Abstract：
:Multiple sclerosis (MS) treatment with new agents is associated with the risk of the development of progressive multifocal leukoencephalopathy (PML). The seropositivity and a high index of anti-John Cunningham virus (JCV) antibodies are some of the risk factors for PML development. The aim of this study was to assess the seroprevalence of anti-JCVAb and JCVAb index (AI), as well as its correlations with demographic and clinical characteristics in treatment-naïve Polish MS patients. This is a multicenter, prospective, and cross-sectional study involving 665 MS patients. The overall prevalence of anti-JCVAb was 65.3%, while 63.1% of seropositive patients had an index level of >1.5. The seroprevalence was shown to increase along with the patient's age. Except for age, the prevalence of anti-JCVAb was not associated with demographic or clinical data. No correlations between the index levels and the demographic or clinical data were observed. In Poland, the seroprevalence of anti-JCVAb in treatment-naïve MS patients is one of the highest in Europe. The majority of seropositive patients had an anti-JCV antibody level denoting a high-risk category. This means that we need further studies to be conducted on the individualization of MS treatment in order to provide patients with an appropriate therapeutic safety level.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Bonek R,Guenter W,Jałowiński R,Karbicka A,Litwin A,Maciejowski M,Zajdel R,Petit V,Rejdak Kdoi
10.3390/jcm9123867subject
Has Abstractpub_date
2020-11-27 00:00:00issue
12issn
2077-0383pii
jcm9123867journal_volume
9pub_type
杂志文章abstract：OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060148
更新日期：2018-06-11 00:00:00
abstract：BACKGROUND:Mismatch of intramedullary nails with the bowing of femur is a frequent clinical finding. Previous studies showed inconsistent results. METHODS:We present an algorithm of region growing territory method to get the radii of the anterior bowing of femur. We also tested it on ten radiographs. Plain radiographs...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101598
更新日期：2019-10-03 00:00:00
abstract：:Neutrophil extracellular traps (NETs) are supposed to play a central role in atherothrombosis. We measured circulating citrullinated histone H3 (H3Cit) and cell-free DNA (cfDNA), which serve as surrogate markers of NET formation, in 79 patients with peripheral artery disease (PAD) following infrainguinal angioplasty w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020304
更新日期：2020-01-22 00:00:00
abstract：BACKGROUND:Inflammation is often considered relating to pediatric obstructive sleep apnea (OSA). We conducted a study investigating cytokines, including Il-17 and Il-23, in children with OSA before and after adenotonsillectomy (T&A), compared with controls. METHODS:Children with OSA between age 4 and 12 receiving T&A ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041028
更新日期：2020-04-05 00:00:00
abstract：:Cardiovascular disease (CVD) is the number one cause of deaths worldwide, with yearly deaths due to atherothrombosis-i [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111895
更新日期：2019-11-06 00:00:00
abstract：:Several conditions can lead to the development of a subchondral cyst. The mechanism by which the cysts form, their location, and their severity depend on the underlying pathology, although the exact pathogenesis is not fully elucidated. Treatment options vary according to the location of the cyst, with less invasive p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051358
更新日期：2020-05-06 00:00:00
abstract：:We aimed to test the association between low-density lipoprotein cholesterol (LDL-C) and cardiovascular disease (CVD), cancer, and all-cause mortality in non-statin users. A total of 347,971 subjects in Kangbuk Samsung Health Study (KSHS.57.4% men, mean follow up: 5.64 ± 3.27 years) were tested. To validate these asso...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101571
更新日期：2019-10-01 00:00:00
abstract：:The association between tumor-associated macrophages (TAMs) and the expression of immune checkpoint molecules has not been well described in cutaneous melanoma. We evaluated the correlations between the expression of markers of TAMs, cluster of differentiation 163 (CD163), and immune checkpoint molecules, programmed c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082500
更新日期：2020-08-03 00:00:00
abstract：:With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm7020028
更新日期：2018-02-09 00:00:00
abstract：:Both vasculature and myocardium in the heart are excessively damaged following myocardial infarction (MI), hence therapeutic strategies for treating MI hearts should concurrently aim for true cardiac repair by introducing new cardiomyocytes to replace lost or injured ones. Of them, mesenchymal stem cells (MSCs) have l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051277
更新日期：2020-04-28 00:00:00
abstract：:In the grey zone of testosterone levels between 8 and 12 nmol/L, the usefulness of therapy is controversial; as such, markers of tissue action of androgens may be helpful in adjusting clinical decisions. To better understand the effect of the hypothalamic-pituitary-testicular axis on male accessory secretion, we perfo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122128
更新日期：2019-12-03 00:00:00
abstract：:Attention deficit hyperactivity disorder (ADHD) is a frequent neurodevelopmental disorder that often persists into adulthood. Methylphenidate (MPH) is the first-line treatment for ADHD; however, despite its wide usage, little is known about its neurometabolic effects. Until now, no randomized and blinded clinical tria...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082601
更新日期：2020-08-11 00:00:00
