Abstract：
:C-peptide measurement may represent a better index of pancreatic β-cell function compared to insulin. While insulin is mainly cleared by liver, C-peptide is mainly metabolized by kidneys. The aim of our study was to evaluate the association between baseline plasma C-peptide level and the development of type 2 diabetes independent of glucose and insulin levels and to examine potential effect-modification by variables related to kidney function. We included 5176 subjects of the Prevention of Renal and Vascular End-Stage Disease study without type 2 diabetes at baseline. C-peptide was measured in plasma with an electrochemiluminescent immunoassay. Cox proportional hazards regression was used to evaluate the association between C-peptide level and type 2 diabetes development. Median C-peptide was 722 (566-935) pmol/L. During a median follow-up of 7.2 (6.0-7.7) years, 289 individuals developed type 2 diabetes. In multivariable-adjusted Cox regression models, we observed a significant positive association of C-peptide with the risk of type 2 diabetes independent of glucose and insulin levels (hazard ratio (HR): 2.35; 95% confidence interval (CI): 1.49-3.70). Moreover, we found significant effect modification by hypertension and albuminuria (p < 0.001 and p = 0.001 for interaction, respectively), with a stronger association in normotensive and normo-albuminuric subjects and absence of an association in subjects with hypertension or albuminuria. In this population-based cohort, elevated C-peptide levels are associated with an increased risk of type 2 diabetes independent of glucose, insulin levels, and clinical risk factors. Elevated C-peptide level was not independently associated with an increased risk of type 2 diabetes in individuals with hypertension or albuminuria.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Sokooti S,Kieneker LM,Borst MH,Muller Kobold A,Kootstra-Ros JE,Gloerich J,van Gool AJ,Heerspink HJL,T Gansevoort R,Dullaart RPF,Bakker SJLdoi
10.3390/jcm9093001subject
Has Abstractpub_date
2020-09-17 00:00:00issue
9issn
2077-0383pii
jcm9093001journal_volume
9pub_type
杂志文章abstract：OBJECTIVES:Central neurological manifestations of rheumatoid arthritis (RA) like rheumatoid meningitis (RM) are rare, little known and have a high rate of morbi-mortality. METHODS:We described six cases of RM that were directly related to RA activity after exhaustive assessment. RESULTS:They were mainly women, aged o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061625
更新日期：2020-05-27 00:00:00
abstract：:This study explored the perspectives and experiences of breast cancer patients and medical oncologists with regards to participation in a lifestyle intervention at a tertiary cancer treatment center. A thematic approach was used to understand the context within which a lifestyle intervention was recommended and experi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092815
更新日期：2020-08-31 00:00:00
abstract：:Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV eradication in >95% of cases, no vaccine is available and re-infection can readily occur. Natural killer (NK) cells represent a key cellula...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041030
更新日期：2020-04-06 00:00:00
abstract：:Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110100
更新日期：2017-10-27 00:00:00
abstract：:Survivors of colorectal cancer (CRC) may experience a range of physical, psychosocial, and practical challenges as a consequence of their diagnosis. We assessed the patterns and documented content of follow-up visits within the first three years following treatment, in comparison to survivorship care guidelines. Survi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092725
更新日期：2020-08-24 00:00:00
abstract：BACKGROUND AND AIMS:Endoscopic resection (ER) for submucosal invasive colorectal cancer (T1 CRC) can be grouped as curative ER (C-ER) and non-curative ER (NC-ER). Little is known about the long-term outcomes of patients in these two groups. Therefore, we have evaluated the long-term outcomes in endoscopically resected ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082451
更新日期：2020-07-31 00:00:00
abstract：BACKGROUND:Oral and enteral mucositis due to high-dose cytostatic treatment administered during autologous and allogeneic stem-cell transplantation increases mortality. Salivary secretory immunoglobulin A (sIgA) is a basic pillar of local immunity in the first line of defense. Altered salivary sialoglycoprotein carbohy...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061747
更新日期：2020-06-05 00:00:00
abstract：BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100296
更新日期：2018-09-21 00:00:00
abstract：:Keywords: pulmonary embolism; submassive; survey. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020215
更新日期：2019-02-07 00:00:00
abstract：:Novel strategies are needed to address vaccine hesitancy (VH), which correlates with complementary and alternative medicine (CAM). In Switzerland, CAM providers play important roles in vaccine counseling of vaccine hesitant (VH) parents, and traditional vaccination messaging tends to overlook CAM provider perspectives...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020592
更新日期：2020-02-21 00:00:00
abstract：:Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041204
更新日期：2020-04-22 00:00:00
abstract：:Neutrophil extracellular traps (NETs) are supposed to play a central role in atherothrombosis. We measured circulating citrullinated histone H3 (H3Cit) and cell-free DNA (cfDNA), which serve as surrogate markers of NET formation, in 79 patients with peripheral artery disease (PAD) following infrainguinal angioplasty w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020304
