Abstract：
:Brain-derived neurotrophic factor (BDNF) facilitates neuronal growth and plasticity, and is crucial for learning and memory. Contactin-1 (CNTN1) is a member of the subfamily of neural immunoglobulin and is involved in the formation of axon connections in the developing nervous system. This cross-sectional study investigates whether BDNF and CNTN1 affect susceptibility to attention deficit/hyperactivity disorder (ADHD). A total of 136 drug-naïve patients with ADHD (108 boys and 28 girls) and 71 healthy controls (45 boys and 26 girls) were recruited. Blood samples were obtained to measure the plasma levels of BDNF and CNTN1 in each child. We found that BDNF levels in the ADHD boys exceeded those in the control boys, but BDNF levels in the ADHD girls were lower than those in the control girls. Boys who had higher BDNF levels performed worse on the Wechsler Intelligence Scale for Children-Fourth Edition, but girls who had higher BDNF levels made fewer omission errors in the Conners' Continuous Performance Test. However, CNTN1 level did not differ significantly between patients and controls, and were not correlated to ADHD characteristics, regardless of gender. The findings suggest BDNF may influence sex-specific susceptibility to ADHD, but CNTN1 was not associated with ADHD pathophysiology.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Wang LJ,Wu CC,Lee MJ,Chou MC,Lee SY,Chou WJdoi
10.3390/jcm8091366subject
Has Abstractpub_date
2019-09-02 00:00:00issue
9issn
2077-0383pii
jcm8091366journal_volume
8pub_type
杂志文章abstract：:Chronic pain is one of the major causes of disability in the general population. Even though there are effective treatment options available for reducing symptoms, these treatments often do not have consistent lasting effects. As the usage of mobile devices has increased enormously during the last few years, mobile ap...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113557
更新日期：2020-11-05 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT), but the clinical utility of ALT in detecting and following individuals with NAFLD remains unclear. We conducted a retrospective analysis of 30,988 men and 5204 women with NAFLD diagnosed by ultrasound and stra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040445
更新日期：2019-04-02 00:00:00
abstract：:Stem cells have been the focus of intense research opening up new possibilities for the treatment of various diseases. Mesenchymal stromal cells (MSCs) are multipotent cells with relevant immunomodulatory properties and are thus considered as a promising new strategy for immune disease management. To enhance their eff...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8050626
更新日期：2019-05-08 00:00:00
abstract：BACKGROUND:This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Or...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113435
更新日期：2020-10-26 00:00:00
abstract：BACKGROUND:The management of Helicobacter pylori (H. pylori) infection raises important challenges, still being the most common chronic infection worldwide in all age groups. In high-prevalence regions, paediatric patients need a specific focus, as the acquisition of the infection takes place in childhood. The objectiv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030784
更新日期：2020-03-13 00:00:00
abstract：:Photodynamic therapy (PDT) has become an effective treatment for certain types of solid tumors. The combination of PDT with other therapies has been extensively investigated in recent years to improve its effectiveness and expand its applications. This focused review summarizes the development of a prodrug system in w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8122198
更新日期：2019-12-13 00:00:00
abstract：:T-cell-depleted (TCD) human leukocyte antigen (HLA) haploidentical (haplo) hematopoietic stem cell transplantation (HSCT) (TCD-haplo-HSCT) has had a huge impact on the treatment of many haematological diseases. The adoptive transfer of a titrated number of T cells genetically modified with a gene suicide can improve i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111904
更新日期：2019-11-07 00:00:00
abstract：:Lung cancer is the second most common malignancy. Unfortunately, despite advances in multimodality therapeutics for the disease, the overall five-year survival rate among newly diagnosed lung cancer patients remains in the range region of 15%. In addition, although immune checkpoint inhibitors are increasingly being i...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7100303
更新日期：2018-09-25 00:00:00
abstract：:Most studies on well-being during the COVID-19 pandemic have focused on the mental health of the general population; far less attention has been given to more specific populations, such as patients with mental illness. Indeed, it is important to examine the psychiatric population, given its vulnerability. The present ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113787
更新日期：2020-11-23 00:00:00
abstract：:Continuous renal replacement therapy (CRRT) is an important modality to support critically ill patients, and the need for CRRT treatment has been increasing. However, CRRT management is costly, and the associated resources are limited. Thus, it remains challenging to identify patients that are likely to have a poor ou...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7100334
更新日期：2018-10-08 00:00:00
abstract：:Androgens are essential for the development, differentiation, growth, and function of the prostate through epithelial-stromal interactions. However, androgen concentrations in the hypertrophic human prostate decrease significantly with age, suggesting an inverse correlation between androgen levels and proliferative di...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7040068
更新日期：2018-04-02 00:00:00
abstract：:Primary Sjögren's syndrome (pSS) is a chronic systemic autoimmune rheumatic disease characterized by lymphoplasmacytic infiltration of the salivary and lacrimal glands, whereby sicca syndrome and/or systemic manifestations are the clinical hallmarks, associated with a particular autoantibody profile. pSS is the most f...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072299
更新日期：2020-07-20 00:00:00
