Abstract：
BACKGROUND:Peri-interventional myocardial injury occurs frequently during transcatheter aortic valve implantation (TAVI). We assessed the effect of remote ischemic preconditioning (RIPC) on myocardial injury, acute kidney injury (AKIN) and 6-month mortality in patients undergoing TAVI. METHODS:We performed a prospective single-center controlled trial. Sixty-six patients treated with RIPC prior to TAVI were enrolled in the study and were matched to a control group by propensity-score. RIPC was applied to the upper extremity using a conventional tourniquet. Myocardial injury was assessed using high-sensitive troponin-T (hsTnT), and kidney injury was assessed using serum creatinine levels. Data were compared with the Wilcoxon-Rank and McNemar tests. Mortality was analysed with the log-rank test. RESULTS:TAVI led to a significant rise of hsTnT across all patients (p < 0.001). No significant inter-group difference in maximum troponin release or areas-under-the-curve was detected. Medtronic CoreValve and Edwards Sapien valves showed similar peri-interventional troponin kinetics and patients receiving neither valve did benefit from RIPC. AKIN occurred in one RIPC patient and four non-RIPC patients (p = 0.250). No significant difference in 6-month mortality was observed. No adverse events related to RIPC were recorded. CONCLUSION:Our data do not show a beneficial role of RIPC in TAVI patients for cardio- or renoprotection, or improved survival.
journal_name
J Clin Medjournal_title
Journal of clinical medicineauthors
Flechsig M,Ruf TF,Troeger W,Wiedemann S,Quick S,Ibrahim K,Pfluecke C,Youssef A,Sveric KM,Winzer R,Heinzel FR,Linke A,Strasser RH,Zhang K,Heidrich FMdoi
10.3390/jcm9010160subject
Has Abstractpub_date
2020-01-07 00:00:00issue
1issn
2077-0383pii
jcm9010160journal_volume
9pub_type
杂志文章abstract：:Uric acid urolithiasis constitutes approximately 7-10% of all urinary stones. Previous studies have revealed that patients with gout do not equally have uric acid stones. Instead, the risk of gout in patients with uric acid stones remains controversial. This study aimed to investigate whether there is different associ...
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