Modification of embolic-PVA particles with MR contrast agents.

Abstract:

:We report the synthesis and characterization of polyvinyl alcohol (PVA) embolic particles modified with a clinically approved magnetic resonance (MR) contrast agent. PVA particles are used during transcatheter arterial embolization (TAE) procedures and this minimally invasive technique is a widely employed treatment for inoperable tumors. The PVA particles are injected into tumor vessels and prevent blood flow which results in tumor attenuation. An accurate assessment of the endpoint of embolization is critical to successful TAE procedures. Recent reports suggest that 20% of endpoint determination of TAE procedures by angiographic techniques are erroneous. Real time, in vivo imaging of the embolic particles would overcome this limitation. The contrast-modified PVA particles described here show an 80% decrease in T(1) relaxation times compared to unmodified particles. Images of particles in capillary tubes of similar size to catheters used in TAE procedures are clearly visible by MRI.

journal_name

Magn Reson Med

authors

Cilliers R,Song Y,Kohlmeir EK,Larson AC,Omary RA,Meade TJ

doi

10.1002/mrm.21518

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

898-902

issue

4

eissn

0740-3194

issn

1522-2594

journal_volume

59

pub_type

杂志文章
  • Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy.

    abstract:PURPOSE:To separate the spectrally overlapped lactate and lipid signals at 1.3 ppm using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) based on their large diffusivity difference. METHODS:DW-MRS was applied to the gel phantoms containing lactate and lipid droplets, and to the rat brain tumors. Lactate an...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26144

    authors: Wang AM,Leung GK,Kiang KM,Chan D,Cao P,Wu EX

    更新日期:2017-02-01 00:00:00

  • Interactive continuously moving table (iCMT) large field-of-view real-time MRI.

    abstract::Continuously moving table (CMT) MRI is a new method that is capable of generating 3D, seamless, large field-of-view (FOV) images by acquiring readouts along the patient superior-inferior axis as the subject is translated through the scanner. For applications that require artifact-free images, such as arterial-phase co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20848

    authors: Sabati M,Lauzon ML,Mahallati H,Frayne R

    更新日期:2006-05-01 00:00:00

  • An evaluation of the effect of fasting on the exercise-induced changes in pH and Pi/PCr from skeletal muscle.

    abstract::The changes in the response of skeletal muscle to maximal dynamic exercise were investigated in going from a fasted state to a refed state by means of 31P NMR spectroscopy. It was found that in the fasted state, exercise-induced changes in Pi/PCr and in pH were both inhibited, in comparison with those in the refed sta...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030616

    authors: Lunt JA,Allen PS,Brauer M,Swinamer D,Treiber EO,Belcastro A,Eccles R,King EG

    更新日期:1986-12-01 00:00:00

  • Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes.

    abstract::A novel method based on selective detection of rapidly changing DeltaB(0) magnetic fields and suppression of slowly changing DeltaB(0) fields is presented. The ultimate goal of this work is to present a method that may allow detection of transient and subtle changes in B(0) in cortical tissue associated with electrica...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10159

    authors: Bodurka J,Bandettini PA

    更新日期:2002-06-01 00:00:00

  • Three-dimensional MRI with independent slab excitation and encoding.

    abstract::Three-dimensional MRI is typically performed with the same orientation for radiofrequency slab excitation and slab select phase encoding. We introduce independent slab excitation and encoding to create a new degree of freedom in three-dimensional MRI, which is the angular relationship between the prescribed excitation...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.23043

    authors: Eissa A,Wilman AH

    更新日期:2012-02-01 00:00:00

  • S5FP: spectrally selective suppression with steady state free precession.

    abstract::A method is presented that employs the inherent spectral selectivity of the Steady-State Free Precession (SSFP) pulse sequence to provide a spectral band of suppression. At TE = TR/2, SSFP partitions the magnetization into two phase-opposed spectral components. Z-storing one of these components simultaneously further ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20633

    authors: Derbyshire JA,Herzka DA,McVeigh ER

    更新日期:2005-10-01 00:00:00

  • Water diffusion, T(2), and compartmentation in frog sciatic nerve.

