Abstract:
BACKGROUND:Our study aims to perform a meta-analysis of benefits and risks associated with the use of non-vitamin K oral anticoagulants (NOAC) versus vitamin K antagonists (VKA) in patients with a percutaneous coronary intervention (PCI) with a particular focus on the combination type: dual vs. dual antithrombotic therapy (DAT: NOAC + single antiplatelet therapy (SAPT) vs. DAT: VKA + SAPT), dual vs. triple antithrombotic therapy (DAT: NOAC + SAPT vs. TAT: VKA + dual antiplatelet therapy (DAPT)) or triple vs. triple antithrombotic therapy (TAT: NOAC+DAPT vs. TAT: VKA+DAPT). METHODS:PubMed, EMBASE, and Cochrane databases were searched to identify randomized controlled trials comparing antithrombotic regimens. Four randomized studies (n = 10.969; PIONEER AF-PCI, RE-DUAL PCI, AUGUSTUS, and ENTRUST-AF PCI) were included. The primary outcome was the composite of major bleeding defined by the International Society on Thrombosis and Hemostasis (ISTH) and clinically relevant bleeding requiring medical intervention (CRNM). Secondary outcomes included all-cause mortality, major adverse cardiovascular events (MACE), myocardial infarction (MI), stroke, and stent thrombosis (ST). RESULTS:Combination strategies with NOACs were associated with reduced risk of major bleeding events across different combination strategies as compared to VKA, with the most significant risk reduction when DAT was compared with TAT, namely DAT with NOAC + SAPT was associated with a 37% relative risk reduction (RRR) of major bleeding events as compared to TAT with VKA + DAPT (RR 0.63; 95% CI, 0.50-0.80). The reduction of major bleeding risks is a class effect of NOACs. Combination strategies of NOACs vs. VKAs resulted in a comparable risk of MACE, MI, stroke, ST, or death. CONCLUSIONS:Antithrombotic combinations of NOACs (as DAT or TAT) are safer than VKAs with respect to bleeding risk and result in a satisfactory efficacy with no increase of ischemic or thrombotic events in patients undergoing PCI.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Eyileten C,Postula M,Jakubik D,Toma A,Mirowska-Guzel D,Patti G,Renda G,Siller-Matula JMdoi
10.3390/jcm9041120subject
Has Abstractpub_date
2020-04-14 00:00:00issue
4issn
2077-0383pii
jcm9041120journal_volume
9pub_type
杂志文章abstract::Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020333
更新日期:2020-01-24 00:00:00
abstract::This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103106
更新日期:2020-09-25 00:00:00
abstract:BACKGROUND:Recent research has shown an increased risk of accidents and injuries in ADHD patients, which could potentially be reduced by stimulant treatment. Therefore, the first aim of our study was to evaluate the prevalence of adult ADHD in a trauma surgery population. The second aim was to investigate accident mech...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101643
更新日期:2019-10-08 00:00:00
abstract::This study of parents in Romania explores how perceptions of their couple relationship quality and of factors associated with it (such as sexual communication anxiety and sexual perfectionism) were related to their perception of aspects describing parenting dimensions relevant to the sexual education and sexual health...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030386
更新日期:2019-03-19 00:00:00
abstract::: Deployment or distribution of valuable medical resources has emerged as an increasing challenge to hospital administrators and health policy makers. The hospital emergency department (HED) census and workload can be highly variable. Improvement of emergency services is an important stage in the development of the he...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8122154
更新日期:2019-12-05 00:00:00
abstract::This study evaluated whether inter-hospital transfer (IHT) after the return of spontaneous circulation (ROSC) was associated with poor neurological outcomes after 6 months in post-cardiac-arrest patients treated with targeted temperature management (TTM). We used data from the Korean Hypothermia Network prospective re...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061979
更新日期:2020-06-24 00:00:00
abstract::Endoscopic resection has been the standard treatment for intramucosal esophageal cancers (ECs) because of the low risk of lymph node metastases in the lesions. In recent years, endoscopic submucosal dissection (ESD), which can resect large ECs, has been performed. However, the risk of esophageal stricture after ESD is...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10010020
更新日期:2020-12-23 00:00:00
abstract::The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061718
更新日期:2020-06-03 00:00:00
abstract::Guidelines for the treatment of severe bleeding comprise viscoelastic-test-guided use of coagulation factor concentrates as part of their recommendations. The aim of this study is to investigate the effects of substituting fibrinogen, prothrombin complex concentrate, and a combination of both on conventional coagulati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123805
更新日期:2020-11-25 00:00:00
abstract::Recurrent high-grade glioma (HGG) remains incurable with inevitable evolution of resistance and high inter-patient heterogeneity in time to progression (TTP). Here, we evaluate if early tumor volume response dynamics can calibrate a mathematical model to predict patient-specific resistance to develop opportunities for...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072019
更新日期:2020-06-27 00:00:00
abstract:INTRODUCTION:The laparoscopic approach for TME is proven to be non-inferior in oncological outcome compared to open surgery. Anatomical limitations in the male and obese pelvis with resulting pathological shortcomings and high conversion rates were stimuli for alternative approaches. The transanal approach for TME (TaT...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm10010072
