Abstract:
:The purpose of this study was to compare the thickness of all inner and outer macular layers between ocular hypertension (OHT) and early primary open-angle glaucoma (POAG) using spectral domain optical coherence tomography (SD-OCT) 8 × 8 posterior pole algorithm (8 × 8 PPA). Fifty-seven eyes of 57 OHT individuals and fifty-seven eyes of 57 early POAG patients were included. The thickness of macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform and nuclear layer, photoreceptor layer (PRL) and retinal pigment epithelium were obtained in 64 cells for each macular layer and mean thickness of superior and inferior hemispheres was also calculated. Thinning of superior and inferior hemisphere mean thickness in mRNFL, GCL and IPL and thickening of superior and inferior hemisphere mean thickness in PRL and inferior hemisphere in INL were found in early GPAA group. Otherwise, heatmaps representing cell-to-cell comparisons showed thinning patterns in inner retinal layers (except for INL) and thickening patterns in outer retinal layers in GPAA group. We found that 8 × 8 PPA not only allows the detection of significant thinning patterns in inner retinal layers, but also thickening patterns in outer retinal layers when comparing early POAG eyes to OHT eyes.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Garcia-Medina JJ,Del-Rio-Vellosillo M,Palazon-Cabanes A,Pinazo-Duran MD,Zanon-Moreno V,Villegas-Perez MPdoi
10.3390/jcm9051503subject
Has Abstractpub_date
2020-05-16 00:00:00issue
5issn
2077-0383pii
jcm9051503journal_volume
9pub_type
杂志文章abstract:INTRODUCTION:Exposure to cumulative environmental risk factors across development has been linked to a host of adverse health/functional outcomes. This perspective incorporating information regarding exposure at differing developmental periods is lacking in research surrounding individuals at Clinical High Risk (CHR) f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070994
更新日期:2019-07-09 00:00:00
abstract::Continuous positive airway pressure (CPAP) is the most efficient treatment of obstructive sleep apnea (OSA). Little is known about the impact of spousal relationship profiles on CPAP adherence. We aimed to identify clusters of couples of OSA patients, and their association with CPAP adherence 120 days after CPAP initi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061658
更新日期:2020-06-01 00:00:00
abstract::The aim of this systematic review and meta-analysis was to evaluate the clinical performance of tooth-borne partial and full-coverage fixed dental prosthesis fabricated using hybrid polymer and ceramic CAD/CAM materials regarding their biologic, technical and esthetical outcomes. PICOS search strategy was applied usin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072107
更新日期:2020-07-04 00:00:00
abstract:INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103368
更新日期:2020-10-21 00:00:00
abstract::(1) Background: To evaluate women's satisfaction with the care received during childbirth undergoing labour and how this changes over time. (2) Methods: An observational, multicentre and longitudinal study in two public hospitals of Spain with a convenience sample of 248 women during the post-partum period. Satisfacti...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040434
更新日期:2019-03-29 00:00:00
abstract::Tuberculosis (TB) remains a major health issue worldwide. In order to contain TB infections, improved vaccines as well as accurate and reliable diagnostic tools are desirable. Exosomes are employed for the diagnosis of various diseases. At present, research on exosomes in TB is still at the preliminary stage. Recent s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010145
更新日期:2021-01-04 00:00:00
abstract::Substantial progress in recent years has dramatically increased our knowledge of the molecular basis of cancer, revealing new potential therapeutic targets and paving the way for effective personalised medicine for the treatment of many tumour types. However, pancreatic cancer has been lagging behind in this success a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010149
更新日期:2021-01-04 00:00:00
abstract::(1) Introduction: Several surgical therapy options for the treatment of pathologies of the long biceps tendon (LHB) have been established. However, tenotomy, as well as established tenodesis techniques, has disadvantages, such as cosmetic deformities, functional impairments and residual shoulder pain. This study prese...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10030432
更新日期:2021-01-23 00:00:00
abstract:BACKGROUND:Psoriasis is a chronic inflammatory disease which affects the body far beyond the skin. Whereas there is solid evidence that chronic skin inflammation in psoriasis drives cardiovascular disease, the impact on renal impairment and acute kidney injury (AKI) is still unclear. We aimed to analyze the impact of p...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9093004
更新日期:2020-09-17 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:Journal of clinical medicine
pub_type: 已发布勘误
doi:10.3390/jcm8030389
更新日期:2019-03-20 00:00:00
abstract::There are considerable psychological and psychiatric consequences of the pandemic. Researchers have started to take into account the real or perceived sense of social threats that may be expressed, such as anxiety, depression, and sleep disorders. However, analyses on pandemic-related anxiety, depression, and sleep di...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092872
更新日期:2020-09-05 00:00:00
abstract:INTRODUCTION:Traumatic cervical artery dissections are associated with high mortality and morbidity in severely injured patients. After finding even higher incidences than reported before, we decided to incorporate a dedicated head-and-neck computed tomography angiogram (CT-A) in our imaging routine for patients who ha...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082568
更新日期:2020-08-08 00:00:00
