当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > A Pilot Study on MicroRNA Profile in Tear Fluid to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema.

A Pilot Study on MicroRNA Profile in Tear Fluid to Predict Response to Anti-VEGF Treatments for Diabetic Macular Edema.

Abstract：

:(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a biomarker to predict treatment response to anti-VEGF in DME. (2) Methods: Tear fluid, aqueous, and blood were collected from patients with treatment-naïve DME for miRNA expression profiling with quantitative polymerase chain reaction. Differentially expressed miRNAs between good and poor responders were identified from tear fluid. Bioinformatics analysis with the miEAA tool, miRTarBase Annotations, Gene Ontology categories, KEGG, and miRWalk pathways identified interactions between enriched miRNAs and biological pathways. (3) Results: Of 24 participants, 28 eyes received bevacizumab (15 eyes) or aflibercept (13 eyes). Tear fluid had the most detectable miRNA species (N = 315), followed by serum (N = 309), then aqueous humor (N = 134). MiRNAs that correlated with change in macular thickness were miR-214-3p, miR-320d, and hsa-miR-874-3p in good responders; and miR-98-5p, miR-196b-5p, and miR-454-3p in poor responders. VEGF-related pathways and the angiogenin-PRI complex were enriched in good responders, while transforming growth factor-β and insulin-like growth factor pathways were enriched in poor responders. (4) Conclusions: We reported a panel of novel miRNAs that provide insight into biological pathways in DME. Validation in larger independent cohorts is needed to determine the predictive performance of these miRNA candidate biomarkers.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Chan HW,Yang B,Wong W,Blakeley P,Seah I,Tan QSW,Wang H,Bhargava M,Lin HA,Chai CH,Mangunkusumo EA,Thet N,Yuen YS,Sethi R,Wang S,Hunziker W,Lingam G,Su X

doi

10.3390/jcm9092920

subject

Has Abstract

pub_date

2020-09-10 00:00:00

issue

9

issn

2077-0383

pii

jcm9092920

journal_volume

9

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • Outcomes after In Utero Myelomeningocele Repair Based on Delivery Location.

    abstract：:Maternal and pediatric delivery outcomes may vary in patients who underwent open fetal myelomeningocele repair and elected to deliver at the fetal center where their fetal intervention was performed versus at the referring physician's hospital. A prospective cohort study of 88 patients were evaluated following in uter...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9113443

    authors： Bergh EP,Tsao K,Austin MT,Fletcher SA,Lopez SM,Moise KJ Jr,Johnson A,Papanna R

    更新日期：2020-10-27 00:00:00

  • Autophagy and Inflammasome Activation in Dilated Cardiomyopathy.

    abstract：BACKGROUND:The clinical outcome of patients affected by dilated cardiomyopathy (DCM) is heterogeneous, since its pathophysiology is only partially understood. Interleukin 1β levels could predict the mortality and necessity of cardiac transplantation of DCM patients. OBJECTIVE:To investigate mechanisms triggering steri...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8101519

    authors： Caragnano A,Aleksova A,Bulfoni M,Cervellin C,Rolle IG,Veneziano C,Barchiesi A,Mimmi MC,Vascotto C,Finato N,Sponga S,Livi U,Isola M,Di Loreto C,Bussani R,Sinagra G,Cesselli D,Beltrami AP

    更新日期：2019-09-21 00:00:00

  • A Longitudinal, Population-Level, Big-Data Study of Helicobacter pylori-Related Disease across Western Australia.

    abstract：:Helicobacter pylori, responsible for chronic ulcers and most stomach cancers, infects half of the world's population. The Urea Breath Test (UBT) is one of the most accurate and reliable non-invasive methods for diagnosing active H. pylori infection. The objective was to use longitudinal, population-wide UBT data for W...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111821

    authors： Wise MJ,Lamichhane B,Webberley KM

    更新日期：2019-11-01 00:00:00

  • Adenosine A2B Receptors: An Optional Target for the Management of Irritable Bowel Syndrome with Diarrhea?

    abstract：:Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder, with the characteristic symptoms of chronic abdominal pain and altered bowel habits (diarrhea, constipation, or both). IBS is a highly prevalent condition, which negatively affects quality of life and is a significant burden on global healthcare...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm6110104

    authors： Asano T,Takenaga M

    更新日期：2017-11-03 00:00:00

  • Impaired Skeletal Muscle Kynurenine Metabolism in Patients with Chronic Obstructive Pulmonary Disease.

