当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > Factors Associated with Decisions for Initial Dosing, Up-Titration of Propiverine and Treatment Outcomes in Overactive Bladder Syndrome Patients in a Non-Interventional Setting.

Factors Associated with Decisions for Initial Dosing, Up-Titration of Propiverine and Treatment Outcomes in Overactive Bladder Syndrome Patients in a Non-Interventional Setting.

Abstract：

:Two doses of propiverine ER (30 and 45 mg/d) are available for the treatment of overactive bladder (OAB) syndrome. We have explored factors associated with the initial dosing choice (allocation bias), the decision to adapt dosing (escalation bias) and how dosing relative to other factors affects treatment outcomes. Data from two non-interventional studies of 1335 and 745 OAB patients, respectively, receiving treatment with propiverine, were analyzed post-hoc. Multivariate analysis was applied to identify factors associated with dosing decisions and treatment outcomes. Several parameters were associated with dose choice, escalation to higher dose or treatment outcomes, but only few exhibited a consistent association across both studies. These were younger age for initial dose choice and basal number of urgency and change in incontinence episodes for up-titration. Treatment outcome (difference between values at 12 weeks vs. baseline) for each OAB system was strongly driven by the respective baseline value, whereas no other parameter exhibited a consistent association. Patients starting on the 30 mg dose and escalating to 45 mg after 4 weeks had outcomes comparable with those staying on a starting dose of 30 or 45 mg. We conclude that dose escalation after 4 weeks brings OAB patients with an initially limited improvement to a level seen in initially good responders. Analysis of underlying factors yielded surprisingly little consistent insight.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Amiri M,Schneider T,Oelke M,Murgas S,Michel MC

doi

10.3390/jcm10020311

subject

Has Abstract

pub_date

2021-01-15 00:00:00

issue

2

issn

2077-0383

pii

jcm10020311

journal_volume

10

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • Systematic Multiomic Analysis of Ly75 Gene Expression and Its Prognostic Value Through the Infiltration of Natural Killer (NK) Cells in Skin Cutaneous Melanoma.

    abstract：:Ly75 (also known as DEC-205 or CD205) is expressed in immune cells and cancers and involved in tumor immunity. However, clinical relevance of Ly75 expression in skin cutaneous melanoma (SKCM) have not been comprehensively studied. This study analyzed the correlation between Ly75 mRNA expression and patient survival us...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9051383

    authors： Gil M,Kim KE

    更新日期：2020-05-08 00:00:00

  • Posttraumatic Stress Disorder: Overview of Evidence-Based Assessment and Treatment.

    abstract：:Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm5110105

    authors： Lancaster CL,Teeters JB,Gros DF,Back SE

    更新日期：2016-11-22 00:00:00

  • Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women.

    abstract：:Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061809

    authors： Sfakianoudis K,Simopoulou M,Grigoriadis S,Pantou A,Tsioulou P,Maziotis E,Rapani A,Giannelou P,Nitsos N,Kokkali G,Koutsilieris M,Pantos K

    更新日期：2020-06-10 00:00:00

  • Mindfulness-Based Program Plus Amygdala and Insula Retraining (MAIR) for the Treatment of Women with Fibromyalgia: A Pilot Randomized Controlled Trial.

    abstract：:The lack of highly effective treatments for fibromyalgia (FM) represents a great challenge for public health. The objective of this parallel, pilot randomized controlled trial (RCT) was two-fold: (1) to analyze the clinical effects of mindfulness plus amygdala and insula retraining (MAIR) compared to a structurally eq...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9103246

    authors： Sanabria-Mazo JP,Montero-Marin J,Feliu-Soler A,Gasión V,Navarro-Gil M,Morillo-Sarto H,Colomer-Carbonell A,Borràs X,Tops M,Luciano JV,García-Campayo J

    更新日期：2020-10-11 00:00:00

  • Why, Who, When, and How? Rationale for Considering Allogeneic Stem Cell Transplantation in Children with Sickle Cell Disease.

