当前位置： SCI文献检索 > Journal of Clinical Medicine期刊下所有文献 > High Plasma Branched-Chain Amino Acids Are Associated with Higher Risk of Post-Transplant Diabetes Mellitus in Renal Transplant Recipients.

High Plasma Branched-Chain Amino Acids Are Associated with Higher Risk of Post-Transplant Diabetes Mellitus in Renal Transplant Recipients.

Abstract：

:Post-transplant diabetes mellitus (PTDM) is a serious complication in renal transplant recipients. Branched-chain amino acids (BCAAs) are involved in the pathogenesis of insulin resistance. We determined the association of plasma BCAAs with PTDM and included adult renal transplant recipients (≥18 y) with a functioning graft for ≥1 year in this cross-sectional cohort study with prospective follow-up. Plasma BCAAs were measured in 518 subjects using nuclear magnetic resonance spectroscopy. We excluded subjects with a history of diabetes, leaving 368 non-diabetic renal transplant recipients eligible for analyses. Cox proportional hazards analyses were used to assess the association of BCAAs with the development of PTDM. Mean age was 51.1 ± 13.6 y (53.6% men) and plasma BCAA was 377.6 ± 82.5 µM. During median follow-up of 5.3 (IQR, 4.2-6.0) y, 38 (9.8%) patients developed PTDM. BCAAs were associated with a higher risk of developing PTDM (HR: 1.43, 95% CI 1.08-1.89) per SD change (p = 0.01), independent of age and sex. Adjustment for other potential confounders did not significantly change this association, although adjustment for HbA1c eliminated it. The association was mediated to a considerable extent (53%) by HbA1c. The association was also modified by HbA1c; BCAAs were only associated with renal transplant recipients without prediabetes (HbA1c < 5.7%). In conclusion, high concentrations of plasma BCAAs are associated with developing PTDM in renal transplant recipients. Alterations in BCAAs may represent an early predictive biomarker for PTDM.

journal_name

J Clin Med

journal_title

Journal of clinical medicine

authors

Osté MCJ,Flores-Guerrero JL,Gruppen EG,Kieneker LM,Connelly MA,Otvos JD,Dullaart RPF,Bakker SJL

doi

10.3390/jcm9020511

subject

Has Abstract

pub_date

2020-02-13 00:00:00

issue

2

issn

2077-0383

pii

jcm9020511

journal_volume

9

pub_type

杂志文章

相关文献

Journal of Clinical Medicine文献大全
  • NIV Is not Adequate for High Intensity Endurance Exercise in COPD.

    abstract：:Noninvasive ventilation (NIV) during exercise has been suggested to sustain higher training intensity but the type of NIV interface, patient-ventilator asynchronies (PVA) or technological limitation of the ventilator may interfere with exercise. We assessed whether these parameters affect endurance exercise capacity i...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9041054

    authors： Bonnevie T,Gravier FE,Fresnel E,Kerfourn A,Medrinal C,Prieur G,Combret Y,Muir JF,Cuvelier A,Debeaumont D,Reychler G,Patout M,Viacroze C

    更新日期：2020-04-08 00:00:00

  • Virus-Induced Asthma/Wheeze in Preschool Children: Longitudinal Assessment of Airflow Limitation Using Impulse Oscillometry.

    abstract：:: Several researchers have assessed the utility of Impulse Oscillometry System (IOS) in diagnosing and evaluating the severity of respiratory diseases in childhood, but none has investigated the impact of the fluctuations of IOS parameters in an individualized manner. In this two-year prospective study, we aimed to lo...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8091475

    authors： Konstantinou GN,Papadopoulos NG,Manousakis E,Xepapadaki P

    更新日期：2019-09-16 00:00:00

  • Low-Level Laser Therapy with a 635 nm Diode Laser Affects Orthodontic Mini-Implants Stability: A Randomized Clinical Split-Mouth Trial.

    abstract：BACKGROUND:The study aimed to clinically estimate an influence of a 635 nm diode laser on the stability of orthodontic mini-implants, to assess mini-implants loss, and to evaluate a pain level after the treatment. MATERIALS AND METHODS:The randomized clinical split-mouth trial included 20 subjects (13 women and 7 men;...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9010112

    authors： Flieger R,Gedrange T,Grzech-Leśniak K,Dominiak M,Matys J

    更新日期：2019-12-31 00:00:00

  • Metabolic Syndrome Prevalence in Students Attending West Virginia University.

