Abstract:
:Genetically engineered mouse models provide enormous potential for investigation of the underlying mechanisms of atherosclerotic disease, but noninvasive imaging methods for analysis of atherosclerosis in mice are currently limited. This study aimed to demonstrate the feasibility of MRI to noninvasively visualize atherosclerotic plaques in the thoracic aorta in mice deficient in apolipoprotein-E, who develop atherosclerotic lesions similar to those observed in humans. To freeze motion, MR data acquisition was both ECG- and respiratory-gated. T(1)-weighted MR images were acquired with TR/TE approximately 1000/10 ms. Spatial image resolution was 49 x 98 x 300 micro m(3). MRI revealed a detailed view of the lumen and the vessel wall of the entire thoracic aorta. Comparison of MRI with corresponding cross-sectional histopathology showed excellent agreement of aortic vessel wall area (r = 0.97). Hence, noninvasive MRI should allow new insights into the mechanisms involved in progression and regression of atherosclerotic disease.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Wiesmann F,Szimtenings M,Frydrychowicz A,Illinger R,Hunecke A,Rommel E,Neubauer S,Haase Adoi
10.1002/mrm.10500subject
Has Abstractpub_date
2003-07-01 00:00:00pages
69-74issue
1eissn
0740-3194issn
1522-2594journal_volume
50pub_type
杂志文章abstract:PURPOSE:Magnetization transfer in white matter (WM) causes biexponential relaxation, but most quantitative T1 measurements fit data assuming monoexponential relaxation. The resulting monoexponential T1 estimate varies based on scan parameters and represents a source of variation between studies, especially at high fiel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25729
更新日期:2016-06-01 00:00:00
abstract::In this work we aimed to study the possibility of using supervised classifiers to quantify the main components of carotid atherosclerotic plaque in vivo on the basis of multisequence MRI data. MRI data consisting of five MR weightings were obtained from 25 symptomatic subjects. Histological micrographs of endarterecto...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20828
更新日期:2006-04-01 00:00:00
abstract::Parallel imaging presents a promising approach for MRI of hyperpolarized nuclei, as the penalty in signal-to-noise ratio typically encountered with (1)H MRI due to a reduction in acquisition time can be offset by an increase in flip angle. The signal-to-noise ratio of hyperpolarized MRI generally exhibits a strong dep...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22962
更新日期:2011-12-01 00:00:00
abstract::A receive-only phased-array coil was designed to image the lower extremities. The array consists of four volume coils placed on two cylindrical formers. The coil array has the ability to image both legs simultaneously over a 40 cm longitudinal field of view (FOV). Experiments using phantoms show an increase in signal-...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10712
更新日期:2004-03-01 00:00:00
abstract::How stem cells promote myocardial repair in myocardial infarction (MI) is not well understood. The purpose of this study was to noninvasively monitor and quantify mesenchymal stem cells (MSC) from bone marrow to MI sites using magnetic resonance imaging (MRI). MSC were dual-labeled with an enhanced green fluorescent p...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22735
更新日期:2011-05-01 00:00:00
abstract:PURPOSE:Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in the study design. In the present study, we a...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27165
更新日期:2018-11-01 00:00:00
abstract::Spinal cord (SC) motion is thought to be the dominant source of error in current diffusion and spinal functional MRI (fMRI) methods. However, until now, such motion has not been well characterized in three dimensions. While previous studies have predominantly examined motion in the superior/inferior (S/I) direction, t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21260
更新日期:2007-07-01 00:00:00
abstract::Using a material that already is in widespread use in humans, India ink, the first EPR measurements in a human have been made, using the India ink in a pre-existing tattoo. The EPR spectra of India ink are very sensitive to the partial pressure of oxygen (pO2), thereby making it feasible to use this approach to measur...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910310218
更新日期:1994-02-01 00:00:00
abstract:PURPOSE:Amide-proton transfer (APT) and amine-water proton exchange (APEX) MRI can be viable to map pH-decreasing ischemic regions. However, their exact contributions are unclear. METHODS:We measured APEX- and APT-weighted magnetization transfer ratio asymmetry (denoted as APEXw and APTw), apparent diffusion coefficie...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24639
更新日期:2014-01-01 00:00:00
abstract::A method for evaluating the sensitivity of MRI protocols to changes in an arbitrary number of tissue parameters over a broad range of parameter values is presented. This analysis is useful for choosing an optimal basis set of images for either a "survey" protocol or tissue segmentation algorithms. A survey protocol is...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910130202
更新日期:1990-02-01 00:00:00
abstract:PURPOSE:Reference region models (RRMs) can quantify tumor perfusion in dynamic contrast-enhanced MRI without an arterial input function. Inspection of the RRM reveals that one of the free parameters in the fit is uniquely linked to the reference region and is common to all voxels. A two-step approach is proposed that t...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26530
更新日期:2017-10-01 00:00:00
abstract::A birdcage coil possesses various intrinsic resonant modes. One of the modes produces sinusoidal current distribution around the rung elements of the birdcage and generates a highly uniform B(1) field in the transverse plane. Another mode is the end-ring resonant mode, in which there are no currents in the rungs of th...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200010)44:4<633::aid-mrm18>3.0.c
更新日期:2000-10-01 00:00:00
abstract:PURPOSE:To analyze the effect of B0 field drift on multivoxel MR spectroscopic imaging and to propose an approach for its correction. THEORY AND METHODS:It is shown, both theoretically and in a phantom, that for ∼30 min acquisitions a linear B0 drift (∼0.1 ppm/h) will cause localization errors that can reach several v...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24536
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:To propose and evaluate a deep learning model for rapid and accurate calculation of myocardial T1 /T2 values based on a previously proposed Bloch equation simulation with slice profile correction (BLESSPC) method. METHODS:Deep learning Bloch equation simulations (DeepBLESS) models are proposed for rapid and ac...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28321
