Theoretical analysis of the effect of imperfect slice profiles on tagging schemes for pulsed arterial spin labeling MRI.

Abstract:

:Pulsed arterial spin labeling (ASL) techniques provide a noninvasive method of obtaining qualitative and quantitative perfusion images with MRI. ASL techniques employ inversion recovery and/or saturation recovery to induce perfusion weighting, and thus the performance of these techniques is dependent on the slice profiles of the inversion or saturation pulses. This article systematically examines through simulations the effects of slice profile imperfections on the perfusion signal for nine labeling schemes, including FAIR, FAIRER, and EST (UNFAIR). Each sequence is evaluated for quantitative accuracy, suppression of stationary signal, and magnitude of perfusion signal. Perfusion effects are modeled from a modified Bloch equation and experimentally determined slice profiles. The results show that FAIR, FAIRER, and EST have excellent tissue suppression. The magnitude of the perfusion signal is comparable for FAIR and FAIRER, with EST providing a slightly weaker signal. For quantitative measurements, all three methods underestimate the perfusion signal by more than 20%. Of the additional six ASL techniques examined, only one performed well in this model. This method, which combines inversion and saturation recovery, yields improved signal accuracy (<15% difference from the theoretical value) and tissue suppression similar to that of FAIR and its variants, but has only half the signal. Magn Reson Med 46:141-148, 2001.

journal_name

Magn Reson Med

authors

Keilholz-George SD,Knight-Scott J,Berr SS

doi

10.1002/mrm.1169

subject

Has Abstract

pub_date

2001-07-01 00:00:00

pages

141-8

issue

1

eissn

0740-3194

issn

1522-2594

pii

10.1002/mrm.1169

journal_volume

46

pub_type

杂志文章
  • Nonbalanced SSFP-based quantitative magnetization transfer imaging.

    abstract::The previously reported concept for quantitative magnetization transfer (MT) imaging using balanced steady-state free precession (SSFP) is applied to nonbalanced SSFP sequences. This offers the possibility to derive quantitative MT parameters of targets with high-susceptibility variations such as the musculoskeletal s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22331

    authors: Gloor M,Scheffler K,Bieri O

    更新日期:2010-07-01 00:00:00

  • 3D coronary artery imaging with phase reordering for improved scan efficiency.

    abstract::Three-dimensional (3D) coronary imaging has the potential to overcome problems resulting from vessel tortuosity and to reduce partial volume effects. With these techniques, however, acquisition times are long and respiratory motion artifacts problematical. This work describes the development of a method that applies p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199903)41:3<555::aid-mrm19

    authors: Jhooti P,Keegan J,Gatehouse PD,Collins S,Rowe A,Taylor AM,Firmin DN

    更新日期:1999-03-01 00:00:00

  • Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes.

    abstract::Using NMR spectroscopy, we studied purified, human T lymphocytes in a serum-free medium. Purified cells were entrapped inside agarose beads and induced to proliferate by the mitogens phorbol-12-myristate-13-acetate and ionomycin. T lymphocytes in standard culture and inside agarose beads exhibit comparable viability, ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290307

    authors: Bental M,Deutsch C

    更新日期:1993-03-01 00:00:00

  • Data-driven optimized flip angle selection for T1 estimation from spoiled gradient echo acquisitions.

    abstract:PURPOSE:Define criteria for selection of optimal flip angle sets for T1 estimation and evaluate effects on T1 mapping. THEORY AND METHODS:Flip angle sets for spoiled gradient echo-based T1 mapping were selected by minimizing T1 estimate variance weighted by the joint density of M0 and T1 in an initial acquisition. The...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25920

    authors: Lewis CM,Hurley SA,Meyerand ME,Koay CG

    更新日期:2016-09-01 00:00:00

  • Porous medium 3D flow simulation of contrast media washout in cardiac MRI reflects myocardial injury.

    abstract:PURPOSE:Myocardial blood-flow simulation based on laws of fluid mechanics is a valuable tool for understanding tissue behavior. Our aim is to evaluate the ability of a porous-media flow model approach to reflect disturbed washout of contrast media (CM) from the myocardium as observed by cardiovascular MR. METHODS:A co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27756

    authors: Riazy L,Schaeffter T,Olbrich M,Schueler J,von Knobelsdorff-Brenkenhoff F,Niendorf T,Schulz-Menger J

    更新日期:2019-08-01 00:00:00

  • Dynamic oxygen-enhanced MRI reflects diffusing capacity of the lung.

