Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy.

Abstract:

PURPOSE:To separate the spectrally overlapped lactate and lipid signals at 1.3 ppm using diffusion-weighted magnetic resonance spectroscopy (DW-MRS) based on their large diffusivity difference. METHODS:DW-MRS was applied to the gel phantoms containing lactate and lipid droplets, and to the rat brain tumors. Lactate and lipid signals and their apparent diffusion coefficients were computed from the diffusion-weighted proton spectra. Biexponential fitting and direct spectral subtraction approaches were employed and compared. RESULTS:DW-MRS could effectively separate lactate and lipid signals both in phantoms and rat brain C6 glioma by biexponential fitting. In phantoms, lactate and lipid signals highly correlated with the known lactate concentration and lipid volume fractions. In C6 glioma, both lactate and lipid signals were detected, and the lipid signal was an order of magnitude higher than lactate signal. The spectral subtraction approach using three diffusion weightings also allowed the separation of lactate and lipid signals, yielding results comparable to those by the biexponential fitting approach. CONCLUSION:DW-MRS presents a new approach to separate and quantify spectrally overlapped molecules and/or macromolecules, such as lactate and lipid, by using the diffusivity difference associated with their different sizes or mobility within tissue microstructure. Magn Reson Med 77:480-489, 2017. © 2016 International Society for Magnetic Resonance in Medicine.

journal_name

Magn Reson Med

authors

Wang AM,Leung GK,Kiang KM,Chan D,Cao P,Wu EX

doi

10.1002/mrm.26144

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

480-489

issue

2

eissn

0740-3194

issn

1522-2594

journal_volume

77

pub_type

杂志文章
  • Incorporating dixon multi-echo fat water separation for novel quantitative magnetization transfer of the human optic nerve in vivo.

    abstract:PURPOSE:The optic nerve (ON) represents the sole pathway between the eyes and brain; consequently, diseases of the ON can have dramatic effects on vision. However, quantitative magnetization transfer (qMT) applications in the ON have been limited to ex vivo studies, in part because of the fatty connective tissue that s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26164

    authors: Smith AK,Dortch RD,Dethrage LM,Lyttle BD,Kang H,Welch EB,Smith SA

    更新日期:2017-02-01 00:00:00

  • One- and two-dimensional EPR imaging studies on phantoms and plant specimens.

    abstract::The advantages of electron paramagnetic resonance (EPR) imaging at L-band frequencies are discussed. The construction and calibration of a low-field L-band EPR imaging spectrometer is described with capillary phantoms containing aqueous nitroxides as paramagnetic imaging agents. The peak separation induced by the magn...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910020310

    authors: Fujii H,Berliner LJ

    更新日期:1985-06-01 00:00:00

  • Iterative correction of RF envelope distortion with GRATER-measured waveforms.

    abstract:PURPOSE:To develop and evaluate a method for RF envelope correction without extra hardware or synchronization. METHODS:Transmitted RF waveforms are measured through a simple pulse sequence called the gradient reversal approach to evaluate RF (GRATER). The measured RF waveforms are used to compute predistorted RF wavef...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27930

    authors: Landes VL,Nayak KS

    更新日期:2020-01-01 00:00:00

  • Conversion of arterial input functions for dual pharmacokinetic modeling using Gd-DTPA/MRI and 18F-FDG/PET.

    abstract::Reaching the full potential of magnetic resonance imaging (MRI)-positron emission tomography (PET) dual modality systems requires new methodologies in quantitative image analyses. In this study, methods are proposed to convert an arterial input function (AIF) derived from gadolinium-diethylenetriaminepentaacetic acid ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24318

    authors: Poulin E,Lebel R,Croteau E,Blanchette M,Tremblay L,Lecomte R,Bentourkia M,Lepage M

    更新日期:2013-03-01 00:00:00

  • Graphical programming interface: A development environment for MRI methods.

    abstract:PURPOSE:To introduce a multiplatform, Python language-based, development environment called graphical programming interface for prototyping MRI techniques. METHODS:The interface allows developers to interact with their scientific algorithm prototypes visually in an event-driven environment making tasks such as paramet...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25528

    authors: Zwart NR,Pipe JG

    更新日期:2015-11-01 00:00:00

  • Analytical approach to noncircular section birdcage coil design: verification with a Cassinian oval coil.

    abstract::A general analytical framework is presented for the design of birdcage radiofrequency resonators on cylindrical formers having arbitrary cross-sectional shape. The primary objective of such shapes would be to improve the sensitivity of the NMR experiment to noncircular regions of the human anatomy while maintaining fi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20317

    authors: De Zanche N,Yahya A,Vermeulen FE,Allen PS

    更新日期:2005-01-01 00:00:00

  • Conventions and nomenclature for double diffusion encoding NMR and MRI.

