Abstract：
BACKGROUND:As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients' perceptions of dyspnea and their COPD living disabilities remains a major challenge. We developed patient-reported outcome measures for dyspnea-related behavior and activity limitation (PROMs-D), which consisted of the Activity-limit Dyspnea Scale (ADS) and Self-Limit Dyspnea Scale (SDS), while investigated the usefulness of PROMs-D in identifying frailty. METHODS:We administered PROMs-D and frailty status evaluations in 128 outpatients. RESULTS:We classified 30 (23.4%), 50 (39.0%), and 48 (37.5%) patients as robust, prefrail, and frail, respectively. There was a positive correlation between SDS and ADS (ρ = 0.67, p < 0.001), and both ADS and SDS had high accuracies for detecting frailty (AUC, 0.82 and 0.78, respectively). Moreover, a PROMs-D score that consisted of the sum of ADS and SDS was more effective in stratifying frailty (cutoff value, 2; AUC, 0.85; sensitivity, 60%; specificity, 95%). CONCLUSIONS:PROMs-D could be used as the first step for frailty screening in patients with COPD, and we propose the importance of capturing the troublesome nature of living behaviors due to dyspnea in daily clinical practice.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Oishi K,Matsunaga K,Harada M,Suizu J,Murakawa K,Chikumoto A,Ohteru Y,Matsuda K,Uehara S,Hamada K,Ohata S,Murata Y,Yamaji Y,Asami-Noyama M,Edakuni N,Kakugawa T,Hirano Tdoi
10.3390/jcm9113580subject
Has Abstractpub_date
2020-11-06 00:00:00issue
11issn
2077-0383pii
jcm9113580journal_volume
9pub_type
杂志文章abstract：:Although skin manifestations are quite common in systemic sclerosis (SSc), a link between SSc and psoriasis (PsO) has been poorly investigated. We assessed the Clalit medical database in a cohort study to compare the prevalence of PsO between SSc-patients and SSc-free controls. We also evaluated the SSc-related autoan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040521
更新日期：2019-04-16 00:00:00
abstract：:The aims of the study were to evaluate long-term outcomes after autologous matrix-induced chondrogenesis (AMIC) in the treatment of focal chondral lesions and to assess the possible improvements given by the combination of this technique with bone marrow aspirate concentrate (BMAC). Twenty-four patients (age range 18⁻...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8030392
更新日期：2019-03-21 00:00:00
abstract：BACKGROUND:Asthma patterns are not well established in epidemiological studies. AIM:To assess asthma patterns and risk factors in an adult general population sample. METHODS:In total, 452 individuals reporting asthma symptoms/diagnosis in previous surveys participated in the AGAVE survey (2011-2014). Latent transitio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113632
更新日期：2020-11-11 00:00:00
abstract：:A recent study suggested mortality benefits using vitamin C, hydrocortisone, and thiamine combination therapy (triple therapy) in addition to standard care in patients with severe sepsis and septic shock. In order to further evaluate the effects of triple therapy in real-world clinical practice, we conducted a retrosp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040478
更新日期：2019-04-09 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
abstract：:COVID-19 has catastrophically affected the world's panoramic view of human well-being in terms of healthcare and management. With the increase in the number of cases worldwide, neurological symptoms and psychological illnesses from COVID-19 have increasingly upsurged. Mental health illness and affective disorders, inc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082624
更新日期：2020-08-13 00:00:00
abstract：:The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of ov...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7080193
更新日期：2018-08-01 00:00:00
abstract：:CANTOS reported reduced secondary atherothrombotic events in patients with residual inflammatory risk treated with the inhibitory anti-IL-1β antibody, Canakinumab. Yet, mechanisms that underlie this benefit remain elusive. Recent work has implicated formation of neutrophil extracellular traps (NETosis) in arterial thr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122072
更新日期：2019-11-26 00:00:00
abstract：:Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome allowed the discovery of new therapeutic targets and predictive ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030802
更新日期：2020-03-16 00:00:00
abstract：:This study proposes a method for measuring the volumetric change of alveolar bone after dental implant surgery using computed tomography (CT). A total of 40 implants in 20 patients (15 males and 5 females) were selected. The types of implants used were group 1: 24 CMI IS-II Active implants (Neobiotech Co., Seoul, Repu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041238
更新日期：2020-04-24 00:00:00
abstract：:The aim of this article is to investigate pathological subjects from a population through different physical factors. To achieve this, particle swarm optimization (PSO) and K-means (KM) clustering algorithms have been combined (PSO-KM). Datasets provided by the literature were divided into three clusters based on age ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7040065
更新日期：2018-03-28 00:00:00
abstract：:C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development of type 2 diabetes...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093001