    abstract：BACKGROUND:Loss of peripheral muscle oxidative phenotype, cognitive impairment, and depression are well-recognized systemic manifestations of chronic obstructive pulmonary disease (COPD). Kynurenine (KYN), known to be associated with disturbed mental health, can be metabolized in muscle by kynurenine aminotransferases ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8070915

    authors： Gosker HR,Clarke G,de Theije CC,Cryan JF,Schols AMWJ

    更新日期：2019-06-26 00:00:00

  • Accuracy of a Symptom-Based Approach to Identify Hypertensive Emergencies in the Emergency Department.

    abstract：BACKGROUND:A hierarchical symptoms-based diagnostic strategy relying on the presence of five main symptoms (chest pain, acute dyspnea, neurological symptoms, headache, visual impairment) was recently proposed to diagnose patients with hypertensive emergency. However, poor scientific evidence is available about the role...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9072201

    authors： Vallelonga F,Carbone F,Benedetto F,Airale L,Totaro S,Leone D,Astarita A,Avenatti E,Maule S,Veglio F,Lupia E,Milan A

    更新日期：2020-07-12 00:00:00

  • Procedural Sedation Using a Propofol-Ketamine Combination (Ketofol) vs. Propofol Alone in the Loop Electrosurgical Excision Procedure (LEEP): A Randomized Controlled Trial.

    abstract：BACKGROUND:Although the loop electrosurgical excision procedure (LEEP) is a brief procedure, it can cause severe pain and discomfort to patients in the absence of adequate sedation. An admixture of ketamine with propofol (ketofol), may reduce patient movement due to insufficient sedation while providing hemodynamic and...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8070943

    authors： Oh C,Kim Y,Eom H,Youn S,Lee S,Ko YB,Yoo HJ,Chung W,Lim C,Hong B

    更新日期：2019-06-28 00:00:00

  • Reliability of the Scapula Reposition Test in Subjects with Rotator Cuff Tendinopathy and Scapular Dyskinesis.

    abstract：:The Scapula Reposition Test (SRT) is proposed to determine if a relationship exists between scapular dyskinesis and shoulder pathology. The purpose of this study was to evaluate intra-rater and inter-rater reliability of the SRT in subjects with rotator cuff tendinopathy and scapular dyskinesis. In addition, we compar...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9010080

    authors： Fernandez-Matias R,Gallardo-Zamora P,Sanchez-Aguilera CL,Mardones-Varela H,Gallego-Izquierdo T,Pecos-Martin D

    更新日期：2019-12-28 00:00:00

  • 1,25(OH)2D3 Differently Affects Immunomodulatory Activities of Mesenchymal Stem Cells Depending on the Presence of TNF-α, IL-1β and IFN-γ.

    abstract：:Periodontal ligament-derived mesenchymal stem cells (hPDLSCs) possess immunomodulatory abilities which are strongly enhanced by various inflammatory cytokines. Vitamin D3 has anti-inflammatory effects on hPDLSCs and immune cells. However, no study to date has directly compared the influence of 1,25(OH)2D3 on the immun...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122211

    authors： Behm C,Blufstein A,Gahn J,Kubin B,Nemec M,Moritz A,Rausch-Fan X,Andrukhov O

    更新日期：2019-12-14 00:00:00

  • Micropulse Laser Treatment of Retinal Diseases.

    abstract：:Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. This kind of treatment is safe and cheap, and contrary to classic laser photocoagulat...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8020242

    authors： Gawęcki M

    更新日期：2019-02-13 00:00:00

  • Same-Day Versus Non-Simultaneous Extracorporeal Membrane Oxygenation Support for In-Hospital Cardiac Arrest Complicating Acute Myocardial Infarction.

    abstract：BACKGROUND:Although extracorporeal membrane oxygenation (ECMO) is used for hemodynamic support for in-hospital cardiac arrest (IHCA) complicating acute myocardial infarction (AMI), there are limited data on the outcomes stratified by the timing of initiation of this strategy. METHODS:Adult (>18 years) AMI admissions w...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082613

    authors： Vallabhajosyula S,Patlolla SH,Bell MR,Cheungpasitporn W,Stulak JM,Schears GJ,Barsness GW,Holmes DR

    更新日期：2020-08-12 00:00:00

  • Glutathione Metabolism, Mitochondria Activity, and Nitrosative Stress in Patients Treated for Mandible Fractures.

    abstract：:The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures. The study group consist...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8010127

    authors： Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Sidun J,Domel E,Dąbrowski JR,Ładny JR,Morawska K,Zalewska A

    更新日期：2019-01-21 00:00:00

  • The GALNT14 Genotype Predicts Postoperative Outcome of Pancreatic Ductal Adenocarcinoma.