    abstract：:Considering the progress made in the management of sickle cell disease during the past 30 years, along with the excellent results obtained with hematopoietic stem cell transplantation (SCT), it is important to reexamine why, who, when and how to recommend allogeneic SCT in children with sickle cell disease. While sick...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8101523

    authors： Bernaudin F

    更新日期：2019-09-22 00:00:00

  • Creating and Validating the DESEA Questionnaire for Men and Women.

    abstract：:In clinical practice, it is essential to be able to identify hypoactive sexual desire disorder (HSDD), with its different severity levels and assess the influence the subject's relationship has on the issue. In order to do this, questionnaires are needed that comprise appropriate psychometric properties. We analyzed t...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9072301

    authors： Cabello-Santamaría F,Cabello-García MA,Aragón-Vela J,Del Río FJ

    更新日期：2020-07-20 00:00:00

  • Affected Ovary Relative Volume: A Novel Sonographic Predictor of Ovarian Reserve in Patients with Unilateral Endometrioma-A Pilot Study.

    abstract：BACKGROUND:The assessment of ovarian reserve in the case of endometrioma is of pivotal importance for planning a tailored management. However, both the antral follicle count (AFC) and the antimüllerian hormone (AMH) dosage are subject to a fair degree of variability in ovarian endometriosis. This study aimed to identif...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9124076

    authors： Cosma S,Carosso AR,Moretto M,Borella F,Ferraioli D,Bovetti M,Gervasoni F,Filippini C,Revelli A,Ferrero S,Benedetto C

    更新日期：2020-12-17 00:00:00

  • Do Chronic Obstructive Pulmonary Diseases (COPD) Self-Management Interventions Consider Health Literacy and Patient Activation? A Systematic Review.

    abstract：:Self-management (SM) includes activities that patients initiate and perform in the interest of controlling their disease and maintaining good health and well-being. This review examines the health literacy and patient activation elements of self-management interventions for Chronic Obstructive Pulmonary Diseases (COPD...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9030646

    authors： Yadav UN,Lloyd J,Hosseinzadeh H,Baral KP,Harris MF

    更新日期：2020-02-28 00:00:00

  • Cardiac Output Evaluation on Septic Shock Patients: Comparison between Calibrated and Uncalibrated Devices during Vasopressor Therapy.

    abstract：:There are no reliable, non-invasive methods to accurately measure cardiac output (CO) in septic patients. MostCare (Vytech Health™, Vygon, Padova, Italy), is a beat-to-beat, self calibrated method for CO measurement based on continuous analysis of reflected arterial pressure waveforms. We enrolled 40 patients that wer...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10020213

    authors： Persona P,Valeri I,Saraceni E,De Cassai A,Calabrese F,Navalesi P

    更新日期：2021-01-09 00:00:00

  • Heterogeneity of Vascular Endothelial Cells, De Novo Arteriogenesis and Therapeutic Implications in Pancreatic Neuroendocrine Tumors.

    abstract：:Arteriogenesis supplies oxygen and nutrients in the tumor microenvironment (TME), which may play an important role in tumor growth and metastasis. Pancreatic neuroendocrine tumors (pNETs) are the second most common pancreatic malignancy and are frequently metastatic on presentation. Nearly a third of pNETs secrete bio...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8111980

    authors： Ren B,Rose JB,Liu Y,Jaskular-Sztul R,Contreras C,Beck A,Chen H

    更新日期：2019-11-14 00:00:00

  • Cellular Proliferation, Dermal Repair, and Microbiological Effectiveness of Ultrasound-Assisted Wound Debridement (UAW) Versus Standard Wound Treatment in Complicated Diabetic Foot Ulcers (DFU): An Open-Label Randomized Controlled Trial.

    abstract：:We aimed to evaluate the effects of ultrasound-assisted wound (UAW) debridement on cellular proliferation and dermal repair in complicated diabetic foot ulcers as compared to diabetic foot ulcers receiving surgical/sharp wound debridement. A randomized controlled trial was performed involving 51 outpatients with compl...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9124032

    authors： Lázaro-Martínez JL,Álvaro-Afonso FJ,Sevillano-Fernández D,García-Álvarez Y,Sanz-Corbalan I,García-Morales E

