Abstract：
:Community-acquired pneumonia (CAP) remains the first cause of morbidity and mortality worldwide due to infection. Several aspects such as severity and host response are related to its clinical course and outcome. Beyond the acute implications that the infection provokes in the host, pneumonia also has long-term negative consequences. Among them, cardiovascular complications and mortality are the most outstanding. Therefore, an adequate recognition and stratification of the risk of complications and mortality is crucial. Many biomarkers have been studied for these reasons, considering that each biomarker mirrors a different aspect. Moreover, the clinical application of many of them is still being deliberated because of their limitations and the heterogeneity of the disease. In this review, we examine some of the most relevant biomarkers that we have classified as cardiac and non-cardiac. We discuss some classic biomarkers and others that are considered novel biomarkers, which are mainly involved in cardiovascular risk.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Méndez R,Aldás I,Menéndez Rdoi
10.3390/jcm9020549subject
Has Abstractpub_date
2020-02-18 00:00:00issue
2issn
2077-0383pii
jcm9020549journal_volume
9pub_type
杂志文章,评审abstract：:The abnormal activation of the tryptophan catabolites pathway (TRYCATs) is observed in patients suffering from cerebrovascular disease, including stroke. A previous study confirmed that lower bioavailability of tryptophan for serotonin synthesis was characterized in the patients during the acute stroke phase. Interest...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122133
更新日期：2019-12-03 00:00:00
abstract：:Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110100
更新日期：2017-10-27 00:00:00
abstract：:Proteasome inhibitor bortezomib has been used in the treatment of refractory cases of acute and chronic antibody-mediated rejection (AMR) in kidney transplant recipients. However, its efficacy and safety as a primary treatment for early AMR has been scarcely investigated. We herein present our preliminary experience w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020529
更新日期：2020-02-15 00:00:00
abstract：:Bioimpedance spectroscopy (BIS) is a noninvasive method used to evaluate body fluid volume status in dialysis patients, but reports on its effectiveness in pediatrics are scarce. We investigated the correlation between BIS and clinical characteristics and identified the changes in patients whose dialysis prescription ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010079
更新日期：2020-12-28 00:00:00
abstract：BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072209
更新日期：2020-07-13 00:00:00
abstract：BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100296
更新日期：2018-09-21 00:00:00
abstract：:A 37 year-old man presented to the Emergency Department (ED) with new onset seizure and fall from standing.[...]. ...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm5040046
更新日期：2016-04-12 00:00:00
abstract：INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103368
更新日期：2020-10-21 00:00:00
abstract：:Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081102
更新日期：2019-07-25 00:00:00
abstract：:The aim of this study was to determine the prevalence of early chronic kidney disease (EKD) (stages 1 and 2) and the factors associated. This was a populational study including individuals from 18-75 years randomly selected from 18 Primary Healthcare centers in the area of Barcelonès Nord and Maresme (Catalunya, Spain...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091384
更新日期：2019-09-04 00:00:00
abstract：:Postoperative atrial fibrillation (POAF) is linked with increased morbidity, mortality rate and financial liability. About 20-50% of patients experience POAF after coronary artery bypass graft (CABG) surgery. Numerous review articles and meta-analyses have investigated links between patient clinical risk factors, demo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041139
更新日期：2020-04-16 00:00:00
abstract：:Pancreatic pathology, comprising acute and chronic pancreatitis, autoimmune pancreatitis and pancreatic neoplasms, primarily presents with gastrointestinal symptoms and signs; however, it is well recognized that it can also associate a wide range of extra-digestive features. Among these systemic manifestations, cutane...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082611
更新日期：2020-08-12 00:00:00
abstract：:Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041085
更新日期：2020-04-11 00:00:00
abstract：:The outcome of patients with hepatocellular carcinoma (HCC) is still poor. Decorin is a small leucine-rich proteoglycan, which exerts antiproliferative and antiangiogenic properties in vitro. We aimed to investigate the associations of decorin with physical function and prognosis in patients with HCC. We enrolled 65 p...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040936
更新日期：2020-03-28 00:00:00
abstract：:(1) Background: Acute respiratory distress syndrome (ARDS) following cardiac arrest is common and associated with in-hospital mortality. We aim to investigate whether lung compliance during targeted temperature management is associated with neurological outcome in patients with ARDS after out-of-hospital cardiac arres...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020527
更新日期：2020-02-14 00:00:00