    abstract::A potential relationship between structural compartments in neural tissue and NMR parameters may increase the specificity of MRI in diagnosing diseases. Nevertheless, our understanding of MR of nerves and white matter is limited, particularly the influence of various water compartments on the MR signal is not known. I...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199911)42:5<911::aid-mrm11

    authors: Peled S,Cory DG,Raymond SA,Kirschner DA,Jolesz FA

    更新日期:1999-11-01 00:00:00

  • Detection of subnanotesla oscillatory magnetic fields using MRI.

    abstract:PURPOSE:Direct mapping of neuronal currents using MRI would have fundamental impacts on brain functional imaging. Previous reports indicated that the stimulus-induced rotary saturation (SIRS) mechanism had the best potential of direct detection of neural oscillations; however, it lacked the high-sensitivity level neede...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25553

    authors: Jiang X,Sheng J,Li H,Chai Y,Zhou X,Wu B,Guo X,Gao JH

    更新日期:2016-02-01 00:00:00

  • 3D single-shot VASO using a Maxwell gradient compensated GRASE sequence.

    abstract::The vascular space occupancy (VASO) method was recently proposed as a functional MRI (fMRI) method that is capable of detecting activation-related changes in blood volume (CBV), without the need for a blood-pool contrast agent. In the present work we introduce a new whole-brain VASO technique that is based on a parall...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22000

    authors: Poser BA,Norris DG

    更新日期:2009-07-01 00:00:00

  • Sodium NMR imaging of lung water in rats.

    abstract::Coronal proton and sodium images of control rats and rats with either increased permeability edema produced by intravenous alloxan (300 mg/kg) or increased pressure edema produced by saline infusion (2 ml/min) were obtained. Axial chest CT images were used to monitor the development of pulmonary edema. Immediately aft...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910060403

    authors: Kundel HL,Shetty A,Joseph PM,Summers RM,Kassab EA,Moore B

    更新日期:1988-04-01 00:00:00

  • Stability assessment of gadolinium complexes by P-31 and H-1 relaxometry.

    abstract::Longitudinal P-31 relaxation rate enhancements of phosphate groups have been measured at pH 7-7.2 and 310 degrees K on aqueous solutions containing adenosine triphosphate (ATP), phosphocreatine (PCr), inorganic phosphate (Pi) and some lanthanide complexes (Gd-DOTA, Gd-HPDO3A, Gd-DO3A, Gd-DTPA, Gd-DTPA-BMA). The macroc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310413

    authors: Vander Elst L,Van Haverbeke Y,Goudemant JF,Muller RN

    更新日期:1994-04-01 00:00:00

  • Globally optimal, minimum stored energy, double-doughnut superconducting magnets.

    abstract::The use of the minimum stored energy current density map-based methodology of designing closed-bore symmetric superconducting magnets was described recently. The technique is further developed to cater for the design of interventional-type MRI systems, and in particular open symmetric magnets of the double-doughnut co...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22189

    authors: Tieng QM,Vegh V,Brereton IM

    更新日期:2010-01-01 00:00:00

  • 31P NMR spectroscopy of 9L cell line in culture: differential effects of high temperature on anchored cells and spheroids.

    abstract::The differential effects of high temperature on 9L rat gliosarcoma cells cultured in two distinctive forms, namely, anchored monolayer cells and multicellular spheroids, were investigated using 31P nuclear magnetic resonance spectroscopy. The critical temperatures resulting in irreversible changes in cellular energeti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190233

    authors: Suzuki N,Kwee IL,Tamas LB,Nakada T

    更新日期:1991-06-01 00:00:00

  • Comprehensive approach for correction of motion and distortion in diffusion-weighted MRI.

    abstract::Patient motion and image distortion induced by eddy currents cause artifacts in maps of diffusion parameters computed from diffusion-weighted (DW) images. A novel and comprehensive approach to correct for spatial misalignment of DW imaging (DWI) volumes acquired with different strengths and orientations of the diffusi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10677

    authors: Rohde GK,Barnett AS,Basser PJ,Marenco S,Pierpaoli C

    更新日期:2004-01-01 00:00:00

  • Aortic 4D flow: quantification of signal-to-noise ratio as a function of field strength and contrast enhancement for 1.5T, 3T, and 7T.