abstract：:Improving transgender people's quality of life (QoL) is the most important goal of gender-affirming care. Prospective changes in affect can influence QoL. We aim to assess the impact of initiating gender-affirming hormonal treatment (HT) on affect. In the European Network for the Investigation of Gender Incongruence (...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020296
更新日期：2021-01-14 00:00:00
abstract：:Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology is characterized by a significant cell response to injury and gene expression. No study investigating changes in expression of those genes associated with collagen regeneration and remodeling of extrac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103316
更新日期：2020-10-15 00:00:00
abstract：:Although the use of oral administration of pharmacological all-trans retinoic acid (ATRA) concentration in acute promyelocytic leukaemia (APL) patients was approved for over 20 years and used as standard therapy still to date, the same use in solid cancers is still controversial. In the present review the literature a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9020360
更新日期：2020-01-28 00:00:00
abstract：BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101642
更新日期：2019-10-08 00:00:00
abstract：:Background: Urinary calprotectin is a novel biomarker that distinguishes between intrinsic or prerenal acute kidney injury (AKI) in different studies. However, these studies were based on different populations and different AKI criteria. We evaluated the diagnostic accuracy of urinary calprotectin and compared its dia...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8010074
更新日期：2019-01-10 00:00:00
abstract：PURPOSE:To compare the reliability of five different intraoral scanners (IOSs) in the capture of implant scanbodies (SBs) and to verify the dimensional congruence between the meshes (MEs) of the SBs and the corresponding library file (LF). METHODS:A gypsum cast of a fully edentulous maxilla with six implant analogues ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072174
更新日期：2020-07-09 00:00:00
abstract：:The core conception of sepsis-that it is a dysregulated state-is a powerful and durable idea that has inspired decades of research. But is it true that the body's response to sepsis is dysregulated? To answer that question, this review surveyed the history of trials of experimental sepsis treatments targeting the host...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7090247
更新日期：2018-08-29 00:00:00
abstract：:Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of primary open angle glaucoma (POAG) is unclear and multiple ocular risk factors have been proposed, including intraocular pressure, ocular perfusion...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030761
更新日期：2020-03-11 00:00:00
abstract：:Arteriogenesis supplies oxygen and nutrients in the tumor microenvironment (TME), which may play an important role in tumor growth and metastasis. Pancreatic neuroendocrine tumors (pNETs) are the second most common pancreatic malignancy and are frequently metastatic on presentation. Nearly a third of pNETs secrete bio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111980
更新日期：2019-11-14 00:00:00
abstract：:This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103106
更新日期：2020-09-25 00:00:00
abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061954
更新日期：2020-06-23 00:00:00
abstract：:This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews to 1028 older Taiwanese adults in November 2016. Data on personal fac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7030056
更新日期：2018-03-13 00:00:00
abstract：:(1) Background: Acute respiratory distress syndrome (ARDS) following cardiac arrest is common and associated with in-hospital mortality. We aim to investigate whether lung compliance during targeted temperature management is associated with neurological outcome in patients with ARDS after out-of-hospital cardiac arres...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020527
更新日期：2020-02-14 00:00:00
abstract：:The aim of this study is to determine the accuracy of adrenal vein sampling (AVS) with and without adrenocorticotropic hormone (ACTH) stimulation to distinguish between unilateral and bilateral primary hyperaldosteronism (PA). Retrospective analysis of a prospective database from a referral center between 1984 and 200...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051447
更新日期：2020-05-13 00:00:00
abstract：:We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040911
更新日期：2020-03-26 00:00:00
abstract：:Conventional angiography is used to evaluate and treat possible sources of intraabdominal bleeding, though it may cause complications such as contrast-induced nephropathy (CIN). The study's purpose was to identify factors predicting active extravasation and complications during angiography for acute intraabdominal ble...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6040047
更新日期：2017-04-18 00:00:00
abstract：:Adjustment disorders (AjD) with depressive symptoms following an acquired brain injury (ABI) is a common phenomenon. Although brain injuries are increasing more and more, research on psychological therapies is comparably scarce. The present study compared, by means of a randomized controlled trial (RCT), a newly devel...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061684
更新日期：2020-06-02 00:00:00
abstract：INTRODUCTION:Cardiovascular risk factors, pre-existing comorbidities, molecular factors, and the direct effects of second- and third-generation BCR-ABL1 tyrosine kinase inhibitors on the vascular endothelium contribute to the progression of cardiovascular (CV) events, especially atherothrombotic conditions. The study o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103269
更新日期：2020-10-12 00:00:00
