Abstract：
:Clinical trials in attention-deficit/hyperactivity disorder (ADHD) have typically measured outcome using clinician ratings on the Attention-Deficit/Hyperactivity Disorder Rating Scale, Fourth Edition (ADHD-RS-IV) and the Clinical Global Impression-Improvement (CGI-I) scale. Remission has been defined as an endpoint score of less than or equal to 18 on the ADHD-RS-IV (or a mean score of 1). Responders have been defined as patients who achieve a CGI-I score of much or very much improved (1 or 2). There is a lack of agreement in the literature on what percent change in symptoms on the ADHD-RS-IV should be used to define improvement or remission. This study uses data from a clinical trial of a methylphenidate extended release (MPH-MLR; Aptensio XR®) phase III clinical trial to attempt to determine the percent change of symptoms that best corresponds with improvement and remission. Symptom remission at endpoint (ADHD-RS-IV total score ≤18) was most closely aligned with a ≥46% reduction in ADHD-RS-IV total score. Clinical improvement was most closely aligned with a ≥40% reduction in ADHD-RS-IV total score. The three different measures of outcome were strongly aligned during double blind and open label treatment, and were independent of subtype status. Our data suggest that at least 40% improvement in symptoms is needed to achieve a robust response at endpoint.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Weiss M,Childress A,Nordbrock E,Adjei AL,Kupper RJ,Mattingly Gdoi
10.3390/jcm8040461subject
Has Abstractpub_date
2019-04-05 00:00:00issue
4issn
2077-0383pii
jcm8040461journal_volume
8pub_type
杂志文章abstract：:Acute kidney injury and renal failure are common after heart transplantation. We retrospectively reviewed a national cohort and identified 1129 heart transplant patients. Patients receiving renal replacement therapy after heart transplantation were grouped into the dialysis cohort. The long-term survival and risk fact...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082455
更新日期：2020-07-31 00:00:00
abstract：:Orf virus (OV) is a zoonotic parapoxvirus that causes highly proliferative skin lesions which resolve with minimal inflammation and scarring. OV encodes two immunomodulators, vascular endothelial growth factor (VEGF)-E and interleukin-10 (ovIL-10), which individually modulate skin repair and inflammation. This study e...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9041085
更新日期：2020-04-11 00:00:00
abstract：BACKGROUND:The management of Helicobacter pylori (H. pylori) infection raises important challenges, still being the most common chronic infection worldwide in all age groups. In high-prevalence regions, paediatric patients need a specific focus, as the acquisition of the infection takes place in childhood. The objectiv...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030784
更新日期：2020-03-13 00:00:00
abstract：INTRODUCTION:Dementia is a group of disorders that causes dysfunctions in human cognitive and operating functions. Currently, it is not possible to conduct a fast, low-invasive dementia diagnostic process with the use of peripheral blood biomarkers, however, there is a great deal of research in progress covering this s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9113452
更新日期：2020-10-27 00:00:00
abstract：:Cardiovascular autonomic neuropathy (CAN) is a common complication of diabetes mellitus. Cardiovascular reflex tests (CARTs) are the gold standard in the diagnosis of CAN, but the handgrip test is no longer recommended to be performed. Previously, the inverse association between the presence of hypertension and handgr...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103322
更新日期：2020-10-16 00:00:00
abstract：BACKGROUND:Invasive fungal disease (IFD) is common in solid organ transplant (SOT) recipients and contributes to high morbidity and mortality. Although kidney transplantation (KT) is a commonly performed SOT, data on the risk factors for IFD-related mortality are limited. METHODS:A 1:2 retrospective case-control study...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061824
更新日期：2020-06-11 00:00:00
abstract：:Current therapy of Clostridium difficile diarrhea (CDD) is problematic. Optimal treatment for CDD remains oral vancomycin, but there is little data on oral vancomycin dosing regimens. The objective of this C. difficile diarrhea study was to compare the efficacy of "high dose" vancomycin, 500 mg (PO) q6h, as sole treat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm7040075
更新日期：2018-04-10 00:00:00
