Toward direct mapping of neuronal activity: MRI detection of ultraweak, transient magnetic field changes.

Abstract:

:A novel method based on selective detection of rapidly changing DeltaB(0) magnetic fields and suppression of slowly changing DeltaB(0) fields is presented. The ultimate goal of this work is to present a method that may allow detection of transient and subtle changes in B(0) in cortical tissue associated with electrical currents produced by neuronal activity. The method involves the detection of NMR phase changes that occur during a single-shot spin-echo (SE) echo-planar sequence (EPI) echo time. SE EPI effectively rephases all changes in B(0) that occur on a time scale longer than the echo time (TE) and amplifies all DeltaB(0) changes that occur during TE/2. The method was tested on a phantom that contains wires in which current can be modulated. The sensitivity and flexibility of the technique was demonstrated by modulation of the temporal position and duration of the stimuli-evoked transient magnetic field relative to the 180 RF pulse in the imaging sequence-requiring precise stimulus timing. Currently, with this method magnetic field changes as small as 2 x 10(-10) T (200 pT) and lasting for 40 msec can be detected. Implications for direct mapping of brain neuronal activity with MRI are discussed.

journal_name

Magn Reson Med

authors

Bodurka J,Bandettini PA

doi

10.1002/mrm.10159

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

1052-8

issue

6

eissn

0740-3194

issn

1522-2594

journal_volume

47

pub_type

杂志文章
  • Water in tendon: orientational analysis of the free induction decay.

    abstract::The orientation dependence of the free induction decay (FID) of 1H NMR water signal in ex vivo bovine digital flexor tendon at the native level of hydration is reported. Residual dipolar coupling due to the overall tissue anisotropy produces a 6:1 change in the signal intensity as an angle between the long axis of a s...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20540

    authors: Krasnosselskaia LV,Fullerton GD,Dodd SJ,Cameron IL

    更新日期:2005-08-01 00:00:00

  • TOWERS: T-One with Enhanced Robustness and Speed.

    abstract:PURPOSE:A new T1 mapping method is proposed that is accurate, rapid, and robust to motion. Considering these features, the method is dubbed "T-One with Enhanced Robustness and Speed (TOWERS)." METHODS:TOWERS is composed of inversion recovery (IR) and saturation recovery (SR) acquisitions. In the IR acquisitions, a sli...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25864

    authors: Eldeniz C,Finsterbusch J,Lin W,An H

    更新日期:2016-07-01 00:00:00

  • Robust 4D flow denoising using divergence-free wavelet transform.

    abstract:PURPOSE:To investigate four-dimensional flow denoising using the divergence-free wavelet (DFW) transform and compare its performance with existing techniques. THEORY AND METHODS:DFW is a vector-wavelet that provides a sparse representation of flow in a generally divergence-free field and can be used to enforce "soft" ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25176

    authors: Ong F,Uecker M,Tariq U,Hsiao A,Alley MT,Vasanawala SS,Lustig M

    更新日期:2015-02-01 00:00:00

  • Aortic wall shear stress in Marfan syndrome.

    abstract::The aim of this study was to quantify changes in thoracic aortic wall shear stress (WSS) in asymptomatic patients with Marfan syndrome (MFS) compared with healthy controls. WSS in the thoracic aorta was quantified based on time-resolved 3D phase contrast MRI with three-directional velocity encoding (4D flow MRI, tempo...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.24562

    authors: Geiger J,Arnold R,Herzer L,Hirtler D,Stankovic Z,Russe M,Langer M,Markl M

    更新日期:2013-10-01 00:00:00

  • Automatic in-line quantitative myocardial perfusion mapping: Processing algorithm and implementation.

    abstract:PURPOSE:Quantitative myocardial perfusion mapping has advantages over qualitative assessment, including the ability to detect global flow reduction. However, it is not clinically available and remains a research tool. Building upon the previously described imaging sequence, this study presents algorithm and implementat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27954

    authors: Xue H,Brown LAE,Nielles-Vallespin S,Plein S,Kellman P

    更新日期:2020-02-01 00:00:00

  • Biodegradable, polymer encapsulated, metal oxide particles for MRI-based cell tracking.

    abstract::Metallic particles have shaped the use of magnetic resonance imaging (MRI) for molecular and cellular imaging. Although these particles have generally been developed for extracellular residence, either as blood pool contrast agents or targeted contrast agents, the coopted use of these particles for intracellular label...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,评审

    doi:10.1002/mrm.25263

    authors: Shapiro EM

    更新日期:2015-01-01 00:00:00

  • Generalized matched filtering for time-resolved MR angiography of pulsatile flow.

