Abstract:
:This contribution reports the first direct and noninvasive observation of cerebral glucose in normal anesthetized rats (n = 16) using short-echo-time localized proton NMR spectroscopy (2.35 T, STEAM, TR = 6000 ms, TE = 20 ms, 125 microliters). In addition to resonances from N-acetyl aspartate (NAA), glutamate, total creatine, cholines, taurine, and myoinositol, all spectra exhibit strongly coupled resonances from glucose (3.43, 3.80 ppm) that are readily identifiable using model solutions. The observed level of cerebral glucose in fasted rats covered a range of 15-40% of that of NAA giving absolute concentrations of 1.1-2.8 mM when NAA is taken to be 7 mM. The arterial blood glucose concentration was 7.7 +/- 0.8 mM in the same group of animals.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Gyngell ML,Michaelis T,Hörstermann D,Bruhn H,Hänicke W,Merboldt KD,Frahm Jdoi
10.1002/mrm.1910190243subject
Has Abstractpub_date
1991-06-01 00:00:00pages
489-95issue
2eissn
0740-3194issn
1522-2594journal_volume
19pub_type
杂志文章abstract:PURPOSE:We aimed to develop a novel free-breathing cardiac diffusion tensor MRI (DT-MRI) approach, M2-MT-MOCO, capable of whole left ventricular coverage that leverages second-order motion compensation (M2) diffusion encoding and multitasking (MT) framework to efficiently correct for respiratory motion (MOCO). METHODS...
journal_title:Magnetic resonance in medicine
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更新日期:2020-11-30 00:00:00
abstract::The proton exchange rates between water and the hydroxyl protons of threonine, serine, tyrosine, the amino protons of lysine, and the guanidinium protons of arginine were measured in the pH range 0.5 to 8.5 and for the temperatures 4 degrees C, 10 degrees C, 20 degrees C, 30 degrees C, and 36 degrees C. The intrinsic ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910350106
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abstract::Each k-space segment in multishot diffusion-weighted MRI is affected by a different spatially varying phase which is caused by unavoidable motions and amplified by the diffusion-encoding gradients. A proper image reconstruction therefore requires phase maps for each segment. Such maps are commonly derived from two-dim...
journal_title:Magnetic resonance in medicine
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更新日期:2009-11-01 00:00:00
abstract::This paper presents an improved data reconstruction method for generalized autocalibrating partially parallel acquisitions (GRAPPA) using multicolumn multiline interpolation (MCMLI). Both nearest acquired line (ky) neighboring points and column (kx) neighboring points from all components of an array coil were used to ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20601
更新日期:2005-09-01 00:00:00
abstract::Magnetic resonance imaging has achieved clinical importance and has become the primary tool in the investigation of head, spinal cord, pelvis, cancellous bone, pericardium (with gating), gallbladder, lymph node masses, and very soon, in the evaluation of joints. In many areas, particularly with respiratory and ECG gat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,评审
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更新日期:1985-08-01 00:00:00
abstract:PURPOSE:As prescribed and reliable geometrical entities, phantoms have served as indispensable validation tools in a variety of MR-related topics. Though a number of phantoms have been conceived, certain applications may warrant highly customized geometries. The purpose of this study was to demonstrate the expediency o...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25593
更新日期:2016-01-01 00:00:00
abstract::In this work, substrate selection was monitored in the left ventricle of the canine myocardium by following pyruvate and lactate oxidation under in vivo conditions at basal and elevated workloads. These studies were conducted in the open chest model using dynamic 13C NMR techniques in the presence and absence of dichl...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910380608
更新日期:1997-12-01 00:00:00
abstract::The purpose of this study was to demonstrate the feasibility of dynamic oxygen-enhanced MRI in a clinical setting. We hypothesized that dynamic oxygen enhancement can reflect the regional diffusing capacity of the lung. Ten patients with pulmonary emphysema and seven healthy volunteers were examined with a respiratory...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10168
更新日期:2002-06-01 00:00:00
abstract::A method is presented for the detection of quadrupole splitting in tissue, where the spectral line splittings are typically unobservable. The method used is a study of the rate of rotation of the flip angle as a function of radiofrequency (rf) amplitude. Our results with samples of skeletal muscle and cat brain indica...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910040108
更新日期:1987-01-01 00:00:00
abstract::With standard spectroscopic imaging, high spatial resolution is achieved at the price of a large number of phase-encoding steps, leading to long acquisition times. Fast spatial encoding methods reduce the minimum total acquisition time. In this article, a k-space scanning scheme using a continuous series of growing an...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10622
更新日期:2003-12-01 00:00:00
abstract:PURPOSE:Within multiple sclerosis (MS) lesions iron is present in chronically activated microglia. Thus, iron detection with MRI might provide a biomarker for chronic inflammation within lesions. Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mappi...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25420
更新日期:2015-08-01 00:00:00
abstract::This study investigated the use of dynamic, volumetric MRI to measure 3D skeletal motion. Ten healthy subjects were positioned on a MR-compatible knee loading device and instructed to harmonically flex and extend their knee at 0.5 Hz. The device induced active quadriceps loading with knee flexion, similar to the load ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24362
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:MRI-guided high intensity focused ultrasound (MR-HIFU) allows noninvasive heating of deep tissues. Specifically targeting visceral fat deposits with MR-HIFU could offer an effective therapy for reversing the development of obesity, diabetes, and metabolic syndrome. METHODS:Overweight rats received either MR-HI...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25883
更新日期:2016-07-01 00:00:00
abstract::Spiral k-space magnetic resonance spectroscopic imaging (MRSI) requires high performance from gradient hardware systems. During the readout phase, oscillating gradients are continuously played out, which can cause undesired effects. These effects on the quality of SI data are non-intuitive because of their time-varyin...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20928