abstract::Although remote ischemic preconditioning (RIPC) has been shown to have renoprotective effects, few studies have assessed the effects of RIPC on renal function in living kidney donors. This study investigated whether RIPC performed in living kidney donors could improve residual renal function in donors and outcomes in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050713
更新日期:2019-05-20 00:00:00
abstract:BACKGROUND:To determine the validity of the Quick Sepsis-Related Organ Failure Assessment (qSOFA) in the prediction of outcome (in-hospital and 1-month mortality, intensive care unit (ICU) admission, and hospital and ICU length of stay) in adult patients with or without suspected infections where qSOFA was calculated a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8010061
更新日期:2019-01-08 00:00:00
abstract::This article evaluates the psychometric properties of a new measure for assessing Substance-Related and Addictive Disorders: the Addictive Behavior Questionnaire (ABQ). The ABQ is a self-report measure composed of two sections: the Severity Index (SI) and the Seven Domains Addiction Scale (7DAS). MATERIALS AND METHOD...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7080194
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:In order to promote physical activity (PA) in patients with complicated type 2 diabetes, a better understanding of daily movement is required. We (1) objectively assessed PA in patients with type 2 diabetes, and (2) studied the association between muscle mass, dietary protein intake, and PA. Methods: We perfo...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103104
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND AND AIMS:The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted a validation study of the original MPI, and of adapted versions that accounted for the use of ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111820
更新日期:2019-11-01 00:00:00
abstract::To assess neck disability with respect to jaw disability, craniocervical position, cervical alignment, and sensorimotor impairments in patients with temporomandibular disorders (TMD), a systematic review and meta-analysis of observational studies trials were conducted. The meta-analysis showed statistically significan...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9092806
更新日期:2020-08-30 00:00:00
abstract::The number of healthy and frail older adults is increasing worldwide, especially in industrialized countries, as a result of the increase in life expectancy [...]. ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm10020166
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Several comparison studies have suggested that kidney transplantation (KT) could reduce mortality in patients with end-stage renal disease (ESRD). Selection criteria bias is common in the selection of dialysis patients for control groups. In this study, we compared the survival outcome between KT recipients ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110388
更新日期:2018-10-26 00:00:00
abstract::Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6110100
更新日期:2017-10-27 00:00:00
abstract:BACKGROUND:It has been recommended that any invasive treatment performed in patients with central serous chorioretinopathy (CSCR) not be initiated earlier than four months after disease onset due to the potential for spontaneous remission of symptoms. The goal of this study was to examine the outcome of transfoveal sub...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091398
更新日期:2019-09-06 00:00:00
abstract::Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm3010025
更新日期:2014-01-09 00:00:00
abstract::Our aim was to illustrate our technique of sex-sparing (SS)-robot-assisted radical cystectomy (RARC) in female patients receiving an intracorporeal neobladder (iN). From January 2013 to June 2018, 11 female patients underwent SS-RARC-iN at a single tertiary referral center. Inclusion criteria were a cT ≤ 2 N0 M0 bladd...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020577
更新日期:2020-02-20 00:00:00
abstract::Infections with SARS-CoV-2 can result in severe clinical manifestations. As such patients present with systemic inflammation, we studied the prevalence and predictive value of anemia of inflammation (AI) or functional iron deficiency (FID), originating from immune-mediated alterations of iron homeostasis. Within this ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082429
更新日期:2020-07-29 00:00:00
abstract:BACKGROUND:Hybrid minimally invasive esophagectomy (HMIE) has been proven to be superior when compared with open esophagectomy, with a significant reduction of postoperative morbidity. In HMIE, the laparotomy is replaced by a minimally invasive laparoscopic approach. The radical mediastinal resection plus reconstructio...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070978
更新日期:2019-07-05 00:00:00
abstract::In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071080
更新日期:2019-07-23 00:00:00
abstract::Diabetes mellitus is one of the most prevalent chronic diseases worldwide. Diabetic patients are at risk of developing cataract and present for surgery at an earlier age than non-diabetics. The aim of this study was to review the problems associated with cataract surgery in a diabetic patient. Corneal complications in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050716
更新日期:2019-05-20 00:00:00
abstract::(1) Background: The use of smartphone-based ecological momentary assessment (EMA) questionnaires in affective disorder research has rapidly increased. Though, a thorough understanding of experienced burden of and adherence to EMA is crucial in determining the usefulness of EMA. (2) Methods: Persons with current affect...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020322
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:To compare the clinical, serological and histologic features between male and female patients with Sjögren's syndrome (SS) and explore the potential effect of gender on lymphoma development. METHODS:From a multicenter population (Universities of Udine, Pisa and Athens, Harokopion and Ioannina (UPAHI)) consi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082620
更新日期:2020-08-12 00:00:00