    abstract：:Metabolic Syndrome (MetS) contributes to the development of cardiovascular disease (CVD) and type II diabetes mellitus (T2DM). Few studies have investigated the MetS risk of young adults (18⁻24 years old). This study aims to determine the prevalence of MetS in Appalachian and non-Appalachian students attending West Vi...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7120487

    authors： Olfert MD,Dent A,Wattick RA

    更新日期：2018-11-27 00:00:00

  • Prediction of Submucosal Invasion for Gastric Neoplasms in Endoscopic Images Using Deep-Learning.

    abstract：:Endoscopic resection is recommended for gastric neoplasms confined to mucosa or superficial submucosa. The determination of invasion depth is based on gross morphology assessed in endoscopic images, or on endoscopic ultrasound. These methods have limited accuracy and pose an inter-observer variability. Several studies...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061858

    authors： Cho BJ,Bang CS,Lee JJ,Seo CW,Kim JH

    更新日期：2020-06-15 00:00:00

  • Translational Medicine in Pulmonary-Renal Crosstalk: Therapeutic Targeting of p-Cresyl Sulfate Triggered Nonspecific ROS and Chemoattractants in Dyspneic Patients with Uremic Lung Injury.

    abstract：:Molecular mechanisms and pathological features of p-Cresyl sulfate (PCS)-induced uremic lung injury (ULI) in chronic kidney disease (CKD) remain unclear. We analyzed pleural effusions (PE) from CKD and non-CKD patients for uremic toxins, reactive oxygen species (ROS), and chemotactic cytokines. Correlations between PE...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7090266

    authors： Chang JF,Liang SS,Thanasekaran P,Chang HW,Wen LL,Chen CH,Liou JC,Yeh JC,Liu SH,Dai HM,Lin WN

    更新日期：2018-09-09 00:00:00

  • Abnormal Microvascular Architecture, Fibrosis, and Pericyte Characteristics in the Calf Muscle of Peripheral Artery Disease Patients with Claudication and Critical Limb Ischemia.

    abstract：:Work from our laboratory documents pathological events, including myofiber oxidative damage and degeneration, myofibrosis, micro-vessel (diameter = 50-150 μm) remodeling, and collagenous investment of terminal micro-vessels (diameter ≤ 15 µm) in the calf muscle of patients with Peripheral Artery Disease (PAD). In this...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9082575

    authors： Mietus CJ,Lackner TJ,Karvelis PS,Willcockson GT,Shields CM,Lambert NG,Koutakis P,Fuglestad MA,Hernandez H,Haynatzki GR,Kim JKS,DeSpiegelaere HK,Pipinos II,Casale GP

    更新日期：2020-08-08 00:00:00

  • Psychological and Emotional Impact of Patients Living in Psychiatric Treatment Communities during Covid-19 Lockdown in Italy.

    abstract：:Most studies on well-being during the COVID-19 pandemic have focused on the mental health of the general population; far less attention has been given to more specific populations, such as patients with mental illness. Indeed, it is important to examine the psychiatric population, given its vulnerability. The present ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9113787

    authors： Burrai J,Roma P,Barchielli B,Biondi S,Cordellieri P,Fraschetti A,Pizzimenti A,Mazza C,Ferracuti S,Giannini AM

    更新日期：2020-11-23 00:00:00

  • The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.

    abstract：:This study evaluated the efficacy of Lactobacillus acidophilus YT1 (MENOLACTO) for alleviating menopausal symptoms. This study was a multi-center, randomized, double-blinded, placebo-controlled clinical trial involving female subjects (ages: 40-60 years) with menopausal symptoms and a Kupperman index (KMI) score ≥ 20....

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9072173

    authors： Lim EY,Lee SY,Shin HS,Lee J,Nam YD,Lee DO,Lee JY,Yeon SH,Son RH,Park CL,Heo YH,Kim YT

    更新日期：2020-07-09 00:00:00

  • Incidence and Cost of Acute Kidney Injury in Hospitalized Patients with Infective Endocarditis.

    abstract：:Acute kidney injury (AKI) is a frequent complication of hospitalized patients with infective endocarditis (IE). Further, AKI in the setting of IE is associated with high morbidity and mortality. We aimed to examine the incidence, clinical parameters, and hospital costs associated with AKI in hospitalized patients with...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm8070927

    authors： Ortiz-Soriano V,Donaldson K,Du G,Li Y,Lambert J,Cleland D,Thornton A,Fanucchi LC,Huaman MA,Neyra JA

