Modulation of the pharmacokinetics of macromolecular contrast material by avidin chase: MRI, optical, and inductively coupled plasma mass spectrometry tracking of triply labeled albumin.

Abstract:

:The goal of this work was to develop an MRI method for mapping the clearance of interstitial macromolecular plasma proteins after their extravasation from permeable blood vessels. To that end, a well-defined window of exposure to elevated blood levels was generated by inducing rapid clearance of macromolecular contrast material from the blood. Experimental removal of the intravascular component allowed subsequent tracking of clearance from the interstitial compartment in the absence of further contrast extravasation. The contrast material was based on albumin triply labeled with biotin, fluorescent tag, and GdDTPA, allowing optical, inductively coupled plasma mass spectrometry (ICP-MS) and MRI detection. The biotin tag was used here for in vivo chasing of the contrast material from the blood by intravenous administration of avidin. Upon administration of avidin the contrast material disappeared from the blood vessels and was cleared by the liver and spleen as detected by MRI, fluorescence of blood samples and histological sections, and by ICP-MS. Nonbiotinylated fluorescent albumin was not affected by administration of avidin. Contrast material that extravasated from leaky blood vessels in a VEGF overexpressing tumor, prior to administration of avidin, was not cleared by the addition of avidin and showed continued interstitial convection. Thus, avidin-chase provides an effective tool for in vivo manipulation of the arterial input function by providing experimental control over the rate of clearance of the contrast material from the circulation.

journal_name

Magn Reson Med

authors

Dafni H,Gilead A,Nevo N,Eilam R,Harmelin A,Neeman M

doi

10.1002/mrm.10638

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

904-14

issue

5

eissn

0740-3194

issn

1522-2594

journal_volume

50

pub_type

杂志文章
  • Constrained length minimum inductance gradient coil design.

    abstract::A gradient coil design algorithm capable of controlling the position of the homogeneous region of interest (ROI) with respect to the current-carrying wires is required for many advanced imaging and spectroscopy applications. A modified minimum inductance target field method that allows the placement of a set of constr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910390214

    authors: Chronik BA,Rutt BK

    更新日期:1998-02-01 00:00:00

  • Localized detection of glioma glycolysis using edited 1H MRS.

    abstract::In vivo 1H MRS can be used to detect and quantify the lactate resonance at 1.3 ppm provided that overlapping lipid resonances are eliminated. A homonuclear spectral editing method was developed to acquire uncontaminated 1H spectra of lactate with adiabatic pulses. An advantage of the adiabatic pulse sequence is the ab...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300105

    authors: Schupp DG,Merkle H,Ellermann JM,Ke Y,Garwood M

    更新日期:1993-07-01 00:00:00

  • A numerical approach to non-circular birdcage RF coil optimization: verification with a fourth-order coil.

    abstract::It is demonstrated that birdcage resonators, satisfying conditions of quadrature operation and radiofrequency field homogeneity, can be realized in practice on formers of non-circular cross section described by an equation of the form (x/a)n + (y/b)n = 1 where a and b are constants and n > or = 2 is an integer. Using ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199906)41:6<1180::aid-mrm1

    authors: Riauka TA,De Zanche NF,Thompson R,Vermeulen FE,Capjack CE,Allen PS

    更新日期:1999-06-01 00:00:00

  • Quantitative assessment of improved homogeneity using higher-order shims for spectroscopic imaging of the brain.

    abstract::Magnetic field homogeneity is of major concern for in vivo spectroscopy, and with the increased use of volumetric chemical shift imaging (CSI) techniques, the ability to shim over a large volume of tissue is now one of the primary limiting constraints in performing these studies. In vivo shimming is routinely performe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400307

    authors: Spielman DM,Adalsteinsson E,Lim KO

    更新日期:1998-09-01 00:00:00

  • Slow magic-angle coil spinning: a high-sensitivity and high-resolution NMR strategy for microscopic biological specimens.

    abstract::High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution (1)H NMR sp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22231

    authors: Wong A,Aguiar PM,Sakellariou D

    更新日期:2010-02-01 00:00:00

  • Detection of myocardial infarction in the mini-pig using NMR imaging.

