Abstract：
:Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic instability. Next-generation sequencing has significantly improved the ability of diagnostic research to molecularly characterize and stratify patients. This detailed outcome allowed the discovery of new therapeutic targets and predictive biomarkers, which led to develop novel compounds (e.g., IDH 1 and 2 inhibitors), nowadays commonly used for the treatment of adult relapsed or refractory AML. In this review we summarize the most relevant mutations affecting tumor suppressor genes that contribute to the onset and progression of AML pathology. Epigenetic modifications (TET2, IDH1 and IDH2, DNMT3A, ASXL1, WT1, EZH2), DNA repair dysregulation (TP53, NPM1), cell cycle inhibition and deficiency in differentiation (NPM1, CEBPA, TP53 and GATA2) as a consequence of somatic mutations come out as key elements in acute myeloid leukemia and may contribute to relapse and resistance to therapies. Moreover, spliceosomal machinery mutations identified in the last years, even if in a small cohort of acute myeloid leukemia patients, suggested a new opportunity to exploit therapeutically. Targeting these cellular markers will be the main challenge in the near future in an attempt to eradicate leukemia stem cells.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Panuzzo C,Signorino E,Calabrese C,Ali MS,Petiti J,Bracco E,Cilloni Ddoi
10.3390/jcm9030802subject
Has Abstractpub_date
2020-03-16 00:00:00issue
3issn
2077-0383pii
jcm9030802journal_volume
9pub_type
杂志文章,评审abstract：:Secretogranin III (SCG3) plays a crucial role in the biogenesis of secretory granules in endocrine cells, and thus affects glucose homeostasis by regulating insulin secretion by pancreatic beta cells. Insulin resistance and compensatory hyperinsulinemia are hallmarks of metabolic syndrome (MetS). However, the role of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091436
更新日期：2019-09-11 00:00:00
abstract：:Despite extensive research and development of new treatments, acute myeloid leukemia (AML)-backbone therapy has remained essentially unchanged over the last decades and is frequently associated with poor outcomes. Eradicating the leukemic stem cells (LSCs) is the ultimate challenge in the treatment of AML. Emerging ev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
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更新日期：2020-05-18 00:00:00
abstract：:In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non-hematopoietic tissues including the nervous system. Epo protects cells from apoptosis, reduces inflammatory responses and supports re-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7020024
更新日期：2018-02-02 00:00:00
abstract：:In emergency departments, the most common cause of death associated with suspected infected patients is sepsis. In this study, deep learning algorithms were used to predict the mortality of suspected infected patients in a hospital emergency department. During January 2007 and December 2013, 42,220 patients considered...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111906
更新日期：2019-11-07 00:00:00
abstract：BACKGROUND:Patients with Crohn's disease are at increased risk for fractures due to low bone mineral density (BMD). Real-world data are necessary to optimize surveillance and treatment strategies. METHODS:Patients with Crohn's disease who underwent at least one dual-energy X-ray absorptiometry (DXA) scans were recruit...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122178
更新日期：2019-12-10 00:00:00
abstract：:Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor ou...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100334
更新日期：2018-10-08 00:00:00
abstract：:Multiple sclerosis (MS) treatment with new agents is associated with the risk of the development of progressive multifocal leukoencephalopathy (PML). The seropositivity and a high index of anti-John Cunningham virus (JCV) antibodies are some of the risk factors for PML development. The aim of this study was to assess ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123867
更新日期：2020-11-27 00:00:00
abstract：INTRODUCTION:Telemedicine is believed to be helpful in managing patients suffering from chronic diseases, in particular elderly patients with numerous accompanying conditions. This was the basis for the "GERIATRICS and e-Technology (GER-e-TEC) study", which was an experiment involving the use of the smart MyPredi™ e-pl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123836
更新日期：2020-11-26 00:00:00
abstract：:(1) Background: Acute respiratory distress syndrome (ARDS) following cardiac arrest is common and associated with in-hospital mortality. We aim to investigate whether lung compliance during targeted temperature management is associated with neurological outcome in patients with ARDS after out-of-hospital cardiac arres...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020527
更新日期：2020-02-14 00:00:00
abstract：:Background: Corticosteroids are commonly prescribed for autoimmune conditions, but their impact on preventable hospitalization rates is unclear. This study sought to investigate the effect of corticosteroid use on hospitalization for ambulatory care sensitive conditions among Taiwanese patients with ankylosing spondyl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050614
更新日期：2019-05-07 00:00:00
abstract：:The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6) with three different anesthesia methods in elderly patients undergoing hip fracture surgery. Routine blood test findings, postoperative morbidity, a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061605
更新日期：2020-05-26 00:00:00
abstract：:Diagnoses based on oral fluid biomarkers have been introduced to overcome limitations of periodontal probe-based diagnoses. Diagnostic ability of certain biomarkers for periodontitis have been identified and widely studied, however, such studies targeting gingivitis is scarce. The aims of this study were to determine ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061720
更新日期：2020-06-03 00:00:00
abstract：:Epileptic seizures in critically ill patients represent a major source of concern, because they are associated with significant mortality and morbidity rates. Despite recent advances that have enabled a better understanding of the global epidemiology of this entity, epileptic seizures in critically ill patients remain...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9072218
更新日期：2020-07-13 00:00:00
abstract：:Dilated Cardiomyopathy (DCM) has a straightforward and apparently "simple" definition: a heart muscle disease characterized by left ventricular (LV) or biventricular dilation and systolic dysfunction in the absence of either pressure or volume overload or coronary artery disease sufficient enough to explain the dysfun...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9113385
更新日期：2020-10-22 00:00:00
abstract：:The authors wish to make the following corrections to this paper [...]. ...