    更新日期：2019-06-27 00:00:00

  • Variation of Genes Encoding Tryptophan Catabolites Pathway Enzymes in Stroke.

    abstract：:The abnormal activation of the tryptophan catabolites pathway (TRYCATs) is observed in patients suffering from cerebrovascular disease, including stroke. A previous study confirmed that lower bioavailability of tryptophan for serotonin synthesis was characterized in the patients during the acute stroke phase. Interest...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8122133

    authors： Wigner P,Saluk-Bijak J,Synowiec E,Miller E,Sliwinski T,Cichon N,Bijak M

    更新日期：2019-12-03 00:00:00

  • Posttraumatic Stress Disorder: Overview of Evidence-Based Assessment and Treatment.

    abstract：:Posttraumatic stress disorder (PTSD) is a chronic psychological disorder that can develop after exposure to a traumatic event. This review summarizes the literature on the epidemiology, assessment, and treatment of PTSD. We provide a review of the characteristics of PTSD along with associated risk factors, and describ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm5110105

    authors： Lancaster CL,Teeters JB,Gros DF,Back SE

    更新日期：2016-11-22 00:00:00

  • Tadalafil 5 mg Alone or in Combination with Tamsulosin 0.4 mg for the Management of Men with Lower Urinary Tract Symptoms and Erectile Dysfunction: Results of a Prospective Observational Trial.

    abstract：:Tadalafil 5 mg represents the standard for men with Erectile dysfunction (ED) and lower urinary tract symptoms (LUTS)/benign prostatic enlargement (BPE). We carried out an observational trial aiming to assess the efficacy and safety of Tadalafil compared with Tadalafil plus Tamsulosin. Seventy-five patients complainin...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8081126

    authors： Sebastianelli A,Spatafora P,Frizzi J,Saleh O,Sessa M,De Nunzio C,Tubaro A,Vignozzi L,Maggi M,Serni S,McVary KT,Kaplan SA,Gravas S,Chapple C,Gacci M

    更新日期：2019-07-29 00:00:00

  • Functioning Mediastinal Paraganglioma Associated with a Germline Mutation of von Hippel-Lindau Gene.

    abstract：:We report the case of a 21-year old woman presenting with high blood pressure and raised normetanephrine levels. Indium-111-pentetreotide single photon-emission computed tomography with computed tomography (SPECT/CT) and 2-deoxy-2-[fluorine-18]fluoro-d-glucose (FDG) positron emission tomography/computed tomography (PE...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm7060116

    authors： Bahougne T,Romanet P,Mohamed A,Caselles K,Cuny T,Barlier A,Niccoli P

    更新日期：2018-05-23 00:00:00

  • Differences in Sexually Transmitted Infections between the Precrisis Period (2000⁻2007) and the Crisis Period (2008⁻2014) in Granada, Spain.

    abstract：OBJECTIVE:To analyze the difference in the prevalence of sexually transmitted infections (STIs) between two time periods (2000⁻2007 and 2008⁻2014, with the latter period characterized by the economic crisis), as well as determine differences in sociodemographic factors, clinical care, and risk indicators. METHODS:This...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020277

    authors： Pérez-Morente MÁ,Sánchez-Ocón MT,Martínez-García E,Martín-Salvador A,Hueso-Montoro C,García-García I

    更新日期：2019-02-25 00:00:00

  • Cardiac Output Evaluation on Septic Shock Patients: Comparison between Calibrated and Uncalibrated Devices during Vasopressor Therapy.

    abstract：:There are no reliable, non-invasive methods to accurately measure cardiac output (CO) in septic patients. MostCare (Vytech Health™, Vygon, Padova, Italy), is a beat-to-beat, self calibrated method for CO measurement based on continuous analysis of reflected arterial pressure waveforms. We enrolled 40 patients that wer...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm10020213

    authors： Persona P,Valeri I,Saraceni E,De Cassai A,Calabrese F,Navalesi P

    更新日期：2021-01-09 00:00:00

  • Possible Role of Mitochondrial DNA Mutations in Chronification of Inflammation: Focus on Atherosclerosis.