    abstract：:Pancreatic ductal adenocarcinoma (PDA) is notorious for its poor prognosis. The current mainstay of treatment for PDA is surgical resection followed by adjuvant chemotherapy. However, it is difficult to predict the post-operative outcome because of the lack of reliable markers. The single-nucleotide polymorphism (SNP)...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122225

    authors： Chiang CC,Yeh CT,Hwang TL,Chu YD,Lim SN,Chen CW,Kuo CJ,Le PH,Chen TH,Lin WR

    更新日期：2019-12-16 00:00:00

  • Association of Primary Sjögren's Syndrome and Vitamin B12 Deficiency: A Cross-Sectional Case-Control Study.

    abstract：:Descriptive and retrospective studies without control groups have suggested a possible association between primary Sjögren's syndrome (pSS) and vitamin B12 (B12) deficiency. This is of importance because several mucosal and neurological features are common to these two conditions and could be prevented or reversed in ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9124063

    authors： Urbanski G,Chabrun F,Schaepelynck B,May M,Loiseau M,Schlumberger E,Delattre E,Lavigne C,Lacombe V

    更新日期：2020-12-16 00:00:00

  • The Inflammatory Milieu of Adamantinomatous Craniopharyngioma and Its Implications for Treatment.

    abstract：:Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current trea...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9020519

    authors： Whelan R,Prince E,Gilani A,Hankinson T

    更新日期：2020-02-14 00:00:00

  • NK Cell Reconstitution in Paediatric Leukemic Patients after T-Cell-Depleted HLA-Haploidentical Haematopoietic Stem Cell Transplantation Followed by the Reinfusion of iCasp9-Modified Donor T Cells.

    abstract：:T-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve i...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111904

    authors： Stabile H,Nisti P,Fionda C,Pagliara D,Gaspari S,Locatelli F,Santoni A,Gismondi A

    更新日期：2019-11-07 00:00:00

  • Adult Patient Risk Stratification Using a Risk Score for Periodontitis.

    abstract：BACKGROUND:There is a need for analytical tools predicting the risk of periodontitis. The purpose of this study was to estimate and evaluate a risk score for prediction of periodontitis. MATERIALS AND METHODS:This case-cohort study included a random sample of 155 cases (with periodontitis) and 175 controls (randomly s...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8030307

    authors： de Araújo Nobre M,Ferro A,Maló P

    更新日期：2019-03-05 00:00:00

  • Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review.

    abstract：:The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to c...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9092935

    authors： Campbell CM,Guha A,Haque T,Neilan TG,Addison D

    更新日期：2020-09-11 00:00:00

  • A 26-Year Experience in Chorionic Villus Sampling Prenatal Genetic Diagnosis.

    abstract：:This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study r...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm3030838

    authors： Jorge P,Mota-Freitas MM,Santos R,Silva ML,Soares G,Fortuna AM

    更新日期：2014-07-24 00:00:00

  • Comparison of Percutaneous Endoscopic Surgery and Traditional Anterior Open Surgery for Treating Lumbar Infectious Spondylitis.

    abstract：:Minimally invasive surgery is becoming popular for treating spinal disorders. The advantages of percutaneous endoscopic debridement and drainage (PEDD) for infectious spondylitis include direct observation of the lesion, direct pus drainage, and earlier pain relief. We retrospectively reviewed 37 patients who underwen...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8091356

    authors： Fu TS,Wang YC,Lin TY,Chang CW,Wong CB,Su JY

    更新日期：2019-09-01 00:00:00

  • Maternal Overweight vs. Polycystic Ovary Syndrome: Disentangling Their Impact on Insulin Action in Pregnancy-A Prospective Study.

    abstract：BACKGROUND:To investigate insulin sensitivity and glucose metabolism in pregnant lean and overweight polycystic ovary syndrome (PCOS) patients vs. lean and overweight controls without PCOS. METHODS:Prospective cohort study on 67 pregnant women (31 with PCOS and 36 controls, subdivided into overweight or obese and norm...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10010035

    authors： Feichtinger M,Linder T,Rosicky I,Eppel D,Schatten C,Eppel W,Husslein P,Tura A,Göbl CS

    更新日期：2020-12-24 00:00:00

  • Robotic-Assisted Simple Prostatectomy: A Systematic Review.

    abstract：:Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9061798

    authors： Kordan Y,Canda AE,Köseoğlu E,Balbay D,Laguna MP,de la Rosette J

    更新日期：2020-06-09 00:00:00

  • Tricyclic Antidepressant Use and Risk of Fractures: A Meta-Analysis of Cohort Studies through the Use of Both Frequentist and Bayesian Approaches.

