Abstract：
:MicroRNAs (miRNAs) can provide insight into the pathophysiological states of ocular tissues such as proliferative diabetic retinopathy (PDR). In this study, differences in miRNA expression in vitreous from PDR patients with and without incidence of recurrent vitreous hemorrhage (RVH) after the initial pars-plana vitrectomy (PPV) were analyzed, with the aim of identifying biomarkers for RVH. Fifty-four consented vitreous samples were analyzed from patients undergoing PPV for PDR, of which eighteen samples underwent a second surgery due to RVH. Ten of the sixty-six expressed miRNAs (miRNAs-19a, -20a, -22, -27a, -29a, -93, -126, -128, -130a, and -150) displayed divergences between the PDR vitreous groups and to the control. A significant increase in the miRNA-19a and -27a expression was determined in PDR patients undergoing PPV as compared to the controls. miRNA-20a and -93 were significantly upregulated in primary PPV vitreous samples of patients afflicted with RVH. Moreover, this observed upregulation was not significant between the non-RVH and control group, thus emphasizing the association with RVH incidence. miRNA-19a and -27a were detected as putative vitreous biomarkers for PDR, and elevated levels of miRNA-20a and -93 in vitreous with RVH suggest their biomarker potential for major PDR complications such as recurrent hemorrhage incidence.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Mammadzada P,Bayle J,Gudmundsson J,Kvanta A,André Hdoi
10.3390/jcm8122217subject
Has Abstractpub_date
2019-12-15 00:00:00issue
12issn
2077-0383pii
jcm8122217journal_volume
8pub_type
杂志文章abstract：BACKGROUND:Although early identification of critical illness polyneuropathy (CIP) is necessary, the established diagnostic criteria have several limitations in the intensive care unit (ICU) setting. The purpose of this study was to define simplified diagnostic criteria of CIP that best predict clinical outcomes. METHO...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124029
更新日期：2020-12-13 00:00:00
abstract：:Pulmonary hypertension (PH) in patients with heart failure (HF) contributes to a poorer prognosis. However, in those with dilated cardiomyopathy (DCM), the true prevalence and role of PH is unclear. Therefore, this study aimed to analyze the profile of DCM patients at various levels of PH risk, determined via echocard...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061660
更新日期：2020-06-01 00:00:00
abstract：:Cholangiocarcinoma (CCA) arises from the biliary tract epithelium and accounts for 10-15% of all hepatobiliary malignancies. Depending on anatomic location, CCA is classified as intrahepatic (iCCA), perihilar (pCCA) and distal (dCCA). The best treatment option for pCCA is liver resection and when a radical oncological...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051353
更新日期：2020-05-05 00:00:00
abstract：AIM:Our aim was to investigate the characteristics, treatment and prognosis of patients with myocardial infarction (MI) treated outside a cardiology department (CD), compared with MI patients treated at a CD. METHODS:A cohort of 1310 patients diagnosed with MI at eight Swedish hospitals in 2011 were included in this o...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010106
更新日期：2020-12-30 00:00:00
abstract：:This study sought to determine whether the implementation of regular and structured follow-up of patients with chronic heart failure (CHF), combined with therapeutic education and remote monitoring solution, leads to better management. This was a single-center retrospective study conducted in a cohort of patients with...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103106
更新日期：2020-09-25 00:00:00
abstract：:In the past two decades, multiple studies have been undertaken to elucidate the genetic cause of the predisposition to mismatch repair (MMR)-proficient nonpolyposis colorectal cancer (CRC). Here, we present the proposed candidate genes according to their involvement in specific pathways considered relevant in heredita...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061954
更新日期：2020-06-23 00:00:00
abstract：:Even though the cornea is regarded as an immune-privileged tissue, transplantation always comes with the risk of rejection due to mismatches between donor and recipient. It is common sense that an alternative to corticosteroids as the current gold standard for treatment of corneal transplantation is needed. Since bloo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051280
更新日期：2020-04-28 00:00:00
abstract：:While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103247
更新日期：2020-10-11 00:00:00
abstract：PURPOSE:Evaluating the effects of cibinetide in diabetic macular edema (DME). METHODS:Phase 2 trial. Naïve patients with >400 µm central retinal thickness (CRT) DME in one/both eyes were recruited (May 2016-April 2017) at the Belfast Health and Social Care Trust. The study eye was that with best vision and lowest CRT....
