High-resolution 31 P echo-planar spectroscopic imaging in vivo at 7T.

Abstract:

PURPOSE:Conventional 31 P chemical shift imaging is time-consuming and yields only limited spatial resolution. The purpose of this study was to demonstrate feasibility of 31 P echo-planar spectroscopic imaging (EPSI) in vivo at 7T. METHODS:A 3D 31 P EPSI sequence with trapezoidal-shaped gradient pulses was implemented on a 7T MR scanner. To increase spectral width with reduced demand on gradient performance, a multishot approach was chosen. Acquisition weighting and 31 P-{1 H} double resonance for nuclear Overhauser signal enhancement were applied to increase sensitivity. RESULTS:3D 31 P-{1 H} EPSI data from model solution and from human calf muscle and brain were obtained from voxels with effective sizes of 4.1 to 16.2 cm3 in measurement times of approximately 10 min. Individual spectra showed well-resolved resonances of endogenous 31 P-metabolites without artifacts. Volumetric high-resolution 31 P-metabolite maps in vivo showed metabolic heterogeneity of different tissues. CONCLUSION:In vivo 31 P EPSI at 7T yields high-quality metabolic images. The proposed multishot EPSI technique reduces the measurement times for acquisition of volumetric high-resolution maps of 31 P-metabolites or intracellular pH in human studies. Magn Reson Med 79:1251-1259, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

journal_name

Magn Reson Med

authors

Korzowski A,Bachert P

doi

10.1002/mrm.26785

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

1251-1259

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

79

pub_type

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