    abstract：BACKGROUND:Research findings regarding the association between tricyclic antidepressant (TCA) treatment and the risk of fracture are not consistent; we aimed to assess whether people who take TCAs are at an increased fracture risk. METHODS:Relevant studies published through June 2020 were identified through database s...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9082584

    authors： Wu Q,Xu Y,Bao Y,Alvarez J,Gonzales ML

    更新日期：2020-08-10 00:00:00

  • Quantitative Analysis of the Seminal Plasma Proteome in Secondary Hypogonadism.

    abstract：:In the grey zone of testosterone levels between 8 and 12 nmol/L, the usefulness of therapy is controversial; as such, markers of tissue action of androgens may be helpful in adjusting clinical decisions. To better understand the effect of the hypothalamic-pituitary-testicular axis on male accessory secretion, we perfo...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122128

    authors： Grande G,Vincenzoni F,Mancini F,Barrachina F,Giampietro A,Castagnola M,Urbani A,Oliva R,Milardi D,Pontecorvi A

    更新日期：2019-12-03 00:00:00

  • Molecular Testing in CML between Old and New Methods: Are We at a Turning Point?

    abstract：:Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain (KD) mutation testing have a well consolidated role in the routine management of chronic myeloid leukemia (CML) patients, as they provide precious information for therapeutic decision-making. Molecular response levels are used to define ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9123865

    authors： Soverini S,Bernardi S,Galimberti S

    更新日期：2020-11-27 00:00:00

  • Implication of Ventricular Assist Devices in Extracorporeal Membranous Oxygenation Patients Listed for Heart Transplantation.

    abstract：:The new allocation criteria classify patients on veno-arterial extracorporeal membranous oxygenation (VA-ECMO) as the highest priority for receiving orthotopic heart transplantation (OHT) especially if they are considered not candidates for ventricular assist devices. The outcomes of patients who receive ventricular a...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8050572

    authors： Guha A,Hannawi B,Cruz-Solbes AS,Nguyen DT,Bruckner BA,Trachtenberg B,Graviss EA,Bhimaraj A,Park M,Hussain I,MacGillivray TE,Suarez EE,Estep JD

    更新日期：2019-04-26 00:00:00

  • Accuracy of the Low-Dose ACTH Stimulation Test for Adrenal Insufficiency Diagnosis: A Re-Assessment of the Cut-Off Value.

    abstract：BACKGROUND:The clinical practice shows that many low-dose ACTH-stimulation tests have a false positive result. The aim of the study was to determine the diagnostic accuracy of a low-dose ACTH-stimulation test in the diagnosis of adrenal insufficiency and to define its optimal cut-off. METHODS:We analyzed data from 103...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8060806

    authors： Mongioì LM,Condorelli RA,Barbagallo F,Cannarella R,La Vignera S,Calogero AE

    更新日期：2019-06-05 00:00:00

  • Craniocervical and Cervical Spine Features of Patients with Temporomandibular Disorders: A Systematic Review and Meta-Analysis of Observational Studies.

    abstract：:To assess neck disability with respect to jaw disability, craniocervical position, cervical alignment, and sensorimotor impairments in patients with temporomandibular disorders (TMD), a systematic review and meta-analysis of observational studies trials were conducted. The meta-analysis showed statistically significan...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9092806

    authors： Cuenca-Martínez F,Herranz-Gómez A,Madroñero-Miguel B,Reina-Varona Á,La Touche R,Angulo-Díaz-Parreño S,Pardo-Montero J,Del Corral T,López-de-Uralde-Villanueva I

    更新日期：2020-08-30 00:00:00

  • Red Blood Cell Distribution Width, Disease Severity, and Mortality in Hospitalized Patients with SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis.

    abstract：:The identification of biomarkers predicting disease severity and outcomes is the focus of intense research in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 infection). Ideally, such biomarkers should be easily derivable from routine tests. We conducted a systematic review and meta-analysis ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10020286

    authors： Zinellu A,Mangoni AA

    更新日期：2021-01-14 00:00:00

  • Challenges and Opportunities in the Clinical Development of STING Agonists for Cancer Immunotherapy.

    abstract：:Immune checkpoint inhibitors (ICI) have revolutionised cancer therapy. However, they have been effective in only a small subset of patients and a principal mechanism underlying immune-refractoriness is a 'cold' tumour microenvironment, that is, lack of a T-cell-rich, spontaneously inflamed phenotype. As such, there is...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9103323

    authors： Motedayen Aval L,Pease JE,Sharma R,Pinato DJ

    更新日期：2020-10-16 00:00:00