Anisotropic and restricted diffusion of water in the sciatic nerve: A (2)H double-quantum-filtered NMR study.

Abstract:

:The signals of water in the different compartments of rat sciatic nerve are resolved in the (2)H double-quantum-filtered NMR spectrum, due to their different quadrupolar splittings and relaxation rates. This resolution allowed the independent measurement of the water diffusion coefficients in the different compartments. The water diffusion in all three compartments, the endoneurium, the epineurium and the axon was found to be anisotropic. Parallel to the nerve fiber the average intraxonal water diffusion coefficient was 1.11 x 10(-5) cm(2)/sec, while in the perpendicular direction the diffusion is heavily restricted. The average perpendicular diffusion coefficient ranged from 0.29 x 10(-5) cm(2)/sec to 0.05 x 10(-5) cm(2)/sec for diffusion times of 7 msec and 50 msec, respectively. Assuming restricted diffusion in nonpermeable cylinders, intra-axonal mean diameters of 6.0, 7.4 and 9.0 microm were obtained for nerves taken from three different rats. Magn Reson Med 42:461-466, 1999.

journal_name

Magn Reson Med

authors

Seo Y,Shinar H,Morita Y,Navon G

doi

10.1002/(sici)1522-2594(199909)42:3<461::aid-mrm8>

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

461-6

issue

3

eissn

0740-3194

issn

1522-2594

pii

10.1002/(SICI)1522-2594(199909)42:3<461::AID-MRM8>

journal_volume

42

pub_type

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