Abstract：
:Intervertebral disc pathology is a common disorder that can be caused by genetic, mechanical, and behavioral factors; however, it is possible to slow its progression. Although environmental and behavioral factors were previously considered to be the sole causes of intervertebral disc pathologies such as disc herniation, recent studies have shown that genetic factors also play an important role. This review compares the perception of major risk factors from the last and present centuries. It also examines individual genetic and non-genetic factors acting as risk factors, as well as some approaches for preventing intervertebral disc pathologies, and compares available statistics regarding disc herniation.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Zielinska N,Podgórski M,Haładaj R,Polguj M,Olewnik Łdoi
10.3390/jcm10030409subject
Has Abstractpub_date
2021-01-21 00:00:00issue
3issn
2077-0383pii
jcm10030409journal_volume
10pub_type
杂志文章,评审abstract：:Glaucoma is one of the leading causes of blindness worldwide, and as the proportion of those over age 40 increases, so will the prevalence of glaucoma. The pathogenesis of primary open angle glaucoma (POAG) is unclear and multiple ocular risk factors have been proposed, including intraocular pressure, ocular perfusion...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030761
更新日期：2020-03-11 00:00:00
abstract：OBJECTIVE:To review the current published literature on the use of procalcitonin as a diagnostic and prognostic marker in adult patients with meningitis. METHODS:We conducted a PubMed search to identify all relevant publications regarding the diagnostic and prognostic value of serum procalcitonin in patients with a kn...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm7060148
更新日期：2018-06-11 00:00:00
abstract：OBJECTIVE:Clinical presentation of patients with mitral paravalvular leakage (PVL) varies from asymptomatic to heart failure related with hemolytic anemia or pulmonary hypertension. We aimed to investigate the structural and functional characteristics of mitral PVL by multimodal imaging and their association with the s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020222
更新日期：2021-01-10 00:00:00
abstract：BACKGROUND:In-depth knowledge about potential predictors of mortality in transcatheter aortic valve replacement (TAVR) is still warranted. Currently used risk stratification models for TAVR often fail to reach a holistic approach. We, therefore, aimed to create a new staged risk model for 1-year mortality including sev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101642
更新日期：2019-10-08 00:00:00
abstract：:Natural killer (NK) cells are key players in the immune system. They use receptors on their cell surface to identify target cells. However, to escape being killed by the immune system, cancer cells such as thyroid cancer cells, use various methods to suppress the function of NK cells. Thus, this study aims to elucidat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060842
更新日期：2019-06-12 00:00:00
abstract：:Healthcare resource utilization peaks throughout the first year following acute myocardial infarction (AMI). Data linking the former and outcomes are sparse. We evaluated the associations between subsequent length of in-hospital stay (SLOS) and primary ambulatory visits (PAV) within the first year after AMI and long-t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082528
更新日期：2020-08-05 00:00:00
abstract：:Self-management (SM) includes activities that patients initiate and perform in the interest of controlling their disease and maintaining good health and well-being. This review examines the health literacy and patient activation elements of self-management interventions for Chronic Obstructive Pulmonary Diseases (COPD...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9030646
更新日期：2020-02-28 00:00:00
abstract：:Systemic sclerosis (SSc) is a connective tissue disease that is characterized by widespread skin and internal organ fibrosis vasculopathy and immune response abnormalities, including T, B, natural killer (NK), and natural killer T (NKT) cell involvement. The aim of the study was to investigate the immune cell profile ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8050625
更新日期：2019-05-08 00:00:00
abstract：:Access to in vitro fertilization (IVF) for obese women varies across centers, and the impact of obesity on IVF outcomes is widely discussed. We assessed the impact of obesity and its severity on live birth rate (LBR) after IVF. We included women treated for IVF in our center. Data were prospectively collected in the B...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082414
更新日期：2020-07-28 00:00:00
abstract：BACKGROUND:Due to its unknown etiology, the objective diagnosis and therapeutics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are still challenging. Generally, the patient-reported outcome (PRO) is the major strategy driving treatment response because the patient is the most important judge of whether...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113463
更新日期：2020-10-28 00:00:00
abstract：OBJECTIVES:Composition of saliva reflects the condition of the oral cavity. THE AIM OF THE STUDY:Investigation of the concentrations of MMP-1 (Matrix metalloproteinase-1), MMP-2 (Matrix metalloproteinase-2) and fibronectin in the saliva of patients planned for endodontic treatment or surgical extraction. MATERIAL AND...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123971
更新日期：2020-12-07 00:00:00
abstract：:A higher incidence rate of nocturia in patients with obstructive sleep apnea (OSA) has been observed. We investigated the differences in clinical examinations between OSA patients with and without nocturia, and further compared those with successful and unsuccessful uvulopalatopharyngoplasty (UPPP). This retrospective...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103089
更新日期：2020-09-25 00:00:00
abstract：:We aimed to develop a mathematical model to predict the progression of aortic stenosis (AS) and aortic dilatation (AD) in bicuspid aortic valve patients. Bicuspid AS patients who underwent at least two serial echocardiograms from 2005 to 2017 were enrolled. Mathematical modeling was undertaken to assess (1) the non-li...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091302
更新日期：2019-08-24 00:00:00