abstract：BACKGROUND:For acute adnexal torsion of pregnant women, appropriate treatment based on an accurate diagnosis is especially important for fertility preservation and timely treatment. The 2017 American College of Obstetricians and Gynecologists (ACOG) Committee Opinion No. 723 announced its practice-changing guidelines t...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9072209
更新日期：2020-07-13 00:00:00
abstract：:Thyroid hormones (THs) exert pleiotropic effects in different mammalian organs, including gonads. Genetic and non-genetic factors, such as ageing and environmental stressors (e.g., low-iodine intake, exposure to endocrine disruptors, etc.), can alter T4/T3 synthesis by the thyroid. In any case, peripheral T3, controll...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9061679
更新日期：2020-06-01 00:00:00
abstract：UNLABELLED:The objective of this study was to evaluate the correlation between multiple cardiovascular risk factors (MCRFs) and circulating mononuclear cells (CMCs) in asymptomatic coronary artery disease patients. DESIGN AND METHODS:126 subjects (54 male), aged 48 to 62 years, with asymptomatic coronary artery diseas...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm2030032
更新日期：2013-07-30 00:00:00
abstract：:While satisfactory results have been reported during short-to mid-term follow-up assessments of hemophilic patients who have undergone total knee arthroplasty (TKA), limited literature focusing on long-term survival following TKA exists to date. As part of this investigation, a consecutive series of 78 TKAs in 56 pati...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9103247
更新日期：2020-10-11 00:00:00
abstract：OBJECTIVE:Clinical presentation of patients with mitral paravalvular leakage (PVL) varies from asymptomatic to heart failure related with hemolytic anemia or pulmonary hypertension. We aimed to investigate the structural and functional characteristics of mitral PVL by multimodal imaging and their association with the s...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10020222
更新日期：2021-01-10 00:00:00
abstract：BACKGROUND:Daily management to shield chronic dialysis patients from SARS-CoV-2 contamination makes patient care cumbersome. There are no screening methods to date and a molecular biology platform is essential to perform RT-PCR for SARS-CoV-2; however, accessibility remains poor. Our goal was to assess whether the tool...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm10010004
更新日期：2020-12-22 00:00:00
abstract：:Hepatitis C virus (HCV) infection develops into chronic hepatitis in over two-thirds of acute infections. While current treatments with direct-acting antivirals (DAAs) achieve HCV eradication in >95% of cases, no vaccine is available and re-infection can readily occur. Natural killer (NK) cells represent a key cellula...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9041030
更新日期：2020-04-06 00:00:00
abstract：:The purpose of the present systematic review and meta-analysis was to explore the effects of transcranial direct current stimulation (tDCS) on endurance (i.e., time to task failure (TTF)) and maximal voluntary contraction (MVC). Furthermore, we aimed to analyze whether the duration of stimulation, the brain region tar...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8040536
更新日期：2019-04-18 00:00:00
abstract：:This report describes the trends of chorionic villus sampling (CVS) referred for prenatal genetic diagnosis in the past two and a half decades in a Portuguese Center. Our cohort of 491 CVS was mostly performed by the transcervical method at the 12th gestational week. Data collected within the framework of this study r...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm3030838
更新日期：2014-07-24 00:00:00
abstract：:Numerous studies over the years have shown that oxidative stress plays a major role in the development of the disease. Oxidative stress involvement in COPD opens up the possibility of using antioxidant therapies in the treatment of the disease. However, so far, these therapies have shown no clinical benefit indicating...
journal_title：Journal of clinical medicine
pub_type： 社论
doi：10.3390/jcm8111953
更新日期：2019-11-13 00:00:00
abstract：:The radial nerve is the most frequently injured nerve in the upper extremity. Numerous options in treatment have been described for radial nerve injury, such as neurolysis, nerve grafts, or tendon transfers. Currently, new treatment options are arising, such as platelet-rich plasma (PRP), an autologous product with pr...