    abstract:PURPOSE:To investigate for the first time the feasibility of aortic four-dimensional (4D) flow at 7T, both contrast enhanced (CE) and non-CE. To quantify the signal-to-noise ratio (SNR) in aortic 4D flow as a function of field strength and CE with gadobenate dimeglumine (MultiHance). METHODS:Six healthy male volunteer...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25317

    authors: Hess AT,Bissell MM,Ntusi NA,Lewis AJ,Tunnicliffe EM,Greiser A,Stalder AF,Francis JM,Myerson SG,Neubauer S,Robson MD

    更新日期:2015-05-01 00:00:00

  • Design of adiabatic selective pulses using optimal control theory.

    abstract::Optimal control theory has been applied in the past for the design of RF pulses for selective excitation. This was the outcome of having established the controllability of the MR spin system for the selective excitation problem. "Minimum distance" was the main formulation used for the solution. Because of their robust...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360311

    authors: Rosenfeld D,Zur Y

    更新日期:1996-09-01 00:00:00

  • Quantification of non-water-suppressed MR spectra with correction for motion-induced signal reduction.

    abstract::Intrascan subject movement in clinical MR spectroscopic examinations may result in inconsistent water suppression that distorts the metabolite signals, frame-to-frame variations in spectral phase and frequency, and consequent reductions in the signal-to-noise ratio due to destructive averaging. Frame-to-frame phase/fr...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22119

    authors: Lin JM,Tsai SY,Liu HS,Chung HW,Mulkern RV,Cheng CM,Yeh TC,Chen NK

    更新日期:2009-12-01 00:00:00

  • Three-dimensional reconstruction of limited-view projections for contrast-enhanced magnetic resonance angiography at high temporal and spatial resolution.

    abstract::The feasibility of reconstructing three-dimensional (3D) MRI data sets from limited-view projections is investigated in phantom and in vivo animal studies to improve the temporal resolution of magnetic resonance angiography without sacrificing spatial resolution. Thirty-two pairs of orthogonal biplane projections are ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20727

    authors: Huang Y,Gurr D,Wright GA

    更新日期:2006-01-01 00:00:00

  • Arterial spin labeling perfusion fMRI with very low task frequency.

    abstract::Functional magnetic resonance imaging (fMRI) has become the most widely used modality for visualizing regional brain activation in response to sensorimotor or cognitive tasks. While the majority of fMRI studies have used blood oxygenation level-dependent (BOLD) contrast as a marker for neural activation, baseline drif...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10437

    authors: Wang J,Aguirre GK,Kimberg DY,Roc AC,Li L,Detre JA

    更新日期:2003-05-01 00:00:00

  • NMR dispersion investigations of enzymatically degraded bovine articular cartilage.

    abstract:PURPOSE:Cross-relaxation of protons with (14) N nuclei in proteins enhances relaxivity in the quadrupolar dip range of typically 2-3 MHz Larmor frequency. The magnitude of these dips was suggested as a means of assessing the degeneracy of articular cartilage during osteoarthritis (OA). However, so far only proteoglycan...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25292

    authors: Rössler E,Mattea C,Stapf S

    更新日期:2015-05-01 00:00:00

  • Perfusion imaging using dynamic arterial spin labeling (DASL).

    abstract::Recently, a technique based on arterial spin labeling, called dynamic arterial spin labeling (DASL (Magn Reson Med 1999;41:299-308)), has been introduced to measure simultaneously the transit time of the labeled blood from the labeling plane to the exchange site, the longitudinal relaxation time of the tissue, and the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1136

    authors: Barbier EL,Silva AC,Kim SG,Koretsky AP

    更新日期:2001-06-01 00:00:00

  • Efficient biphasic spin-echo magnetic resonance imaging.

    abstract::The concept of temporal echo multiplexing is defined and used to develop rapid biphasic spin-echo sequences for imaging the heart. Three imaging sequences, based on four-echo and two-echo multiplexing and rapid single echo (i.e., conventional spin-echo imaging), are compared. Preliminary results indicate that two-echo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910110109

    authors: Parker DL,Caputo GR,Frederick PR

    更新日期:1989-07-01 00:00:00

  • MRI visualization of rodent liver structure and peritoneal adhesion with dialyzate enhancement.