    更新日期：2020-12-13 00:00:00

  • Microbiome Patterns in Matched Bile, Duodenal, Pancreatic Tumor Tissue, Drainage, and Stool Samples: Association with Preoperative Stenting and Postoperative Pancreatic Fistula Development.

    abstract：:Postoperative complications after pancreatic surgery are still a significant problem in clinical practice. The aim of this study was to characterize and compare the microbiomes of different body compartments (bile duct, duodenal mucosa, pancreatic tumor lesion, postoperative drainage fluid, and stool samples; preopera...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9092785

    authors： Langheinrich M,Wirtz S,Kneis B,Gittler MM,Tyc O,Schierwagen R,Brunner M,Krautz C,Weber GF,Pilarsky C,Trebicka J,Agaimy A,Grützmann R,Kersting S

    更新日期：2020-08-28 00:00:00

  • Robotic-Assisted Simple Prostatectomy: A Systematic Review.

    abstract：:Contemporary minimally invasive surgical (MIS) treatment options of patients with male Lower Urinary Tract Symptoms (LUTS) in men with prostate glands >80 mL include Holmium Laser Enucleation Prostate (HoLEP), Thulium laser VapoEnucleation Prostate (ThuVEP), and Laparoscopic (LSP) or Robotic-Assisted Simple Prostatect...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9061798

    authors： Kordan Y,Canda AE,Köseoğlu E,Balbay D,Laguna MP,de la Rosette J

    更新日期：2020-06-09 00:00:00

  • Mixed Neuroendocrine Non-Neuroendocrine Neoplasms: A Systematic Review of a Controversial and Underestimated Diagnosis.

    abstract：:Mixed neuroendocrine non-neuroendocrine neoplasms (MiNENs) represent a rare diagnosis of the gastro-entero-pancreatic tract. Evidence from the current literature regarding their epidemiology, biology, and management is of variable quality and conflicting. Based on available data, the MiNEN has an aggressive biological...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9010273

    authors： Frizziero M,Chakrabarty B,Nagy B,Lamarca A,Hubner RA,Valle JW,McNamara MG

    更新日期：2020-01-19 00:00:00

  • Dermatological Manifestations in Inflammatory Bowel Diseases.

    abstract：:Inflammatory bowel diseases (IBDs) may be associated with extra-intestinal manifestations. Among these, mucocutaneous manifestations are relatively frequent, often difficult to diagnose and treat, and may complicate the course of the underlying disease. In the present review, a summary of the most relevant literature ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm10020364

    authors： Antonelli E,Bassotti G,Tramontana M,Hansel K,Stingeni L,Ardizzone S,Genovese G,Marzano AV,Maconi G

    更新日期：2021-01-19 00:00:00

  • Chorioretinal Side Effects of Therapeutic Ocular Irradiation: A Multimodal Imaging Approach.

    abstract：:Radiation chorioretinopathy, radiation maculopathy, and radiation optic neuropathy are the major complications of ophthalmic radiotherapy. Optical coherence tomography (OCT) and OCT angiography (OCTA) are revolutionary imaging methods, allowing the visualization of the retinal cellular architecture and the retinal vas...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9113496

    authors： Midena G,Parrozzani R,Frizziero L,Midena E

    更新日期：2020-10-29 00:00:00

  • History and Evolution of Yttrium-90 Radioembolization for Hepatocellular Carcinoma.

    abstract：:Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer and affects millions worldwide. Due to the lack of effective systemic therapies for HCC, researchers have been investigating the use of locoregional tumor control with Yttrium-90 (Y90) radioembolization since the 1960s. Following the develo...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8010055

    authors： Saini A,Wallace A,Alzubaidi S,Knuttinen MG,Naidu S,Sheth R,Albadawi H,Oklu R

