Abstract：
:Surgery, including minimally invasive surgery, and radiotherapy are key modalities in the treatment of gynecological malignancies. The aim of this review is to offer the multidisciplinary care team a comprehensive summary of the intersections of surgery and radiotherapy in the local treatment of gynecological malignancies. Recent advances in radiotherapy are highlighted. Relevant publications were identified through a review of the published literature. Ovarian, endometrial, cervical, vaginal, and vulvar cancer were included in the search. Current guidelines are summarized. The role of radiotherapy in adjuvant as well as definitive treatment of these entities is synthesized and put into context with surgery, focusing on survival and quality of life. Although these outcomes have improved recently, further research must be focused on the number of life years lost, and the potential morbidity encountered by patients.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Fabian A,Krug D,Alkatout Idoi
10.3390/jcm10010093subject
Has Abstractpub_date
2020-12-29 00:00:00issue
1issn
2077-0383pii
jcm10010093journal_volume
10pub_type
杂志文章,评审abstract：:The type of fixation used in primary total knee replacement (TKR) may influence the risk of prosthetic joint infection (PJI). We conducted a systematic review and meta-analysis to assess published evidence linking type of fixation (cemented, uncemented, or hybrid) with the risk of PJI following primary TKR. Randomised...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060828
更新日期：2019-06-11 00:00:00
abstract：:Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately predict the risk of cancer progression. The pluripotency transcription ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101744
更新日期：2019-10-21 00:00:00
abstract：BACKGROUND:To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. METHODS:This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124016
更新日期：2020-12-11 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
abstract：:Hyperglycemia is a common occurrence in hospitalized patients receiving parenteral and/or enteral nutrition. Although there are several approaches to manage hyperglycemia, there is no consensus on the best practice. We systematically searched PubMed, Embase, Cochrane Central, and ClinicalTrials.gov to identify records...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8070935
更新日期：2019-06-28 00:00:00
abstract：:Percutaneous electrolysis is an emerging intervention proposed for the management of tendinopathies. Tendon pathology is characterized by a significant cell response to injury and gene expression. No study investigating changes in expression of those genes associated with collagen regeneration and remodeling of extrac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103316
更新日期：2020-10-15 00:00:00
abstract：:C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6100094
更新日期：2017-10-07 00:00:00
abstract：:Background: We performed this prospective double-blind randomized controlled trial to identify the effect of a preoperative prophylactic transdermal scopolamine (TDS) patch on postoperative nausea and vomiting (PONV) after retromastoid craniectomy with microvascular decompression (RMC-MVD). Methods: We recruited 38 pa...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010156
更新日期：2020-01-07 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
abstract：:This study was designed to determine the influence of microvesicles (MVs) derived from multipotent stromal cells isolated from human adipose tissue (hASCs) on retinal functionality in dogs with various types of retinal degeneration. The biological properties of hASC-MVs were first determined using an in vitro model of...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm8040510
更新日期：2019-04-13 00:00:00
abstract：:Electrical enabling motor control (eEmc) through transcutaneous spinal cord stimulation is a non-invasive method that can modify the functional state of the sensory-motor system. We hypothesize that eEmc delivery, together with hand training, improves hand function in healthy subjects more than either intervention alo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020195
更新日期：2021-01-07 00:00:00
abstract：:The aim of the study was to examine the usefulness of targeted musculoskeletal ultrasonography (MSUS) in assessing the disease activity of patients with early inflammatory arthritis (EIA). Twenty-eight patients with EIA were enrolled. The MSUS examination of joints with arthritic signs (tenderness or swelling), measur...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020283
更新日期：2021-01-14 00:00:00
abstract：:We report a case of a pregnant woman with nephrotic syndrome due to biopsy-proven focal segmental glomerulosclerosis (FSGS) whose fetus developed echogenic kidneys and severe oligohydramnios by 27 weeks of gestation. Maternal treatment with prednisone resulted in normalization of the amniotic fluid indices and resolut...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm7100324
更新日期：2018-10-04 00:00:00
abstract：:After normal survival has been achieved in most patients with chronic myeloid leukemia (CML), a new goal for treating CML is survival at good quality of life, with treatment discontinuation in sustained deep molecular response (DMR; MR4 or deeper) and treatment-free remission (TFR). Four tyrosine kinase inhibitors (TK...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113671
更新日期：2020-11-16 00:00:00
abstract：BACKGROUND:Several comparison studies have suggested that kidney transplantation (KT) could reduce mortality in patients with end-stage renal disease (ESRD). Selection criteria bias is common in the selection of dialysis patients for control groups. In this study, we compared the survival outcome between KT recipients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7110388
更新日期：2018-10-26 00:00:00
