Abstract:
:Androgen/androgen receptor (AR) signaling is a significant driver of prostate cancer progression, therefore androgen-deprivation therapy (ADT) is often used as a standard form of treatment for advanced and metastatic prostate cancer patients. However, after several years of ADT, prostate cancer progresses to castration-resistant prostate cancer (CRPC). Androgen/AR signaling is still considered an important factor for prostate cancer cell survival following CRPC progression, while recent studies have reported dichotomic roles for androgen/AR signaling. Androgen/AR signaling increases prostate cancer cell proliferation, while simultaneously inhibiting migration. As a result, ADT can induce prostate cancer metastasis. Several C-C motif ligand (CCL)-receptor (CCR) axes are involved in cancer cell migration related to blockade of androgen/AR signaling. The CCL2-CCR2 axis is negatively regulated by androgen/AR signaling, with the CCL22-CCR4 axis acting as a further downstream mediator, both of which promote prostate cancer cell migration. Furthermore, the CCL5-CCR5 axis inhibits androgen/AR signaling as an upstream mediator. CCL4 is involved in prostate carcinogenesis through macrophage AR signaling, while the CCL21-CCR7 axis in prostate cancer cells is activated by tumor necrotic factor, which is secreted when androgen/AR signaling is inhibited. Finally, the CCL2-CCR2 axis has recently been demonstrated to be a key contributor to cabazitaxel resistance in CRPC.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Izumi K,Mizokami Adoi
10.3390/jcm8030354subject
Has Abstractpub_date
2019-03-13 00:00:00issue
3issn
2077-0383pii
jcm8030354journal_volume
8pub_type
杂志文章,评审abstract:BACKGROUND:Wolf-Hirschhorn syndrome (WHS) is a rare disease caused by deletion in the distal moiety of the short arm of chromosome 4. The objectives of this study were to report the most representative oral findings of WHS, relate them with other clinical characteristics of the disease, and establish possible phenotype...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113556
更新日期:2020-11-04 00:00:00
abstract:BACKGROUND:Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological a...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101545
更新日期:2019-09-26 00:00:00
abstract:BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072126
更新日期:2020-07-06 00:00:00
abstract::This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40-60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20....
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072173
更新日期:2020-07-09 00:00:00
abstract::Effective behavior change approaches are necessary to help individuals avoid or mitigate risk factors, engage in behavioral patterns that lead to better health, and consequently, prevent several chronic diseases. Physical inactivity is considered one of the most harmful risk factors for chronic medical conditions, and...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8030295
更新日期:2019-03-01 00:00:00
abstract::(1) Despite many years of research, melanoma still remains a big challenge for modern medicine. The purpose of this article is to review publicly available clinical trials to find trends regarding the number of trials, their location, and interventions including the most frequently studied drugs and their combinations...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8030368
更新日期:2019-03-15 00:00:00
abstract::Despite the excellent overall survival (OS) of patients with chronic myeloid leukemia (CML), a significant proportion will not achieve optimal response to imatinib or second-generation tyrosine kinase inhibitors (2GTKI). For patients with inadequate response to 2GTKIs, alternative 2GTKIs or ponatinib are widely availa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9072251
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:Deep dry needling (DDN) and ischemic compression technic (ICT) may be considered as interventions used for the treatment of Myofascial Pain Syndrome (MPS) in latent myofascial trigger points (MTrPs). The immediate effectiveness of both DDN and ICT on pressure pain threshold (PPT) and skin temperature of the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101632
更新日期:2019-10-05 00:00:00
abstract::Actinic cheilitis (AC) is one of the most frequent pathologies to affect the lips. Studies show that the most commonplace oral malignancy, squamous cell carcinoma (SCC), often emerges from AC lesions. Invasive diagnostic techniques performed on the lips carry a high risk of complications, but reflectance confocal micr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9061987
更新日期:2020-06-25 00:00:00
abstract::Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must repl...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm4020204
更新日期:2015-01-01 00:00:00
abstract::The recent advances in machine perfusion (MP) technology involve settings ranging between hypothermic, subnormothermic, and normothermic temperatures. Tissue level adenosine triphosphate (ATP) is a long-established marker of viability and functionality and is universal for all organs. In the midst of a growing number ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091421
更新日期:2019-09-09 00:00:00
abstract:BACKGROUND AND AIMS:The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted a validation study of the original MPI, and of adapted versions that accounted for the use of ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111820
更新日期:2019-11-01 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been inversely associated with pancreatic cancer. However, the association between commonly used anti-HT medications and risk of pancreatic c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7080197
更新日期:2018-08-02 00:00:00
abstract::Allogeneic stem cell transplantation (allo-SCT) is the preferred curative treatment for several hematological malignancies. The efficacy of allo-SCT depends on the graft-versus-leukemia (GvL) effect. However, the prognosis of patients with relapsed acute myeloid leukemia (AML) following allo-SCT is poor. Donor lymphoc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9010039
更新日期:2019-12-23 00:00:00
abstract::There are differences in the incidence, clinical presentation, molecular pathogenesis, and outcome of colorectal cancer (CRC) based on tumor location. Emerging research suggests that the perioperative carcinoembryonic antigen (CEA) ratio (post-op/pre-op CEA) is a prognostic factor for CRC patients. We aimed to determi...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123848
