Abstract：
:The aim of the study was to evaluate the effect of titanium bone fixations on mitochondrial activity, reactive oxygen species (ROS) production, glutathione metabolism, and selected markers of oxidative/nitrosative stress in the periosteum-like tissue of patients treated with mandible fractures. The study group consisted of 30 patients with bilateral fractures of the mandible body eligible for surgical treatment. Our study is the first one that indicates disturbances of mitochondrial activity as well as a higher production of ROS in the periosteum-like tissue covering titanium fixations of the mandible. We also found significantly higher levels of reduced glutathione and enhanced activity of glutathione reductase in the periosteum homogenates of patients in the study group compared to the control group. Levels of nitrosative (S-nitrosothiols, peroxynitrite, nitrotyrosine) and oxidative stress biomarkers (malondialdehyde, protein carbonyls, dityrosine, kynurenine, and N-formylkynurenine) were statistically elevated in periosteum-like tissue covering titanium fixations. Although exposure to titanium fixations induces local antioxidant mechanisms, patients suffer oxidative damage, and in the periosteum-like tissue the phenomenon of metallosis was observed. Titanium implants cause oxidative/nitrosative stress as well as disturbances in mitochondrial activity.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Borys J,Maciejczyk M,Antonowicz B,Krętowski A,Sidun J,Domel E,Dąbrowski JR,Ładny JR,Morawska K,Zalewska Adoi
10.3390/jcm8010127subject
Has Abstractpub_date
2019-01-21 00:00:00issue
1issn
2077-0383pii
jcm8010127journal_volume
8pub_type
杂志文章abstract：BACKGROUND:As much as there are unmet needs for brief frailty assessment in patients with chronic obstructive pulmonary disease (COPD), the lack of a simplified and comprehensive dyspnea evaluation system that focuses on the patients' perceptions of dyspnea and their COPD living disabilities remains a major challenge. ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113580
更新日期：2020-11-06 00:00:00
abstract：:Right ventricular failure (RVF) is a major risk factor for end organ morbidity and mortality following cardiac surgery. Perioperative RVF is difficult to predict and detect, and to date, no convenient, accurate, or reproducible measure of right ventricular (RV) function is available. Few studies have examined the use ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8040559
更新日期：2019-04-25 00:00:00
abstract：BACKGROUND AND AIM:Although head and/or neck pain attributed to orthostatic hypotension is included in international guidelines, its mechanisms and relevance remain unknown. This study examined the term's relevance and aimed to elucidate the associated clinical features. METHODS:An active stand test was performed to e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124125
更新日期：2020-12-21 00:00:00
abstract：:The aim of this study was to determine whether elevated serum level of uric acid (sUA) could predict renal outcome after contrast-enhanced computerized tomography (CCT). We used a historical cohort of 58,106 non-dialysis adult patients who received non-ionic iso-osmolar CCT from 1 June 2008 to 31 March 2015 to evaluat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8071003
更新日期：2019-07-10 00:00:00
abstract：:We aimed to report an update of the systematic review by Petrén et al. (2003). The objective was to evaluate how orthodontic treatments can affect unilateral posterior crossbite (UPXB) in primary and early mixed dentition. Several databases were consulted, and articles published between January 2002 and March 2020 wer...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010033
更新日期：2020-12-24 00:00:00
abstract：:This study aimed to develop a prognosis-predicting model based on [18F]fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) and clinicopathologic factors in locally advanced cervical cancer patients treated with concurrent chemoradiotherapy (CCRT). The medical records of 270 locally adv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020427
更新日期：2020-02-05 00:00:00
abstract：:The purpose of this study was to investigate the relationship between the retinal pigment epithelium (RPE) and outer retina changes, expressed in terms of sub-RPE illumination (SRI) on optical-coherence tomography (OCT), and central retinal function, measured by visual acuity and focal electroretinogram (fERG), in pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092973
更新日期：2020-09-15 00:00:00
abstract：:The relation between vitamin-D (VD) status and healing after hip fracture had not been sufficiently addressed. Currently serum total 25-hydroxy-VD (t-25OHD) is the most widely used indicator of VD status. It is unclear whether free or bioavailable VD are better markers of 25OHD availability for tissues. Validity of ov...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7080193
更新日期：2018-08-01 00:00:00
abstract：:The discovery of microbial, immunological or molecular markers in saliva offers unique opportunities, and has caused our view of saliva to change drastically in recent years [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9061955
更新日期：2020-06-23 00:00:00
abstract：:The endogenous PP2A inhibitor SET Nuclear Proto-Oncogene (SET) has been reported to play oncogenic roles and determines poor outcomes in colorectal cancer (CRC). Our group previously showed that miR-199b is deregulated in metastatic CRC, and reduced the cell viability and enhanced the sensitivity of CRC cells to stand...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082419
更新日期：2020-07-28 00:00:00
abstract：:The prognosis of multiple myeloma (MM) has improved with the introduction of novel agents. These data are largely derived from clinical trials and might not reflect real-world patient outcomes accurately. We surveyed real-world data from 284 patients newly diagnosed with MM between 2010 and 2018 in Miyazaki Prefecture...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010105
更新日期：2020-12-30 00:00:00
abstract：:The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota in 46 ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113621
更新日期：2020-11-10 00:00:00
