Abstract:
:The ongoing coronavirus disease 2019 (COVID-19) pandemic has resulted in efforts to identify therapies to ameliorate adverse clinical outcomes. The recognition of the key role for increased inflammation in COVID-19 has led to a proliferation of clinical trials targeting inflammation. The purpose of this review is to characterize the current state of immunotherapy trials in COVID-19, and focuses on associated cardiotoxicities, given the importance of pharmacovigilance. The search terms related to COVID-19 were queried in ClinicalTrials.gov. A total of 1621 trials were identified and screened for interventional trials directed at inflammation. Trials (n = 226) were fully assessed for the use of a repurposed drug, identifying a total of 141 therapeutic trials using a repurposed drug to target inflammation in COVID-19 infection. Building on the results of the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial demonstrating the benefit of low dose dexamethasone in COVID-19, repurposed drugs targeting inflammation are promising. Repurposed drugs directed at inflammation in COVID-19 primarily have been drawn from cancer therapies and immunomodulatory therapies, specifically targeted anti-inflammatory, anti-complement, and anti-rejection agents. The proposed mechanisms for many cytokine-directed and anti-rejection drugs are focused on evidence of efficacy in cytokine release syndromes in humans or animal models. Anti-complement-based therapies have the potential to decrease both inflammation and microvascular thrombosis. Cancer therapies are hypothesized to decrease vascular permeability and inflammation. Few publications to date describe using these drugs in COVID-19. Early COVID-19 intervention trials have re-emphasized the subtle, but important cardiotoxic sequelae of potential therapies on outcomes. The volume of trials targeting the COVID-19 hyper-inflammatory phase continues to grow rapidly with the evaluation of repurposed drugs and late-stage investigational agents. Leveraging known clinical safety profiles and pharmacodynamics allows swift investigation in clinical trials for a novel indication. Physicians should remain vigilant for cardiotoxicity, often not fully appreciated in small trials or in short time frames.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Campbell CM,Guha A,Haque T,Neilan TG,Addison Ddoi
10.3390/jcm9092935subject
Has Abstractpub_date
2020-09-11 00:00:00issue
9issn
2077-0383pii
jcm9092935journal_volume
9pub_type
杂志文章,评审abstract::Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm5110105
更新日期:2016-11-22 00:00:00
abstract:BACKGROUND:Exocrine pancreatic insufficiency results from the destruction of the pancreatic parenchyma and is diagnosed by using direct or indirect tests, both of which have shortcomings. Chronic pancreatitis is the most frequent cause of this pathology in adults. METHODS:Patients meeting radiological or histological ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9062014
更新日期:2020-06-26 00:00:00
abstract::Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection of the basal epithelial cells, HPV causes numerous malignancies and noncancerous cutaneous manifestations. Noncancerous cutaneous manifestations of HPV, including common, plantar, plane, and anogenital warts, are among the most c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4050832
更新日期:2015-04-24 00:00:00
abstract::microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression by either blocking translation or inducing degradation of target mRNA. miRNAs play essential roles in diverse biological and pathological processes, including development of hepatic fibrosis. Hepatic stellate cells (HSCs) play a central role in...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm5030038
更新日期:2016-03-16 00:00:00
abstract::Chronic Obstructive Pulmonary Disease (COPD) is a complex disease defined by airflow limitation and characterized by a spectrum of treatable and untreatable pulmonary and extra-pulmonary disease characteristics. Nonpharmacological management related to physical activity, physical capacity, body composition, breathing ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051311
更新日期:2020-05-02 00:00:00
abstract::Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions. Invasive diagnostic techniques performed on the lips carry a high risk of complications, but reflectance confocal micr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061987
更新日期:2020-06-25 00:00:00
abstract:BACKGROUND:Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. METHODS:Whole blood from ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050708
更新日期:2019-05-18 00:00:00
abstract::The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning. Lack of UBE3A protein expression leads to Angelman syndrome (AS), wh...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9051573
更新日期:2020-05-22 00:00:00
abstract::For a long time, the stem cell regenerative paradigm has been based on the assumption that progenitor cells play a critical role in tissue repair by means of their plasticity and differentiation potential. However, recent works suggest that the mechanism underlying the benefits of stem cell transplantation might relat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm2040302
更新日期:2013-12-17 00:00:00
abstract::Interventions for main carers of adult patients with anorexia nervosa (AN) can reduce the caregiving burden and increase caregiver skills. However, the effectiveness and feasibility for carers of adolescent patients, the optimal form of the intervention and long-term outcomes are largely unknown. We evaluated the effi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061912
更新日期:2020-06-18 00:00:00
abstract:INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113452
更新日期:2020-10-27 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a poor-prognosis cancer due to its high rate of recurrence. microRNAs (miRNAs) are a class of small non-coding RNA molecules that affect crucial processes in cancer development. The objective of this study is to identify the role of miRNAs in patient bone marrow (BM) and explore the f...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm4081600
更新日期:2015-08-14 00:00:00
abstract:BACKGROUND:In hemodialysis patients, extracellular water (ECW) overload predicts all-cause and cardiovascular mortality. The primary aim of the present study was to analyze changes in post-dialysis (i.e., following removal of excess ECW) ECW, intracellular water (ICW), and the overhydration (OH) parameter over time. Ad...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113616