    abstract::Spin-echo images of 10 myocardial infarcts in nine mini-pigs were obtained at 30 h, 3 days, and approximately 10 days postinfarction. Infarcts were not detected at all at 30 h in five out of five cases examined. At 3 days postembolization (six cases) one infarct was certainly detected, whilst at 10 days (nine cases) a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910050302

    authors: Checkley D,Loveday BE,Waterton JC,Zhu XP,Isherwood I

    更新日期:1987-09-01 00:00:00

  • Pseudo-projection-driven, self-gated cardiac cine imaging using cartesian golden step phase encoding.

    abstract:PURPOSE:To develop and evaluate a novel two-dimensional self-gated imaging technique for free-breathing cardiac cine MRI that is free of motion-detection overhead and requires minimal planning for motion tracking. METHODS:Motion along the readout direction was extracted solely from normal Cartesian imaging readouts ne...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25834

    authors: Guo L,Derbyshire JA,Herzka DA

    更新日期:2016-08-01 00:00:00

  • Improved quantification of in vivo 1H NMR spectra by optimization of signal acquisition and processing and by incorporation of prior knowledge into the spectral fitting.

    abstract::Quantification of localized in vivo brain 1H spectra is in general very difficult due to excessive spectral overlap. In addition, intensity distortions may result from the effects of the NMR pulse sequence on the spins. This paper describes an approach to solving these problems. It comprises optimization of the pulse ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910150212

    authors: de Graaf AA,Bovée WM

    更新日期:1990-08-01 00:00:00

  • A one-step biomarker quantification methodology for DCE-MRI of adnexal masses: Capturing kinetic pattern from early to late enhancement.

    abstract:PURPOSE:To develop a one-step quantification approach that accounts for joint preprocessing and quantification of whole-range kinetics (early and late-phase washout) of dynamic contrast-enhanced (DCE) MRI of indeterminate adnexal masses. METHODS:Preoperative DCE-MRI of 43 (24 benign, 19 malignant) sonographically inde...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26743

    authors: Fathi Kazerooni A,Nabil M,Haghighat Khah H,Parviz S,Gity M,Saligheh Rad H

    更新日期:2018-02-01 00:00:00

  • Noninvasive analysis of aldose reductase activities in rat testis: 3-FDG NMR spectroscopy and imaging.

    abstract::Noninvasive investigation of aldose reductase activities in rat testis was performed using 3-fluoro-3-deoxy-D-glucose (3-FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290417

    authors: Nakada T,Kwee IL

    更新日期:1993-04-01 00:00:00

  • MRI-guided radiofrequency thermal ablation of implanted VX2 liver tumors in a rabbit model: demonstration of feasibility at 0.2 T.

    abstract::Successful radiofrequency (RF) thermal ablation was performed on VX2 tumors implanted in 23 rabbit livers under magnetic resonance (MR) guidance using a C-arm-shaped low-field 0.2 T system. RF application and immediate postprocedure MRI of all animals was performed [T2-weighted, turbo short tau inversion recovery (STI...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199907)42:1<141::aid-mrm19

    authors: Merkle EM,Boll DT,Boaz T,Duerk JL,Chung YC,Jacobs GH,Varnes ME,Lewin JS

    更新日期:1999-07-01 00:00:00

  • Water in tendon: orientational analysis of the free induction decay.

    abstract::The orientation dependence of the free induction decay (FID) of 1H NMR water signal in ex vivo bovine digital flexor tendon at the native level of hydration is reported. Residual dipolar coupling due to the overall tissue anisotropy produces a 6:1 change in the signal intensity as an angle between the long axis of a s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20540

    authors: Krasnosselskaia LV,Fullerton GD,Dodd SJ,Cameron IL

    更新日期:2005-08-01 00:00:00

  • Low peak power multiband spokes pulses for B1 (+) inhomogeneity-compensated simultaneous multislice excitation in high field MRI.

    abstract:PURPOSE:To design low peak and integrated power simultaneous multislice excitation radiofrequency pulses with transmit field inhomogeneity compensation in high field MRI. THEORY AND METHODS:The "interleaved greedy and local optimization" algorithm for small-tip-angle spokes pulses is extended to design multiband (MB) ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25455

    authors: Sharma A,Bammer R,Stenger VA,Grissom WA

    更新日期:2015-09-01 00:00:00

  • Analysis of the evolution of focal cerebral ischemia in the rat using the eigenimage filter.