abstract：:We aimed to investigate the cross-sectional and longitudinal associations of electrocardiogram (ECG)-based QT, QTc, JT, JTc, and QRS intervals with cognitive function and brain magnetic resonance imaging (MRI) measurements in a cohort of older individuals at increased risk for cardiovascular disease, but free of known...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040911
更新日期：2020-03-26 00:00:00
abstract：:Prediction of recurrences after catheter ablation of atrial fibrillation (AF) remains challenging. We sought to investigate the long-term outcomes after AF catheter ablation. A total of 2221 consecutive patients who underwent catheter ablation for symptomatic AF were included in this study (mean age 55 ± 11 years, 20....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103164
更新日期：2020-09-30 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Elderly and/or frail women with ovarian cancer are often undertreated. The aim of the study is to compare the effects of age and frailty on surgical approaches, postoperative complications, and prognosis in elderly women with ovarian cancer. METHODS:A retrospective multicenter study of women ≥...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051339
更新日期：2020-05-04 00:00:00
abstract：:We aimed to determine if low body weight (LBW) status (<50 kg) is independently associated with increased risk of ischemic stroke and bleeding in Thai patients with non-valvular atrial fibrillation (NVAF). (1) Background: It has been unclear whether LBW influence clinical outcome of patients with NVAF. (2) Methods: Th...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092713
更新日期：2020-08-22 00:00:00
abstract：:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7040068
更新日期：2018-04-02 00:00:00
abstract：:Background The use of computed tomography (CT) for coronavirus disease 2019 (COVID-19) diagnosis in an area of northern Italy with a high incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may have identified more patients with this disease than RT-PCR in the very early onset of the CO...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123935
更新日期：2020-12-04 00:00:00
abstract：:Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art, and media all have a decisive role in the culture of organ donation...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7030045
更新日期：2018-03-05 00:00:00
abstract：:Branched-chain amino acid (BCAA) and insulin-like growth factor 1 (IGF-1) are essential for muscle protein synthesis. We investigated the association of serum BCAA and IGF-1 levels with sarcopenia and gait speed in 192 patients with liver cirrhosis (LC). Sarcopenia was diagnosed according to the Japan Society of Hepat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103239
更新日期：2020-10-10 00:00:00
abstract：:The evolution of implant dentistry since the discovery of the osseointegration concept has been remarkable [...]. ...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm9051575
更新日期：2020-05-22 00:00:00
abstract：:Considering the progress made in the management of sickle cell disease during the past 30 years, along with the excellent results obtained with hematopoietic stem cell transplantation (SCT), it is important to reexamine why, who, when and how to recommend allogeneic SCT in children with sickle cell disease. While sick...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101523
更新日期：2019-09-22 00:00:00
abstract：:Differentiation syndrome (DS) is a potentially fatal adverse drug reaction caused by the so-called differentiating agents such as all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), used for remission induction in the treatment of the M3 subtype of acute myeloid leukemia (AML), acute promyelocytic leukemia (APL...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9103342
更新日期：2020-10-18 00:00:00
abstract：OBJECTIVES:We systematically reviewed the literature to address the question of which of the three hemodynamic factors predicts prognosis best in heart failure patients when directly compared to each other: cardiac output, preload or afterload. METHODS:Prognostic studies in heart failure (HF) were searched that includ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101757
更新日期：2019-10-22 00:00:00
abstract：:Objective: To determine blood transfusion practices, risk factors, and outcomes associated with the use of blood products in the setting of the acute management of burn patients at the Victorian Adult Burn Service. Background: Patients with burn injuries have variable transfusion requirements, based on a multitude of ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030476
更新日期：2021-01-27 00:00:00
abstract：:Joint bleeding represents the most commonly reported type of hemorrhage in patients affected by hemophilia. Although the widespread use of prophylaxis has been able to significantly reduce the onset of arthropathy, it has been shown that a non-negligible percentage of patients develop degenerative changes in their joi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm6080077
更新日期：2017-07-31 00:00:00
abstract：BACKGROUND AND AIMS:Data from clinical trials suggest that biological drugs may improve the outcomes in Crohn's disease (CD) by reducing the need for surgery or hospitalization. The aim of this study is to evaluate the time-trends of the use of biological drugs and other treatments for CD, and its relationship with out...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092896
更新日期：2020-09-08 00:00:00
abstract：:(1) Background: Intravitreal anti-vascular endothelial growth factor (anti-VEGF) is an established treatment for center-involving diabetic macular edema (ci-DME). However, the clinical response is heterogeneous. This study investigated miRNAs as a biomarker to predict treatment response to anti-VEGF in DME. (2) Method...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092920
更新日期：2020-09-10 00:00:00
abstract：:Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and mortality. Diverse bacterial communities have been identified in DFUs/DFIs, playing a significant role in infection prognosis. However...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111935
更新日期：2019-11-10 00:00:00
abstract：BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072066
更新日期：2020-07-01 00:00:00
