Abstract:
:The aim of this study was to elucidate the lifelong disease progression of chronic obstructive pulmonary disease (COPD) with biomarker changes and identify their influencing factors, by utilizing a new analysis method, Statistical Restoration of Fragmented Time-course (SReFT). Individual patient data (n = 1025) participating in the Study to Understand Mortality and MorbidITy (SUMMIT, NCT01313676), which was collected within the observational period of 4 years, were analyzed. The SReFT analysis suggested that scores of St. George's Respiratory Questionnaire and COPD assessment test, representative scores of the health-related quality of life (HRQOL) questionnaire, increased consistently for 30 years of disease progression, which was not detected by conventional analysis with a linear mixed effect model. It was estimated by the SReFT analysis that normalized forced expiratory volume in one second for age, sex, and body size (%FEV1) reduced for the initial 10 years from the onset of the disease but thereafter remained constant. The analysis of HRQOL scores and lung functions suggested that smoking cessation slowed COPD progression by approximately half and that exacerbation accelerated it considerably. In conclusion, this retrospective study utilizing SReFT elucidated the progression of COPD over 30 years and associated quantitative changes in the HRQOL scores and lung functions.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kawamatsu S,Jin R,Araki S,Yoshioka H,Sato H,Sato Y,Hisaka Adoi
10.3390/jcm9082676subject
Has Abstractpub_date
2020-08-18 00:00:00issue
8issn
2077-0383pii
jcm9082676journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Mismatch of intramedullary nails with the bowing of femur is a frequent clinical finding. Previous studies showed inconsistent results. METHODS:We present an algorithm of region growing territory method to get the radii of the anterior bowing of femur. We also tested it on ten radiographs. Plain radiographs...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101598
更新日期:2019-10-03 00:00:00
abstract::Stem cells have been the focus of intense research opening up new possibilities for the treatment of various diseases. Mesenchymal stromal cells (MSCs) are multipotent cells with relevant immunomodulatory properties and are thus considered as a promising new strategy for immune disease management. To enhance their eff...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm8050626
更新日期:2019-05-08 00:00:00
abstract::Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6110100
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100296
更新日期:2018-09-21 00:00:00
abstract::Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091377
更新日期:2019-09-03 00:00:00
abstract::Hereditary hemorrhagic telangiectasia (HHT) is characterized by mucocutaneous telangiectases and visceral vascular malformations. Individuals suffering from HHT have a significantly increased risk of bacterial infections, but the mechanisms involved in this are not clear. White blood cell subpopulations were estimated...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9030767
更新日期:2020-03-12 00:00:00
abstract::Irritable bowel syndrome (IBS) is a disorder of the brain-gut axis; the pathophysiological mechanisms include altered colonic motility, bile acid metabolism, neurohormonal regulation, immune dysfunction, alterations in the epithelial barrier and secretory properties of the gut. This article reviews the mechanisms, eff...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6110101
更新日期:2017-10-27 00:00:00
abstract::Alzheimer's disease (AD), the most common cause of dementia, is a neurodegenerative disease that seriously threatens human health and life quality. The main pathological features of AD include the widespread deposition of amyloid-beta and neurofibrillary tangles in the brain. So far, the pathogenesis of AD remains elu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072042
更新日期:2020-06-29 00:00:00
abstract::Suprascapular neuropathy is an uncommon but increasingly recognized cause of shoulder pain and dysfunction due to nerve entrapment. The aim of this review is to summarize some important aspects of this shoulder pathology. An extensive research was performed on PubMed and Clinical Key. The goal was to collect all the a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082331
更新日期:2020-07-22 00:00:00
abstract:INTRODUCTION:Traumatic cervical artery dissections are associated with high mortality and morbidity in severely injured patients. After finding even higher incidences than reported before, we decided to incorporate a dedicated head-and-neck computed tomography angiogram (CT-A) in our imaging routine for patients who ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082568
更新日期:2020-08-08 00:00:00
abstract::The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020300
更新日期:2021-01-15 00:00:00
abstract::Apurinic/apyrimidinic endonuclease 1/redox effector factor 1 (APEX1) has been known to play key roles in DNA repair, the regulation of diverse transcriptional activity, and cellular responses to redox activity. This study aimed to examine serum APEX1 (s-APEX1) expression as a possible screening biomarker for clear cel...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8081151
更新日期:2019-08-01 00:00:00
abstract::Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010156
更新日期:2020-01-07 00:00:00