    abstract::Generating flow-specific images (arteriograms, venograms) with optimal signal-to-noise ratios for time-resolved MR angiography is a conditional maximum problem, and its solutions are generalized matched filters. We have investigated six matched filters, corresponding to all possible combinations of three flow suppress...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910300511

    authors: Wang Y,Weber DM,Korosec FR,Mistretta CA,Grist TM,Swan JS,Turski PA

    更新日期:1993-11-01 00:00:00

  • Quantifying the intra- and extravascular contributions to spin-echo fMRI at 3 T.

    abstract::Functional MRI (fMRI) by means of spin-echo (SE) techniques provides an interesting alternative to gradient-echo methods because the contrast is based primarily on dynamic averaging associated with the blood oxygenation level-dependent (BOLD) effect. In this article the contributions from different brain compartments ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20221

    authors: Jochimsen TH,Norris DG,Mildner T,Möller HE

    更新日期:2004-10-01 00:00:00

  • Detection and volume determination of colonic tumors in Min mice by magnetic resonance micro-imaging.

    abstract::We applied MRI to the in vivo detection of spontaneous colorectal tumors in a unique mouse model, the Fox Chase Cancer Center (FCCC) ApcMIN mouse. Unlike other Min (multiple intestinal neoplasia) strains, FCCC ApcMIN animals develop an appreciable number of tumors in the large intestine, which makes them an appropriat...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20175

    authors: Hensley HH,Chang WC,Clapper ML

    更新日期:2004-09-01 00:00:00

  • Fast, three-dimensional free-breathing MR imaging of myocardial infarction: a feasibility study.

    abstract::Imaging delayed hyperenhancement of myocardial infarction is most commonly performed using an inversion recovery (IR) prepared 2D breathhold segmented k-space gradient echo (FGRE) sequence. Since only one slice is acquired per breathhold in this technique, 12-16 successive breathholds are required for complete anatomi...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20061

    authors: Saranathan M,Rochitte CE,Foo TK

    更新日期:2004-05-01 00:00:00

  • Single acquisition electrical property mapping based on relative coil sensitivities: A proof-of-concept demonstration.

    abstract:PURPOSE:All methods presented to date to map both conductivity and permittivity rely on multiple acquisitions to compute quantitatively the magnitude of radiofrequency transmit fields, B1+. In this work, we propose a method to compute both conductivity and permittivity based solely on relative receive coil sensitivitie...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25399

    authors: Marques JP,Sodickson DK,Ipek O,Collins CM,Gruetter R

    更新日期:2015-07-01 00:00:00

  • Accelerated cardiac magnetic resonance imaging in the mouse using an eight-channel array at 9.4 Tesla.

    abstract::MRI has become an important tool to noninvasively assess global and regional cardiac function, infarct size, or myocardial blood flow in surgically or genetically modified mouse models of human heart disease. Constraints on scan time due to sensitivity to general anesthesia in hemodynamically compromised mice frequent...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.22605

    authors: Schneider JE,Lanz T,Barnes H,Stork LA,Bohl S,Lygate CA,Ordidge RJ,Neubauer S

    更新日期:2011-01-01 00:00:00

  • Combined dynamic contrast-enhanced liver MRI and MRA using interleaved variable density sampling.

    abstract:PURPOSE:To develop and evaluate a method for volumetric contrast-enhanced MRI of the liver, with high spatial and temporal resolutions, for combined dynamic imaging and MR angiography (MRA) using a single injection of contrast agent. METHODS:An interleaved variable density (IVD) undersampling pattern was implemented i...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25195

    authors: Salmani Rahimi M,Korosec FR,Wang K,Holmes JH,Motosugi U,Bannas P,Reeder SB

    更新日期:2015-03-01 00:00:00

  • On the use of Bayesian probability theory for analysis of exponential decay data: an example taken from intravoxel incoherent motion experiments.

    abstract::Traditionally, the method of nonlinear least squares (NLLS) analysis has been used to estimate the parameters obtained from exponential decay data. In this study, we evaluated the use of Bayesian probability theory to analyze such data; specifically, that resulting from intravoxel incoherent motion NMR experiments. An...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910290510

    authors: Neil JJ,Bretthorst GL

    更新日期:1993-05-01 00:00:00

  • Continuously moving table MRI with golden angle radial sampling.