    abstract：:Chronification of inflammation is the process that lies at the basis of several human diseases that make up to 80% of morbidity and mortality worldwide. It can also explain a great deal of processes related to aging. Atherosclerosis is an example of the most important chronic inflammatory pathology in terms of public ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9040978

    authors： Orekhov AN,Nikiforov NN,Ivanova EA,Sobenin IA

    更新日期：2020-04-01 00:00:00

  • Long-Term Efficacy of the Workshop Vs. Online SUCCEAT (Supporting Carers of Children and Adolescents with Eating Disorders) Intervention for Parents: A Quasi-Randomised Feasibility Trial.

    abstract：:Interventions for main carers of adult patients with anorexia nervosa (AN) can reduce the caregiving burden and increase caregiver skills. However, the effectiveness and feasibility for carers of adolescent patients, the optimal form of the intervention and long-term outcomes are largely unknown. We evaluated the effi...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9061912

    authors： Truttmann S,Philipp J,Zeiler M,Franta C,Wittek T,Merl E,Schöfbeck G,Koubek D,Laczkovics C,Imgart H,Zanko A,Auer-Welsbach E,Treasure J,Karwautz AFK,Wagner G

    更新日期：2020-06-18 00:00:00

  • Why Have Detection, Understanding and Management of Kidney Hypoxic Injury Lagged Behind those for the Heart?

    abstract：:The outcome of patients with acute myocardial infarction (AMI) has dramatically improved over recent decades, thanks to early detection and prompt interventions to restore coronary blood flow. In contrast, the prognosis of patients with hypoxic acute kidney injury (AKI) remained unchanged over the years. Delayed diagn...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8020267

    authors： Abassi Z,Rosen S,Lamothe S,Heyman SN

    更新日期：2019-02-21 00:00:00

  • Help-Seeking in Suicidal Situations: Paramount and yet Challenging. Interactions between Significant Others of Suicidal Persons and Health Care Providers.

    abstract：:Significant others are often crucial for suicidal persons or suicide attempters' access to care, yet little is known about their efforts to seek help. This article presents the findings of a qualitative pilot study carried out in Switzerland on the help-seeking process of 18 significant others, their perception of the...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm6020017

    authors： Castelli Dransart DA,Guerry S

    更新日期：2017-02-13 00:00:00

  • Combining Novel Biomarkers for Risk Stratification of Two-Year Cardiovascular Mortality in Patients with ST-Elevation Myocardial Infarction.

    abstract：:ST-elevation myocardial infarction (STEMI) is one of the main reasons for morbidity and mortality worldwide. In addition to the classic biomarker NT-proBNP, new biomarkers like ST2 and Pentraxin-3 (Ptx-3) have emerged as potential tools in stratifying risk in cardiac patients. Indeed, multimarker approaches to estimat...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9020550

    authors： Zagidullin N,Motloch LJ,Gareeva D,Hamitova A,Lakman I,Krioni I,Popov D,Zulkarneev R,Paar V,Kopp K,Jirak P,Ishmetov V,Hoppe UC,Tulbaev E,Pavlov V

    更新日期：2020-02-18 00:00:00

  • Interaction of the p.Q141K Variant of the ABCG2 Gene with Clinical Data and Cytokine Levels in Primary Hyperuricemia and Gout.

    abstract：:Gout is an inflammatory arthritis influenced by environmental risk factors and genetic variants. The common dysfunctional p.Q141K allele of the ABCG2 gene affects gout development. We sought after the possible association between the p.Q141K variant and gout risk factors, biochemical, and clinical determinants in hype...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111965

    authors： Horváthová V,Bohatá J,Pavlíková M,Pavelcová K,Pavelka K,Šenolt L,Stibůrková B

    更新日期：2019-11-14 00:00:00

  • Carcinoid Heart Disease and Decreased Overall Survival among Patients with Neuroendocrine Tumors: A Retrospective Multicenter Latin American Cohort Study.

    abstract：:The background to this study was that factors associated with carcinoid heart disease (CHD) and its impacts on overall survival (OS) are scantly investigated in patients (pts) with neuroendocrine tumors (NETs). In terms of materials and methods, a retrospective multicenter cohort study was conducted of factors associa...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8030405

    authors： Uema D,Alves C,Mesquita M,Nuñez JE,Siepmann T,Angel M,Rego JFM,Weschenfelder R,Rocha Filho DR,Costa FP,Barros M,O'Connor JM,Illigens BM,Riechelmann RP

    更新日期：2019-03-23 00:00:00

  • Collaborating with Complementary and Alternative Medicine (CAM) Providers When Writing HPV Vaccine Review Articles.

