Abstract:
INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this subject. Research on dementia biomarkers in serum validates anticipated health and economic benefits from early screening tests. Biomarkers are also essential for improving the process of developing new drugs. METHODS:The result analysis, of current studies on selected biomarker concentrations (Aβ40, Aβ42, t-tau, and YKL-40) and their combination in the serum of patients with dementia and mild cognitive disorders, involved a search for papers available in Medline, PubMed, and Web of Science databases published from 2000 to 2020. RESULTS:The results of conducted cross-sectional studies comparing Aβ40, Aβ42, and Aβ42/Aβ40 among people with cognitive disorders and a control group are incoherent. Most of the analyzed papers showed an increase in t-tau concentration in diagnosed Alzheimer's disease (AD) patients' serum, whereas results of mild cognitive impairment (MCI) groups did not differ from the control groups. In several papers on the concentration of YKL-40 and t-tau/Aβ42 ratio, the results were promising. To date, several studies have only covered the field of biomarker concentrations in dementia disorders other than AD. CONCLUSIONS:Insufficient amyloid marker test repeatability may result either from imperfection of the used laboratorial techniques or inadequate selection of control groups with their comorbidities. On the basis of current knowledge, t-tau, t-tau/Aβ42, and YKL-40 seem to be promising candidates as biomarkers of cognitive disorders in serum. YKL-40 seems to be a more useful biomarker in early MCI diagnostics, whereas t-tau can be used as a marker of progress of prodromal states in mild AD. Due to the insignificant number of studies conducted to date among patients with dementia disorders other than AD, it is not possible to make a sound assessment of their usefulness in dementia differential diagnostics.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Wilczyńska K,Waszkiewicz Ndoi
10.3390/jcm9113452subject
Has Abstractpub_date
2020-10-27 00:00:00issue
11issn
2077-0383pii
jcm9113452journal_volume
9pub_type
杂志文章,评审abstract::Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...
journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
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journal_title:Journal of clinical medicine
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abstract::This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
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journal_title:Journal of clinical medicine
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更新日期:2020-12-30 00:00:00
abstract::While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...
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abstract::Sarcoidosis is a systemic disease of unknown etiology characterized by the presence of noncaseating granulomas that can occur in any organ, most commonly the lungs. Early and accurate diagnosis of sarcoidosis remains challenging because initial presentations may vary, many patients are asymptomatic, and there is no si...
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical medicine
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pub_type: 杂志文章,评审
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103121
更新日期:2020-09-27 00:00:00
abstract::Sickle cell disease (SCD) prevalence has increased rapidly in Europe as a result of an increase in the life expectancy of these patients and the arrival of SCD migrants from Africa. The aim of our study was to compare the phenotypes of adult patients born in Sub-Saharan Africa (SSA) who migrated to France with those o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2019-12-09 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2019-08-11 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2020-06-06 00:00:00
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-02-18 00:00:00
abstract::In the past, numerous non-operative treatments for adolescent idiopathic scoliosis (AIS), including exercise, physical therapy, electrical stimulation, and brace treatment, have been tried to delay or prevent the curve progression. Of these, brace treatment is the only option that is widely accepted and has demonstrat...
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更新日期:2018-06-04 00:00:00
abstract::The causes of disordered sleep, frequently reported by patients with inflammatory bowel diseases (IBD), are poorly understood. The study aimed to evaluate sleep quality in IBD patients and to identify factors affecting their sleep. IBD patients (n = 133) and healthy controls (HC; n = 57) were included in the study and...
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更新日期:2020-12-13 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4071348
更新日期:2015-06-26 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-05-10 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-06-19 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
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更新日期:2019-05-22 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2020-11-26 00:00:00
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journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2020-11-24 00:00:00
abstract::Long noncoding RNAs (lncRNAs) are involved in diverse physiological and pathological processes by modulating gene expression. They have been found to be dysregulated in the brain and cerebrospinal fluid of patients with neurodegenerative diseases, and are considered promising therapeutic targets for treatment. Among t...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
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更新日期:2018-11-21 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2020-01-22 00:00:00
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journal_title:Journal of clinical medicine
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更新日期:2020-02-03 00:00:00