Abstract:
:In in vivo (1)H spectroscopy, the signal at 1.32 ppm is usually assigned to lactate. This resonance position is shared with threonine at physiological pH. The similarity of spectral patterns of lactate and threonine renders the separate measurement of either threonine or lactate without and even with editing technically challenging. In this study, the threonine signal was detected using a single-shot multiple-bond editing technique and quantified in vivo in both rat and human brains. A threonine concentration was estimated at 0.8 +/- 0.3 mM (mean +/- SD, n = 6) in the rat brain and at approximately 0.33 mM in the human brain.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Marjanska M,Henry PG,Uğurbil K,Gruetter Rdoi
10.1002/mrm.21492subject
Has Abstractpub_date
2008-02-01 00:00:00pages
245-51issue
2eissn
0740-3194issn
1522-2594journal_volume
59pub_type
杂志文章abstract::At TE values of 136 ms, it has recently been shown that the lactate methyl signal, when obtained with a stimulated-echo (STE) sequence, is modulated at the zero-quantum (ZQ) frequency when TM is varied. Here we describe an additional modulation of the ZQ lactate signal, due to spin-spin coupling, that results in a 10-...
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更新日期:1993-02-01 00:00:00
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