journal_title：Journal of clinical medicine
pub_type：
doi：10.3390/jcm7020013
更新日期：2018-01-29 00:00:00
abstract：:Chronic stress is thought to be involved in the occurrence and progression of multiple diseases, via mechanisms that still remain largely unknown. Interestingly, key regulators of the stress response, such as members of the corticotropin-releasing-hormone (CRH) family of neuropeptides and receptors, are now known to b...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8101669
更新日期：2019-10-12 00:00:00
abstract：:Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9051383
更新日期：2020-05-08 00:00:00
abstract：:Drug-induced immune thrombocytopenia (DITP) is a life-threatening clinical syndrome that is under-recognized and difficult to diagnose. Many drugs can cause immune-mediated thrombocytopenia, but the most commonly implicated are abciximab, carbamazepine, ceftriaxone, eptifibatide, heparin, ibuprofen, mirtazapine, oxali...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm9072212
更新日期：2020-07-13 00:00:00
abstract：:Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their accurate diagnoses and treatment is a challenge for improving prognoses. This study aimed to as...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9124103
更新日期：2020-12-19 00:00:00
abstract：:Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9061809
更新日期：2020-06-10 00:00:00
abstract：BACKGROUND:The clinical outcome of patients affected by dilated cardiomyopathy (DCM) is heterogeneous, since its pathophysiology is only partially understood. Interleukin 1β levels could predict the mortality and necessity of cardiac transplantation of DCM patients. OBJECTIVE:To investigate mechanisms triggering steri...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101519
更新日期：2019-09-21 00:00:00
abstract：:Cytoreductive surgery (CRS) with or without hyperthermic intraperitoneal chemotherapy (HIPEC) is associated with improved survival for patients with colorectal peritoneal metastases (CR-PM). However, the role of neoadjuvant chemotherapy (NAC) prior to CRS-HIPEC is poorly understood. A retrospective review of adult pat...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9030748
更新日期：2020-03-10 00:00:00
abstract：:Once thought to be uncommon, celiac disease has now become a common disease globally. While avoidance of the gluten-containing diet is the only effective treatment so far, many new targets are being explored for the development of new drugs for its treatment. The endpoints of therapy include not only reversal of sympt...
journal_title：Journal of clinical medicine
pub_type： 杂志文章,评审
doi：10.3390/jcm8060885
更新日期：2019-06-21 00:00:00
abstract：:CD73, a cell-surface protein encoded by the gene NT5E, is overexpressed in glioblastoma (GBM), where it contributes to the tumor's pathophysiology via the generation of immunosuppressive adenosine. Adenosinergic signaling, in turn, drives immunosuppression of natural killer (NK) cells through metabolic and functional ...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8101526
更新日期：2019-09-23 00:00:00
abstract：:Both nuclear and mitochondrial DNA defects can cause isolated cytochrome c oxidase (COX; complex IV) deficiency, leading to the development of the mitochondrial disease. We report a 52-year-old female patient who presented with a late-onset, progressive cerebellar ataxia, tremor and axonal neuropathy. No family histor...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8060789
更新日期：2019-06-04 00:00:00
abstract：BACKGROUND:Although extracorporeal membrane oxygenation (ECMO) is used for hemodynamic support for in-hospital cardiac arrest (IHCA) complicating acute myocardial infarction (AMI), there are limited data on the outcomes stratified by the timing of initiation of this strategy. METHODS:Adult (>18 years) AMI admissions w...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm9082613
更新日期：2020-08-12 00:00:00
abstract：BACKGROUND:Both old age and institutionalization in aged care homes come with a significant risk of developing several long-term mental and neurological disorders, but there has been no definitive meta-analysis of data from studies to determine the pooled estimate of central nervous system (CNS) medicines use in aged c...
journal_title：Journal of clinical medicine
pub_type： 杂志文章
doi：10.3390/jcm8091292
更新日期：2019-08-23 00:00:00
