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Utility of ALT Concentration in Men and Women with Nonalcoholic Fatty Liver Disease: Cohort Study.

Abstract：

:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT), but the clinical utility of ALT in detecting and following individuals with NAFLD remains unclear. We conducted a retrospective analysis of 30,988 men and 5204 women with NAFLD diagnosed by ultrasound and stratified them according to sex-specific ALT quartiles. We compared metabolic variables at baseline and repeated ultrasound after at least 6 months among ALT quartiles (Q) in men (Q1 5-24, Q2 25-33, Q3 34-48, Q4 ≥ 49 IU/L) and women (Q1 5-14, Q2 15-20, Q3 21-28, Q4 ≥ 29 IU/L). Prevalence of obesity (BMI ≥ 25 kg/m²) and metabolic abnormalities (glucose intolerance, hypertension) significantly (p < 0.001) increased from ALT Q1 to Q4 in both men and women at baseline. After a mean follow-up of 4.93 years, 17.6% of men and 31.1% of women resolved their NAFLD. The odds ratio (OR) of resolving significantly (p < 0.001) decreased by quartiles even after multiple adjustments. The adjusted OR for resolution in Q4 was 0.20 (0.18-0.23) in men and 0.35 (0.26-0.47) in women compared with Q1. Individuals with NAFLD span the full range of ALT concentrations, but those with the highest ALT have the worst metabolic profile and persistent NAFLD.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Sung KC,Lee MY,Lee JY,Lee SH,Kim SH,Kim SH

doi

10.3390/jcm8040445

subject

Has Abstract

pub_date

2019-04-02 00:00:00

issue

4

issn

2077-0383

pii

jcm8040445

journal_volume

8

pub_type

杂志文章

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