Abstract：
:(1) Despite many years of research, melanoma still remains a big challenge for modern medicine. The purpose of this article is to review publicly available clinical trials to find trends regarding the number of trials, their location, and interventions including the most frequently studied drugs and their combinations. (2) We surveyed clinical trials registered in the International Clinical Trials Registry Platform (ICTRP), one of the largest databases on clinical trials. The search was performed on 30 November 2018 using the term "melanoma". Data have been supplemented with the information obtained from publicly available data repositories including PubMed, World Health Organization, National Cancer Institute, Centers for Disease Control and Prevention, European Cancer Information System, and many others to bring the historical context of this study. (3) Among the total of 2563 clinical trials included in the analysis, most have been registered in the USA (1487), which is 58% of the total. The most commonly studied drug in clinical trials was ipilimumab, described as applied intervention in 251 trials. (4) An increase in the number of melanoma clinical trials using immunomodulating monoclonal antibody therapies, small molecule-targeted therapies (inhibitors of BRAF, MEK, CDK4/6), and combination therapies is recognized. This illustrates the tendency towards precision medicine.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Wróbel S,Przybyło M,Stępień Edoi
10.3390/jcm8030368subject
Has Abstractpub_date
2019-03-15 00:00:00issue
3issn
2077-0383pii
jcm8030368journal_volume
8pub_type
杂志文章,评审abstract：:Substantial progress in recent years has dramatically increased our knowledge of the molecular basis of cancer, revealing new potential therapeutic targets and paving the way for effective personalised medicine for the treatment of many tumour types. However, pancreatic cancer has been lagging behind in this success a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010149
更新日期：2021-01-04 00:00:00
abstract：:The aim of this study was to determine the prevalence of early chronic kidney disease (EKD) (stages 1 and 2) and the factors associated. This was a populational study including individuals from 18-75 years randomly selected from 18 Primary Healthcare centers in the area of Barcelonès Nord and Maresme (Catalunya, Spain...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091384
更新日期：2019-09-04 00:00:00
abstract：:MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitre...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8122217
更新日期：2019-12-15 00:00:00
abstract：:There are no reliable, non-invasive methods to accurately measure cardiac output (CO) in septic patients. MostCare (Vytech Health™, Vygon, Padova, Italy), is a beat-to-beat, self calibrated method for CO measurement based on continuous analysis of reflected arterial pressure waveforms. We enrolled 40 patients that wer...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020213
更新日期：2021-01-09 00:00:00
abstract：:Diabetes mellitus is one of the most prevalent chronic diseases worldwide. Diabetic patients are at risk of developing cataract and present for surgery at an earlier age than non-diabetics. The aim of this study was to review the problems associated with cataract surgery in a diabetic patient. Corneal complications in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8050716
更新日期：2019-05-20 00:00:00
abstract：:Organ transplantation is a new issue in medical science. It is an important achievement and a sign of the progression and ability of medical centers around the world. Governments, populations, the medical community and people involved in culture, art, and media all have a decisive role in the culture of organ donation...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7030045
更新日期：2018-03-05 00:00:00
abstract：PURPOSE:The risk of epiphora after medial maxillectomy with lacrimal duct transection is difficult to assess. The data available in the literature are inconclusive due to various operating techniques used by the authors of medical publications, different additional procedures aimed at improving tear drainage after maxi...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020245
更新日期：2021-01-12 00:00:00
abstract：BACKGROUND:To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. METHODS:This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was in...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124016
更新日期：2020-12-11 00:00:00
abstract：:Examination of the corneal surface by in vivo confocal microscopy (IVCM) allows for objective identification of corneal and conjunctival cell phenotypes to evaluate different epithelialization patterns. Detection of a corneal-conjunctival epithelial transition could be considered as a sign of restored epithelial funct...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113574
更新日期：2020-11-06 00:00:00
abstract：BACKGROUND:The results of several studies have suggested that infections and sepsis, either bacterial or viral, might be associated with elevated plasma proprotein convertase subtilisin/kexin type 9 (PCSK9) levels. Since there are no data on PCSK9 levels and antibiotic resistance or the severity of disease in patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101742
更新日期：2019-10-20 00:00:00
abstract：:The UBE3A gene codes for a protein with two known functions, a ubiquitin E3-ligase which catalyzes ubiquitin binding to substrate proteins and a steroid hormone receptor coactivator. UBE3A is most famous for its critical role in neuronal functioning. Lack of UBE3A protein expression leads to Angelman syndrome (AS), wh...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051573
更新日期：2020-05-22 00:00:00
abstract：:Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5030034
更新日期：2016-03-07 00:00:00
abstract：:Intervertebral disc pathology is a common disorder that can be caused by genetic, mechanical, and behavioral factors; however, it is possible to slow its progression. Although environmental and behavioral factors were previously considered to be the sole causes of intervertebral disc pathologies such as disc herniatio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10030409
更新日期：2021-01-21 00:00:00
