Abstract:
BACKGROUND:Due to its unknown etiology, the objective diagnosis and therapeutics of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) are still challenging. Generally, the patient-reported outcome (PRO) is the major strategy driving treatment response because the patient is the most important judge of whether changes are meaningful. METHODS:In order to determine the overall characteristics of the main outcome measurement applied in clinical trials for CFS/ME, we systematically surveyed the literature using two electronic databases, PubMed and the Cochrane Library, throughout June 2020. We analyzed randomized controlled trials (RCTs) for CFS/ME focusing especially on main measurements. RESULTS:Fifty-two RCTs out of a total 540 searched were selected according to eligibility criteria. Thirty-one RCTs (59.6%) used single primary outcome and others adapted ≥2 kinds of measurements. In total, 15 PRO-derived tools were adapted (50 RCTs; 96.2%) along with two behavioral measurements for adolescents (4 RCTs; 7.7%). The 36-item Short Form Health Survey (SF-36; 16 RCTs), Checklist Individual Strength (CIS; 14 RCTs), and Chalder Fatigue Questionnaire (CFQ; 11 RCTs) were most frequently used as the main outcomes. Since the first RCT in 1996, Clinical Global Impression (CGI) and SF-36 have been dominantly used each in the first and following decade (26.1% and 28.6%, respectively), while both CIS and Multidimensional Fatigue Inventory (MFI) have been the preferred instruments (21.4% each) in recent years (2016 to 2020). CONCLUSIONS:This review comprehensively provides the choice pattern of the assessment tools for interventions in RCTs for CFS/ME. Our data would be helpful practically in the design of clinical studies for CFS/ME-related therapeutic development.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Kim DY,Lee JS,Son CGdoi
10.3390/jcm9113463subject
Has Abstractpub_date
2020-10-28 00:00:00issue
11issn
2077-0383pii
jcm9113463journal_volume
9pub_type
杂志文章,评审abstract::CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8101526
更新日期:2019-09-23 00:00:00
abstract::Despite the overall success of cochlear implantation, language outcomes remain suboptimal and subject to large inter-individual variability. Early auditory rehabilitation techniques have mostly focused on low-level sensory abilities. However, a new body of literature suggests that cognitive operations are critical for...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041058
更新日期:2020-04-08 00:00:00
abstract::TPK1 mutations are a rare, but potentially treatable, cause of thiamine deficiency. Diagnosis is challenging given the phenotypic overlap that exists with other metabolic and neurological disorders. We report a case of TPK1-related disease presenting with Leigh-like syndrome and review the diagnostic utility of thiami...
journal_title:Journal of clinical medicine
pub_type:
doi:10.3390/jcm8070991
更新日期:2019-07-08 00:00:00
abstract:BACKGROUND:There is a paucity of head-to-head comparisons of the efficacy and harms of pharmacological treatments for systemic sclerosis-related interstitial lung disease (SSc-ILD). METHODS:We conducted a network meta-analysis (NMA) in order to compare the effects of different treatments with the placebo on change in ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9082560
更新日期:2020-08-07 00:00:00
abstract:BACKGROUND:Residual coronary artery disease (CAD) has been associated with worsened prognosis in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS). The residual SYNTAX Score (rSS) aims to assess residual CAD after PCI. The association between kidney function and rSS has not...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8060810
更新日期:2019-06-06 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death. Soluble receptor for glycation end products (sRAGE), which is modulated by anti-hypertensive (HT) medications, has been inversely associated with pancreatic cancer. However, the association between commonly used anti-HT medications and risk of pancreatic c...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7080197
更新日期:2018-08-02 00:00:00
abstract::The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular dis...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8040424
更新日期:2019-03-28 00:00:00
abstract:INTRODUCTION:Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are an increasing tumor entity. Since many patients are diagnosed at an advanced stage, treatment is still challenging and dependent on many tumor and patient specific factors. Therefore, the aim of the present study was to elucidate the expression...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103368
更新日期:2020-10-21 00:00:00
abstract:BACKGROUND:Anemia of Chronic Disease (ACD) can negatively influence the clinical course of Inflammatory Bowel Disease (IBD) patients. The aim of this study was to evaluate the effect of Vedolizumab on ACD in IBD. METHODS:Clinical data of 75 IBD patients (25 Crohn's disease (CD) and 50 Ulcerative Colitis (UC)) receivin...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9072126
更新日期:2020-07-06 00:00:00
abstract::Lung cancer is the second most common malignancy. Unfortunately, despite advances in multimodality therapeutics for the disease, the overall five-year survival rate among newly diagnosed lung cancer patients remains in the range region of 15%. In addition, although immune checkpoint inhibitors are increasingly being i...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7100303
更新日期:2018-09-25 00:00:00
abstract:BACKGROUND AND AIMS:The markers of renal damage defining subclinical AKI are not widely used in children undergoing allogeneic hematopoietic stem cell transplantation (alloHSCT). The aim of the study was to evaluate serum and urinary clusterin as indices of kidney injury after alloHSCT in relation to damage (kidney inj...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082599
更新日期:2020-08-11 00:00:00
abstract:BACKGROUND:Spironolactone, a non-selective mineralocorticoid receptor antagonist, can protect against cardiac fibrosis and left ventricular dysfunction, and improve endothelial dysfunction and proteinuria. However, the safety and effects of spironolactone on patient-centered cardiovascular and renal endpoints remain un...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7110459
更新日期:2018-11-21 00:00:00
abstract::In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not only the process of carcinogenesis through cancer-related inflammation mechanisms, but also tumor progression, invasion, and metastasis. In particular, tumor-associated macrophages (TAMs) are the most abundant leucocyte sub...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9103226