    abstract::Stejskal and Tanner's ingenious pulsed field gradient design from 1965 has made diffusion NMR and MRI the mainstay of most studies seeking to resolve microstructural information in porous systems in general and biological systems in particular. Methods extending beyond Stejskal and Tanner's design, such as double diff...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.25901

    authors: Shemesh N,Jespersen SN,Alexander DC,Cohen Y,Drobnjak I,Dyrby TB,Finsterbusch J,Koch MA,Kuder T,Laun F,Lawrenz M,Lundell H,Mitra PP,Nilsson M,Özarslan E,Topgaard D,Westin CF

    更新日期:2016-01-01 00:00:00

  • Determination of knee joint cartilage thickness using three-dimensional magnetic resonance chondro-crassometry (3D MR-CCM).

    abstract::The objective of this article was to analyze the accuracy and precision with which the quantitative distribution of articular cartilage can be determined in the knee joint using MRI. A three-dimensional (3D) technique that accounts for the out-of-plane deviation of the interface normal in strongly curved joint surface...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910360213

    authors: Eckstein F,Gavazzeni A,Sittek H,Haubner M,Lösch A,Milz S,Englmeier KH,Schulte E,Putz R,Reiser M

    更新日期:1996-08-01 00:00:00

  • Validation of 13C NMR measurements of liver glycogen in vivo.

    abstract::The natural abundance 13C NMR intensity of the glycogen C1 resonance was measured in the surgically exposed liver of rabbits in vivo (n = 17) by integration from 98 to 104 ppm and compared double blindedly to the subsequent biochemical measurement. Coil loading was measured each time from a reference sphere at the coi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910310602

    authors: Gruetter R,Magnusson I,Rothman DL,Avison MJ,Shulman RG,Shulman GI

    更新日期:1994-06-01 00:00:00

  • T2 measurement in articular cartilage: impact of the fitting method on accuracy and precision at low SNR.

    abstract::T2 relaxation time is a promising MRI parameter for the detection of cartilage degeneration in osteoarthritis. However, the accuracy and precision of the measured T2 may be substantially impaired by the low signal-to-noise ratio of images available from clinical examinations. The purpose of this work was to assess the...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22178

    authors: Raya JG,Dietrich O,Horng A,Weber J,Reiser MF,Glaser C

    更新日期:2010-01-01 00:00:00

  • The fractionated dipole antenna: A new antenna for body imaging at 7 Tesla.

    abstract:PURPOSE:Dipole antennas in ultrahigh field MRI have demonstrated advantages over more conventional designs. In this study, the fractionated dipole antenna is presented: a dipole where the legs are split into segments that are interconnected by capacitors or inductors. METHODS:A parameter study has been performed on di...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25596

    authors: Raaijmakers AJ,Italiaander M,Voogt IJ,Luijten PR,Hoogduin JM,Klomp DW,van den Berg CA

    更新日期:2016-03-01 00:00:00

  • Early changes in water diffusion, perfusion, T1, and T2 during focal cerebral ischemia in the rat studied at 8.5 T.

    abstract::The time evolution of water diffusion, perfusion, T1, and T2 is investigated at high magnetic field (8.5 T) following permanent middle cerebral artery occlusion in the rat. Cerebral blood flow maps were obtained using arterial spin tagging. Although the quantitative perfusion measurements in ischemic tissue still pose...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/(sici)1522-2594(199903)41:3<479::aid-mrm9>

    authors: Calamante F,Lythgoe MF,Pell GS,Thomas DL,King MD,Busza AL,Sotak CH,Williams SR,Ordidge RJ,Gadian DG

    更新日期:1999-03-01 00:00:00

  • The uncommon longitudinal relaxation dispersion of human brain white matter.

    abstract::Human brain white matter exhibits an uncommonly strong dispersion of 1/T1 at high fields. An additional relaxation pathway via the myelin lipids, which are not directly visible to medical NMR due to their fast T2 decay, is proposed. Relaxation dispersion data are successfully analyzed on the basis of this model. ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910090319

    authors: Fischer HW,Van Haverbeke Y,Schmitz-Feuerhake I,Muller RN

    更新日期:1989-03-01 00:00:00

  • Experimental encephalomyelitis modulates inositol and taurine in the spinal cord of Biozzi mice.

