Editing through multiple bonds: threonine detection.

Abstract:

:In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.

journal_name

Magn Reson Med

authors

Marjanska M,Henry PG,Uğurbil K,Gruetter R

doi

10.1002/mrm.21492

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

245-51

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

59

pub_type

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