abstract：:Diabetic retinopathy (DR) is reaching epidemic levels globally due to the increase in prevalence of diabetes mellitus (DM). DR also has detrimental effects to quality of life, as it is the leading cause of blindness in the working-age population and the most common cause of vision loss in individuals with DM. Over sev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8071033
更新日期：2019-07-14 00:00:00
abstract：:The focus of the presented work was to isolate and characterize circulating endometrial cells (CECs) enriched from peripheral blood (PB) of patients with diagnosed endometriosis. The molecular characteristics of CECs could be supportive for an understanding of endometriosis pathogenesis and treatment decisions in the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111938
更新日期：2019-11-11 00:00:00
abstract：:Postoperative atrial fibrillation (POAF) is linked with increased morbidity, mortality rate and financial liability. About 20-50% of patients experience POAF after coronary artery bypass graft (CABG) surgery. Numerous review articles and meta-analyses have investigated links between patient clinical risk factors, demo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041139
更新日期：2020-04-16 00:00:00
abstract：BACKGROUND:In late December 2019, a new pandemic caused by the SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) infection began to spread around the world. The new situation gave rise to severe health threats, economic uncertainty, and social isolation, causing potential deleterious effects on people's phys...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103250
更新日期：2020-10-12 00:00:00
abstract：:The innate immunity has evolved during millions of years, and thus, equivalent or comparable components are found in most vertebrates, invertebrates, and even plants. It constitutes the first line of defense against molecules, which are either pathogen-derived or a danger signal themselves, and not seldom both. These ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111981
更新日期：2019-11-14 00:00:00
abstract：:With this Editorial we want to present the Special Issue "Big Data and Precision Medicine Series I: Lung Cancer Early Diagnosis" to the scientific community, which aims to gather experts on the early detection of lung cancer in order to implement common efforts in the fight against cancer. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm7020028
更新日期：2018-02-09 00:00:00
abstract：BACKGROUND AND PURPOSE:The aim of the study was to determine the effects of post-traumatically released High Mobility Group Box-1 protein (HMGB1) and extracellular histones on cardiomyocytes (CM). We also evaluated a therapeutic option to capture circulating histones after trauma, using a hemadsorption filter to treat ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051421
更新日期：2020-05-11 00:00:00
abstract：:Effective behavior change approaches are necessary to help individuals avoid or mitigate risk factors, engage in behavioral patterns that lead to better health, and consequently, prevent several chronic diseases. Physical inactivity is considered one of the most harmful risk factors for chronic medical conditions, and...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8030295
更新日期：2019-03-01 00:00:00
abstract：:Oxidative stress arises when cellular antioxidant defences become overwhelmed by a surplus generation of reactive oxygen species (ROS). Once this occurs, many cellular biomolecules such as DNA, lipids, and proteins become susceptible to free radical-induced oxidative damage, and this may consequently lead to cellular ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6110100
更新日期：2017-10-27 00:00:00
abstract：:Healthcare resource utilization peaks throughout the first year following acute myocardial infarction (AMI). Data linking the former and outcomes are sparse. We evaluated the associations between subsequent length of in-hospital stay (SLOS) and primary ambulatory visits (PAV) within the first year after AMI and long-t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082528
更新日期：2020-08-05 00:00:00
abstract：:This study investigated associations of perceived environmental factors with leisure-time physical activity (LTPA) and screen time (ST) among older adults. A cross-sectional study was conducted by administering computer-assisted telephone interviews to 1028 older Taiwanese adults in November 2016. Data on personal fac...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7030056
更新日期：2018-03-13 00:00:00
abstract：:Disrupting the process of memory reconsolidation could be a promising treatment for addiction. However, its application may be constrained by the intensity of addiction memory. This study aimed to develop and initially validate a new measure, the Addiction Memory Intensity Scale (AMIS), for assessing the intensity of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7120467
更新日期：2018-11-22 00:00:00
abstract：:(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a biomarker to predict treatment response to anti-VEGF in DME. (2) Method...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092920
更新日期：2020-09-10 00:00:00
abstract：:(1) Background: We evaluated macular ganglion cell layer-inner plexiform layer (GCL-IPL) thickness in patients with primary macula-off rhegmatogenous retinal detachment (RRD) treated with scleral buckling (SB) or pars plana vitrectomy (PPV) using spectral domain optical coherence tomography (SD-OCT). (2) Methods: In t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051411
更新日期：2020-05-10 00:00:00
abstract：:The use of artificial intelligence (AI) to support clinical medical decisions is a rather promising concept. There are two important factors that have driven these advances: the availability of data from electronic health records (EHR) and progress made in computational performance. These two concepts are interrelated...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9010248
更新日期：2020-01-17 00:00:00
