Convex gradient optimization for increased spatiotemporal resolution and improved accuracy in phase contrast MRI.

Abstract:

PURPOSE:To evaluate convex gradient optimization (CVX) for increased spatiotemporal resolution and improved accuracy for phase-contrast MRI (PC-MRI). METHODS:A conventional flow-compensated and flow-encoded (FCFE) PC-MRI sequence was compared with a CVX PC-MRI sequence using numerical simulations, flow phantom experiments, and in vivo experiments. Flow measurements within the ascending aorta, main pulmonary artery, and right/left pulmonary arteries of normal volunteers (N = 10) were acquired at 3T and analyzed using a conventional FCFE sequence and a CVX sequence with either higher spatial resolution or higher temporal resolution. All sequences mitigated chemical shift-induced phase errors and used equivalent breath-hold durations. RESULTS:Chemical shift-optimized PC-MRI has increased sequence efficiency when using CVX, which can provide either higher spatial or higher temporal resolution compared with conventional FCFE PC-MRI. Numerical simulations, flow phantom experiments, and in vivo experiments indicate that CVX measurements of total flow and peak velocity are increased and more accurate when compared with FCFE. CONCLUSION:CVX PC-MRI increases sequence efficiency while reducing chemical shift-induced phase errors. This can be used to provide either higher spatial or higher temporal resolution than conventional chemical shift-mitigated PC-MRI methods to provide more accurate measurements of blood flow and peak velocity.

journal_name

Magn Reson Med

authors

Middione MJ,Wu HH,Ennis DB

doi

10.1002/mrm.25059

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1552-64

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

72

pub_type

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