abstract::Hepatobiliary complications in children with sickle cell disease (SCD) are rarely reported but can be life-threatening. We retrospectively assessed their prevalence in a cohort of 616 children followed in a French university-hospital SCD reference center. Eligibility criteria were the following: age <18 years, seen at...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091481
更新日期:2019-09-18 00:00:00
abstract:OBJECTIVE:Clinical presentation of patients with mitral paravalvular leakage (PVL) varies from asymptomatic to heart failure related with hemolytic anemia or pulmonary hypertension. We aimed to investigate the structural and functional characteristics of mitral PVL by multimodal imaging and their association with the s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10020222
更新日期:2021-01-10 00:00:00
abstract:BACKGROUND:To study the impact of MRI characteristics and of targeted biopsy (TB) core number on the final grade group (GG) prediction. MATERIALS AND METHODS:The cohort was 478 consecutive patients who underwent radical prostatectomy (RP) after positive mpMRI (multiparametric magnetic resonance imaging) followed by fu...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010225
更新日期:2020-01-15 00:00:00
abstract::Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072299
更新日期:2020-07-20 00:00:00
abstract::Ovarian endometrioma are found in up to 40% of women with endometriosis and 50% of infertile women. The best surgical approach for endometrioma and its impact on pregnancy rates is still controversial. Therefore, we conducted a literature review on surgical management of ovarian endometrioma and its impact on pregnanc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10030414
更新日期:2021-01-22 00:00:00
abstract::Increased the incidence of prediabetes and type 2 diabetes (T2D) worldwide raises an urgent need to develop effective tools for early disease detection to facilitate future preventive interventions and improve patient's care. We evaluated the suitability of diabetes-related miR-375 and miR-9 as earlier biomarkers for ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7020012
更新日期:2018-01-26 00:00:00
abstract:BACKGROUND:The Dyskinesia Impairment Scale (DIS) is a new assessment scale for dystonia and choreoathetosis in children and youth with dyskinetic cerebral palsy. Today, the Burke-Fahn-Marsden Dystonia Rating Scale (BFM) is mostly used to assess dystonia in children with inherited dystonia. The aim of this study was to ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082597
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND AND AIM:Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features. METHODS:An active stand test was performed to e...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9124125
更新日期:2020-12-21 00:00:00
abstract::Decompensated cirrhosis predisposes to infectious diseases and acute-on-chronic liver failure (ACLF) in critically ill patients. Infections like spontaneous bacterial peritonitis (SBP) are frequently associated with multi-organ failure and increased mortality. Consequently, reliable predictors of outcome and early dia...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092865
更新日期:2020-09-04 00:00:00
abstract::Here we describe our modified surgical technique of bilateral pubococcygeus plication (BPCP) for cystocele repair and assess its safety and long-term outcomes. This is a prospective study of 147 consecutive women who underwent BPCP for cystocele between January 2010 to January 2018. Inclusion criteria was naïve women ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103318
更新日期:2020-10-16 00:00:00
abstract::Although the introduction of bortezomib as a therapeutic strategy has improved the overall survival of multiple myeloma (MM) patients, 15-20% of high-risk patients do not respond to bortezomib over time or become resistant to treatment. Therefore, the development of new therapeutic strategies, such as combination ther...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020552
更新日期:2020-02-18 00:00:00
abstract::Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103081
更新日期:2020-09-24 00:00:00
abstract:INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103368
更新日期:2020-10-21 00:00:00
abstract::Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041204
更新日期:2020-04-22 00:00:00
abstract::Conventional 3D multicellular tumor spheroids of head and neck squamous cell carcinoma (HNSCC) consisting exclusively of cancer cells have some limitations. They are compact cell aggregates that do not interact with their extracellular milieu, thus suffering from both insufficient extracellular matrix (ECM) deposition...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101686
更新日期:2019-10-15 00:00:00
abstract::(1) Background: Acute respiratory distress syndrome (ARDS) following cardiac arrest is common and associated with in-hospital mortality. We aim to investigate whether lung compliance during targeted temperature management is associated with neurological outcome in patients with ARDS after out-of-hospital cardiac arres...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020527
更新日期:2020-02-14 00:00:00
abstract::The aim of this article is to investigate pathological subjects from a population through different physical factors. To achieve this, particle swarm optimization (PSO) and K-means (KM) clustering algorithms have been combined (PSO-KM). Datasets provided by the literature were divided into three clusters based on age ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7040065
更新日期:2018-03-28 00:00:00