journal_title：Journal of clinical medicine
pub_type： 已发布勘误
doi：10.3390/jcm8050574
更新日期：2019-04-26 00:00:00
abstract：:The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8020256
更新日期：2019-02-18 00:00:00
abstract：BACKGROUND:Depression is commonly treated with anti-depressant medication and/or psychological interventions. Patients with depression are common users of complementary therapies, such as acupuncture, either as a replacement for, or adjunct to, their conventional treatments. This systematic review and meta-analysis exa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081140
更新日期：2019-07-31 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071003
更新日期：2019-07-10 00:00:00
abstract：:Abnormalities in body composition are associated with poor prognosis in cancer patients. We investigated the association between body composition and 90-day mortality in cancer patients who developed septic shock. We included consecutive septic shock patients with active cancer from 2010 to 2017. The muscle area at th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101583
更新日期：2019-10-02 00:00:00
abstract：OBJECTIVE:To investigate the risk and risk factors for suicide attempt by patients with regular migraines (RM) and status migrainosus (SM) in Taiwan. METHODS:We analyzed a subset of the National Health Insurance Research Database of Taiwan and enrolled patients (≥20 years old) who had ever received a diagnosis of RM o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090269
更新日期：2018-09-11 00:00:00
abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061954
更新日期：2020-06-23 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051447
更新日期：2020-05-13 00:00:00
abstract：:Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50-150 μm) remodeling, and collagenous investment of terminal micro-vessels (diameter ≤ 15 µm) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082575
更新日期：2020-08-08 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081251
更新日期：2019-08-19 00:00:00
abstract：:Here we describe our modified surgical technique of bilateral pubococcygeus plication (BPCP) for cystocele repair and assess its safety and long-term outcomes. This is a prospective study of 147 consecutive women who underwent BPCP for cystocele between January 2010 to January 2018. Inclusion criteria was naïve women ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103318
更新日期：2020-10-16 00:00:00
abstract：BACKGROUND:It has been recommended that any invasive treatment performed in patients with central serous chorioretinopathy (CSCR) not be initiated earlier than four months after disease onset due to the potential for spontaneous remission of symptoms. The goal of this study was to examine the outcome of transfoveal sub...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091398
更新日期：2019-09-06 00:00:00
abstract：:Ventilator-associated pneumonia (VAP) is a well-known complication of patients on invasive mechanical ventilation. The main cause of acute respiratory distress syndrome (ARDS) is pneumonia. ARDS can occur in patients with community-acquired or nosocomial pneumonia. Data regarding ARDS incidence, related pathogens, and...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113508
更新日期：2020-10-29 00:00:00
abstract：:Sepsis is a major cause of death in intensive care units worldwide. The acute phase of sepsis is often accompanied by sepsis-associated encephalopathy, which is highly associated with increased mortality. Moreover, in the chronic phase, more than 50% of surviving patients suffer from severe and long-term cognitive def...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030703
更新日期：2020-03-05 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is a pandemic viral disease originated in Wuhan, China, in December 2019, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The severe form of the disease is often associated with acute respiratory distress syndrome (ARDS), and most critically ill patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092762
更新日期：2020-08-26 00:00:00
abstract：:The new allocation criteria classify patients on veno-arterial extracorporeal membranous oxygenation (VA-ECMO) as the highest priority for receiving orthotopic heart transplantation (OHT) especially if they are considered not candidates for ventricular assist devices. The outcomes of patients who receive ventricular a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050572
更新日期：2019-04-26 00:00:00