更新日期:2020-11-27 00:00:00
abstract::This study reports the integrated analysis of two phase III studies of meropenem-vaborbactam in the treatment of acute bacterial infections. Targeting Antibiotic Non-Susceptible Gram-Negative Organisms (TANGO) I compared the clinical efficacy and tolerability of meropenem-vaborbactam and piperacillin-tazobactam in the...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101650
更新日期:2019-10-11 00:00:00
abstract::Minimal residual disease evaluation refers to a series of molecular and immunophenotypical techniques aimed at detecting submicroscopic disease after therapy. As such, its application in acute myeloid leukemia has greatly increased our ability to quantify treatment response, and to determine the chemosensitivity of th...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm6060057
更新日期:2017-06-03 00:00:00
abstract::Subthreshold micropulse laser treatment has been intensively used for selected retinal diseases in the last decade; however, the exact mechanism of the action of lasers in the subthreshold micropulse mode is not yet fully understood. This kind of treatment is safe and cheap, and contrary to classic laser photocoagulat...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8020242
更新日期:2019-02-13 00:00:00
abstract::Overactivated osteoclasts lead to many bone diseases, including osteoporosis and rheumatoid arthritis. The p38 MAPK (p38) is an essential regulator of the receptor activator of nuclear factor-κB ligand (RANKL)-mediated osteoclastogenesis and bone loss. We previously reported TAT conjugated thioredoxin-interacting prot...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040431
更新日期:2019-03-29 00:00:00
abstract::Amiodarone is recommended for shock-refractory ventricular arrhythmia during resuscitation; however, it is unknown whether amiodarone is effective for preventing ventricular arrhythmia recurrence in out-of-hospital cardiac arrest (OHCA) survivors treated with targeted temperature management (TTM). We investigated the ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020244
更新日期:2019-02-13 00:00:00
abstract::The vaginal microbiota plays a critical role in pregnancy. Bacteria from Lactobacillus spp. are thought to maintain immune homeostasis and modulate the inflammatory responses against pathogens implicated in cervical shortening, one of the risk factors for spontaneous preterm birth. We studied vaginal microbiota in 46 ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9113621
更新日期:2020-11-10 00:00:00
abstract:BACKGROUND:Congenital factor (F) VII deficiency is a rare coagulation factor deficiency with an estimated incidence of 1 per 500,000 individuals. Patients with severe FVII deficiency present a broad range of clinical presentations. Alloimmunization against exogenous FVII, as the main challenge of replacement therapy, i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm10020211
更新日期:2021-01-08 00:00:00
abstract::Congenital lactic acidosis (CLA) is a rare condition in most instances due to a range of inborn errors of metabolism that result in defective mitochondrial function. Even though the implementation of next generation sequencing has been rapid, the diagnosis rate for this highly heterogeneous allelic condition remains l...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8111811
更新日期:2019-11-01 00:00:00
abstract::This phase II randomized controlled trial tested whether intracoronary autologous CD34+ cell therapy could further improve left ventricular (LV) systolic function in patients with diffuse coronary artery disease (CAD) with relatively preserved LV ejection fraction (defined as LVEF >40%) unsuitable for coronary interve...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041043
更新日期:2020-04-07 00:00:00
abstract::The neuropsychiatric symptoms of multiple sclerosis (MS), such as anxiety and depression, can result from disease activity itself as well as psychological reaction to an unfavorable diagnosis. Accordingly, the literature reports evidence of increased anxiety-like behavior in experimental autoimmune encephalomyelitis (...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8020162
更新日期:2019-02-01 00:00:00
abstract::Paravalvular leak (PVL) is an important complication of transcatheter aortic valve implantation (TAVI) and is associated with poor prognosis. We aimed to identify the risk factors for PVL after TAVI including patient (calcium amount or location), device (leakage-proof or not), and procedural (oversizing index (OI)) fa...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9123936
更新日期:2020-12-04 00:00:00
abstract::Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment in older populations in industrialized nations. AMD is a late-onset deterioration of photoreceptors and retinal pigment epithelium in the central retina caused by various environmental and genetic factors. Great strides i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm4020343
更新日期:2015-02-12 00:00:00
abstract::Pediatric Adamantinomatous Craniopharyngiomas (ACPs) are histologically benign brain tumors that often follow an aggressive clinical course. Their suprasellar location leaves them in close proximity to critical neurological and vascular structures and often results in significant neuroendocrine morbidity. Current trea...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9020519
更新日期:2020-02-14 00:00:00
abstract::Tadalafil is a phosphodiesterase 5 (PDE5) inhibitor with a long half-life, high selectivity, and rapid onset of action. Because the safety of using PDE5 inhibitors as therapeutic agents for fetal growth restriction (FGR) has been a problem worldwide, this paper primarily focuses on the safety assessments performed in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060856
更新日期:2019-06-15 00:00:00
abstract::This Special Issue on lung diseases is aimed at giving emergent researchers and clinicians an important forum to share their original research and expert reviews on key topics within respiratory diseases. This Special Issue will be of interest to general physicians and respiratory specialist and will equip the reader ...
journal_title:Journal of clinical medicine
pub_type: 社论
doi:10.3390/jcm8122060
更新日期:2019-11-23 00:00:00