abstract：:Minimally invasive surgery is becoming popular for treating spinal disorders. The advantages of percutaneous endoscopic debridement and drainage (PEDD) for infectious spondylitis include direct observation of the lesion, direct pus drainage, and earlier pain relief. We retrospectively reviewed 37 patients who underwen...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091356
更新日期：2019-09-01 00:00:00
abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5030034
更新日期：2016-03-07 00:00:00
abstract：:Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020244
更新日期：2019-02-13 00:00:00
abstract：:Methotrexate (MTX) is a remarkable drug with a key role in the management of rheumatoid arthritis (RA) at every stage of its evolution. Its attributes include good overall efficacy for signs and symptoms, inhibition of structural damage and preservation of function with acceptable and manageable safety, a large dose-t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040515
更新日期：2019-04-15 00:00:00
abstract：:C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6100094
更新日期：2017-10-07 00:00:00
abstract：:Both pre-gestational maternal obesity (PGMO) and excessive gestational weight gain (EGWG) increase the risk of gestational diabetes mellitus (GDM). Here, we conducted a retrospective study to comparatively examine the relation between fetal birth weight (FW) and placental weight (PW) in PGMO (n = 100) compared to EGWG...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113530
更新日期：2020-10-31 00:00:00
abstract：:Bronchiectasis and asthma may share some characteristics and some patients may have both conditions. The present study aimed to examine the rationale of prophylactic inhaled corticosteroids (ICS) prescription in children with bronchiectasis. Data of children with radiologically established bronchiectasis were retrospe...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124009
更新日期：2020-12-11 00:00:00
abstract：:: Several researchers have assessed the utility of Impulse Oscillometry System (IOS) in diagnosing and evaluating the severity of respiratory diseases in childhood, but none has investigated the impact of the fluctuations of IOS parameters in an individualized manner. In this two-year prospective study, we aimed to lo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091475
更新日期：2019-09-16 00:00:00
abstract：:Elevated distractibility is one of the major contributors to alcohol hangover-induced behavioral deficits. Yet, the basic mechanisms driving increased distractibility during hangovers are still not very well understood. Aside from impairments in attention and psychomotor functions, changes in stimulus-response binding...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030778
更新日期：2020-03-12 00:00:00
abstract：:Ongoing outbreak of pneumonia caused by novel coronavirus (2019-nCoV) began in December 2019 in Wuhan, China, and the number of new patients continues to increase. Even though it began to spread to many other parts of the world, such as other Asian countries, the Americas, Europe, and the Middle East, the impact of se...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040944
更新日期：2020-03-30 00:00:00
abstract：:Pulmonary vein (PV) enlargement is associated with atrial fibrillation (AF). However, the predictive value of PV volume for new-onset AF has not been determined. We retrospectively assessed and enrolled non-AF subjects who underwent echocardiography and cardiac CT angiography (CCTA) around the same time and evaluated ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9020401
更新日期：2020-02-02 00:00:00
abstract：OBJECTIVE:Clinical presentation of patients with mitral paravalvular leakage (PVL) varies from asymptomatic to heart failure related with hemolytic anemia or pulmonary hypertension. We aimed to investigate the structural and functional characteristics of mitral PVL by multimodal imaging and their association with the s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020222
更新日期：2021-01-10 00:00:00
abstract：:We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves' ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092814
更新日期：2020-08-31 00:00:00
abstract：:Both vasculature and myocardium in the heart are excessively damaged following myocardial infarction (MI), hence therapeutic strategies for treating MI hearts should concurrently aim for true cardiac repair by introducing new cardiomyocytes to replace lost or injured ones. Of them, mesenchymal stem cells (MSCs) have l...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051277
更新日期：2020-04-28 00:00:00
abstract：:(1) Background: To examine trends in incidence and outcomes of urinary tract infections (UTIs) among men and women with or without chronic obstructive pulmonary disease (COPD), and to identify the predictors for in-hospital mortality (IHM). (2) Methods: We included patients (aged ≥40 years) who were hospitalized with ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123979
更新日期：2020-12-09 00:00:00
abstract：:Exercise has health benefits and prevents a range of chronic diseases caused by physiological and biological changes in the whole body. Generally, the metabolic regulation of skeletal muscle through exercise is known to have a protective effect on the pathogenesis of metabolic syndrome, non-alcoholic fatty liver disea...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030385
更新日期：2021-01-20 00:00:00
abstract：BACKGROUND:There are limited data for non-vitamin K antagonist oral anticoagulants (NOACs) impact on outcomes for patients with atrial fibrillation (AF) and valvular heart diseases (VHDs). METHODS:We identified patients with AF and associated Evaluated Heartvalves, Rheumatic or Artificial (EHRA) type 2 VHDs, and who h...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101624
更新日期：2019-10-04 00:00:00
abstract：:Rhinosinusitis (RS) is a common disease in children, significantly affecting their quality of life. Chronic rhinosinusitis (CRS) is frequently linked to other respiratory diseases, including asthma. Children affected by CRS may be candidates for surgery in the case of failure of maximal medical therapy comprising thre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050684
更新日期：2019-05-15 00:00:00