更新日期：2020-09-17 00:00:00
abstract：:Both pre-gestational maternal obesity (PGMO) and excessive gestational weight gain (EGWG) increase the risk of gestational diabetes mellitus (GDM). Here, we conducted a retrospective study to comparatively examine the relation between fetal birth weight (FW) and placental weight (PW) in PGMO (n = 100) compared to EGWG...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113530
更新日期：2020-10-31 00:00:00
abstract：:Community-acquired pneumonia (CAP) remains the first cause of morbidity and mortality worldwide due to infection. Several aspects such as severity and host response are related to its clinical course and outcome. Beyond the acute implications that the infection provokes in the host, pneumonia also has long-term negati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020549
更新日期：2020-02-18 00:00:00
abstract：:Paraneoplastic neurological syndromes (PNSs) are a heterogeneous group of rare immune-mediated diseases associated with cancer. The aim of this study was to investigate the prevalence of PNSs in the province of Brescia. PNS prevalence was calculated using the Lombardy regional hospital admission records from 1998 to 2...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103105
更新日期：2020-09-25 00:00:00
abstract：:The factors that contribute to the development of ulcerative colitis (UC), are still not fully identified. Disruption of the colon barrier is one of the first events leading to invasion of bacteria and activation of the immune system. The colon barrier is strongly influenced by sphingolipids. Sphingolipids impact cell...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070971
更新日期：2019-07-04 00:00:00
abstract：:It has been widely underlined that both gynaecological malignancies and urogynaecological disorders are often associated with high stress and have a negative impact on the quality of life and psychological well-being of women affected. Knowledge of the pelvic anatomy is crucial in recommending and carrying out the lea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092804
更新日期：2020-08-30 00:00:00
abstract：:Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010156
更新日期：2020-01-07 00:00:00
abstract：:Disrupting the process of memory reconsolidation could be a promising treatment for addiction. However, its application may be constrained by the intensity of addiction memory. This study aimed to develop and initially validate a new measure, the Addiction Memory Intensity Scale (AMIS), for assessing the intensity of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120467
更新日期：2018-11-22 00:00:00
abstract：:Antiretroviral therapy (ART) has significantly improved life expectancy of infected subjects, generating a new epidemiological setting of people aging withHuman Immunodeficiency Virus (HIV). People living with HIV (PLWH), having longer life expectancy, now face several age-related conditions as well as side effects of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081254
更新日期：2019-08-19 00:00:00
abstract：:The aim of this study was to assess the efficacy of anti-endomysium antibodies (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric population. A retrospective study of pediatric patients who underwent a CD serological markers study: EMA and anti-tissue transglutaminase antibodies (anti-TG2)....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122179
更新日期：2019-12-11 00:00:00
abstract：:Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051383
更新日期：2020-05-08 00:00:00
abstract：:In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach. Moreover, despite the use of high-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111951
更新日期：2019-11-12 00:00:00
abstract：:Subungual osteochondroma (SO) is an infrequent and non-malignant bone tumour of the distal phalanx, especially prominent in paediatric populations. The aim of this research was to describe a case series of paediatric feet with SO which received surgical treatments. The secondary purpose was to compare these descriptiv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041122
更新日期：2020-04-14 00:00:00
abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101526
更新日期：2019-09-23 00:00:00
abstract：:Multiple sclerosis (MS) treatment with new agents is associated with the risk of the development of progressive multifocal leukoencephalopathy (PML). The seropositivity and a high index of anti-John Cunningham virus (JCV) antibodies are some of the risk factors for PML development. The aim of this study was to assess ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123867
更新日期：2020-11-27 00:00:00
abstract：BACKGROUND AND AIM:Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features. METHODS:An active stand test was performed to e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124125
更新日期：2020-12-21 00:00:00
abstract：:Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical tr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082461
更新日期：2020-07-31 00:00:00
abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061954
更新日期：2020-06-23 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and affects millions worldwide. Due to the lack of effective systemic therapies for HCC, researchers have been investigating the use of locoregional tumor control with Yttrium-90 (Y90) radioembolization since the 1960s. Following the develo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010055
更新日期：2019-01-07 00:00:00