    abstract::The purpose of this study was to demonstrate the feasibility of dynamic oxygen-enhanced MRI in a clinical setting. We hypothesized that dynamic oxygen enhancement can reflect the regional diffusing capacity of the lung. Ten patients with pulmonary emphysema and seven healthy volunteers were examined with a respiratory...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10168

    authors: Ohno Y,Hatabu H,Takenaka D,Van Cauteren M,Fujii M,Sugimura K

    更新日期:2002-06-01 00:00:00

  • Diffusion sensitivity of 3D-GRASE in arterial spin labeling perfusion.

    abstract:PURPOSE:To evaluate the role of true diffusion and flow-related pseudodiffusion in cerebral blood flow (CBF) quantification using arterial spin labeling (ASL) with single-shot or segmented 3D gradient and spin echo (GRASE) readouts. THEORY:The extended phase graph (EPG) algorithm, originally designed to model the effe...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27058

    authors: He X,Wengler K,Schweitzer ME

    更新日期:2018-08-01 00:00:00

  • Insights into tissue microstructure using a double diffusion encoding sequence on a clinical scanner: Validation and application to experimental tumor models.

    abstract:PURPOSE:To present a double diffusion encoding MRI sequence on a clinical scanner to analyze micro-structure and micro-vasculature of tumors. METHODS:The sequence was tested on phantoms, asparaguses, and 2 tumors allografts in a rodent. Results were analyzed using an adapted VERDICT model to estimate microstructural p...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28012

    authors: Duchêne G,Abarca-Quinones J,Leclercq I,Duprez T,Peeters F

    更新日期:2020-04-01 00:00:00

  • Phosphonate-modified GdDTPA complexes. I. NMRD study of the solution behavior of new tissue-specific contrast agents.

    abstract::NMRD profiles, the magnetic field dependence of the water proton longitudinal relaxation rates, have been acquired for two new diphosphonate-modified GdDTPA complexes currently under evaluation as relaxation agents for the MRI detection of soft-tissue calcifications. Fresh dilute solutions show profiles identical to t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170118

    authors: Adzamli IK,Blau M

    更新日期:1991-01-01 00:00:00

  • Spin-locking versus chemical exchange saturation transfer MRI for investigating chemical exchange process between water and labile metabolite protons.

    abstract::Chemical exchange saturation transfer (CEST) and spin-locking (SL) experiments were both able to probe the exchange process between protons of nonequivalent chemical environments. To compare the characteristics of the CEST and SL approaches in the study of chemical exchange effects, we performed CEST and SL experiment...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22721

    authors: Jin T,Autio J,Obata T,Kim SG

    更新日期:2011-05-01 00:00:00

  • An optimized center-out k-space trajectory for multishot MRI: comparison with spiral and projection reconstruction.

    abstract::A method for collecting MRI data on a set of rotated trajectories that begin at the center of k-space is outlined. It is theoretically slightly faster, slightly less susceptible to off-resonance and motion-induced phase, and produces images with slightly better signal-to-noise ratio than methods using Archimedean spir...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199910)42:4<714::aid-mrm13

    authors: Pipe JG

    更新日期:1999-10-01 00:00:00

  • Three-dimensional MRI with independent slab excitation and encoding.

    abstract::Three-dimensional MRI is typically performed with the same orientation for radiofrequency slab excitation and slab select phase encoding. We introduce independent slab excitation and encoding to create a new degree of freedom in three-dimensional MRI, which is the angular relationship between the prescribed excitation...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23043

    authors: Eissa A,Wilman AH

    更新日期:2012-02-01 00:00:00

  • Selection and evaluation of optimal two-dimensional CAIPIRINHA kernels applied to time-resolved three-dimensional CE-MRA.

    abstract:PURPOSE:To develop and validate a method for choosing the optimal two-dimensional CAIPIRINHA kernel for subtraction contrast-enhanced MR angiography (CE-MRA) and estimate the degree of image quality improvement versus that of some reference acceleration parameter set at R ≥ 8. METHODS:A metric based on patient-specifi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25366

    authors: Weavers PT,Borisch EA,Riederer SJ

    更新日期:2015-06-01 00:00:00

  • Inductively coupled Helmholtz coil on a dedicated imaging platform for the in vivo 1H-MRS measurement of intramyocellular lipids in the hind leg of rats.