    abstract:PURPOSE:Continuously moving table (CMT) MRI is a high throughput technique that has multiple applications in whole-body imaging. In this work, CMT MRI based on golden angle (GA, 111.246° azimuthal step) radial sampling is developed at 3 Tesla (T), with the goal of increased flexibility in image reconstruction using arb...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25531

    authors: Sengupta S,Smith DS,Welch EB

    更新日期:2015-12-01 00:00:00

  • A continuum of T 2 * components: Flexible fast fraction mapping in sodium MRI.

    abstract:PURPOSE:Parameter mapping in sodium MRI data is challenging due to inherently low SNR and spatial resolution, prompting the need to employ robust models and estimation techniques. This work aims to develop a continuum model of sodium T 2 ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27659

    authors: Syeda W,Blunck Y,Kolbe S,Cleary JO,Johnston LA

    更新日期:2019-06-01 00:00:00

  • Partial Fourier techniques in single-shot cross-term spatiotemporal encoded MRI.

    abstract:PURPOSE:Cross-term spatiotemporal encoding (xSPEN) is a single-shot approach with exceptional immunity to field heterogeneities, the images of which faithfully deliver 2D spatial distributions without requiring a priori information or using postacquisition corrections. xSPEN, however, suffers from signal-to-noise ratio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26824

    authors: Zhang Z,Frydman L

    更新日期:2018-03-01 00:00:00

  • Diffusion/perfusion MR imaging of acute cerebral ischemia.

    abstract::In vivo echo-planar MR imaging was used to measure apparent diffusion coefficients (ADC) of cerebral tissues in a comprehensive noninvasive evaluation of early ischemic brain damage induced by occlusion of the middle cerebral artery (MCA) in a cat model of acute regional stroke. Within 10 min after arterial occlusion,...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910190220

    authors: Kucharczyk J,Mintorovitch J,Asgari HS,Moseley M

    更新日期:1991-06-01 00:00:00

  • Flow-gated phase-contrast MRI using radial acquisitions.

    abstract::Phase-contrast (PC) MRI is a noninvasive method for imaging blood and tissue velocity. PC experiments are typically segmented into many cardiac cycles in order to obtain sufficient spatial and temporal resolution, and thus require a gating signal to properly combine the data from multiple cardiac cycles. Although the ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.20187

    authors: Thompson RB,McVeigh ER

    更新日期:2004-09-01 00:00:00

  • Black-blood native T1 mapping: Blood signal suppression for reduced partial voluming in the myocardium.

    abstract:PURPOSE:To study the feasibility of black-blood contrast in native T1 mapping for reduction of partial voluming at the blood-myocardium interface. METHODS:A saturation pulse prepared heart-rate-independent inversion recovery (SAPPHIRE) T1 mapping sequence was combined with motion-sensitized driven-equilibrium (MSDE) b...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26378

    authors: Weingärtner S,Meßner NM,Zöllner FG,Akçakaya M,Schad LR

    更新日期:2017-08-01 00:00:00

  • Sensitivity profiles from an array of coils for encoding and reconstruction in parallel (SPACE RIP).

    abstract::A new parallel imaging technique was implemented which can result in reduced image acquisition times in MRI. MR data is acquired in parallel using an array of receiver coils and then reconstructed simultaneously with multiple processors. The method requires the initial estimation of the 2D sensitivity profile of each ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/1522-2594(200008)44:2<301::aid-mrm18>3.0.c

    authors: Kyriakos WE,Panych LP,Kacher DF,Westin CF,Bao SM,Mulkern RV,Jolesz FA

    更新日期:2000-08-01 00:00:00

  • Multicenter validation of spin-density projection-assisted R2-MRI for the noninvasive measurement of liver iron concentration.

    abstract:PURPOSE:Magnetic resonance imaging (MRI)-based techniques for assessing liver iron concentration (LIC) have been limited by single scanner calibration against biopsy. Here, the calibration of spin-density projection-assisted (SDPA) R2-MRI (FerriScan®) in iron-overloaded β-thalassemia patients treated with the iron chel...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1002/mrm.24854

    authors: St Pierre TG,El-Beshlawy A,Elalfy M,Al Jefri A,Al Zir K,Daar S,Habr D,Kriemler-Krahn U,Taher A

    更新日期:2014-06-01 00:00:00

  • Effects of anesthesia on renal function and metabolism in rats assessed by hyperpolarized MRI.

