Abstract：
:Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson's disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. While several functions have been ascribed to DJ-1 (most notably protection from oxidative stress), its contribution to PD pathogenesis is not yet clear. Here we provide an overview of the clinical research to date on DJ-1 and the current state of knowledge regarding DJ-1 characterization in the human brain. The relevance of DJ-1 as a PD biomarker is also discussed, as are studies exploring DJ-1 as a possible therapeutic target for PD and neurodegeneration.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Repici M,Giorgini Fdoi
10.3390/jcm8091377subject
Has Abstractpub_date
2019-09-03 00:00:00issue
9issn
2077-0383pii
jcm8091377journal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:Cesarean deliveries represent a large percentage of deliveries worldwide. Patients undergoing repeat cesarean deliveries are known to have increased risks for surgical complications. However, little is known regarding potential differences in pain. We sought to compare postoperative opioid consumption and pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122221
更新日期：2019-12-16 00:00:00
abstract：:In December 2019, a novel coronavirus, SARS-CoV-2, appeared, causing a wide range of symptoms, mainly respiratory infection. In March 2020, the World Health Organization (WHO) declared Coronavirus Disease 2019 (COVID-19) a pandemic, therefore the efforts of scientists around the world are focused on finding the right ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061917
更新日期：2020-06-19 00:00:00
abstract：:With the improvement in survival rate, cardiotoxicity has emerged as a significant adverse effect of cancer therapy. Early diagnosis of subclinical cardiac injury may allow the initiation of cardioprotective therapy and preventing the interruption of optimal cancer therapy and the development of irreversible cardiac d...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010154
更新日期：2021-01-05 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051421
更新日期：2020-05-11 00:00:00
abstract：:Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately predict the risk of cancer progression. The pluripotency transcription ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101744
更新日期：2019-10-21 00:00:00
abstract：:Graves' orbitopathy (GO) is the most common extrathyroidal manifestation of Graves' disease (GD). Our aim was to assess the efficacy and safety of Tocilizumab (TCZ) in GO refractory to conventional therapy. This was an open-label multicenter study of glucocorticoid-resistant GO treated with TCZ. The main outcomes were...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092816
更新日期：2020-08-31 00:00:00
abstract：:The aim of this study was to evaluate the ability of a PIPS (photon-induced photoacoustic streaming) Er:YAG laser to reduce the root canal system bacterial count in vivo in comparison to the traditional irrigation technique. The post-operative patients' quality of life (QoL) after endodontic therapy was evaluated thro...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123915
更新日期：2020-12-02 00:00:00
abstract：:This study aimed to evaluate the effect of bladder neck preservation (BNP) on long-term urinary continence after robot-assisted laparoscopic prostatectomy (RALP). We systematically searched the PubMed, Embase, and Cochrane Library databases to identify studies that assessed the difference in urinary continence and onc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8122068
更新日期：2019-11-24 00:00:00
abstract：:Central serous chorioretinopathy (CSC) is a complex and not entirely understood retinal disease. The aim of our research was to describe a novel optical coherence tomography (OCT) finding named "choroidal rift", which may be identified in the choroid of eyes with CSC. We collected data from 357 patients (488 eyes) wit...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072260
更新日期：2020-07-16 00:00:00
abstract：:Accurate assessment of nodal metastasis in head and neck squamous cell carcinoma (SCC) is important, and diffusion-weighted imaging (DWI) has emerged as a potential technique in differentiating benign from malignant lymph nodes (LNs). This study aims to evaluate the diagnostic performance of texture analysis using app...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111767
更新日期：2019-10-23 00:00:00
abstract：:Sarcopenia is defined as a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength. It has been identified as one of the most common comorbidities associated with femoral neck fracture (FNF). The aim of this review was to evaluate the impact of physical therapy on FNF patients' ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103115
更新日期：2020-09-26 00:00:00
abstract：:Helicobacter pylori, responsible for chronic ulcers and most stomach cancers, infects half of the world's population. The Urea Breath Test (UBT) is one of the most accurate and reliable non-invasive methods for diagnosing active H. pylori infection. The objective was to use longitudinal, population-wide UBT data for W...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111821
更新日期：2019-11-01 00:00:00
abstract：:The aim of this study was to assess the efficacy of anti-endomysium antibodies (EMA) as a serological marker for celiac disease (CD) diagnosis in a pediatric population. A retrospective study of pediatric patients who underwent a CD serological markers study: EMA and anti-tissue transglutaminase antibodies (anti-TG2)....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122179
更新日期：2019-12-11 00:00:00
