Abstract:
:High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution (1)H NMR spectroscopic approach using magic-angle coil spinning. We demonstrate its potential for intact tissues by combining a resonant microcoil with a large-volume commercial magic-angle spinning rotor, where the microcoil offers incredible sensitivity and the large-volume magic-angle spinning rotor provides stable slow magic-angle spinning. This approach provides high-resolution spectra with high sensitivity and the preservation of living biologic specimens for an accurate chemical analysis.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wong A,Aguiar PM,Sakellariou Ddoi
10.1002/mrm.22231subject
Has Abstractpub_date
2010-02-01 00:00:00pages
269-74issue
2eissn
0740-3194issn
1522-2594journal_volume
63pub_type
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