abstract：:The purpose of this study is to describe the Minimally Invasive Intraoral Approach (MIIA) performed on selected cases of abscesses and neck phlegmons of odontogenic origin when the infection has not spread beyond the inferior mandibular margin. This technique allows us to avoid cervicotomy by a direct approach to the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092971
更新日期：2020-09-14 00:00:00
abstract：:The investigation of the potential association between ischemic stroke and subclinical atrial fibrillation (SCAF) is important for secondary prevention. We aimed to determine whether SCAF can be predicted by atrial substrate measurement with P wave signal-averaged electrocardiography (SAECG). We recruited 125 consecut...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041134
更新日期：2020-04-15 00:00:00
abstract：:This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101674
更新日期：2019-10-13 00:00:00
abstract：OBJECTIVE:To analyse the published evidence of the validity of DIAGNDOdent and VistaProof in diagnosing carious depths in pre-cavitated lesions. Material and methods: A systematic review was carried out after identifying a total of 184 articles, including 27 concerning the qualitative review and a subsequent meta-analy...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010020
更新日期：2019-12-19 00:00:00
abstract：:There is a large body of research showing that psychological treatment can be effectively delivered via the internet, and Digital Mental Health Services (DMHS) are now delivering those interventions in routine care. However, not all attempts to translate these research outcomes into routine care have been successful. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081239
更新日期：2019-08-17 00:00:00
abstract：:Continuous positive airway pressure (CPAP) is the most efficient treatment of obstructive sleep apnea (OSA). Little is known about the impact of spousal relationship profiles on CPAP adherence. We aimed to identify clusters of couples of OSA patients, and their association with CPAP adherence 120 days after CPAP initi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061658
更新日期：2020-06-01 00:00:00
abstract：:Obstructive sleep apnea (OSA) is a chronic and prevalent disorder, strongly associated with cardiovascular disease (CVD). The apnea-hypopnea index (AHI), or respiratory event index (REI), and the oxygen desaturation index (ODI) are the clinical metrics of sleep apnea in terms of diagnosis and severity. However, AHI, o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082475
更新日期：2020-08-01 00:00:00
abstract：:Fine needle aspiration cytology (FNAC) is an important diagnostic tool for tumors of the head and neck. However, non-diagnostic or inconclusive results may occur and lead to delay in treatment. The aim of this study was to evaluate the factors that predict a successful FNAC. A retrospective search was performed to ide...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122050
更新日期：2019-11-22 00:00:00
abstract：:Overactivated osteoclasts lead to many bone diseases, including osteoporosis and rheumatoid arthritis. The p38 MAPK (p38) is an essential regulator of the receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone loss. We previously reported TAT conjugated thioredoxin-interacting prot...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040431
更新日期：2019-03-29 00:00:00
abstract：:About one-fifth of couples has fertility problems in Western countries. Male factors are present in about half of them, either alone or in combination with female causes. Therefore, both partners should be evaluated simultaneously. The fertility status and/or specific conditions of each partner influence the clinical ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061644
更新日期：2020-05-30 00:00:00
abstract：:The repair of bone defects caused by trauma, infection or tumor resection is a major clinical orthopedic challenge. The application of bone grafts in orthopedic procedures is associated with a problem of inadequate vascularization in the initial phase after implantation. Meanwhile, the survival of cells within the imp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101602
更新日期：2019-10-03 00:00:00
abstract：:Epithelial to mesenchymal transition (EMT) induces cell migration, invasion, and drug resistance, and consequently, contributes to cancer metastasis and disease aggressiveness. This study attempted to address crucial biological parameters to correlate EMT and drug-treated cancer cells traversing through microcapillari...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081194
更新日期：2019-08-09 00:00:00
abstract：:The clinical use of virtual reality (VR) has proven its efficacy, especially when used as an exposure technique. A prominent property of VR's utility is its equivalence with the reality it represents. In this study, we explored this equivalence in a clinical context using neuroimaging. A sample of 32 adults with speci...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122139
更新日期：2019-12-04 00:00:00
abstract：:Focal Segmental Glomerulosclerosis (FSGS) recurrence after kidney transplantation (KTx) is relatively frequent and is associated with poor graft survival. The aim of this study was to investigate which management strategies were associated with better outcomes in our cohort of KTx recipients with primary FSGS. We retr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030373
更新日期：2021-01-20 00:00:00
abstract：BACKGROUND:There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS:We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9082560
更新日期：2020-08-07 00:00:00