    abstract::In this high resolution magnetic resonance spectroscopic study of experimental allergic encephalomyelitis (EAE) and Semliki Forest virus (SFV) infection of the Biozzi AB/H mouse, marked increases in the initially low levels of N-trimethyl compounds in the spinal cord were observed during probable demyelinating episode...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910320603

    authors: Preece NE,Amor S,Baker D,Gadian DG,O'Neill JK,Urenjak J

    更新日期:1994-12-01 00:00:00

  • Image reconstruction algorithm for motion insensitive MR Fingerprinting (MRF): MORF.

    abstract:PURPOSE:The purpose of this study is to increase the robustness of MR fingerprinting (MRF) toward subject motion. METHODS:A novel reconstruction algorithm, MOtion insensitive MRF (MORF), was developed, which uses an iterative reconstruction based retrospective motion correction approach. Each iteration loops through t...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27227

    authors: Mehta BB,Ma D,Pierre EY,Jiang Y,Coppo S,Griswold MA

    更新日期:2018-12-01 00:00:00

  • iDQC anisotropy map imaging for tumor tissue characterization in vivo.

    abstract::Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anis...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21925

    authors: Branca RT,Chen YM,Mouraviev V,Galiana G,Jenista ER,Kumar C,Leuschner C,Warren WS

    更新日期:2009-04-01 00:00:00

  • Investigation and modeling of magnetization transfer effects in two-dimensional multislice turbo spin echo sequences with low constant or variable flip angles at 3 T.

    abstract::Magnetization transfer effects represent a major source of contrast in multislice turbo spin echo sequences (TSE)/fast spin echo sequences. Generally, low refocusing flip angles have become common in such MRI sequences, especially to mitigate specific absorption rate problems. Since the strength of magnetization trans...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22145

    authors: Weigel M,Helms G,Hennig J

    更新日期:2010-01-01 00:00:00

  • Fast and accurate measurements of T1 using a multi-readout single inversion-recovery sequence.

    abstract::TOMROP is a multiple readout single inversion-recovery sequence which may potentially allow the measurement of multi-exponential T1 recoveries in vivo by NMR imaging. It is shown that several important modifications must be made to this sequence to permit T1 to be measured accurately and reliably. With these modificat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910260109

    authors: Gowland PA,Leach MO

    更新日期:1992-07-01 00:00:00

  • Manganese-enhanced magnetic resonance imaging of mouse brain after systemic administration of MnCl2: dose-dependent and temporal evolution of T1 contrast.

    abstract::Manganese is a useful contrast agent for MRI of animals. Previously, it has been shown that systemic doses of MnCl(2) provide unique contrast in the rodent brain, enabling visualization of neuroarchitecture. The present work investigates the dose and temporal dependence of brain enhancement after i.v. administration o...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20368

    authors: Lee JH,Silva AC,Merkle H,Koretsky AP

    更新日期:2005-03-01 00:00:00

  • Model of the human vasculature for studying the influence of contrast injection speed on cerebral perfusion MRI.

    abstract::Simulations of dynamic susceptibility contrast (DSC) MRI are frequently performed by assuming a certain shape for the input function and the microvascular response function. However, to investigate the influence of parameters that will affect the shape of the input function, a more complex model of the human vasculatu...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10567

    authors: van Osch MJ,Vonken EJ,Wu O,Viergever MA,van der Grond J,Bakker CJ

    更新日期:2003-09-01 00:00:00

  • Inductively coupled Helmholtz coil on a dedicated imaging platform for the in vivo 1H-MRS measurement of intramyocellular lipids in the hind leg of rats.

    abstract::Skeletal muscle triglycerides are markers for insulin resistance in type 2 diabetes. Recently, MR spectroscopy was adapted for in vivo measurement of triglycerides in animal models and for the characterization of new therapeutic approaches. Because of small MR spectroscopy voxel sizes used in skeletal muscles, surface...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22149

    authors: Neumaier M,Niessen HG,Kaulisch T,Stiller D

    更新日期:2009-10-01 00:00:00

  • Sodium imaging of human brain at 7 T with 15-channel array coil.

    abstract::Signal-to-noise ratio (SNR) is a major challenge to sodium magnetic resonance imaging. Phased array coils have been shown significantly improving SNR in proton imaging over volume coils. This study investigates SNR advantage of a 15-channel array head coil (birdcage volume coil for transmit/receive and 15-channel arra...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24192

    authors: Qian Y,Zhao T,Wiggins GC,Wald LL,Zheng H,Weimer J,Boada FE

    更新日期:2012-12-01 00:00:00

  • Improved reproducibility of right ventricular volumes and function estimation from cardiac magnetic resonance images using level-set models.