abstract：:The incidence of acute and chronic pancreatitis is increasing in the United States. Rates of acute pancreatitis (AP) are similar in both sexes, but chronic pancreatitis (CP) is more common in males. When stratified by etiology, women have higher rates of gallstone AP, while men have higher rates of alcohol- and tobacc...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm10020300
更新日期：2021-01-15 00:00:00
abstract：:Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm5110105
更新日期：2016-11-22 00:00:00
abstract：BACKGROUND:Current therapeutic options in the course of metastatic castration-resistant prostate cancers (mCRPC) reinforce the need for reliable tools to characterize the tumor in a dynamic way. Circulating tumor cells (CTCs) have emerged as a viable solution to the problem, whereby patients with a variety of solid tum...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072066
更新日期：2020-07-01 00:00:00
abstract：:Clinically, in young immunocompetent adults, Epstein-Barr virus (EBV) usually manifests as infectious mononucleosis (IM). Typical clinical findings of EBV IM include fever, profound fatigue, pharyngitis, bilateral posterior cervical adenopathy, and splenomegaly. Respiratory involvement with EBV IM may occur, but is di...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm6090083
更新日期：2017-09-04 00:00:00
abstract：:The focus of the presented work was to isolate and characterize circulating endometrial cells (CECs) enriched from peripheral blood (PB) of patients with diagnosed endometriosis. The molecular characteristics of CECs could be supportive for an understanding of endometriosis pathogenesis and treatment decisions in the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111938
更新日期：2019-11-11 00:00:00
abstract：:The outcome of patients with acute myocardial infarction (AMI) has dramatically improved over recent decades, thanks to early detection and prompt interventions to restore coronary blood flow. In contrast, the prognosis of patients with hypoxic acute kidney injury (AKI) remained unchanged over the years. Delayed diagn...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020267
更新日期：2019-02-21 00:00:00
abstract：:Diagnoses based on oral fluid biomarkers have been introduced to overcome limitations of periodontal probe-based diagnoses. Diagnostic ability of certain biomarkers for periodontitis have been identified and widely studied, however, such studies targeting gingivitis is scarce. The aims of this study were to determine ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061720
更新日期：2020-06-03 00:00:00
abstract：:The aim of this study was to analyze the value of urine α- and π-GST in monitoring and predicting kidney graft function following transplantation. In addition, urine samples from corresponding organ donors was analyzed and compared with graft function after organ donation from brain-dead and living donors. Urine sampl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111899
更新日期：2019-11-07 00:00:00
abstract：:Nonalcoholic fatty liver disease (NAFLD) is the most common cause of elevated alanine aminotransferase (ALT), but the clinical utility of ALT in detecting and following individuals with NAFLD remains unclear. We conducted a retrospective analysis of 30,988 men and 5204 women with NAFLD diagnosed by ultrasound and stra...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8040445
更新日期：2019-04-02 00:00:00
abstract：:The purpose of this study is to describe the Minimally Invasive Intraoral Approach (MIIA) performed on selected cases of abscesses and neck phlegmons of odontogenic origin when the infection has not spread beyond the inferior mandibular margin. This technique allows us to avoid cervicotomy by a direct approach to the ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092971
更新日期：2020-09-14 00:00:00
abstract：:Immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by isolated thrombocytopenia defined as platelet count in peripheral blood <100 × 109/L. Hypovitaminosis D is very common in children with autoimmune diseases. To analyze whether hypovitaminosis D is associated with the clinical presentatio...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8111861
更新日期：2019-11-03 00:00:00
abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8020277
更新日期：2019-02-25 00:00:00
abstract：:Primary Sjögren's Syndrome (pSS) is an autoimmune disease mainly affecting salivary and lacrimal glands. Previous pSS studies have relied on primary cell culture models or cancer cell lines with limited relevance to the disease. Our objective was to generate and characterize immortalized salivary gland epithelial cell...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123820
更新日期：2020-11-25 00:00:00
abstract：:In patients with Cushing's disease (CD), prompt diagnosis and treatment are essential for favorable long-term outcomes, although this remains a challenging task. The differential diagnosis of CD is still difficult in some patients, even with an organized stepwise diagnostic approach. Moreover, despite the use of high-...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8111951
更新日期：2019-11-12 00:00:00
abstract：:Small-intestinal neuroendocrine tumors (SI-NETs) are the most prevalent small bowel neoplasms with an increasing frequency. In the multimodal management of SI-NETs, surgery plays a key role, either in curative intent, even if R0 resection is feasible in only 20% of patients due to advanced stage at diagnosis, or palli...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072319
更新日期：2020-07-21 00:00:00
abstract：:Osteonecrosis of the jaw (ONJ) is a disease that affects the jaw. It is mainly related to radiation or bisphosphonates therapy, and the symptoms and signs consist of pain, bone exposure, inflammation of the surrounding soft tissue swelling, and secondary infection or drainage. In the case of advanced disease of the ma...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113516
更新日期：2020-10-30 00:00:00
abstract：:This study investigated physical activity (PA) and sedentary time (SED) in relation to hippocampal gray matter volume (GMV) in pediatric overweight/obesity. Ninety-three children (10 ± 1 year) were classified as overweight, obesity type I, or type II-III. PA was assessed with non-dominant wrist accelerometers. GMV was...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041080
更新日期：2020-04-10 00:00:00