    abstract:PURPOSE:Anesthesia is necessary for most animal studies requiring invasive procedures. It is well documented that various types of anesthesia modulate a wide variety of important metabolic and functional processes in the body, and as such, represent a potential limitation in the study design. In the present study, we a...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.27165

    authors: Qi H,Mariager CØ,Lindhardt J,Nielsen PM,Stødkilde-Jørgensen H,Laustsen C

    更新日期:2018-11-01 00:00:00

  • B1AC-MAMBA: B1 array combined with multiple-acquisition micro B0 array parallel magnetic resonance imaging.

    abstract::The combination of an in-plane B(1) sensitivity encoding (SENSE) technique with a simultaneous multiple-slice B(0) field step technique (multiple-acquisition micro B(0) array (MAMBA)) has produced high scan time reduction factors (R < or = 8). In this study, two slices were acquired simultaneously in combination with ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.10464

    authors: Paley MN,Lee KJ,Wild JM,Fichele S,Whitby EH,Wilkinson ID,Van Beek EJ,Griffiths PD

    更新日期:2003-06-01 00:00:00

  • In vitro 1H NMR "mapping" of human intervertebral discs.

    abstract::Human intervertebral discs were investigated by 1H NMR in vitro. The measured parameters of samples differently located in discs give the "maps" of discs. The spin-lattice relaxation-time maps show similar structure to dry matter and bound water maps, which might mean the future possibility to detect certain disc proc...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910030122

    authors: Furó I,Bobest M,Pócsik I,Tompa K

    更新日期:1986-02-01 00:00:00

  • Accelerated MR parameter mapping with low-rank and sparsity constraints.

    abstract:PURPOSE:To enable accurate magnetic resonance (MR) parameter mapping with accelerated data acquisition, utilizing recent advances in constrained imaging with sparse sampling. THEORY AND METHODS:A new constrained reconstruction method based on low-rank and sparsity constraints is proposed to accelerate MR parameter map...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.25421

    authors: Zhao B,Lu W,Hitchens TK,Lam F,Ho C,Liang ZP

    更新日期:2015-08-01 00:00:00

  • Determination of regional brain temperature using proton magnetic resonance spectroscopy to assess brain-body temperature differences in healthy human subjects.

    abstract::Proton magnetic resonance spectroscopy ((1)H MRS) was used to determine brain temperature in healthy volunteers. Partially water-suppressed (1)H MRS data sets were acquired at 3T from four different gray matter (GM)/white matter (WM) volumes. Brain temperatures were determined from the chemical-shift difference betwee...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.21100

    authors: Childs C,Hiltunen Y,Vidyasagar R,Kauppinen RA

    更新日期:2007-01-01 00:00:00

  • A comprehensive approach for correcting voxel-wise b-value errors in diffusion MRI.

    abstract:PURPOSE:In diffusion MRI, the actual b-value played out on the scanner may deviate from the nominal value due to magnetic field imperfections. A simple image-based correction method for this problem is presented. METHODS:The apparent diffusion constant (ADC) of a water phantom was measured voxel-wise along 64 diffusio...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.28078

    authors: Lee Y,Kettinger AO,Wilm BJ,Deichmann R,Weiskopf N,Lambert C,Pruessmann KP,Nagy Z

    更新日期:2020-06-01 00:00:00

  • Susceptibility contrast imaging of cerebral blood volume: human experience.

    abstract::Magnetic resonance (MR) can offer a unique window on the structure/function relationships in the brain, by utilizing the established link between tissue function, metabolism, and hemodynamics. This report focuses on recent applications of MR-based cerebral blood volume (CBV) imaging in humans. Our methodology uses hig...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.1910220227

    authors: Rosen BR,Belliveau JW,Aronen HJ,Kennedy D,Buchbinder BR,Fischman A,Gruber M,Glas J,Weisskoff RM,Cohen MS

    更新日期:1991-12-01 00:00:00

  • Generalization of intravoxel incoherent motion model by introducing the notion of continuous pseudodiffusion variable.

    abstract:PURPOSE:A generalized intravoxel incoherent motion (IVIM) model, called the GIVIM, was proposed to better account for complex perfusion present in the tissues having various vessels and flow regimes, such as the liver. THEORY AND METHODS:The notions of continuous pseudodiffusion variable as well as perfusion fraction ...

    journal_title:Magnetic resonance in medicine

    pub_type: 杂志文章

    doi:10.1002/mrm.26064

    authors: Kuai ZX,Liu WY,Zhang YL,Zhu YM

    更新日期:2016-11-01 00:00:00