Abstract：
:The aim of this systematic review with meta-analysis was to investigate the available literature on transoral approaches in the treatment of hypopharyngeal squamous cell carcinoma, with a special focus on transoral robotic surgery (TORS). A systematic review was conducted according to the PRISMA (preferred reporting items for systematic reviews and meta-analyses) check-list, and 15 studies were included. Five of the included studies evaluated TORS, while ten studies focused on transoral laser microsurgery (TLM) for the treatment of early or advanced stage hypopharyngeal cancer. Overall, survival rates of TLM and TORS studies, analyzed together in the cumulative meta-analysis, were 66.4% (95% confidence interval (CI) 54.3%⁻76.7%) at 36+ months of follow up. The TORS subgroup showed a higher cumulative survival rate (85.5%, 95% CI 55.8%⁻96.5%) compared to TLM (58.5%, 95% CI 46.6%⁻69.6%). Cumulative data showed that 29.3% (95% CI 24.0%⁻35.3%) of deaths were attributable to cancer. The results were similar between TLM and TORS studies. The larynx function preservation cumulative rate was 94.3% (95% CI 91.8%⁻96.1%). The results were similar among the two subgroups. The present review supports the use of transoral approaches in the treatment of hypopharyngeal cancer. TORS is oncologically sound and provides excellent functional results with low complication rates.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
De Virgilio A,Iocca O,Malvezzi L,Di Maio P,Pellini R,Ferreli F,Cugini G,Colombo G,Spriano Gdoi
10.3390/jcm8020256subject
Has Abstractpub_date
2019-02-18 00:00:00issue
2issn
2077-0383pii
jcm8020256journal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:Both old age and institutionalization in aged care homes come with a significant risk of developing several long-term mental and neurological disorders, but there has been no definitive meta-analysis of data from studies to determine the pooled estimate of central nervous system (CNS) medicines use in aged c...
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更新日期：2019-08-23 00:00:00
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更新日期：2020-06-29 00:00:00
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更新日期：2019-10-02 00:00:00
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更新日期：2020-10-21 00:00:00
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journal_title：Journal of clinical medicine
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更新日期：2020-12-18 00:00:00
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更新日期：2020-12-30 00:00:00
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更新日期：2021-01-14 00:00:00
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更新日期：2020-04-21 00:00:00
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journal_title：Journal of clinical medicine
pub_type： 杂志文章
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更新日期：2019-10-09 00:00:00
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更新日期：2020-11-30 00:00:00
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更新日期：2018-06-15 00:00:00
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更新日期：2020-02-28 00:00:00
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更新日期：2019-11-11 00:00:00
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