    abstract::The eigenimage filter was used to evaluate the results of a MRI study of cerebral ischemia in a rat model. This linear filter segments a desired feature in an image sequence from other features which may interfere with its observation. The animals were imaged temporally, after occlusion of the middle cerebral artery, ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910260207

    authors: Peck DJ,Spickler EM,Knight RA,Hearshen DO,Windham JP

    更新日期:1992-08-01 00:00:00

  • Diffusion tensor imaging of in vivo and excised rat spinal cord at 7 T with an icosahedral encoding scheme.

    abstract::Regional values of fractional anisotropy (FA) and mean diffusivity (D(av)) of in vivo and excised rat spinal cords were measured using an iscosahedral encoding scheme that is based on 21 uniformly distributed and alternating gradient directions with an echo planar imaging (EPI) readout. Based on the water phantom stud...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20304

    authors: Madi S,Hasan KM,Narayana PA

    更新日期:2005-01-01 00:00:00

  • Susceptibility contrast imaging of cerebral blood volume: human experience.

    abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910220227

    authors: Rosen BR,Belliveau JW,Aronen HJ,Kennedy D,Buchbinder BR,Fischman A,Gruber M,Glas J,Weisskoff RM,Cohen MS

    更新日期:1991-12-01 00:00:00

  • Investigation and modeling of magnetization transfer effects in two-dimensional multislice turbo spin echo sequences with low constant or variable flip angles at 3 T.

    abstract::Magnetization transfer effects represent a major source of contrast in multislice turbo spin echo sequences (TSE)/fast spin echo sequences. Generally, low refocusing flip angles have become common in such MRI sequences, especially to mitigate specific absorption rate problems. Since the strength of magnetization trans...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22145

    authors: Weigel M,Helms G,Hennig J

    更新日期:2010-01-01 00:00:00

  • Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ.

    abstract::It is shown that the effect of pH changes can be measured in proton NMR spectra through the pH sensitivity of the signal intensities of metabolite protons exchanging with water. To observe this phenomenon, pulse sequences must be used that can sensitively observe these exchangeable protons under physiological conditio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910400105

    authors: Mori S,Eleff SM,Pilatus U,Mori N,van Zijl PC

    更新日期:1998-07-01 00:00:00

  • Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung.

    abstract::The purpose of this study was to demonstrate the feasibility of dynamic oxygen-enhanced MRI in a clinical setting. We hypothesized that dynamic oxygen enhancement can reflect the regional diffusing capacity of the lung. Ten patients with pulmonary emphysema and seven healthy volunteers were examined with a respiratory...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10168

    authors: Ohno Y,Hatabu H,Takenaka D,Van Cauteren M,Fujii M,Sugimura K

    更新日期:2002-06-01 00:00:00

  • Water diffusion, T(2), and compartmentation in frog sciatic nerve.

    abstract::A potential relationship between structural compartments in neural tissue and NMR parameters may increase the specificity of MRI in diagnosing diseases. Nevertheless, our understanding of MR of nerves and white matter is limited, particularly the influence of various water compartments on the MR signal is not known. I...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199911)42:5<911::aid-mrm11

    authors: Peled S,Cory DG,Raymond SA,Kirschner DA,Jolesz FA

    更新日期:1999-11-01 00:00:00

  • High-resolution Fourier-encoded sub-millisecond echo time musculoskeletal imaging at 3 Tesla and 7 Tesla.

    abstract:PURPOSE:The feasibility of imaging musculoskeletal fibrous tissue components, such as menisci, ligaments, and tendons, with a conventional spoiled gradient echo technique is explored in vivo at 3 T and 7 T. METHODS:To this end, the echo time (TE1 ) of a conventional Fourier-encoded multicontrast three-dimensional SGPR...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24578

    authors: Deligianni X,Bär P,Scheffler K,Trattnig S,Bieri O

    更新日期:2013-11-01 00:00:00

  • Hyperpolarized 13C MRI of the pulmonary vasculature and parenchyma.

    abstract::The study of lung perfusion in normal and diseased subjects is of great interest to physiologists and physicians. In this work we demonstrate the application of a liquid-phase hyperpolarized (HP) carbon-13 ((13)C) tracer to magnetic resonance imaging (MRI) of the pulmonary vasculature and pulmonary perfusion in a porc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21168

    authors: Ishii M,Emami K,Kadlecek S,Petersson JS,Golman K,Vahdat V,Yu J,Cadman RV,MacDuffie-Woodburn J,Stephen M,Lipson DA,Rizi RR

