Vessel-specific quantification of blood oxygenation with T2-relaxation-under-phase-contrast MRI.

Abstract:

PURPOSE:Measurement of venous oxygenation (Yv) is a critical step toward quantitative assessment of brain oxygen metabolism, a key index in many brain disorders. The present study aims to develop a noninvasive, rapid, and reproducible method to measure Yv in a vessel-specific manner. THEORY:The method, T2-Relaxation-Under-Phase-Contrast MRI, utilizes complex subtraction of phase-contrast to isolate pure blood signal, applies nonslice-selective T2-preparation to measure T2, and converts T2 to oxygenation using a calibration plot. METHODS:Following feasibility demonstration, several technical aspects were examined, including validation with an established global Yv technique, test-retest reproducibility, sensitivity to detect oxygenation changes due to hypoxia and caffeine challenges, applicability of echo-planar-imaging (EPI) acquisition to shorten scan duration, and ability to study veins with a caliber of 1-2 mm. RESULTS:T2-Relaxation-Under-Phase-Contrast was able to simultaneously measure Yv in all major veins in the brain, including sagittal sinus, straight sinus, great vein, and internal cerebral vein. T2-Relaxation-Under-Phase-Contrast results showed an excellent agreement with the reference technique, high sensitivity to oxygenation changes, and test-retest variability of 3.5 ± 1.0%. The use of segmented-EPI was able to reduce the scan duration to 1.5 minutes. It was also feasible to study pial veins and deep veins. CONCLUSION:T2-Relaxation-Under-Phase-Contrast MRI is a promising technique for vessel-specific oxygenation measurement.

journal_name

Magn Reson Med

authors

Krishnamurthy LC,Liu P,Ge Y,Lu H

doi

10.1002/mrm.24750

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

978-89

issue

3

eissn

0740-3194

issn

1522-2594

journal_volume

71

pub_type

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