更新日期：2020-01-22 00:00:00
abstract：:Hypothermic machine perfusion (HMP) has been introduced as an alternative to static cold storage (SCS) in kidney transplantation, but its true benefit in the clinical routine remains incompletely understood. The aim of this study was to assess the effect of HMP vs. SCS in kidney transplantation. All kidney transplants...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072311
更新日期：2020-07-21 00:00:00
abstract：BACKGROUND:Acute respiratory distress syndrome (ARDS) is associated with both high morbidity and mortality in intensive care units worldwide. Patients with ARDS often require parenteral nutrition with lipid emulsions as essential components. In the present study, we assessed the immunomodulatory and apoptotic effects o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072048
更新日期：2020-06-29 00:00:00
abstract：BACKGROUND:The study aimed to clinically estimate an influence of a 635 nm diode laser on the stability of orthodontic mini-implants, to assess mini-implants loss, and to evaluate a pain level after the treatment. MATERIALS AND METHODS:The randomized clinical split-mouth trial included 20 subjects (13 women and 7 men;...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010112
更新日期：2019-12-31 00:00:00
abstract：:We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124032
更新日期：2020-12-13 00:00:00
abstract：INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) f...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070994
更新日期：2019-07-09 00:00:00
abstract：:Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051383
更新日期：2020-05-08 00:00:00
abstract：:To demonstrate the association of the serum creatinine/serum cystatin C ratio (sarcopenia index, SI) with clinical outcomes including cardiovascular and bleeding risk in older patients who underwent percutaneous coronary intervention (PCI), we analyzed a multicenter nation-wide pooled registry. A total of 1086 older p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103121
更新日期：2020-09-27 00:00:00
abstract：:Before eosinophils migrate into the bronchial lumen, they promote airway structural changes after contact with pulmonary cells and extracellular matrix components. We aimed to investigate the impact of eosinophil adhesion to their viability and pro-proliferative effect on airway smooth muscle (ASM) cells and pulmonary...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091274
更新日期：2019-08-22 00:00:00
abstract：BACKGROUND:The heat produced during implant site osteotomy can potentially interfere with and influence the osseointegration process of a dental implant. The objective of this in vitro investigation was to measure the temperature changes during simulated osteotomies in bovine rib bone. The measurements were made at the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010148
更新日期：2020-01-05 00:00:00
abstract：:The application of biomarkers in medicine is evolving. Biomarkers do not only give us a better understanding of pathogenesis, but also increase treatment efficacy and safety, further enabling more precise clinical care. This paper focuses on the current use of biomarkers in atopic dermatitis, new developments and futu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm4030479
更新日期：2015-03-16 00:00:00
abstract：:Objectives/Hypothesis: Stenosis of the middle meatus antrostomy (MMA) represents a major cause of recurrent disease following endoscopic sinus surgery (ESS). Various strategies have been developed to prevent the occurrence of MMA stenosis. The aim of the present study was to evaluate the effects of spray cryotherapy (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010088
更新日期：2019-12-29 00:00:00
abstract：BACKGROUND:To compare the clinical, serological and histologic features between male and female patients with Sjögren's syndrome (SS) and explore the potential effect of gender on lymphoma development. METHODS:From a multicenter population (Universities of Udine, Pisa and Athens, Harokopion and Ioannina (UPAHI)) consi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082620
更新日期：2020-08-12 00:00:00
abstract：:Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061809
更新日期：2020-06-10 00:00:00
abstract：:Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Vi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120487
更新日期：2018-11-27 00:00:00
abstract：:Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free surv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8070952
更新日期：2019-06-30 00:00:00
abstract：BACKGROUND:'Gaming Disorder' (GD) has received increased medical attention and official recognition from both the American Psychiatric Association (APA) and the World Health Organization (WHO). Although these two medical organizations have independently developed promising clinical diagnostic frameworks to assess disor...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101691
更新日期：2019-10-15 00:00:00
abstract：:We evaluated the incidence of temporomandibular disorder (TMD) in patients with rheumatoid arthritis (RA) and examined the association between TMD and RA, through longitudinal follow-up. Population data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 was used. From 514,866 s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9093005
更新日期：2020-09-17 00:00:00
abstract：:Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092869
更新日期：2020-09-04 00:00:00