更新日期:2020-12-28 00:00:00
abstract:BACKGROUND:Metabolic syndrome is associated with low-grade systemic inflammation, which is a key driver of premature atherosclerosis. We characterized immune cell behavior in metabolic syndrome, its consequences, and the potential involvement of the CX3CL1/CX3CR1 and CCL2/CCR2 chemokine axes. METHODS:Whole blood from ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050708
更新日期:2019-05-18 00:00:00
abstract::This study aimed to assess the efficacy of canal filling material removal using three different techniques after filling with a Gutta-Percha (GP) cone and calcium silicate-based sealer, by measuring the percentage of volume debris of GP and sealer remaining intracanal with micro computed tomography (micro-CT). The fil...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8070984
更新日期:2019-07-07 00:00:00
abstract:BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072126
更新日期:2020-07-06 00:00:00
abstract::We evaluated the incidence of temporomandibular disorder (TMD) in patients with rheumatoid arthritis (RA) and examined the association between TMD and RA, through longitudinal follow-up. Population data from the Korean National Health Insurance Service-Health Screening Cohort from 2002 to 2015 was used. From 514,866 s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9093005
更新日期:2020-09-17 00:00:00
abstract:PURPOSE:Evaluating the effects of cibinetide in diabetic macular edema (DME). METHODS:Phase 2 trial. Naïve patients with >400 µm central retinal thickness (CRT) DME in one/both eyes were recruited (May 2016-April 2017) at the Belfast Health and Social Care Trust. The study eye was that with best vision and lowest CRT....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072225
更新日期:2020-07-14 00:00:00
abstract::Previous studies have shown better clinical outcomes after total hip arthroplasty (THA) compared to hemiarthroplasty (HA) for displaced femoral neck fracture. However, few studies have focused on the surgical risks of the two procedures. Therefore, we investigated the perioperative complications of HA and THA in femor...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103203
更新日期:2020-10-03 00:00:00
abstract:OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020277
更新日期:2019-02-25 00:00:00
abstract::In addition to its regulatory function in the formation of red blood cells (erythropoiesis) in vertebrates, Erythropoietin (Epo) contributes to beneficial functions in a variety of non-hematopoietic tissues including the nervous system. Epo protects cells from apoptosis, reduces inflammatory responses and supports re-...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7020024
更新日期:2018-02-02 00:00:00
abstract::The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9092973
更新日期:2020-09-15 00:00:00
abstract:INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this s...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9113452
更新日期:2020-10-27 00:00:00
abstract::While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103247
更新日期:2020-10-11 00:00:00
abstract:BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082599
更新日期:2020-08-11 00:00:00
abstract::Branched-chain amino acid (BCAA) and insulin-like growth factor 1 (IGF-1) are essential for muscle protein synthesis. We investigated the association of serum BCAA and IGF-1 levels with sarcopenia and gait speed in 192 patients with liver cirrhosis (LC). Sarcopenia was diagnosed according to the Japan Society of Hepat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103239
更新日期:2020-10-10 00:00:00
abstract::The purpose of this study was to report on the clinical usefulness of the Liver Disease Quality of Life Instrument (LDQOL) 1.0, which was prospectively measured in chronic hepatitis B patients. We regularly followed up with patients with chronic hepatitis B between 2008 and 2010 who were enrolled in the study, and the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050656
更新日期:2019-05-10 00:00:00
abstract::Post-stroke fatigue (PSF) is one of the most serious sequelae, which often interferes with the rehabilitation process and impairs the functional recovery of patients. Due to insufficient evidence, it is unclear which specific pharmacological interventions should be recommended. Therefore, in this paper, we compare the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9030621
更新日期:2020-02-25 00:00:00
abstract:BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101642
更新日期:2019-10-08 00:00:00
abstract::Objectives/Hypothesis: Stenosis of the middle meatus antrostomy (MMA) represents a major cause of recurrent disease following endoscopic sinus surgery (ESS). Various strategies have been developed to prevent the occurrence of MMA stenosis. The aim of the present study was to evaluate the effects of spray cryotherapy (...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9010088
更新日期:2019-12-29 00:00:00
abstract::Patients with chronic obstructive pulmonary disease (COPD), asthma and interstitial lung diseases (ILD) frequently suffer from cardiovascular comorbidities (CVC). Exercise training is a cornerstone intervention for the management of these conditions, however recommendations on tailoring programmes to patients sufferin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091458
更新日期:2019-09-13 00:00:00
abstract::This study aimed to investigate the periodontal health of patients with established rheumatoid arthritis (RA) in relation to oral microbiota, systemic and oral inflammatory mediators, and RA disease activity. Forty patients underwent full-mouth dental/periodontal and rheumatological examination, including collection o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8050630
更新日期:2019-05-08 00:00:00