls (HC; n = 57) were included in the study and...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-10 00:00:00
abstract：:Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111895
更新日期：2019-11-06 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-06-08 00:00:00
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pub_type： 杂志文章
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更新日期：2020-06-03 00:00:00
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更新日期：2019-11-11 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-11-27 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-06-29 00:00:00
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更新日期：2019-08-19 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-17 00:00:00
abstract：:Background: Patients with pulmonary embolism (PE) may suffer from long-term consequences, including decreased functional capacity. Data on pulmonary rehabilitation (PR) in patients with PE are scarce, and no data on outpatient PR are available so far. Methods: We analyzed data of 22 PE patients who attended outpatient...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061811
更新日期：2020-06-10 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092814
更新日期：2020-08-31 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the association between acute kidney injury (AKI) and in-hospital mortality (IHM) in a large nationwide cohort of elderly subjects in Italy. METHODS:We analyzed the hospitalization data of all patients aged ≥65 years, who were discharged with a diagnosis of AKI, whic...
journal_title：Journal of clinical medicine
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doi：10.3390/jcm8091371
更新日期：2019-09-02 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2020-09-27 00:00:00
