Assessment and compensation of susceptibility artifacts in gradient echo MRI of hyperpolarized 3He gas.

Abstract:

:The effects of macroscopic background field gradients upon 2D gradient echo images of inhaled (3)He in the human lung were investigated at 1.5 T. Effective compensation of in-slice signal loss in (3)He gradient echo images was then demonstrated using a multiple acquisition interleaved single gradient echo sequence. This method restores signal dephasing through a combination of separate images acquired with different slice refocusing gradients. In vivo imaging of volunteers with the sequence shows substantial restoration of signal at the lung periphery and close to blood vessels. The technique presented may be useful when using (3)He MRI for volumetric measurements of lung ventilation and in studies using (3)He combined with intravenous contrast as a means of assessing lung ventilation/perfusion (V/Q).

journal_name

Magn Reson Med

authors

Wild JM,Fichele S,Woodhouse N,Paley MN,Swift A,Kasuboski L,van Beek EJ

doi

10.1002/mrm.10549

subject

Has Abstract

pub_date

2003-08-01 00:00:00

pages

417-22

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

50

pub_type

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