Abstract:
PURPOSE:MRI-guided high intensity focused ultrasound (MR-HIFU) allows noninvasive heating of deep tissues. Specifically targeting visceral fat deposits with MR-HIFU could offer an effective therapy for reversing the development of obesity, diabetes, and metabolic syndrome. METHODS:Overweight rats received either MR-HIFU of visceral fat, sham treatment, no treatment, or ex vivo temperature calibration. Conventional MR thermometry methods are not effective in fat tissue. Therefore, the T2 of fat was used to estimate heating in adipose tissue. RESULTS:HIFU treated rats lost 7.5% of their body weight 10 days after HIFU, compared with 1.9% weight loss in sham animals (P = 0.008) and 1.3% weight increase in untreated animals (P = 0.004). Additionally, the abdominal fat volume in treated animals decreased by 8.2 mL 7 days after treatment (P = 0.002). The T2 of fat at 1.5 Tesla increased by 3.3 ms per °C. The fat T2 was 103.3 ms before HIFU, but increased to 128.7 ms (P = 0.0005) after HIFU at 70 watts for 16 s and to 131.9 ms (P = 0.0005) after HIFU at 100 watts for 16 s. CONCLUSION:These experiments demonstrate that MR-HIFU of visceral fat could provide a safe, effective, and noninvasive weight loss therapy for combating obesity and the subsequent medical complications. Magn Reson Med 76:282-289, 2016. © 2015 Wiley Periodicals, Inc.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Winter PM,Lanier M,Partanen A,Dumoulin Cdoi
10.1002/mrm.25883subject
Has Abstractpub_date
2016-07-01 00:00:00pages
282-9issue
1eissn
0740-3194issn
1522-2594journal_volume
76pub_type
杂志文章abstract:PURPOSE:The goal of this work was to detect disease-related microstructural changes to the liver using magnetic resonance imaging. Chronic liver disease can cause microstructural changes in the liver that reduce plasma access to the perisinusoidal space--the site of exchange between the blood plasma and the hepatic par...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24619
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abstract::The goal of this work was to develop an MRI method for mapping the clearance of interstitial macromolecular plasma proteins after their extravasation from permeable blood vessels. To that end, a well-defined window of exposure to elevated blood levels was generated by inducing rapid clearance of macromolecular contras...
journal_title:Magnetic resonance in medicine
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abstract:PURPOSE:Despite the increasing understanding of major depressive disorder (MDD) using neuroimaging techniques, the topological organization of anatomical networks underlying MDD remains unclear. METHODS:The topological organization of brain anatomical networks was explored using complex network approaches. Diffusion t...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25036
更新日期:2014-11-01 00:00:00
abstract::Perfusion-based event-related functional MRI was performed by measuring flow-sensitive alternating inversion recovery (FAIR) signal changes during repeated single-trial, short visual stimulation (250 msec). In the visual cortex activation area, the blood flow increases immediately after the stimulus, reaches the maxim...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199912)42:6<1011::aid-mrm3
更新日期:1999-12-01 00:00:00
abstract::The image intensity in magnetic resonance magnitude images in the presence of noise is shown to be governed by a Rician distribution. Low signal intensities (SNR < 2) are therefore biased due to the noise. It is shown how the underlying noise can be estimated from the images and a simple correction scheme is provided ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910340618
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abstract::A new 3D acquisition regimen that enables the collection of conventional, water-suppressed, and fat-suppressed images with no increase in scan times compared with currently implemented 3D sequences is presented. The method is based on conventional 3D steady state with interleaved selective excitation of the fat resona...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910310403
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abstract::A single slice of z-magnetization is used to generate high-speed images. The slice selection step is achieved using two sin-sinc pulses. This procedure eliminates the need for continual slice gradient reversal, a requirement for the FLASH technique. The RAPID imaging method has less inherent T1 and/or T2 dependence th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050213
更新日期:1987-08-01 00:00:00
abstract::The myelin sheath, which is wrapped around the axons in the brain, can be affected by many diseases, resulting in cognitive and physical disability. Other work showed water in the myelin sheath has a T2 approximately 15 ms. The current standard technique to estimate the fraction of myelin water in vivo is to collect m...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.10713