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072225
更新日期：2020-07-14 00:00:00
abstract：:Since the discovery of the causal association between human papillomavirus (HPV) and cervical cancer, efforts to develop an effective prophylactic vaccine to prevent high-risk HPV infections have been at the forefront of modern medical research. HPV causes 530,000 cervical cancer cases worldwide, which is the second m...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm4040614
更新日期：2015-04-03 00:00:00
abstract：:Despite extensive research and development of new treatments, acute myeloid leukemia (AML)-backbone therapy has remained essentially unchanged over the last decades and is frequently associated with poor outcomes. Eradicating the leukemic stem cells (LSCs) is the ultimate challenge in the treatment of AML. Emerging ev...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9051513
更新日期：2020-05-18 00:00:00
abstract：INTRODUCTION:Telemedicine is believed to be helpful in managing patients suffering from chronic diseases, in particular elderly patients with numerous accompanying conditions. This was the basis for the "GERIATRICS and e-Technology (GER-e-TEC) study", which was an experiment involving the use of the smart MyPredi™ e-pl...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9123836
更新日期：2020-11-26 00:00:00
abstract：BACKGROUND:Hand osteoarthritis (OA) is one of the most common joint diseases, but studies on biomarkers are rare. The aim of this explorative study was (a) to evaluate potential biomarkers of hand OA, (b) to identify an optimal time point to sample venous blood, and (c) to correlate biomarker levels with radiological a...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101545
更新日期：2019-09-26 00:00:00
abstract：:Age-related macular degeneration is the leading cause of blindness in the developed world. Since advanced glycation end products (AGEs) are implicated in the pathogenesis of AMD through various lines of evidence, we investigated the potential of fructosamine-3-kinase (FN3K) in the disruption of retinal AGEs, drusenoid...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9092869
更新日期：2020-09-04 00:00:00
abstract：:Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8081126
更新日期：2019-07-29 00:00:00
abstract：:Osteonecrosis of the jaw (ONJ) is a disease that affects the jaw. It is mainly related to radiation or bisphosphonates therapy, and the symptoms and signs consist of pain, bone exposure, inflammation of the surrounding soft tissue swelling, and secondary infection or drainage. In the case of advanced disease of the ma...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113516
更新日期：2020-10-30 00:00:00
abstract：:The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment for lymphedema, it has hardly been described as a treatment for LM. Virtual...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm8030371
更新日期：2019-03-15 00:00:00
abstract：:Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9040978
更新日期：2020-04-01 00:00:00
abstract：:The outcome of coronavirus disease 2019 (COVID-19) is associated with organ damage; however, the information about the relationship between acute kidney injury (AKI) and COVID-19 is still rare. We evaluated the clinical features and prognosis of COVID-19 patients with AKI according to the AKI severity. Medical data of...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061718
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:The aim of this study was to investigate the association between acute kidney injury (AKI) and in-hospital mortality (IHM) in a large nationwide cohort of elderly subjects in Italy. METHODS:We analyzed the hospitalization data of all patients aged ≥65 years, who were discharged with a diagnosis of AKI, whic...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091371
更新日期：2019-09-02 00:00:00
abstract：:With the expanded legalization of marijuana, its medical and recreational use have sharply increased over the past decade. A wide array of new forms of cannabis is available on the market today, and the potencies are ten times those of forms previously tested, meaning that the true impact of marijuana on the cardiovas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061925
更新日期：2020-06-19 00:00:00
abstract：:Liver transplantation is increasingly dependent on the use of extended criteria donors (ECD) to increase the organ donor pool and address rising demand. This has necessitated the adoption of innovative technologies and strategies to protect these higher-risk grafts from the deleterious effects of traditional preservat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041046
更新日期：2020-04-07 00:00:00
abstract：:Ongoing outbreak of pneumonia caused by novel coronavirus (2019-nCoV) began in December 2019 in Wuhan, China, and the number of new patients continues to increase. Even though it began to spread to many other parts of the world, such as other Asian countries, the Americas, Europe, and the Middle East, the impact of se...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9040944
更新日期：2020-03-30 00:00:00
abstract：:: Several researchers have assessed the utility of Impulse Oscillometry System (IOS) in diagnosing and evaluating the severity of respiratory diseases in childhood, but none has investigated the impact of the fluctuations of IOS parameters in an individualized manner. In this two-year prospective study, we aimed to lo...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091475
更新日期：2019-09-16 00:00:00
abstract：:Limited information on the effect of antiretroviral treatment (ART) on vascular function in South Africans of African descent living with human immunodeficiency virus (HIV) is available. The relationship between ART, vascular function and cardiovascular risk factors in South Africans of African ancestry with HIV was t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10030392
更新日期：2021-01-20 00:00:00
abstract：:Antibiotic treatment in paediatric rhinosinusitis is still a matter of debate, as the current guidelines have been drafted mainly based on clinical studies published before 2013. Recent modifications in the epidemiological basis of the disease might mean that current treatments are not completely adequate considering ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8081162
更新日期：2019-08-03 00:00:00
abstract：:Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm6020017
更新日期：2017-02-13 00:00:00
abstract：:To define the role of spleen stiffness (SS) and liver stiffness (LS) in myelofibrosis and other Philadelphia (Ph)-negative myeloproliferative neoplasms (MPNs), we studied, by ultrasonography (US) and elastography (ES), 70 consecutive patients with myelofibrosis (MF) (no.43), essential thrombocythemia (ET) (no.10), and...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072149
更新日期：2020-07-08 00:00:00
abstract：:Pain is the main impetus for osteoarthritis (OA) patients to seek healthcare including joint replacement. The pain experience in OA is heterogeneous and affected by factors across multiple domains-peripheral, psychological, and neurological. This indicates the existence of homogenous subgroups/phenotypes within OA pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030632
更新日期：2020-02-27 00:00:00
abstract：BACKGROUND:Bioelectrical impedance analysis (BIA) is a simple and rapid technique to measure body composition (BC). Validity of BIA in patients with low body mass index (BMI) remains controversial. We assessed the validity of several BIA equations to evaluate fat-free mass (FFM), fat mass (FM) and muscle mass in patien...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9113664
更新日期：2020-11-14 00:00:00
