Abstract:
INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) for developing a psychotic disorder. METHODS:CHR individuals (n = 35) and healthy volunteers (n = 28) completed structured clinical interviews as well as our group's newly developed Individual and Structural Exposure to Stress in Psychosis-risk-states (ISESP) interview. Lifetime cumulative scores were calculated, and severity of stress was reported for multiple developmental periods/ages. Group differences were tested, and associations with current symptom domains were examined. RESULTS:Significant group differences were not observed for lifetime cumulative events, though CHR trended toward endorsing more events and greater stress severity. For stress severity across development, there were trending group differences for the 11-13 age range, and significant group differences for the 14-18 age range; notably, comparisons for earlier time points did not approach statistical significance. Associations between negative symptoms and cumulative severity of exposure were observed. DISCUSSION:Results suggest exploring exposure to cumulative environmental risk factors/stressors and stress severity across developmental periods is generally informative and possibly specifically so for predictive models and diathesis-stress psychosis risk conceptualizations.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Vargas T,Zou DS,Conley RE,Mittal VAdoi
10.3390/jcm8070994subject
Has Abstractpub_date
2019-07-09 00:00:00issue
7issn
2077-0383pii
jcm8070994journal_volume
8pub_type
杂志文章abstract:OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7060148
更新日期:2018-06-11 00:00:00
abstract:BACKGROUND:There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS:We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082560
更新日期:2020-08-07 00:00:00
abstract::Preterm infants are at higher risk for both symmetrical and asymmetrical head molding. This study involved 3D stereophotogrammetry to assess the cranial growth, molding, and incidence of deformational plagiocephaly (DP) in preterm children compared to term born children. Thirty-four preterm infants and 34 term born co...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101665
更新日期:2019-10-11 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092762
更新日期:2020-08-26 00:00:00
abstract::Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 children followed in a French university-hospital SCD reference center. Eligibility criteria were the following: age <18 years, seen at...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091481
更新日期:2019-09-18 00:00:00
abstract:BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2021-01-08 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-07-29 00:00:00
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journal_title:Journal of clinical medicine
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abstract::The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
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更新日期:2021-01-06 00:00:00
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pub_type: 杂志文章
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更新日期:2019-05-17 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2017-10-07 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041028
更新日期:2020-04-05 00:00:00
abstract:BACKGROUND:This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Or...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113435
更新日期:2020-10-26 00:00:00
abstract::Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive def...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9030703
更新日期:2020-03-05 00:00:00
abstract::For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm2040302
更新日期:2013-12-17 00:00:00
abstract::TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Diagnosis is challenging given the phenotypic overlap that exists with other metabolic and neurological disorders. We report a case of TPK1-related disease presenting with Leigh-like syndrome and review the diagnostic utility of thiami...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm8070991
更新日期:2019-07-08 00:00:00
abstract::In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not only the process of carcinogenesis through cancer-related inflammation mechanisms, but also tumor progression, invasion, and metastasis. In particular, tumor-associated macrophages (TAMs) are the most abundant leucocyte sub...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103226
更新日期:2020-10-08 00:00:00
abstract::Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041204
更新日期:2020-04-22 00:00:00
abstract::The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine sampl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111899
更新日期:2019-11-07 00:00:00
abstract:PURPOSE:To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). METHODS:A gypsum cast of a fully edentulous maxilla with six implant analogues ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072174
更新日期:2020-07-09 00:00:00
abstract:INTRODUCTION:The oxytocin challenge test (OCT) used to be one of the most important tools in assessing fetal well-being before ultrasonography became prevalent. We show that, after modifying the classification of the results and the intervention algorithm, OCT can still be a useful tool in present-day obstetrics. MATE...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010131
更新日期:2020-01-03 00:00:00
abstract::Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041085
更新日期:2020-04-11 00:00:00
abstract::Chronic Obstructive Pulmonary Disease (COPD) is a complex disease defined by airflow limitation and characterized by a spectrum of treatable and untreatable pulmonary and extra-pulmonary disease characteristics. Nonpharmacological management related to physical activity, physical capacity, body composition, breathing ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051311
更新日期:2020-05-02 00:00:00
abstract::Creatinine is produced in muscle metabolism as the end-product of creatine phosphate and is subsequently excreted principally by way of the kidneys, predominantly by glomerular filtration. Blood creatinine assays constitute the most common clinically relevant measure of renal function. The use of individual patient-le...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4071348
更新日期:2015-06-26 00:00:00
abstract::The repair of bone defects caused by trauma, infection or tumor resection is a major clinical orthopedic challenge. The application of bone grafts in orthopedic procedures is associated with a problem of inadequate vascularization in the initial phase after implantation. Meanwhile, the survival of cells within the imp...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8101602
更新日期:2019-10-03 00:00:00
abstract::Background: We decided to investigate whether aneurysm wall enhancement (AWE) on high-resolution vessel wall magnetic resonance imaging (HR VW-MRI) coexists with the conventional risk factors for aneurysm rupture. Methods: We performed HR VW-MRI in 46 patients with 64 unruptured small intracranial aneurysms. Patient d...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020225
更新日期:2021-01-10 00:00:00
abstract::Stress response to robot-assisted colorectal surgery is largely unknown. Therefore, we conducted a prospective comparative nonrandomized study evaluating the perioperative dynamics of chemokines: IL-8/CXCL8, MCP-1/CCL2, MIP-1α/CCL3, MIP-1β/CCL4, RANTES/CCL5, and eotaxin-1/CCL11 in 61 colorectal cancer patients followi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2019-06-19 00:00:00
abstract::Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that support...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6060060
更新日期:2017-06-09 00:00:00
abstract:PURPOSE:To investigate the value of visual acuity and patient-perceived visual function test when subretinal drusenoid deposits (SDD) are incorporated into the classification of age-related macular degeneration (AMD). A total of 50 participants were recruited into the study in these groups: healthy ageing (n = 11), int...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092832
更新日期:2020-09-01 00:00:00
abstract::Tens of millions of patients are affected by liver disease worldwide. Many of these patients can benefit from cell therapy involving living metabolically active cells, either by treatment of their liver disease, or by prevention of their disease phenotype. Cell therapies, including hepatocyte transplantation and bioar...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm3030997
更新日期:2014-09-05 00:00:00