    abstract::Skeletal muscle triglycerides are markers for insulin resistance in type 2 diabetes. Recently, MR spectroscopy was adapted for in vivo measurement of triglycerides in animal models and for the characterization of new therapeutic approaches. Because of small MR spectroscopy voxel sizes used in skeletal muscles, surface...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22149

    authors: Neumaier M,Niessen HG,Kaulisch T,Stiller D

    更新日期:2009-10-01 00:00:00

  • Proton NMR study of the state of water in fibrin gels, plasma, and blood clots.

    abstract::A proton NMR relaxation and pulsed field gradient self-diffusion study of water in fibrin gels, plasma, and blood clots has been performed with special emphasis on the effect of the sol-gel and shrinkage transitions. Deuteron NMR in fibrin gels was also studied to supplement the proton data. It is shown that a measure...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910140111

    authors: Blinc A,Lahajnar G,Blinc R,Zidansek A,Sepe A

    更新日期:1990-04-01 00:00:00

  • Phase-cycled simultaneous multislice balanced SSFP imaging with CAIPIRINHA for efficient banding reduction.

    abstract:PURPOSE:To present a time-efficient technique for banding reduction in balanced steady-state free precession (bSSFP) imaging using phase-cycled simultaneous multislice (SMS) acquisition with CAIPIRINHA (controlled aliasing in parallel imaging results in higher acceleration). THEORY:The proposed technique exploits the ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26076

    authors: Wang Y,Shao X,Martin T,Moeller S,Yacoub E,Wang DJ

    更新日期:2016-12-01 00:00:00

  • Magnetic resonance imaging of blood vessels at high fields: in vivo and in vitro measurements and image simulation.

    abstract::Unusually high image contrast in vivo magnetic resonance imaging of the brain becomes observable at high magnetic fields when the blood oxygenation level is lowered. The cause of the contrast has been attributed to a magnetic susceptibility effect induced by paramagnetic deoxyhemoglobin in red cells. When the cylinder...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910160103

    authors: Ogawa S,Lee TM

    更新日期:1990-10-01 00:00:00

  • Unifying linear prior-information-driven methods for accelerated image acquisition.

    abstract::In the ongoing quest for faster imaging and higher spatial resolution, several methods have been developed to speed up data acquisition by incorporating prior information about the object being imaged. This study shows that many of these methods can be integrated into a single common equation. The unified framework pr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1242

    authors: Tsao J,Behnia B,Webb AG

    更新日期:2001-10-01 00:00:00

  • Transmurally differentiated measurement of ATP hydrolysis rates in the in vivo porcine hearts.

    abstract:PURPOSE:Compare the transmural distribution of forward creatine kinase reaction (kf,CK ) and ATP hydrolysis rate (kr,ATPase ) in the myocardium of normal porcine heart. Rate constants were extracted from partially relaxed spectra by applying the T1nom method, effectively reducing data acquisition time by up to an order...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26162

    authors: Jang A,Xiong Q,Zhang P,Zhang J

    更新日期:2016-05-01 00:00:00

  • PRESTO-SENSE: an ultrafast whole-brain fMRI technique.

    abstract::A new ultrafast MR imaging method is proposed and tested, which enables whole-brain fMRI with a true temporal resolution of 1 sec. The method combines a 3D PRESTO pulse sequence with the concept of sensitivity-encoding with multiple receiver coils (SENSE). The so-called PRESTO-SENSE technique is demonstrated on a set ...

    journal_title:Magnetic resonance in medicine

    pub_type: 临床试验,杂志文章

    doi:10.1002/1522-2594(200006)43:6<779::aid-mrm1>3.0.co

    authors: Golay X,Pruessmann KP,Weiger M,Crelier GR,Folkers PJ,Kollias SS,Boesiger P

    更新日期:2000-06-01 00:00:00

  • Mapping connectomes with diffusion MRI: deterministic or probabilistic tractography?

    abstract:PURPOSE:Human connectomics necessitates high-throughput, whole-brain reconstruction of multiple white matter fiber bundles. Scaling up tractography to meet these high-throughput demands yields new fiber tracking challenges, such as minimizing spurious connections and controlling for gyral biases. The aim of this study ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27471

    authors: Sarwar T,Ramamohanarao K,Zalesky A

    更新日期:2019-02-01 00:00:00

  • Vessel-specific quantification of blood oxygenation with T2-relaxation-under-phase-contrast MRI.

    abstract:PURPOSE:Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. THEORY:The method, T2-Relaxation-U...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24750

    authors: Krishnamurthy LC,Liu P,Ge Y,Lu H

    更新日期:2014-03-01 00:00:00

  • Measurements of T(1) -relaxation in ex vivo prostate tissue at 132 μT.

