Dextran-magnetite: a contrast agent for sodium-23 MRI.

Abstract:

:Dextran-magnetite, a superparamagnetic compound, is a powerful relaxation reagent for sodium. Administered intravenously, it is confined mainly to the vasculature and eliminates the signal from plasma sodium, a significant component of the tissue sodium signal. Applications of dextran-magnetite for in vivo sodium imaging of a normal rat and rats with a tumor and experimentally induced peripheral edema are shown. Our results indicate that dextran-magnetite may be useful for improving tumor detection and for imaging of edema. To our knowledge, this is the first report of a contrast agent suitable for sodium magnetic resonance imaging.

journal_name

Magn Reson Med

authors

Summers RM,Joseph PM,Renshaw PF,Kundel HL

doi

10.1002/mrm.1910080406

subject

Has Abstract

pub_date

1988-12-01 00:00:00

pages

427-39

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

8

pub_type

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