更新日期:2006-07-01 00:00:00
abstract::Skeletal muscle triglycerides are markers for insulin resistance in type 2 diabetes. Recently, MR spectroscopy was adapted for in vivo measurement of triglycerides in animal models and for the characterization of new therapeutic approaches. Because of small MR spectroscopy voxel sizes used in skeletal muscles, surface...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22149
更新日期:2009-10-01 00:00:00
abstract::High polarization of nuclear spins in liquid state through hyperpolarized technology utilizing dynamic nuclear polarization has enabled the direct monitoring of (13)C metabolites in vivo at a high signal-to-noise ratio. Acquisition time limitations due to T(1) decay of the hyperpolarized signal require accelerated ima...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22233
更新日期:2010-02-01 00:00:00
abstract::Recovery of the cerebral cortex after 10 min of cardiac arrest was studied in rat using noninvasive MRI techniques. The apparent diffusion coefficient (ADC) of brain water was imaged to document reversal of the metabolic impairment. Perfusion-weighted imaging and blood oxygen level dependent (BOLD) imaging were perfor...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910390516
更新日期:1998-05-01 00:00:00
abstract::MRI of hyperpolarized (129)Xe dissolved in pulmonary tissues, and blood has the potential to offer a new tool for regional evaluation of pulmonary gas exchange and perfusion; however, the extremely short T2* and low magnetization density make it difficult to acquire the image. In this study, an ultrashort echo-time se...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24452
更新日期:2013-07-01 00:00:00
abstract::Focused ultrasound heating of ex vivo bovine kidney and liver was monitored using magnetic resonance imaging (MRI) to investigate the quantitative relationship between time-dependent temperature elevations and altered contrast in MR images due to thermal coagulation. Proton resonance frequency shift MR thermometry was...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199902)41:2<321::aid-mrm16
更新日期:1999-02-01 00:00:00
abstract::Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910300405
更新日期:1993-10-01 00:00:00
abstract:PURPOSE:Intracranial and intraspinal compliance are parameters of interest in the diagnosis and prediction of treatment outcome in patients with normal pressure hydrocephalus and other forms of communicating hydrocephalus. A noninvasive method to estimate the spinal cerebrospinal fluid (CSF) pulse wave velocity (PWV) a...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.28430
更新日期:2021-01-01 00:00:00
abstract::Phosphorus NMR can measure myocardial tissue pH from the chemical shift of inorganic phosphate (Pi) in isolated buffer-perfused hearts, but in vivo the Pi peak originating from the myocardium is obscured by the resonance of 2,3-diphosphoglycerate (DPG) in the blood, making pH difficult to determine. Taking advantage o...
journal_title:Magnetic resonance in medicine
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更新日期:1991-02-01 00:00:00
abstract::The presence of macroscopic vessels within the tumor region is a potential confounding factor in MR-based dynamic susceptibility contrast (DSC)-enhanced glioma grading. In order to distinguish between such vessels and the elevated cerebral blood volume (CBV) of brain tumors, we propose a vessel segmentation technique ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21944
更新日期:2009-05-01 00:00:00
abstract::A 3-T study is presented, comparing the ability of two (1) H spectroscopy pulse sequences, Carr-Purcell point resolved spectroscopy (CPRESS; TE = 45 msec), and conventional PRESS (TE = 35 msec), to separate between groups of 20 normal control (NC) and 20 mild cognitive impairment (MCI) subjects. Both sequences showed ...
journal_title:Magnetic resonance in medicine
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更新日期:2011-06-01 00:00:00
abstract:PURPOSE:The primary purpose of this study is to propose a method for the simultaneous quantitative three-dimensional (3D) mapping of conductivity and susceptibility using double-echo ultrashort echo time (UTE) imaging. The secondary purpose is to investigate the changes of these properties over time during in vitro hem...
journal_title:Magnetic resonance in medicine
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更新日期:2016-07-01 00:00:00
abstract::MnCl(2) was injected intrathecally through the cisterna magna in rats, allowing infusion of divalent manganese ions (Mn(++)) into the CSF space and thence into the brain, without breaking the blood-brain barrier (BBB). Mn(++) uptake and washout dynamics in the brain were measured by serial T(1)-weighted MRI and EPI T(...
journal_title:Magnetic resonance in medicine
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更新日期:2004-05-01 00:00:00
abstract::The application of T1 rho an an alternative contrast parameter in high-field magnetic resonance histology (MRH) has been investigated. Spectroscopic measurements of T1 rho were performed on 5.75% agar and 1.0 mM MnCI2 phantoms at 9.4 T to validate the accuracy of the imaging measurements. Image studies were performed ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910350520
更新日期:1996-05-01 00:00:00
abstract::Functional MRI (fMRI) by means of spin-echo (SE) techniques provides an interesting alternative to gradient-echo methods because the contrast is based primarily on dynamic averaging associated with the blood oxygenation level-dependent (BOLD) effect. In this article the contributions from different brain compartments ...
journal_title:Magnetic resonance in medicine
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更新日期:2004-10-01 00:00:00
abstract::Parallel magnetic resonance imaging in k-space such as generalized auto-calibrating partially parallel acquisition exploits spatial correlation among neighboring signals over multiple coils in calibration to estimate missing signals in reconstruction. It is often challenging to achieve accurate calibration information...
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更新日期:2012-06-01 00:00:00
abstract:PURPOSE:To develop an accelerated, robust, and accurate diffusion MRI acquisition and reconstruction technique for submillimeter whole human brain in vivo scan on a clinical scanner. METHODS:We extend the ultra-high resolution diffusion MRI acquisition technique, gSlider, by allowing undersampling in q-space and radio...
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更新日期:2020-10-01 00:00:00