    abstract::The proton T(1) was measured at 132 μT in ex vivo prostate tissue specimens from radical prostatectomies of 35 patients with prostate cancer. Each patient provided two specimens. The NMR and MRI measurements involved proton repolarization, a field of typically 150 mT and detection of the 5.6-kHz signal with a supercon...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24177

    authors: Busch S,Hatridge M,Mößle M,Myers W,Wong T,Mück M,Chew K,Kuchinsky K,Simko J,Clarke J

    更新日期:2012-04-01 00:00:00

  • Sensitivity profiles from an array of coils for encoding and reconstruction in parallel (SPACE RIP).

    abstract::A new parallel imaging technique was implemented which can result in reduced image acquisition times in MRI. MR data is acquired in parallel using an array of receiver coils and then reconstructed simultaneously with multiple processors. The method requires the initial estimation of the 2D sensitivity profile of each ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200008)44:2<301::aid-mrm18>3.0.c

    authors: Kyriakos WE,Panych LP,Kacher DF,Westin CF,Bao SM,Mulkern RV,Jolesz FA

    更新日期:2000-08-01 00:00:00

  • Linear combination of multiecho data: short T2 component selection.

    abstract::The myelin sheath, which is wrapped around the axons in the brain, can be affected by many diseases, resulting in cognitive and physical disability. Other work showed water in the myelin sheath has a T2 approximately 15 ms. The current standard technique to estimate the fraction of myelin water in vivo is to collect m...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10713

    authors: Jones CK,Xiang QS,Whittall KP,MacKay AL

    更新日期:2004-03-01 00:00:00

  • Relationships between tissue microstructure and the diffusion tensor in simulated skeletal muscle.

    abstract:PURPOSE:To establish a series of relationships defining how muscle microstructure and diffusion tensor imaging (DTI) are related. METHODS:The relationship among key microstructural features of skeletal muscle (fiber size, fibrosis, edema, and permeability) and the diffusion tensor were systematically simulated over ph...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26993

    authors: Berry DB,Regner B,Galinsky V,Ward SR,Frank LR

    更新日期:2018-07-01 00:00:00

  • Voxelwise analysis of simultaneously acquired and spatially correlated 18 F-fluorodeoxyglucose (FDG)-PET and intravoxel incoherent motion metrics in breast cancer.

    abstract:PURPOSE:Diffusion-weighted imaging (DWI) and 18 F-fluorodeoxyglucose-positron emission tomography (18 F-FDG-PET) independently correlate with malignancy in breast cancer, but the relationship between their structural and metabolic metrics is not completely understood. This study spatially correlates diffusion, perfusio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26505

    authors: Ostenson J,Pujara AC,Mikheev A,Moy L,Kim SG,Melsaether AN,Jhaveri K,Adams S,Faul D,Glielmi C,Geppert C,Feiweier T,Jackson K,Cho GY,Boada FE,Sigmund EE

    更新日期:2017-09-01 00:00:00

  • Application of parallel imaging to fMRI at 7 Tesla utilizing a high 1D reduction factor.

    abstract::Gradient-echo EPI, blood oxygenation level-dependent (BOLD) functional MRI (fMRI) using parallel imaging (PI) is demonstrated at 7 Tesla with 16 channels, a fourfold 1D reduction factor (R), and fourfold maximal aliasing. The resultant activation detection in finger-tapping fMRI studies was robust, in full agreement w...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20934

    authors: Moeller S,Van de Moortele PF,Goerke U,Adriany G,Ugurbil K

    更新日期:2006-07-01 00:00:00

  • Quantification of the pulse wave velocity of the descending aorta using axial velocity profiles from phase-contrast magnetic resonance imaging.

    abstract::The pulse wave velocity (PWV) of aortic blood flow is considered a surrogate for aortic compliance. A new method using phase-contrast (PC)-MRI is presented whereby the spatial and temporal profiles of axial velocity along the descending aorta can be analyzed. Seventeen young healthy volunteers (the YH group), six olde...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21034

    authors: Yu HY,Peng HH,Wang JL,Wen CY,Tseng WY

    更新日期:2006-10-01 00:00:00

  • Adaptive self-calibrating iterative GRAPPA reconstruction.

    abstract::Parallel magnetic resonance imaging in k-space such as generalized auto-calibrating partially parallel acquisition exploits spatial correlation among neighboring signals over multiple coils in calibration to estimate missing signals in reconstruction. It is often challenging to achieve accurate calibration information...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23188

    authors: Park S,Park J

    更新日期:2012-06-01 00:00:00