Abstract:
:A localized proton 2D double-quantum (DQ) spin-echo spectroscopy technique was implemented on 1.5 T clinical MRI scanners for the detection of gamma-aminobutyrate (GABA) in the brain. The 2D approach facilitates separation of peaks overlapping with GABA in 1D DQ-filtered (DQF) spectra. This technique was applied to four normal adult volunteers and four children with intractable epilepsy. The coefficient of variation of the level of GABA and overlapping macromolecules at F2 = 3.0 ppm and F1 = 4.8 ppm was 0.08 in normal subjects. Three patients received 2D MRS scans before and after initiation of the ketogenic diet (KD): one patient showed a trend of decreasing GABA throughout the study, and two patients showed low initial GABA levels that increased over time. In addition to major metabolites and GABA, low-level metabolites (valine, leucine, and glutathione) were also identified in the 2D spectra.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wang ZJ,Bergqvist C,Hunter JV,Jin D,Wang DJ,Wehrli S,Zimmerman RAdoi
10.1002/mrm.10429subject
Has Abstractpub_date
2003-04-01 00:00:00pages
615-9issue
4eissn
0740-3194issn
1522-2594journal_volume
49pub_type
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journal_title:Magnetic resonance in medicine
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doi:10.1002/1522-2594(200103)45:3<356::aid-mrm1046>3.0
更新日期:2001-03-01 00:00:00
abstract::This contribution reports the first direct and noninvasive observation of cerebral glucose in normal anesthetized rats (n = 16) using short-echo-time localized proton NMR spectroscopy (2.35 T, STEAM, TR = 6000 ms, TE = 20 ms, 125 microliters). In addition to resonances from N-acetyl aspartate (NAA), glutamate, total c...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910190243
更新日期:1991-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910340508
更新日期:1995-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24129
更新日期:2012-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2001-02-01 00:00:00
abstract::We developed a live high-field multiple-mouse magnetic resonance imaging method to increase the throughput of imaging studies involving large numbers of mice. Phantom experiments were performed in 7 shielded radiofrequency (RF) coils for concurrent imaging on a 7 Tesla MRI scanner outfitted with multiple transmit and ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20683
更新日期:2005-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25456
更新日期:2015-09-01 00:00:00
abstract::Measurements of the volume magnetic susceptibility of solids using the classical Gouy balance approach are hampered by variations in apparent density of the packed powder. In this paper a quantitative NMR measurement of the volume magnetic susceptibility of powdered solids is described and the volume susceptibility of...
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doi:10.1002/mrm.1910370404
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更新日期:2003-06-01 00:00:00
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doi:10.1002/mrm.1910150212
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更新日期:2015-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:1988-09-01 00:00:00
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更新日期:1996-06-01 00:00:00
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更新日期:2010-05-01 00:00:00
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