abstract：:(1) Background: Omega-3 fatty acids (ω3FAs) are known to improve protein anabolism, increase the sensitivity to anabolic stimuli, decrease lipogenesis, and stimulate lipid oxidation. We aim to investigate whether ω3FAs are associated with the prevalence of sarcopenic obesity (SO). (2) Methods: Data were obtained from ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123856
更新日期：2020-11-27 00:00:00
abstract：INTRODUCTION:The oxytocin challenge test (OCT) used to be one of the most important tools in assessing fetal well-being before ultrasonography became prevalent. We show that, after modifying the classification of the results and the intervention algorithm, OCT can still be a useful tool in present-day obstetrics. MATE...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010131
更新日期：2020-01-03 00:00:00
abstract：:Antibiotic treatment in paediatric rhinosinusitis is still a matter of debate, as the current guidelines have been drafted mainly based on clinical studies published before 2013. Recent modifications in the epidemiological basis of the disease might mean that current treatments are not completely adequate considering ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081162
更新日期：2019-08-03 00:00:00
abstract：:Hybrid transplantation of skeletal muscle-derived multipotent stem cells (Sk-MSCs) and bioabsorbable polyglyconate (PGA) felt was studied as a novel regeneration therapy for the transected recurrent laryngeal nerve (RLN). Sk-MSCs were isolated from green fluorescence protein transgenic mice and then expanded and trans...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7090276
更新日期：2018-09-12 00:00:00
abstract：:The prognostic significance of sarcopenia in unresectable advanced esophageal cancer remains unclear. Our study retrospectively evaluated 176 consecutive Japanese patients with esophageal squamous cell carcinoma who had been diagnosed with unresectable advanced cancer in Aichi Cancer Center Hospital between January 20...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101647
更新日期：2019-10-09 00:00:00
abstract：PURPOSE:Multidisciplinary approach is widely advised for an effective care of patients with neuroendocrine neoplasia (NEN). Since data on efficacy of multidisciplinary management of NENs patients in referral centers are scanty, this study aimed at analyzing the modality of presentation and clinical outcome of patients ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060910
更新日期：2019-06-25 00:00:00
abstract：BACKGROUND:The assessment of ovarian reserve in the case of endometrioma is of pivotal importance for planning a tailored management. However, both the antral follicle count (AFC) and the antimüllerian hormone (AMH) dosage are subject to a fair degree of variability in ovarian endometriosis. This study aimed to identif...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124076
更新日期：2020-12-17 00:00:00
abstract：:Most human papillomavirus (HPV) antiviral strategies have focused upon inhibiting viral DNA replication, but it is increasingly apparent that viral DNA levels can be chemically controlled by approaches that promote its instability. HPVs and other DNA viruses have a tenuous relationship with their hosts. They must repl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm4020204
更新日期：2015-01-01 00:00:00
abstract：:Surgery, including minimally invasive surgery, and radiotherapy are key modalities in the treatment of gynecological malignancies. The aim of this review is to offer the multidisciplinary care team a comprehensive summary of the intersections of surgery and radiotherapy in the local treatment of gynecological malignan...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10010093
更新日期：2020-12-29 00:00:00
abstract：BACKGROUND:The American Indian Navajo and Goshute peoples are underserved patient populations residing in the Four Corners area of the United States and Ibupah, Utah, respectively. METHODS:We conducted a cross-sectional study of epidemiological factors and lipid biomarkers that may be associated with type II diabetes,...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113590
更新日期：2020-11-07 00:00:00
abstract：BACKGROUND:Early identification of cerebral palsy (CP) during infancy will provide opportunities for early therapies and treatments. The aim of the present study was to present a novel machine-learning model, the Computer-based Infant Movement Assessment (CIMA) model, for clinically feasible early CP prediction based o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9010005
更新日期：2019-12-18 00:00:00
abstract：:Endometrial cancer (EC) is the sixth most common cancer in women worldwide and its mortality is directly associated with the presence of poor prognostic factors driving tumor recurrence. Stratification systems are based on few molecular, and mostly clinical and pathological parameters, but these systems remain inaccur...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061900
更新日期：2020-06-17 00:00:00
abstract：BACKGROUND:Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. METHODS:A 1:2 retrospective case-control study...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061824
更新日期：2020-06-11 00:00:00
abstract：BACKGROUND:'Gaming Disorder' (GD) has received increased medical attention and official recognition from both the American Psychiatric Association (APA) and the World Health Organization (WHO). Although these two medical organizations have independently developed promising clinical diagnostic frameworks to assess disor...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101691
更新日期：2019-10-15 00:00:00
abstract：:Internet gaming disorder (IGD) is a new disease proposed by the Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5), and has been studied extensively in relation to depression and impulsivity. The relationship between resilience and disease has been found in a variety of addictive disorders, bu...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081102
更新日期：2019-07-25 00:00:00
abstract：:The type of fixation used in primary total knee replacement (TKR) may influence the risk of prosthetic joint infection (PJI). We conducted a systematic review and meta-analysis to assess published evidence linking type of fixation (cemented, uncemented, or hybrid) with the risk of PJI following primary TKR. Randomised...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060828
更新日期：2019-06-11 00:00:00
abstract：:Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity. Its large extracellular tail is structured in several ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4061293
更新日期：2015-06-17 00:00:00