更新日期:2020-11-01 00:00:00
abstract:PURPOSE:MRI-guided high intensity focused ultrasound (MR-HIFU) allows noninvasive heating of deep tissues. Specifically targeting visceral fat deposits with MR-HIFU could offer an effective therapy for reversing the development of obesity, diabetes, and metabolic syndrome. METHODS:Overweight rats received either MR-HI...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25883
更新日期:2016-07-01 00:00:00
abstract::The most widely-used functional magnetic resonance imaging (fMRI) technique is based on the blood oxygenation level dependent (BOLD) effect, which requires at least partial uncoupling between cerebral blood flow (CBF) and oxygen consumption changes during increased mental activity. To compare BOLD and CBF effects duri...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910380110
更新日期:1997-07-01 00:00:00
abstract::Multiple-slice perfusion imaging by continuous arterial spin labeling (CASL) is made possible by amplitude modulation (AM) of the labeling RF pulse, but perfusion sensitivity is reduced relative to the single-slice technique. A computer model of the Bloch equations for velocity driven adiabatic fast passage was develo...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20604
更新日期:2005-09-01 00:00:00
abstract::Cerebral metabolite concentrations and water content were measured by means of localized proton magnetic resonance spectroscopy in 50 children, while metabolite peak ratios in short echo time spectra were evaluated in 173 examinations. Normative curves for normal development were established for two cerebral locations...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300405
更新日期:1993-10-01 00:00:00
abstract::A gradient technique to measure electron paramagnetic resonance spectra simultaneously at several different locations is described. The technique is based on the use of point probes containing paramagnetic centers. The value of the magnetic field gradient is chosen to be sufficient to separate the EPR signals from the...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910300210
更新日期:1993-08-01 00:00:00
abstract::The changes in the response of skeletal muscle to maximal dynamic exercise were investigated in going from a fasted state to a refed state by means of 31P NMR spectroscopy. It was found that in the fasted state, exercise-induced changes in Pi/PCr and in pH were both inhibited, in comparison with those in the refed sta...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910030616
更新日期:1986-12-01 00:00:00
abstract::To increase image acquisition efficiency, we develop alternative gradient encoding strategies designed to provide spatial encoding complementary to the spatial encoding provided by the multiple receiver coil elements in parallel image acquisitions. Intuitively, complementary encoding is achieved when the magnetic fiel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.24114
更新日期:2012-10-01 00:00:00
abstract:PURPOSE:The goal of this study is to characterize and improve the accuracy of 2D magnetic resonance fingerprinting (MRF) scans in the presence of slice profile (SP) and B1 imperfections, which are two main factors that affect quantitative results in MRF. METHODS:The SP and B1 imperfections are characterized and correc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26580
更新日期:2017-11-01 00:00:00
abstract::Sinusoidal capillarization induces microcirculatory changes in liver cirrhosis and fibrosis. The purpose of this study was to assess whether contrast-enhanced MRI can be used to demonstrate the effects of sinusoidal capillarization in liver fibrosis. Dynamic MRI after injection of a low-molecular-weight contrast agent...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10420
更新日期:2003-04-01 00:00:00
abstract::Nanostructured hydrogels have been developed as synthetic tissues and scaffolds for cell and drug delivery, and as guides for tissue regeneration. A fundamental problem in the development of synthetic hydrogels is that implanted gel structure is difficult to monitor noninvasively. This work demonstrates that the aggre...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22570
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:Conventional 31 P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of 31 P echo-planar spectroscopic imaging (EPSI) in vivo at 7T. METHODS:A 3D 31 P EPSI sequence with trapezoidal-shaped gradient pulses was implemented...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26785
更新日期:2018-03-01 00:00:00
abstract::Since its inception, functional magnetic resonance imaging (fMRI) has seen rapid progress in the application to neuroscience. Common gradient-recalled acquisition methods are susceptible to static field inhomogeneities, resulting in signal loss at the medial temporal area important for memory function or at the basal ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/(sici)1522-2594(199910)42:4<631::aid-mrm3>
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To establish a cardiac signal from scattering matrix or scattering coefficient measurements made on a 7T 8-channel parallel transmit (pTx) system, and to evaluate its use for cardiac gating. METHODS:Measurements of the scattering matrix and scattering coefficients were acquired using a monitoring pulse sequenc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27038
更新日期:2018-08-01 00:00:00
abstract::The mechanics of the macrocirculation are examined as a basis for imaging blood flow within the system. The macrocirculation is defined as that part of the circulation in which inertial forces are not negligible compared to viscous forces and as such in human subjects comprises the heart and large blood vessels. Becau...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910140204
更新日期:1990-05-01 00:00:00
abstract::Parallel imaging based on generalized autocalibrating partially parallel acquisitions is widely used in the clinical routine. To date, no detailed analysis has been presented describing the dependence of the image quality on the reconstruction and acquisition parameters such as the number of autocalibration signal (AC...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22803
更新日期:2011-08-01 00:00:00
abstract:PURPOSE:To demonstrate the feasibility of mapping gas exchange with single breath-hold hyperpolarized (HP) 129 Xe in humans, acquiring parametric maps of lung physiology. The potential benefit of acceleration using parallel imaging for this application is also explored. METHODS:Six healthy volunteers were scanned with...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27765
更新日期:2019-09-01 00:00:00