    abstract::This study investigated the use of peritoneal dialysis fluid (dialyzate) as a MR contrast agent to visualize the liver structure and peritoneal adhesion in rats at 7 T. Intraperitoneal injection of dialyzate (approximately 0.1 ml/g) yielded excellent and consistent intraperitoneal enhancement that delineated the liver...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21506

    authors: Cheung JS,Guo H,Leung JC,Man K,Lai KN,Wu EX

    更新日期:2008-05-01 00:00:00

  • Slow magic-angle coil spinning: a high-sensitivity and high-resolution NMR strategy for microscopic biological specimens.

    abstract::High-resolution magic-angle spinning has become a valuable tool to study biologic samples; however, there are only a few high-resolution magic-angle spinning methodologies that have been explored specifically to deal with small semisolid biomaterials such as tissues. Here, we report a novel high-resolution (1)H NMR sp...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22231

    authors: Wong A,Aguiar PM,Sakellariou D

    更新日期:2010-02-01 00:00:00

  • MRI relaxation fluctuations in acute reperfused hemorrhagic infarction.

    abstract::MRI evaluations of intramyocardial hemorrhage in acute infarction have relied on T(2) and T(2)(*) shortening only. We propose a more comprehensive evaluation of hemorrhagic infarction based on the concept that fluctuations in T(2) and T(1) relaxation in acute reperfused infarction will reflect transient edema and hemo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21079

    authors: Foltz WD,Yang Y,Graham JJ,Detsky JS,Wright GA,Dick AJ

    更新日期:2006-12-01 00:00:00

  • Arrays of mutually coupled receiver coils: theory and application.

    abstract::Specialized receiver coils having a small sensitive region can provide an improvement in SNR for MR imaging and spectroscopy, at the expense of limiting the usable field of view. This work presents a technique for designing coil arrays that allows the size and location of the sensitive region to be selected remotely. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910170128

    authors: Wright SM,Magin RL,Kelton JR

    更新日期:1991-01-01 00:00:00

  • Response of choline metabolites to docetaxel therapy is quantified in vivo by localized (31)P MRS of human breast cancer xenografts and in vitro by high-resolution (31)P NMR spectroscopy of cell extracts.

    abstract::Choline-containing compounds (CCCs) are elevated in breast cancer, and detected in vivo by the (1)H MRS total choline (tCho) resonance (3.25 ppm) and the (31)P MRS phosphomonoester (PME) resonance (3.8 ppm). Both the tCho and PME resonances decrease early after initiation of successful therapy. The single major compon...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21333

    authors: Morse DL,Raghunand N,Sadarangani P,Murthi S,Job C,Day S,Howison C,Gillies RJ

    更新日期:2007-08-01 00:00:00

  • Variable flip angle 3D-GRASE for high resolution fMRI at 7 tesla.

    abstract:PURPOSE:To evaluate the use of variable flip angle refocusing pulse trains in single-shot three-dimensional gradient and spin-echo (3D-GRASE) to reduce blurring and increase the spatial coverage for high spatial resolution T2 -weighted functional MRI at 7 Tesla. METHODS:Variable flip angle refocusing schemes in 3D-GRA...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25979

    authors: Kemper VG,De Martino F,Yacoub E,Goebel R

    更新日期:2016-09-01 00:00:00

  • Simulation-based investigation of partially parallel imaging with a linear array at high accelerations.

    abstract::Partially parallel imaging strategies such as SMASH, SENSE, and PILS rely on the sensitivity distribution of phased array RF coils to reduce MRI imaging time. Using an N-element phased array, these techniques allow maximum accelerations, L, such that L < or = N, with acceleration defined as the factor by which scan ti...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10113

    authors: Bankson JA,Wright SM

    更新日期:2002-04-01 00:00:00

  • Intracellular redox state revealed by in vivo (31) P MRS measurement of NAD(+) and NADH contents in brains.

    abstract:PURPOSE:Nicotinamide adenine dinucleotide (NAD), in oxidized (NAD(+) ) or reduced (NADH) form, plays key roles in cellular metabolism. Intracellular NAD(+) /NADH ratio represents the cellular redox state; however, it is difficult to measure in vivo. We report here a novel in vivo (31) P MRS method for noninvasive measu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24859

    authors: Lu M,Zhu XH,Zhang Y,Chen W

    更新日期:2014-06-01 00:00:00