更新日期:2020-10-08 00:00:00
abstract::C-reactive protein (CRP) and myxovirus resistance protein A (MxA) are associated with bacterial and viral infections, respectively. We conducted a prospective, multicenter, cross-sectional study of adults and children with febrile upper respiratory tract infections (URIs) to evaluate the diagnostic accuracy of a rapid...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm6100094
更新日期:2017-10-07 00:00:00
abstract::Many studies have shown a global efficacy of laparoscopic surgery for patients with endometriosis in reducing painful symptoms and improving quality of life (QoL) in the short and long-term. The aim of this study was to analyze the different trajectories of long-term evolution in QoL and symptoms following surgical tr...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082461
更新日期:2020-07-31 00:00:00
abstract::: Pulmonary fibrosis (PF) is a very rare condition in children, which may be observed in specific forms of interstitial lung disease. None of the clinical, radiological, or histological descriptions used for PF diagnosis in adult patients, especially in situations of idiopathic PF, can apply to pediatric situations. T...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8091312
更新日期:2019-08-26 00:00:00
abstract::Intravenous lipid emulsions are an essential component of parenteral nutrition regimens. Originally employed as an efficient non-glucose energy source to reduce the adverse effects of high glucose intake and provide essential fatty acids, lipid emulsions have assumed a larger therapeutic role due to research demonstra...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm5030034
更新日期:2016-03-07 00:00:00
abstract::Pancreatic cancer is a lethal cancer with an increasing incidence. Despite improvements in chemotherapy, patients with pancreatic cancer continue to face poor prognoses. Endoscopic ultrasound-guided tissue acquisition (EUS-TA) is the primary method for obtaining tissue samples of pancreatic cancer. Due to advancements...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8081173
更新日期:2019-08-05 00:00:00
abstract::The main objective was to assess the efficacy of botulinum toxin-based treatment for sialorrhea in adult patients with Parkinson's disease. The search was performed by using the Medline-PubMed, EMBASE and Cochrane Library databases from January 2000⁻December 2017, in English/Spanish in patients with Parkinson's diseas...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8030317
更新日期:2019-03-06 00:00:00
abstract::Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm9040978
更新日期:2020-04-01 00:00:00
abstract::The authors wish to make the following corrections to this paper [...]. ...
journal_title:Journal of clinical medicine
pub_type: 已发布勘误
doi:10.3390/jcm8030389
更新日期:2019-03-20 00:00:00
abstract:BACKGROUND:The aim of this systematic review and meta-analysis was to determine the fracture resistance and survival rate of partial indirect restorations inlays, onlays, and overlays fabricated using computer-aided design and computer-aided manufacturing (CAD-CAM) technology from ceramics, composite resin, resin nanoc...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm8111932
更新日期:2019-11-09 00:00:00
abstract::Acute retinal necrosis (ARN) is a rare viral endophthalmitis, and human herpesvirus is the principal pathogen. Early diagnosis and treatment are critical to avoid visual impairment by ARN, and pars plana vitrectomy (PPV) is required in advanced cases. In this study, we evaluated the transition of viral load in ocular ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9041204
更新日期:2020-04-22 00:00:00
abstract:BACKGROUND:The purpose of this prospective study was to evaluate the role of 18F-Fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for assessing treatment response in patients with pulmonary multidrug-resistant tuberculosis (MDR-TB). METHODS:The study subjects were four patients di...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7120559
更新日期:2018-12-17 00:00:00
abstract:BACKGROUND:The thyroid plays a key role in development and homeostasis, but it has been difficult to establish causality with diseases and phenotypic traits because of several potential confounders. METHODS:To determine the causal effect of euthyroid function, we conducted a two-sample Mendelian randomization study of...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm7100296
更新日期:2018-09-21 00:00:00
abstract::The endogenous PP2A inhibitor SET Nuclear Proto-Oncogene (SET) has been reported to play oncogenic roles and determines poor outcomes in colorectal cancer (CRC). Our group previously showed that miR-199b is deregulated in metastatic CRC, and reduced the cell viability and enhanced the sensitivity of CRC cells to stand...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9082419
更新日期:2020-07-28 00:00:00
abstract::In the statin era, the incidence of atherosclerotic cardiovascular diseases (ASCVD) in patients with familial hypercholesterolemia (FH) has not been updated. We aimed to determine the incidence of ASCVD in patients with FH-phenotype (FH-P) and to compare it with that of normal low-density lipoprotein cholesterol (LDL-...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8071080
更新日期:2019-07-23 00:00:00
abstract:INTRODUCTION:Cardiovascular risk factors, pre-existing comorbidities, molecular factors, and the direct effects of second- and third-generation BCR-ABL1 tyrosine kinase inhibitors on the vascular endothelium contribute to the progression of cardiovascular (CV) events, especially atherothrombotic conditions. The study o...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm9103269
更新日期:2020-10-12 00:00:00
abstract::Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1) is a devastating autosomal recessive disorder due to mutations in TYMP, which cause a loss of function of thymidine phosphorylase (TP), nucleoside accumulation in plasma and tissues, and mitochondrial dysfunction. The clinical picture includes progre...
journal_title:Journal of clinical medicine
pub_type: 杂志文章,评审
doi:10.3390/jcm7110389
更新日期:2018-10-26 00:00:00
abstract::The aim of this study was to investigate the prescribing cascade phenomenon of dopaminergic drugs such as levodopa in the management of gastroprokinetic drugs induced parkinsonism. Based on the Korea National Health Insurance Service (NHIS)-Senior Cohort Database, we analyzed patients aged ≥65 years, between 2009 and ...
journal_title:Journal of clinical medicine
pub_type: 杂志文章
doi:10.3390/jcm8091496
更新日期:2019-09-19 00:00:00