    更新日期：2019-01-07 00:00:00

  • Differences in Sexually Transmitted Infections between the Precrisis Period (2000⁻2007) and the Crisis Period (2008⁻2014) in Granada, Spain.

    abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020277

    authors： Pérez-Morente MÁ,Sánchez-Ocón MT,Martínez-García E,Martín-Salvador A,Hueso-Montoro C,García-García I

    更新日期：2019-02-25 00:00:00

  • Detection of BRAFV600E in Liquid Biopsy from Patients with Papillary Thyroid Cancer Is Associated with Tumor Aggressiveness and Response to Therapy.

    abstract：:The detection of rare mutational targets in plasma (liquid biopsy) has emerged as a promising tool for the assessment of patients with cancer. We determined the presence of cell-free DNA containing the BRAFV600E mutations (cfBRAFV600E) in plasma samples from 57 patients with papillary thyroid cancer (PTC) with somatic...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082481

    authors： Jensen K,Thakur S,Patel A,Mendonca-Torres MC,Costello J,Gomes-Lima CJ,Walter M,Wartofsky L,Burman KD,Bikas A,Ylli D,Vasko VV,Klubo-Gwiezdzinska J

    更新日期：2020-08-02 00:00:00

  • Correction: Ono, S.; Lam, S.; Nagahara, M.; Hoon, D.S.B. Circulating microRNA Biomarkers as Liquid Biopsy for Cancer Patients: Pros and Cons of Current Assays. J. Clin. Med. 2015, 4, 1890-1907.

    abstract：:The authors wish to make the following corrections to this paper [1]:[...]. ...

    journal_title：Journal of clinical medicine

    pub_type： 已发布勘误

    doi：10.3390/jcm5090081

    authors： Ono S,Lam S,Nagahara M,Hoon DS

    更新日期：2016-09-12 00:00:00

  • Economical Analysis of Different Clinical Approaches in Pre-Viability Amniorrhexis-A Case Series.

    abstract：:Prolonged oligohydramnios following extreme preterm prelabour rupture of membranes (EPPROM) is traditionally associated with a high morbidity and mortality to both the mother and the baby. The clinical maternal evaluation and fetal ultrasound assessment may provide important prognostic information for the clinicians a...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm3010025

    authors： Engemise S,Thompson F,Davies W

    更新日期：2014-01-09 00:00:00

  • Phacotrabeculectomy versus Phaco with Implantation of the Ex-PRESS Device: Surgical and Refractive Outcomes-A Randomized Controlled Trial.

    abstract：:The aim of this study was to compare surgical and refractive outcomes between phacotrabeculectomy (P-Trab) and phaco with Ex-PRESS (P-Ex-PRESS) for glaucoma at a 6-month follow-up. This prospective randomized controlled trial included 81 eyes; 43 eyes (53%) and 38 eyes (47%) were assigned to the P-Ex-PRESS and P-Trab ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10030424

    authors： Konopińska J,Byszewska A,Saeed E,Mariak Z,Rękas M

    更新日期：2021-01-22 00:00:00

  • Partial Achilles Tendon Rupture-A Neglected Entity: A Narrative Literature Review on Diagnostics and Treatment Options.

    abstract：:Partial ruptures in the Achilles tendon are rather uncommon and are often misinterpreted as aggravated Achilles tendinopathy, and not always considered as a differential diagnosis. The aim of this literature review was to characterize typical symptoms, to provide an overview of available diagnosis and treatment option...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9103380

    authors： Gatz M,Spang C,Alfredson H

    更新日期：2020-10-21 00:00:00

  • Advancements in Pharmacotherapy for Noncancerous Manifestations of HPV.

    abstract：:Human papillomavirus (HPV) is the most common sexually transmitted disease. Via infection of the basal epithelial cells, HPV causes numerous malignancies and noncancerous cutaneous manifestations. Noncancerous cutaneous manifestations of HPV, including common, plantar, plane, and anogenital warts, are among the most c...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm4050832

    authors： Kollipara R,Ekhlassi E,Downing C,Guidry J,Lee M,Tyring SK

    更新日期：2015-04-24 00:00:00

  • Adrenal Vein Sampling to Distinguish Between Unilateral and Bilateral Primary Hyperaldosteronism: To ACTH Stimulate or Not?