    abstract::This study aims to assess whether an alternative method, that is based on volumetric surface detection (VoSD) without tracing and is totally free of geometric assumptions, can improve the reproducibility of right ventricular (RV) volume quantification from cardiac magnetic resonance (CMR) images, in comparison with a ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21157

    authors: Catalano O,Corsi C,Antonaci S,Moro G,Mussida M,Frascaroli M,Baldi M,Caiani E,Lamberti C,Cobelli F

    更新日期:2007-03-01 00:00:00

  • Metabolic assessment of a migraine model using relaxation-enhanced 1 H spectroscopy at ultrahigh field.

    abstract:PURPOSE:This study evaluates biochemical imbalances in a rat model that reflects dysfunctional pathways in migraine. The high sensitivity and spectral dispersion available to 1 H MRS at 21.1 T expands metabolic profiling in this migraine model to include lactate (Lac), taurine (Tau), aspartate, and Gly-a mixture of gly...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26811

    authors: Abad N,Rosenberg JT,Roussel T,Grice DC,Harrington MG,Grant SC

    更新日期:2018-03-01 00:00:00

  • Dynamic 31 P spectroscopic imaging of skeletal muscles combining flyback echo-planar spectroscopic imaging and compressed sensing.

    abstract:PURPOSE:Dynamic phosphorus MR spectroscopic imaging (31 P-MRSI) experiments require temporal resolution on the order of seconds to concurrently assess different muscle groups. A highly accelerated pulse sequence combining flyback echo-planar spectroscopic imaging (EPSI) and compressed sensing was developed and tested i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27682

    authors: Santos-Díaz A,Harasym D,Noseworthy MD

    更新日期:2019-06-01 00:00:00

  • A 32-channel lattice transmission line array for parallel transmit and receive MRI at 7 tesla.

    abstract::Transmit and receive RF coil arrays have proven to be particularly beneficial for ultra-high-field MR. Transmit coil arrays enable such techniques as B(1) (+) shimming to substantially improve transmit B(1) homogeneity compared to conventional volume coil designs, and receive coil arrays offer enhanced parallel imagin...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22413

    authors: Adriany G,Auerbach EJ,Snyder CJ,Gözübüyük A,Moeller S,Ritter J,Van de Moortele PF,Vaughan T,Uğurbil K

    更新日期:2010-06-01 00:00:00

  • Novel insights into in-vivo diffusion tensor cardiovascular magnetic resonance using computational modeling and a histology-based virtual microstructure.

    abstract:PURPOSE:To develop histology-informed simulations of diffusion tensor cardiovascular magnetic resonance (DT-CMR) for typical in-vivo pulse sequences and determine their sensitivity to changes in extra-cellular space (ECS) and other microstructural parameters. METHODS:We synthesised the DT-CMR signal from Monte Carlo r...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27561

    authors: Rose JN,Nielles-Vallespin S,Ferreira PF,Firmin DN,Scott AD,Doorly DJ

    更新日期:2019-04-01 00:00:00

  • Pulsatile flow artifacts in 3D magnetic resonance imaging.

    abstract::Some of the important features of how pulsatile flow generates artifacts in three-dimensional magnetic resonance imaging are analyzed and demonstrated. Time variations in the magnetic resonance signal during the heart cycle lead to more complex patterns of artifacts in 3D imaging than in 2D imaging. The appearance and...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300305

    authors: Frank LR,Buxton RB,Kerber CW

    更新日期:1993-09-01 00:00:00

  • Measuring extracellular volume fraction by MRI: First verification of values given by clinical sequences.

    abstract:PURPOSE:To verify MR measurements of myocardial extracellular volume fraction (ECV) based on clinically applicable T1-mapping sequences against ECV measurements by radioisotope tracer in pigs and to relate the results to those obtained in volunteers. METHODS:Between May 2016 and March 2017, 8 volunteers (25 ± 4 years,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27938

    authors: Nordlund D,Xanthis C,Bidhult S,Jablonowski R,Kanski M,Kopic S,Carlsson M,Engblom H,Aletras AH,Arheden H

    更新日期:2020-02-01 00:00:00

  • Direct imaging of hyperpolarized 129Xe alveolar gas uptake in a mouse model of emphysema.

    abstract::MRI of hyperpolarized (129)Xe dissolved in pulmonary tissues, and blood has the potential to offer a new tool for regional evaluation of pulmonary gas exchange and perfusion; however, the extremely short T2* and low magnetization density make it difficult to acquire the image. In this study, an ultrashort echo-time se...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24452

    authors: Iguchi S,Imai H,Hori Y,Nakajima J,Kimura A,Fujiwara H

    更新日期:2013-07-01 00:00:00