    更新日期:2007-03-01 00:00:00

  • Improved large tip angle parallel transmission pulse design through a perturbation analysis of the Bloch equation.

    abstract::Parallel transmission has emerged as an efficient means for implementing multidimensional spatially selective radiofrequency excitation pulses. To date, most theoretical and experimental work on parallel transmission radiofrequency (RF) pulse design is based on the small-tip-angle approximation to the Bloch equation. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22827

    authors: Zheng H,Zhao T,Qian Y,Ibrahim TS,Boada FE

    更新日期:2011-09-01 00:00:00

  • SLIP, a lipid suppression technique to improve image contrast in inflow angiography.

    abstract::In rapidly acquired gradient echo images, lipid regions usually appear as areas of high signal intensity. In 2D inflow angiograms processed by the maximum intensity projection algorithm, this high lipid signal may prevent angiographic visualization of some blood vessels. We present a new approach to suppress the lipid...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910210110

    authors: Doyle M,Matsuda T,Pohost GM

    更新日期:1991-09-01 00:00:00

  • An optimized center-out k-space trajectory for multishot MRI: comparison with spiral and projection reconstruction.

    abstract::A method for collecting MRI data on a set of rotated trajectories that begin at the center of k-space is outlined. It is theoretically slightly faster, slightly less susceptible to off-resonance and motion-induced phase, and produces images with slightly better signal-to-noise ratio than methods using Archimedean spir...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199910)42:4<714::aid-mrm13

    authors: Pipe JG

    更新日期:1999-10-01 00:00:00

  • Metabolic assessment of a migraine model using relaxation-enhanced 1 H spectroscopy at ultrahigh field.

    abstract:PURPOSE:This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to 1 H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of gly...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26811

    authors: Abad N,Rosenberg JT,Roussel T,Grice DC,Harrington MG,Grant SC

    更新日期:2018-03-01 00:00:00

  • x-f Choice: reconstruction of undersampled dynamic MRI by data-driven alias rejection applied to contrast-enhanced angiography.

    abstract::A technique for reconstructing dynamic undersampled MRI data, termed "x-f choice," was developed and applied to dynamic contrast-enhanced MR angiography (DCE-MRA). Regular undersampling in k-t space (a hybrid of k-space and time) creates aliasing in the conjugate x-f space that must be resolved. When regions in the ob...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21008

    authors: Malik SJ,Schmitz S,O'Regan D,Larkman DJ,Hajnal JV

    更新日期:2006-10-01 00:00:00

  • Simultaneous Quantification of Bone Edema/Adiposity and Structure in Inflamed Bone Using Chemical Shift-Encoded MRI in Spondyloarthritis.

    abstract:PURPOSE:To evaluate proton density fat fraction (PDFF) and R2* as markers of bone marrow composition and structure in inflamed bone in patients with spondyloarthritis. METHODS:Phantoms containing fat, water, and trabecular bone were constructed with proton density fat fraction (PDFF) and bone mineral density (BMD) val...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26729

    authors: Bray TJP,Bainbridge A,Punwani S,Ioannou Y,Hall-Craggs MA

    更新日期:2018-02-01 00:00:00

  • Use of a projection reconstruction method to decrease motion sensitivity in diffusion-weighted MRI.

    abstract::Diffusion-weighted MRI is a clinically useful technique, but its utility is compromised by high sensitivity to patient motion. Use of radial-scan data acquisition and projection reconstruction, rather than the conventional Fourier imaging method, can substantially reduce the sensitivity to global translational motion ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290619

    authors: Gmitro AF,Alexander AL

    更新日期:1993-06-01 00:00:00

  • Sweep MRI with algebraic reconstruction.

    abstract::In the recently proposed technique Sweep Imaging with Fourier Transform (SWIFT), frequency-modulated radiofrequency pulses are used in concert with simultaneous acquisition to facilitate MRI of samples with very short transverse relaxation time. In the present work, sweep MRI is reviewed from a reconstruction perspect...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22516

    authors: Weiger M,Hennel F,Pruessmann KP

    更新日期:2010-12-01 00:00:00