    abstract：:The aim of this study is to determine the accuracy of adrenal vein sampling (AVS) with and without adrenocorticotropic hormone (ACTH) stimulation to distinguish between unilateral and bilateral primary hyperaldosteronism (PA). Retrospective analysis of a prospective database from a referral center between 1984 and 200...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9051447

    authors： Sung TY,Alobuia WM,Tyagi MV,Ghosh C,Kebebew E

    更新日期：2020-05-13 00:00:00

  • Correction: Langeskov-Christensen, M., et al. Aerobic Capacity Is Not Associated with Most Cognitive Domains in Patients with Multiple Sclerosis-A Cross-Sectional Investigation. Journal of Clinical Medicine 2018, 7, 272.

    abstract：:The authors wish to make the following corrections to this paper [...]. ...

    journal_title：Journal of clinical medicine

    pub_type： 已发布勘误

    doi：10.3390/jcm8050574

    authors： Langeskov-Christensen M,Eskildsen S,Stenager E,Jensen HB,Nielsen HH,Petersen T,Hvid LG,Hämäläinen P,Marstrand L,Dalgas U

    更新日期：2019-04-26 00:00:00

  • Clinical and Histopathologic Features of Interstitial Lung Disease in Erdheim⁻Chester Disease.

    abstract：:Limited information is available regarding interstitial lung disease (ILD) in Erdheim⁻Chester disease (ECD), a rare multisystemic non-Langerhans cell histiocytosis. Sixty-two biopsy-confirmed ECD patients were divided into those with no ILD (19.5%), minimal ILD (32%), mild ILD (29%), and moderate/severe ILD (19.5%), b...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7090243

    authors： Haroutunian SG,O'Brien KJ,Estrada-Veras JI,Yao J,Boyd LC,Mathur K,Gahl WA,Mirmomen SM,Malayeri AA,Kleiner DE,Jaffe ES,Gochuico BR

    更新日期：2018-08-28 00:00:00

  • Lipid Droplets Define a Sub-Population of Breast Cancer Stem Cells.

    abstract：:Tumor recurrence is now the leading cause of breast cancer-related death. These recurrences are believed to arise from residual cancer stem cells that survive initial therapeutic intervention. Therefore, a comprehensive understanding of cancer stem cell biology is needed to generate more effective therapies. Here we i...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9010087

    authors： Hershey BJ,Vazzana R,Joppi DL,Havas KM

    更新日期：2019-12-29 00:00:00

  • SOX2 Expression Is an Independent Predictor of Oral Cancer Progression.

    abstract：:Potentially malignant oral lesions, mainly leukoplakia, are common. Malignant transformation varies widely, even in the absence of histological features such as dysplasia. Hence, there is a need for novel biomarker-based systems to more accurately predict the risk of cancer progression. The pluripotency transcription ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8101744

    authors： de Vicente JC,Donate-Pérez Del Molino P,Rodrigo JP,Allonca E,Hermida-Prado F,Granda-Díaz R,Rodríguez Santamarta T,García-Pedrero JM

    更新日期：2019-10-21 00:00:00

  • Procedural Sedation Using a Propofol-Ketamine Combination (Ketofol) vs. Propofol Alone in the Loop Electrosurgical Excision Procedure (LEEP): A Randomized Controlled Trial.

    abstract：BACKGROUND:Although the loop electrosurgical excision procedure (LEEP) is a brief procedure, it can cause severe pain and discomfort to patients in the absence of adequate sedation. An admixture of ketamine with propofol (ketofol), may reduce patient movement due to insufficient sedation while providing hemodynamic and...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8070943

    authors： Oh C,Kim Y,Eom H,Youn S,Lee S,Ko YB,Yoo HJ,Chung W,Lim C,Hong B

    更新日期：2019-06-28 00:00:00