Abstract:
:A novel method based on selective detection of rapidly changing DeltaB(0) magnetic fields and suppression of slowly changing DeltaB(0) fields is presented. The ultimate goal of this work is to present a method that may allow detection of transient and subtle changes in B(0) in cortical tissue associated with electrical currents produced by neuronal activity. The method involves the detection of NMR phase changes that occur during a single-shot spin-echo (SE) echo-planar sequence (EPI) echo time. SE EPI effectively rephases all changes in B(0) that occur on a time scale longer than the echo time (TE) and amplifies all DeltaB(0) changes that occur during TE/2. The method was tested on a phantom that contains wires in which current can be modulated. The sensitivity and flexibility of the technique was demonstrated by modulation of the temporal position and duration of the stimuli-evoked transient magnetic field relative to the 180 RF pulse in the imaging sequence-requiring precise stimulus timing. Currently, with this method magnetic field changes as small as 2 x 10(-10) T (200 pT) and lasting for 40 msec can be detected. Implications for direct mapping of brain neuronal activity with MRI are discussed.
journal_name
Magn Reson Medjournal_title
Magnetic resonance in medicineauthors
Bodurka J,Bandettini PAdoi
10.1002/mrm.10159subject
Has Abstractpub_date
2002-06-01 00:00:00pages
1052-8issue
6eissn
0740-3194issn
1522-2594journal_volume
47pub_type
杂志文章abstract::The orientation dependence of the free induction decay (FID) of 1H NMR water signal in ex vivo bovine digital flexor tendon at the native level of hydration is reported. Residual dipolar coupling due to the overall tissue anisotropy produces a 6:1 change in the signal intensity as an angle between the long axis of a s...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20540
更新日期:2005-08-01 00:00:00
abstract:PURPOSE:A new T1 mapping method is proposed that is accurate, rapid, and robust to motion. Considering these features, the method is dubbed "T-One with Enhanced Robustness and Speed (TOWERS)." METHODS:TOWERS is composed of inversion recovery (IR) and saturation recovery (SR) acquisitions. In the IR acquisitions, a sli...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25864
更新日期:2016-07-01 00:00:00
abstract:PURPOSE:To investigate four-dimensional flow denoising using the divergence-free wavelet (DFW) transform and compare its performance with existing techniques. THEORY AND METHODS:DFW is a vector-wavelet that provides a sparse representation of flow in a generally divergence-free field and can be used to enforce "soft" ...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.25176
更新日期:2015-02-01 00:00:00
abstract::The aim of this study was to quantify changes in thoracic aortic wall shear stress (WSS) in asymptomatic patients with Marfan syndrome (MFS) compared with healthy controls. WSS in the thoracic aorta was quantified based on time-resolved 3D phase contrast MRI with three-directional velocity encoding (4D flow MRI, tempo...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.24562
更新日期:2013-10-01 00:00:00
abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27954
更新日期:2020-02-01 00:00:00
abstract::Metallic particles have shaped the use of magnetic resonance imaging (MRI) for molecular and cellular imaging. Although these particles have generally been developed for extracellular residence, either as blood pool contrast agents or targeted contrast agents, the coopted use of these particles for intracellular label...
journal_title:Magnetic resonance in medicine
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更新日期:2015-01-01 00:00:00
abstract::Generating flow-specific images (arteriograms, venograms) with optimal signal-to-noise ratios for time-resolved MR angiography is a conditional maximum problem, and its solutions are generalized matched filters. We have investigated six matched filters, corresponding to all possible combinations of three flow suppress...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.1910300511
更新日期:1993-11-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20221
更新日期:2004-10-01 00:00:00
abstract::We applied MRI to the in vivo detection of spontaneous colorectal tumors in a unique mouse model, the Fox Chase Cancer Center (FCCC) ApcMIN mouse. Unlike other Min (multiple intestinal neoplasia) strains, FCCC ApcMIN animals develop an appreciable number of tumors in the large intestine, which makes them an appropriat...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20175
更新日期:2004-09-01 00:00:00
abstract::Imaging delayed hyperenhancement of myocardial infarction is most commonly performed using an inversion recovery (IR) prepared 2D breathhold segmented k-space gradient echo (FGRE) sequence. Since only one slice is acquired per breathhold in this technique, 12-16 successive breathholds are required for complete anatomi...