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abstract::Conventional approaches for MR elastography (MRE) using surface drivers have difficulty achieving sufficient shear wave propagation in the prostate gland due to attenuation. In this study we evaluate the feasibility of generating shear wave propagation in the prostate gland using a transurethral device. A novel transu...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.22038
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abstract::Chemical shift-based multipoint water-fat separation methods have been applied in balanced steady-state free precession (bSSFP) sequences because of the high signal-to-noise-ratio (SNR) attainable. In this approach the echo formation is approximated to occur concurrently for both water and fat at an echo time (TE) equ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21303
更新日期:2007-08-01 00:00:00
abstract:PURPOSE:To develop a three-dimensional, free-breathing, late gadolinium enhancement (3D FB-LGE) cardiovascular magnetic resonance (CMR) technique, and to compare it with clinically used two-dimensional breath-hold LGE (2D BH-LGE). METHODS:The proposed 3D FB-LGE method consisted of inversion preparation, inversion dela...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26234
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To characterize and optimize 19 F MRI for different perfluorocarbons (PFCs) at 3T and quantify the loss of acquisition efficiency as a function of different temperature and cellular conditions. METHODS:The T1 and T2 relaxation times of the commonly used PFCs perfluoropolyether (PFPE), perfluoro-15-crown-5-ethe...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26317
更新日期:2017-06-01 00:00:00
abstract::It is well known that when compared to conventional spin-echo (CSE) imaging for equivalent effective echo times, fast spin-echo (FSE) imaging experiments yield higher signal intensities for coupled spin systems, such as that for lipid. One hypothesis put forth for this phenomenon is the removal of scalar coupling-base...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910350409
更新日期:1996-04-01 00:00:00
abstract::31P NMR spectroscopy was used to study renal allografts in rats subjected to allograft rejection, cyclosporine toxicity, ischemia, and ureteral obstruction. Parameters of relative peak areas and intracellular pH were accurately distinguished among the different causes of graft dysfunction. Ureteral obstruction was cle...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910050405
更新日期:1987-10-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2017-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.26162
更新日期:2016-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26485
更新日期:2017-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21095
更新日期:2006-12-01 00:00:00
abstract::The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k-space, combined wit...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20103
更新日期:2004-07-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910370117
更新日期:1997-01-01 00:00:00
abstract::Electron Spin Echo Envelope Modulation (ESEEM) data are reported for three gadolinium (III) chelates, Gd-EDTA, Gd-DTPA, and Gd-TTHA, in frozen D2O/CH3OD glasses. This series includes Gd-DTPA, an MRI contrast agent that is in clinical use. Three-pulse electron spin echo modulation patterns can be modeled to yield geome...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910320613
更新日期:1994-12-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2021-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
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更新日期:2020-02-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20977
更新日期:2006-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.28378
更新日期:2020-12-01 00:00:00
abstract::Given its greater availability and lower cost, (129) Xe apparent diffusion coefficient (ADC) MRI offers an alternative to (3) He ADC MRI. To demonstrate the feasibility of hyperpolarized (129) Xe ADC MRI, we present results from healthy volunteers (HV), chronic obstructive pulmonary disease (COPD) subjects, and age-ma...
journal_title:Magnetic resonance in medicine
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更新日期:2011-04-01 00:00:00
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journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.21683
更新日期:2008-10-01 00:00:00
abstract::Accelerated magnetic resonance imaging techniques reduce signal acquisition time by undersampling k-space. A fundamental problem in accelerated magnetic resonance imaging is the recovery of quality images from undersampled k-space data. Current state-of-the-art recovery algorithms exploit the spatial and temporal stru...
journal_title:Magnetic resonance in medicine
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更新日期:2013-09-01 00:00:00
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journal_title:Magnetic resonance in medicine
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更新日期:2003-03-01 00:00:00