    abstract：:Novel strategies are needed to address vaccine hesitancy (VH), which correlates with complementary and alternative medicine (CAM). In Switzerland, CAM providers play important roles in vaccine counseling of vaccine hesitant (VH) parents, and traditional vaccination messaging tends to overlook CAM provider perspectives...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9020592

    authors： Deml MJ,Dietrich LG,Wingeier B,Etter G,Gallmann C,Berger C,Suggs LS,Huber BM,Tarr PE

    更新日期：2020-02-21 00:00:00

  • The Application of Virtual Reality for Preoperative Planning of Lymphovenous Anastomosis in a Patient with a Complex Lymphatic Malformation.

    abstract：:The management of lymphatic malformations (LMs) is challenging, particularly for large and complex lesions involving anatomical structures in the adjacent tissue. While lymphovenous anastomosis (LVA) has been reported as an effective treatment for lymphedema, it has hardly been described as a treatment for LM. Virtual...

    journal_title：Journal of clinical medicine

    pub_type：

    doi：10.3390/jcm8030371

    authors： Giacalone G,Yamamoto T,Belva F,Hayashi A,Dori Y,Zviman MM,Gysen M,Nam HH,Jolley MA,Kato M

    更新日期：2019-03-15 00:00:00

  • Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations.

    abstract：:Photodynamic therapy (PDT) is an anticancer strategy utilizing light-mediated activation of a photosensitizer (PS) which has accumulated in tumor and/or surrounding vasculature. Upon activation, the PS mediates tumor destruction through the generation of reactive oxygen species and tumor-associated vasculature damage,...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9020333

    authors： Beltrán Hernández I,Yu Y,Ossendorp F,Korbelik M,Oliveira S

    更新日期：2020-01-24 00:00:00

  • Validation and Adaptation of the Multidimensional Prognostic Index in an Older Australian Cohort.

    abstract：BACKGROUND AND AIMS:The Multidimensional Prognostic Index (MPI), an objective and quantifiable tool based on the Comprehensive Geriatric Assessment, has been shown to predict adverse outcomes in European cohorts. We conducted a validation study of the original MPI, and of adapted versions that accounted for the use of ...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8111820

    authors： Bryant K,Sorich MJ,Woodman RJ,Mangoni AA

    更新日期：2019-11-01 00:00:00

  • Normothermic Machine Perfusion (NMP) of the Liver as a Platform for Therapeutic Interventions during Ex-Vivo Liver Preservation: A Review.

    abstract：:Liver transplantation is increasingly dependent on the use of extended criteria donors (ECD) to increase the organ donor pool and address rising demand. This has necessitated the adoption of innovative technologies and strategies to protect these higher-risk grafts from the deleterious effects of traditional preservat...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章,评审

    doi：10.3390/jcm9041046

    authors： Dengu F,Abbas SH,Ebeling G,Nasralla D

    更新日期：2020-04-07 00:00:00

  • Accuracy of the Low-Dose ACTH Stimulation Test for Adrenal Insufficiency Diagnosis: A Re-Assessment of the Cut-Off Value.

    abstract：BACKGROUND:The clinical practice shows that many low-dose ACTH-stimulation tests have a false positive result. The aim of the study was to determine the diagnostic accuracy of a low-dose ACTH-stimulation test in the diagnosis of adrenal insufficiency and to define its optimal cut-off. METHODS:We analyzed data from 103...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm8060806

    authors： Mongioì LM,Condorelli RA,Barbagallo F,Cannarella R,La Vignera S,Calogero AE

    更新日期：2019-06-05 00:00:00

  • Hemodynamic Profiles of Cardiogenic Shock Depending on Their Etiology.

    abstract：:The pathophysiology of cardiogenic shock (CS) varies depending on its etiology, which may lead to different hemodynamic profiles (HP) and may help tailor therapy. We aimed to assess the HP of CS patients according to their etiologies of acute myocardial infarction (AMI) and acute decompensated chronic heart failure (A...

    journal_title：Journal of clinical medicine

    pub_type： 杂志文章

    doi：10.3390/jcm9113384

    authors： Gaubert M,Laine M,Resseguier N,Aissaoui N,Puymirat E,Lemesle G,Michelet P,Hraiech S,Lévy B,Delmas C,Bonello L

    更新日期：2020-10-22 00:00:00