journal_title:Magnetic resonance in medicine
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doi:10.1002/mrm.20061
更新日期:2004-05-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25399
更新日期:2015-07-01 00:00:00
abstract::MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequent...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.22605
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25195
更新日期:2015-03-01 00:00:00
abstract::Traditionally, the method of nonlinear least squares (NLLS) analysis has been used to estimate the parameters obtained from exponential decay data. In this study, we evaluated the use of Bayesian probability theory to analyze such data; specifically, that resulting from intravoxel incoherent motion NMR experiments. An...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910290510
更新日期:1993-05-01 00:00:00
abstract:PURPOSE:Continuously moving table (CMT) MRI is a high throughput technique that has multiple applications in whole-body imaging. In this work, CMT MRI based on golden angle (GA, 111.246° azimuthal step) radial sampling is developed at 3 Tesla (T), with the goal of increased flexibility in image reconstruction using arb...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25531
更新日期:2015-12-01 00:00:00
abstract:PURPOSE:Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27659
更新日期:2019-06-01 00:00:00
abstract:PURPOSE:Cross-term spatiotemporal encoding (xSPEN) is a single-shot approach with exceptional immunity to field heterogeneities, the images of which faithfully deliver 2D spatial distributions without requiring a priori information or using postacquisition corrections. xSPEN, however, suffers from signal-to-noise ratio...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26824
更新日期:2018-03-01 00:00:00
abstract::In vivo echo-planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion,...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910190220
更新日期:1991-06-01 00:00:00
abstract::Phase-contrast (PC) MRI is a noninvasive method for imaging blood and tissue velocity. PC experiments are typically segmented into many cardiac cycles in order to obtain sufficient spatial and temporal resolution, and thus require a gating signal to properly combine the data from multiple cardiac cycles. Although the ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.20187
更新日期:2004-09-01 00:00:00
abstract:PURPOSE:To study the feasibility of black-blood contrast in native T1 mapping for reduction of partial voluming at the blood-myocardium interface. METHODS:A saturation pulse prepared heart-rate-independent inversion recovery (SAPPHIRE) T1 mapping sequence was combined with motion-sensitized driven-equilibrium (MSDE) b...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26378
更新日期:2017-08-01 00:00:00
abstract::A new parallel imaging technique was implemented which can result in reduced image acquisition times in MRI. MR data is acquired in parallel using an array of receiver coils and then reconstructed simultaneously with multiple processors. The method requires the initial estimation of the 2D sensitivity profile of each ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/1522-2594(200008)44:2<301::aid-mrm18>3.0.c
更新日期:2000-08-01 00:00:00
abstract:PURPOSE:Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chel...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章,多中心研究
doi:10.1002/mrm.24854
更新日期:2014-06-01 00:00:00
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journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.27165
更新日期:2018-11-01 00:00:00
abstract::The combination of an in-plane B(1) sensitivity encoding (SENSE) technique with a simultaneous multiple-slice B(0) field step technique (multiple-acquisition micro B(0) array (MAMBA)) has produced high scan time reduction factors (R < or = 8). In this study, two slices were acquired simultaneously in combination with ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.10464
更新日期:2003-06-01 00:00:00
abstract::Human intervertebral discs were investigated by 1H NMR in vitro. The measured parameters of samples differently located in discs give the "maps" of discs. The spin-lattice relaxation-time maps show similar structure to dry matter and bound water maps, which might mean the future possibility to detect certain disc proc...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910030122
更新日期:1986-02-01 00:00:00
abstract:PURPOSE:To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. THEORY AND METHODS:A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter map...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.25421
更新日期:2015-08-01 00:00:00
abstract::Proton magnetic resonance spectroscopy ((1)H MRS) was used to determine brain temperature in healthy volunteers. Partially water-suppressed (1)H MRS data sets were acquired at 3T from four different gray matter (GM)/white matter (WM) volumes. Brain temperatures were determined from the chemical-shift difference betwee...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.21100
更新日期:2007-01-01 00:00:00
abstract:PURPOSE:In diffusion MRI, the actual b-value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image-based correction method for this problem is presented. METHODS:The apparent diffusion constant (ADC) of a water phantom was measured voxel-wise along 64 diffusio...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.28078
更新日期:2020-06-01 00:00:00
abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.1910220227
更新日期:1991-12-01 00:00:00
abstract:PURPOSE:A generalized intravoxel incoherent motion (IVIM) model, called the GIVIM, was proposed to better account for complex perfusion present in the tissues having various vessels and flow regimes, such as the liver. THEORY AND METHODS:The notions of continuous pseudodiffusion variable as well as perfusion fraction ...
journal_title:Magnetic resonance in medicine
pub_type: 杂志文章
doi:10.1002/mrm.26064
更新日期:2016-11-01 00:00:00