abstract：:Multidrug resistant Gram-Negative Bacterial Infections (MR-GNBI) are an increasing cause of mortality in acute myeloid leukemia (AML), compromising the success of antineoplastic therapy. We prospectively explored a novel strategy, including mandatory fluoroquinolone prophylaxis, weekly surveillance cultures (SC) and t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111985
更新日期：2019-11-15 00:00:00
abstract：:Chronic pain is one of the major causes of disability in the general population. Even though there are effective treatment options available for reducing symptoms, these treatments often do not have consistent lasting effects. As the usage of mobile devices has increased enormously during the last few years, mobile ap...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113557
更新日期：2020-11-05 00:00:00
abstract：:Pediatric cancer survivors are at increased risk for psychological distress. We sought to understand the severity and symptoms' co-occurrence among pediatric survivors compared to controls by rating both self- and parent-reported symptomatology. Forty survivors (22 males; mean age at study time: 12.9 years) participat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113444
更新日期：2020-10-27 00:00:00
abstract：:Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible in only 20% of patients due to advanced stage at diagnosis, or palli...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072319
更新日期：2020-07-21 00:00:00
abstract：:The burden of cardiovascular disease and death in chronic kidney disease (CKD) outpaces that of the other diseases and is not adequately described by traditional risk factors alone. Diminished activity of paraoxonase (PON)-1 is associated with increased oxidant stress, a common feature underlying the pathogenesis of C...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071034
更新日期：2019-07-15 00:00:00
abstract：:Mitochondrial respiratory chain (MRC) disorders have a multifaceted clinical presentation and genetic origin[...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm7040066
更新日期：2018-03-29 00:00:00
abstract：:Polycystic ovary syndrome (PCOS) is a common condition, affecting 5⁻10% of women of reproductive age worldwide. It has serious reproductive implications and causes mood disorders and metabolic disorders, such as type-2 diabetes. Because PCOS reflects multiple abnormalities, there is no single drug that can treat all i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7070179
更新日期：2018-07-22 00:00:00
abstract：:One in every four deaths is due to cancer in Europe. In view of its increasing incidence, cancer became the leading cause of death and disease burden in Denmark, France, the Netherlands, and the UK. Without essential improvements in cancer prevention, an additional 775,000 cases of annual incidence have been prognosed...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9092749
更新日期：2020-08-25 00:00:00
abstract：:The selection of a highly-viable single embryo in assisted reproductive technology requires an acceptable predictive method in order to reduce the multiple pregnancy rate and increase the success rate. In this study, the metabolomic profiling of growing and impaired embryos was assessed on the fifth day of fertilizati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124094
更新日期：2020-12-18 00:00:00
abstract：:Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090266
更新日期：2018-09-09 00:00:00
abstract：:Rheumatoid arthritis (RA) is a systemic autoimmune disease, caused by both genetic and environmental factors. Recently, investigators have focused on the gut microbiota, which is thought to be an environmental agent affecting the development of RA. Here we review the evidence from animal and human studies that support...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6060060
更新日期：2017-06-09 00:00:00
abstract：:We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124032
更新日期：2020-12-13 00:00:00
abstract：:Cardiogenic shock (CS), as the most severe form of heart failure, is associated with very high mortality rates despite therapeutic advances in the last decades. Gender differences in outcomes have been widely reported regarding several cardiovascular diseases. The aim of our study was to evaluate potential gender disp...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103117
更新日期：2020-09-27 00:00:00
abstract：:The superiority of distinct anesthesia methods for geriatric hip fracture surgery remains unclear. We evaluated high mobility group box-1 (HMGB1) and interleukin-6 (IL-6) with three different anesthesia methods in elderly patients undergoing hip fracture surgery. Routine blood test findings, postoperative morbidity, a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061605
更新日期：2020-05-26 00:00:00
abstract：INTRODUCTION:Telemedicine is believed to be helpful in managing patients suffering from chronic diseases, in particular elderly patients with numerous accompanying conditions. This was the basis for the "GERIATRICS and e-Technology (GER-e-TEC) study", which was an experiment involving the use of the smart MyPredi™ e-pl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123836
更新日期：2020-11-26 00:00:00
abstract：:The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061718
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:Neoadjuvant therapy (NAT) represents a paradigm shift in the management of patients with pancreatic ductal adenocarcinoma (PDAC) with perceived benefits including a higher R0 rate. However, it is unclear whether NAT affects the sites and patterns of recurrence after surgery. This review seeks to compare site...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072132
更新日期：2020-07-06 00:00:00