更新日期:2020-11-10 00:00:00
abstract::Elevated blood pressure (BP) is a major cause of death, yet hypertension commonly goes undetected. Owing to its nature, it is typically asymptomatic until later in its progression when the vessel or organ structure has already been compromised. Therefore, noninvasive and continuous BP measurement methods are needed to...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9041203
更新日期:2020-04-22 00:00:00
abstract::The aim of this study was to determine whether elevated serum level of uric acid (sUA) could predict renal outcome after contrast-enhanced computerized tomography (CCT). We used a historical cohort of 58,106 non-dialysis adult patients who received non-ionic iso-osmolar CCT from 1 June 2008 to 31 March 2015 to evaluat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071003
更新日期:2019-07-10 00:00:00
abstract::Limited evidence is available comparing the differences between pre-operative and post-operative 3D implant positions from the viewpoint of prosthetics. We aimed to investigate the differences between preplanned positions of virtual provisional restorations and their actual positions following fully guided single-impl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040490
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Patients with diabetic kidney disease (DKD) are at higher risk of hypoglycemia than diabetic patients without DKD. We aimed to investigate the temporal trends of severe hypoglycemia in advanced DKD patients transitioning to dialysis and examine risk factors associated with severe hypoglycemia. We also invest...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040420
更新日期:2019-03-27 00:00:00
abstract::Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with significant morbidity and mortality. The autonomic nervous system (ANS) plays an important role in the initiation and development of AF, causing alterations in atrial structure and electrophysiological defects. The intrinsic ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103081
更新日期:2020-09-24 00:00:00
abstract:PURPOSE:Evaluating the effects of cibinetide in diabetic macular edema (DME). METHODS:Phase 2 trial. Naïve patients with >400 µm central retinal thickness (CRT) DME in one/both eyes were recruited (May 2016-April 2017) at the Belfast Health and Social Care Trust. The study eye was that with best vision and lowest CRT....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072225
更新日期:2020-07-14 00:00:00
abstract::Duchenne muscular dystrophy (DMD), the most severe form of dystrophinopathy, is quite homogeneous with regards to its causative biochemical defect, i.e., complete dystrophin deficiency, but not so much with regards to its phenotype. For instance, muscle weakness progresses to the loss of independent ambulation at a va...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8050649
更新日期:2019-05-10 00:00:00
abstract::The type of fixation used in primary total knee replacement (TKR) may influence the risk of prosthetic joint infection (PJI). We conducted a systematic review and meta-analysis to assess published evidence linking type of fixation (cemented, uncemented, or hybrid) with the risk of PJI following primary TKR. Randomised...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060828
更新日期:2019-06-11 00:00:00
abstract::Our study aimed to clarify the neuroimaging correlates of suicide attempt by comparing differences in functional magnetic resonance imaging (fMRI) among depressed suicide attempters, depressed patients without suicide attempt history, and healthy controls through comprehensive and novel fMRI analyses and methods in th...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111966
更新日期:2019-11-14 00:00:00
abstract::Paragangliomas and pheochromytomas (PPGLs) exhibit variable malignancy, advanced/hormonally active/progressive need therapy. PRRT (Peptide Receptor Radionuclide Therapy) could be an option for these patients. To evaluate the effectiveness of PRRT (90Y DOTATATE), based on overall survival (OS) and progression-free surv...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070952
更新日期:2019-06-30 00:00:00
abstract::Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092869
更新日期:2020-09-04 00:00:00
abstract::This article presents the technical aspects of the Polish fetal cardiac interventions (FCI) program, including preparation of the team and modifications in the technique of the procedure that aim to increase its safety for the mother and the fetus. Over 9 years, 128 FCI in 113 fetuses have been performed: 94 balloon a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092888
更新日期:2020-09-07 00:00:00
abstract::Hemorrhagic strokes account for half of all strokes seen in children, and the etiologies of these hemorrhagic strokes differ greatly from those seen in adult patients. This review gives an overview about incidence and etiologies as well as presentation of children with intracerebral hemorrhage and with differential di...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9051518
更新日期:2020-05-18 00:00:00
abstract::Coronavirus disease 2019 (COVID-19), due to the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become an epidemiological threat and a worldwide concern. SARS-CoV-2 has spread to 210 countries worldwide and more than 6,500,000 confirmed cases and 384,643 deaths have been reported, while the number of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061753
更新日期:2020-06-05 00:00:00
abstract::In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9061954
更新日期:2020-06-23 00:00:00
abstract::Creatinine is produced in muscle metabolism as the end-product of creatine phosphate and is subsequently excreted principally by way of the kidneys, predominantly by glomerular filtration. Blood creatinine assays constitute the most common clinically relevant measure of renal function. The use of individual patient-le...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4071348
更新日期:2015-06-26 00:00:00
abstract::We aim to examine how season and temperature levels affect physical activity using a wearable device among patients scheduled to undergo surgical resection of lung cancer. Physical activity (PA) data from the wearable device were analyzed by seasons for 555 preoperative lung cancer patients from the CATCH-LUNG cohort ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9020349
更新日期:2020-01-27 00:00:00